• the designation of a different individual as the Institutional Official;
• administrative modifications that affect the reporting channels of the IACUC, the institutional official, or the veterinarian;
• modifications to IACUC procedures;
• change in the veterinarian designated as having program authority;
• change in the veterinarian's authority or responsibility;
• modifications to the occupational health program or the training program; and
• changes in the species or approximate numbers of animals housed at the institution.

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