The illustration below was presented XIV World Congress of Pharmacology July 7-12, 2002
![Role of NFkB and p44/42 pathways in lipopolysaccharide-induced increase of anandamide synthesis in RAW264.7 macrophages](https://webarchive.library.unt.edu/eot2008/20090113203916im_/http://www.niaaa.nih.gov/NR/rdonlyres/7447929D-6A72-4B1E-A14E-EB09D1FBC226/0/nfkb_role_med.gif)
In RAW264.7 macrophages LPS induces the synthesis of anandamide, but not 2-AG, via a transcriptional mechanism independent of PAF that involves NFkB and the p44/42 signaling pathways and most likely targets a NAPE-specific phospholipid D (PLD).
Updated: August 2002