Primate Resources

Center Access Criteria and Procedures

The National Primate Research Center (NPRC) facilities and resources enable NPRC staff scientists and investigators from the host institution and others across the country to collaborate on their research projects. The centers' specialized resources are intended to support investigators who receive their primary research project funding from NIH, but they also may be used by investigators who are funded by other federal, state, and local agencies, as well as by research foundations and the private sector. Together the NPRCs have more than 26,000 animals representing more than 20 species of nonhuman primates, mostly macaques.

Each NPRC has a Visiting Scientist Program that offers advanced training and research in nonhuman primate biology. Collaborative arrangements between investigators and center scientific staff are encouraged and can be developed on studies related to major human diseases, subject to the availability of resources and center staff time. Nonhuman primate blood samples, organs, and biological fluids are available through the NPRCs. The following standardized criteria and procedures have been implemented at each NPRC to facilitate utilization of center resources:

Access Criteria

• The nature and scope of the proposed research must be best conducted with nonhuman primates and be compatible with available center resources.
• The proposed research must have high scientific merit as determined by peer review.
• NIH–funded research takes precedence over research activities funded by other sources.
• Grants must contain appropriate budgets for the NPRC portion, including animal per diem costs.
• Availability of NPRC resources, including animals, space, research services and support, and special requirements—such as biosafety facilities— are also limiting factors that must be considered by the investigator.
• Because of potential contamination (e.g., viral, microbial), movement of animals into or out of the NPRC facilities is not allowed. Thus, the proposed research using live animals must use NPRC animals, and the research must be conducted at the NPRC.

Access Procedures

• An initial research proposal must be submitted by the researcher to the NPRC prior to submitting an application for funding. The director then consults with the research services, veterinary, and colony management staff members at the center to assess resource availability and project feasibility. (Note that special requests or conditions regarding animals of certain age, gender, weight, or other stipulations affect the NPRC's capability to meet the researcher's needs.)
• When resource availability and project feasibility have been established, the NPRC staff will provide budget information to the researcher regarding the center costs to be included in the formal research proposal.
• The scientific merit of the proposal must then be evaluated through the NIH peer review process or through a similar process at other agencies. However, small pilot projects with other funding sources may be considered. In the latter case, the peer review is conducted by the NPRC Research Advisory Committee.
• In addition to the scientific peer review, a protocol approved by the Institutional Animal Care and Use Committees (IACUC) at both the investigator's institution and the NPRC must be in place. Protocols must also be established to address biosafety concerns.
• When the investigator has received notification of funding, the NPRC director should be advised immediately so that the resources at the center may be reserved for the funded proposal.
• Biological materials such as blood samples, organ tissues, and biological fluids can be obtained by contacting the directors and staff of the NPRCs.

All publications resulting from research conducted at or with NPRC resources must bear an appropriate acknowledgment of NCRR support.

Inquiries

For additional information about the Visiting Scientist Program and resources available at a specific center, including applying to utilize a center's resources, contact the center director or appropriate contact person listed in this directory.

California National Primate Research Center

Research Emphasis/Objectives

The California National Primate Research Center (NPRC) is a research unit of the University of California, Davis. Its mission is to provide interdisciplinary programs in biomedical research on significant human health-related problems in which nonhuman primates are the most appropriate model for the research.

Current Research

The center has a diverse program of research utilizing nonhuman primates. Research projects encompass many aspects of biology and medicine, including AIDS and other infectious diseases; reproductive issues such as those associated with conception, pregnancy, and fetal growth and development; neurodegenerative conditions such as Alzheimer's disease; nutritional deficiencies; pulmonary disorders such as asthma, emphysema, and other chronic obstructive lung diseases; xenotransplantation; cell- and gene-based therapies; acute and chronic stress; temperament and biobehavioral organization; social relationships; neurobiology; cognitive function; and behavioral development.

Services Provided

Research units include brain, mind, and behavior; reproductive sciences; respiratory diseases; and virology and immunology; as well as an affiliate research program, core services, and the primate services and medicine division. Research opportunities are available for investigators from national and international institutions, as well as scientists within the UC Davis research community. The NPRC is also home to the Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases under the direction of Alice Tarantal, Ph.D.

To Outside Investigators

Specimens

Organs and tissues are provided when available; other biological samples are provided on special request. Shipping, collecting, and processing costs are charged to the requestor.

To Collaborating Scientists

Scientists wishing to conduct research at the center must have their projects reviewed and approved by the center director, research advisory committee, and campus animal care review committee. The center's services are available to collaborating scientists on a fee-for-service basis. Services include:

Core Science

Endocrine Core
Immunology Core
Inhalation Exposure Core
Computational Imaging Core
Pathogen Detection Core
Behavioral Assessment Core Contact Core Directors at 530-752-0447.

Primate Medicine

Preventive medicine and epidemiologic evaluation, surgery, radiology, therapeutics, specialized medical procedures.

Diagnostic Pathology and Clinical Laboratory Services

Bacteriology, biochemistry, hematology, parasitology, pathology, virology.

Animals

Center breeding colony: cynomolgus macaque ( Macaca fascicularis ), rhesus macaque ( M. mulatta ). Center research colony: Callicebus moloch, M. mulatta, M. fascicularis .

Contact Information

California National Primate Research Center
University of California, Davis
Davis, CA 95616

Web site: www.cnprc.ucdavis.edu

Grant No.: P51 RR000169

Center Director and Contact
Dallas M. Hyde, Ph.D.
530-752-0420; Fax: 530-754-6228
E-mail: dmhyde@ucdavis.edu

Additional Contact
Jenny Short
530-752-7169

Principal Investigator
Barry M. Klein, Ph.D.

The center is located on a 300-acre tract three miles from the main campus of the University of California, Davis. The university administers the center and provides its academic setting.

New England National Primate Research Center

Research Emphasis/Objectives

The New England National Primate Research Center support studies of HIV/SIV/AIDS, oncogenic herpesviruses, other infectious diseases, behavioral biology, neurodegenerative diseases, neurochemistry, brain imaging, and neuropharmacology.

Current Research

Use of simian immunodeficiency virus (SIV) as a model for AIDS in rhesus monkeys, host and viral determinants of AIDS pathogenesis, strategies for vaccine development, immune-based therapeutic strategies, pathogenesis of opportunistic infections. Elucidation of spontaneous diseases of nonhuman primates and development of new models for comparable human diseases. Neurobiology and behavioral pharmacology of cocaine abuse with emphasis on mechanisms of action, behavioral effects, and treatment. Use of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) model for Parkinson's disease, to develop imaging agents for chronic neurologic disorders, to monitor disease progression and effectiveness of therapeutic strategies. Drug discovery and development for central nervous system disorders.

Services Provided

To Outside Investigators

Specimens

Tissue specimens, organs, blood, skeletal structures, viral specimens, etc. Animals for approved research projects are provided from breeding colonies or other sources as required. Costs are normally assumed by the individual requesting the specimens.

To Collaborating Scientists

Scientists wishing to conduct research at the center must have projects reviewed and approved by the center's animal allocation committee. A brochure explaining the collaborative research program is available from the center. Most services are provided on a fee-for-service basis. They include veterinary services, animals and animal care, surgical and radiographic services, timed mating, biocontainment, pathology services, and professional and technical expertise.

Animals

Colonies of rhesus macaque ( Macaca mulatta ), cynomolgus macaque ( M. fascicularis ), common marmoset ( Callithrix jacchus ), and squirrel monkey ( Saimiri sciureus ). Other species can be obtained. Animals with exceptional characteristics (specific-pathogen-free, timed pregnancy, surgically altered, etc.) can be made available if needed.

Contact Information

New England National Primate Research Center
One Pine Hill Drive
P.O. Box 9102
Southborough, MA 01772-9102

Web site: www.hms.harvard.edu/nerprc

Grant No.: P51 RR000168

Center Director and Contact
Ronald C. Desrosiers, Ph.D.
508-624-8002; Fax: 508-460-0612
E-mail: ronald_desrosiers@hms.harvard.edu

Additional Contact
James T. Wortham, M.P.A.
508-624-8003
E-mail: james_wortham@hms.harvard.edu

Principal Investigator
Joseph B. Martin, M.D., Ph.D.

The center is located on 135 acres in Southborough, Massachusetts, about 30 miles from Boston. Harvard Medical School administers the center and provides its academic setting.

Oregon National Primate Research Center

Research Emphasis/Objectives

The Oregon National Primate Research Center supports studies in the reproductive sciences, neuroscience, pathobiology, and immunology.

Current Research

Control of folliculogenesis and the corpus luteum, factors that control sperm motility and maturation, hormonal control of parturition, steroid receptors in primate reproductive tract and brain tissues, implantation, in vitro fertilization, and embryonic stem cells. Neurological processes in regeneration of neural tissue, interactions between neural and immune systems, factors controlling differentiation and growth of neurons and glia, degenerative diseases, developmental neurobiology, and control of reproduction and of food intake. Pathobiology and immunology, human and animal models related to AIDS and other viral infections.

Services Provided

To Outside Investigators

Tissue specimens, organs, etc., when available. Costs are normally assumed by the requestor.

To Collaborating Scientists

Scientists wishing to conduct research must have their projects approved by the Institutional Animal Care and Use Committee and the research advisory subcommittee. Most services are provided on a fee-for-service basis. They include:

Medical Services

Physiological data, surgery, ultrasound, DEXA scanning.

Colony Operations

Primates, guinea pigs, mice, hamsters, rats, rabbits.

Pathology

Necropsies, tissue distribution, consultation.

Microscopy and Image Analysis Services

Confocal microscopy and stereology.

Data Processing

Comprehensive animal information system, consultation and support on statistical processing, extensive radioimmunoassay support.

Library

8,300 books, 15,250 bound journals, 200 journal subscriptions, MEDLARS searching services, PriMed database, Internet.

Endocrine Services Laboratory

Steroid and protein hormone radioimmunoassays.

Medical Illustrations and Photography

Animals

Japanese macaque ( Macaca fuscata ), rhesus macaque ( M. mulatta ), pigtailed macaque ( M. nemestrina ); includes an outdoor troop of about 300 M. fuscata and a colony of 3,800 M. mulatta .

Molecular Biology Core

DNA synthesis and sequencing, cDNA probes, real-time PCR, consultation.

Cell Culture Core

Maintenance of cell lines, media preparation.

Morphology Core

Tissue embedding and sectioning, immunohistochemistry, in situ hybridization.

Assisted Reproductive Technologies Core

Procedures related to in vitro fertilization, nuclear transfer, intracytoplasmic sperm injection, culture media, gamete preservation.

Electrophysiology Core

Provides electrophysiology recordings from neurons in brain slices, from cells in tissue explants, and from cultured cells that can be used to determine experimentally induced changes in the electrical properties of cells.

Contact Information

Oregon National Primate Research Center
505 N.W. 185th Avenue
Beaverton, OR 97006

Web site: onprc.ohsu.edu

Grant No.: P51 RR000163

Center Director and Contact
Nancy L. Haigwood, Ph.D.
503-690-5500; Fax: 503-690-5569
E-mail: HaigwooN@ohsu.edu

Additional Contact
P. Michael Conn, Ph.D.
503-690-5297; Fax: 503-690-5569
E-mail: connm@ohsu.edu

Principal Investigator
Joseph Robertson, M.D.

The center is located on the 247-acre Oregon Health Sciences University West campus 12 miles from downtown Portland. OHSU administers the center and provides its academic setting.

Southwest National Primate Research Center

Research Emphasis/Objectives

The Southwest National Primate Research Center (NPRC) supports studies of nonhuman primate models of human diseases, including common chronic diseases and infectious diseases and the effects that genetics and the environment have on physiological processes and disease susceptibility.

Current Research

Genetics

Genetic and environmental bases for susceptibility to atherosclerosis, hypertension, osteoporosis, obesity, and infectious diseases; construction of baboon and rhesus gene maps; genomic screening for disease-related genes; genetic management strategies for research colonies; development of new genetic analytic strategies and software.

Infectious Diseases

AIDS; hepatitis B, C, and E; herpes B and other herpesviruses; Chagas disease; emerging viral diseases; fundamental research and vaccine; and drug testing.

Neonatal Diseases

Bronchopulmonary dysplasia and chronic lung disease of infancy.

Physiology

Control of ingestive behavior, dietary effects on blood pressure, brain imaging, lipid metabolism, gene therapy.

Pathobiology

Spontaneous diseases and experimental models of diseases.

Behavior

Impact of enrichment strategies on behavior and well-being, genetic and endocrine effects on maternal behavior.

Services Provided

To Outside Investigators

The NPRC encourages the use of its resources by investigators from the national and international biomedical research communities. The NPRC is also available for collaborative research initiatives involving center staff and outside investigators. In general, expenses are assumed by the initiating investigator, and collaborative research efforts are covered by grants acquired collaboratively.

Specimens

Banked serum, tissue, and DNA samples; fresh blood, serum, plasma, tissues, and organs.

Animals

Baboon ( Papio ) species, chimpanzees ( Pan troglodytes ), rhesus macaques ( Macaca mulatta ), miscellaneous primate species, as required for specific research purposes.

Veterinary Technical Services

Timed pregnancies, tether, radiography, sonography, endoscopy, experimental surgery, experimental diets, nursery, behavioral assessment.

Pathology

Necropsies, clinical chemistry, hematology, histology, bacteriology, virology, parasitology.

Data Services

Colony database system, genetic analysis software, genetic typing services.

Contact Information

Southwest National Primate Research Center
Southwest Foundation for Biomedical Research
Post Office Box 760549
San Antonio, TX 78245-0549

Web site: www.snprc.org

Grant No.: P51 RR013986

Center Director
John L. VandeBerg, Ph.D.
E-mail: jlv@darwin.sfbr.org

Principal Investigator
John C. Kerr, J.D.

The center is located on the 397-acre campus of the Southwest Foundation for Biomedical Research, approximately 12 miles from downtown San Antonio and 7 miles from the University of Texas Health Science Center at San Antonio. The Southwest Foundation administers the center.

Tulane National Primate Research Center

Research Emphasis/Objectives

The Tulane National Primate Research Center is heavily focused on infectious disease research and also has a significant program in gene therapy that capitalizes on a unique colony of macaques with Krabbe disease.

Current Research

The major areas of infectious disease research at the Center are currently AIDS, Lyme disease, and biodefense-related agents, with additional programs involving tuberculosis, microsporidiosis, and malaria. The AIDS-related research is quite diverse, covering pathogenesis, vaccine development, microbicides, and the origins of AIDS. These are multidisciplinary studies involving investigators in numerous Divisions at the TNPRC and collaborators outside the Center. The gene therapy program involves both traditional viral-vector-mediated gene transfer as well as nonhuman primate mesenchymal and embryonic stem cells. For more information, visit: www.tnprc.tulane.edu

Services Provided - To Outside Invetigators

Specimens: Tissue specimens, blood, and other bodily fluids are provided when available. Collection, processing, and shipping costs are normally assumed by the requestor.

Services Provided - To Collaborating Scientists

The TNPRC provides highly integrated clinical and laboratory support for studies using nonhuman primates. This includes a full-time staff of clinical veterinarians and technicians and core services commonly used for infectious disease and gene therapy research including: 1) Diagnostic Parasitology; 2) Vector-Borne Diseases (maintains arthropods that are important for the study of vector-borne diseases); 3) DNA Microarray and Gene Expression; 4) Anatomic Pathology; 5) Clinical Pathology; 6) Molecular Pathology; 7) Confocal Microscopy and Image Analysis; 8) Flow Cytometry; 9) Cellular Immunology; 10) Virus Characterization, Isolation, and Production; 11) Pathogen Detection and Quantification; 12) Infectious Disease Aerobiology; 13) Genetics and Genome Banking; 14) Vector Development and Production; and 15) Nonhuman Primate Stem Cell Production. For more information, visit www.tnprc.tulane.edu/research_resou.html.

Animals

Rhesus macaques (Macaca mulatta) of both Indian and Chinese origin are available. Other species can be obtained. Most of the rhesus macaques are specific-pathogen free (B virus, SIV, SRV, and STLV1 negative).

Contact Information

Tulane National Primate Research Center
18703 Three Rivers Road
Covington, LA 70433

Web site: www.tnprc.tulane.edu

Grant No.: P51 RR000164

Center Director and Contact
Andrew A. Lackner, D.V.M., Ph.D., Dipl. A.C.V.P.
985-871-6201; Fax: 985-871-6569
E-mail: info@tpc.tulane.edu

Additional Contact
Mike W. Aertker, M.S.E., M.B.A.
985-871-6200
E-mail: aertker@tulane.edu

Principal Investigator
Benjamin P. Sachs, M.B., B.S., DPH, FACOG

The Center is part of the Tulane University Health Sciences Center along with the School of Medicine and School of Public Health & Tropical Medicine and is located on 500 acres near Covington, Louisiana, 35 miles from the main campus.

Washington National Primate Research Center

Research Emphasis/Objectives

The Washington National Primate Research Center is committed to facilitation of nonhuman primate-related research through collaborative efforts of core and affiliate scientists. Current biomedical research projects emphasize neurological sciences, animal models, AIDS, virology, immunogenetics, cardiovascular function, developmental biology, and endocrinology and metabolism.

Current Research

Core Staff

Primate neuroscience, neural control of limb movement, vestibular and oculomotor interactions, neural mechanisms of vision, molecular structure of neuronal membranes, animal model development, virology, viral pathogenesis, vaccine development, therapeutic evaluation, genetic regulation of B cell function, primate major histocompatibility complex, viral translation, intracellular signaling, transplantation, gene therapy, and immunology.

Affiliated Staff

Neurological Sciences

Structure and development of monkey visual cortex, auditory physiology, retinal development, basal ganglia function.

Animal Models

AIDS model systems, enteric pathogens, antiviral drugs, reproductive health, venereal disease, chlamydia, chancroid, fetal alcohol syndrome, parkinsonism, experimental allergic encephalomyelitis, systemic candidiasis.

Cardiovascular Disease and Function

Arterial smooth muscle cells in atherosclerosis, evaluating blood compatibility of biomaterials, fetal hemoglobin synthesis.

Developmental Biology

Hyaline membrane disease, respiratory distress syndrome, visual development, effect of epileptic drugs on development, cognitive development.

Endocrinology and Metabolism Research

Reproductive physiology, regulation of glucagon, role of somatostatin in physiology and control of somatostatin secretion, methanol effects, methylmercury effects, parenteral nutrition, bone loss and gain, diabetes endocrine research.

Transplantation and Prosthesis Development

Bone marrow transplantation, neurotransplantation, cochlear prosthetics, arterial graft development, stem cell transplantation, pancreatic transplantation.

Services Provided

Affiliate Scientists/Outside Investigators

The NPRC is committed to providing complete access to center resources for the research community to facilitate all aspects of nonhuman primate-related research. The center provides substantial assistance for collaborative research projects based at the center, including scientific and technical assistance with protocol development, grant submission, data collection and interpretation, and manuscript preparation. A computer database of more than 80,000 bibliographic records (1985 to present) of scientific literature on nonhuman primates is available for lease on PC-compatible computer systems. This database includes full citation and indexing information.

Primate Information Center

Develops indexes of comprehensive, worldwide bibliographic information regarding biomedical research on nonhuman primates. Provides published and custom bibliographies.

Primate Resource Referral Service
(formerly Primate Supply Information Clearinghouse)

Provides communication links—by telephone and through semimonthly publication of the New Listings Bulletin —between U.S. scientists in need of primates or tissues and institutions that can meet their needs. A registry of primate colonies and special services is being developed. This service is further described elsewhere in this Directory, and
at pin.primate.wisc.edu/idp/idp/entry/463

Tissue Distribution Program (TDP)

Provides samples of blood and all major tissues, either fresh, fixed, or frozen for shipment to investigators throughout the United States.

Pathology

Provides complete pathology services including gross necropsy, biopsy, histologic evaluation, special diagnostic staining, and immunohistochemical and in situ hybridization studies.

Scientific Illustration and Editing

Neurohistology

Immunologic Typing

Primate Colony Division

Primate health care, surgical procedures, imaging facilities, genetic characterization, clinical laboratory, round-the-clock nursery care, computerized genealogic and clinical records, psychological well-being, preventive medicine.

Biostructure Technology Laboratory

Bioengineering

Instrumentation development, computer programming.

Animals

Cynomolgus macaque ( Macaca fascicularis ), rhesus monkey ( M. mulatta ), pigtailed macaque ( M. nemestrina ), yellow baboon ( Papio cynocephalus ).

Collections

A broad variety of collections are archived encompassing developmental and physiologic data for the nonhuman primate.

Contact Information

Washington National Primate Research Center
University of Washington
I-421 Health Sciences
Box 357330
Seattle, WA 98195-7330

Web site: www.wanprc.org/WaNPRC

Grant No.: P51 RR000166

Center Director and Contact
David M. Anderson, D.V.M.
206-543-1430; Fax: 206-616-6771
E-mail: directorsoffice@bart.rprc.washington.edu

Tissue Distribution
206-543-6999
E-mail: necropsy@bart.NPRC.washington.edu

Principal Investigator
Sidney D. Nelson, Ph.D.

The center is located in the Warren G. Magnuson Health Sciences Center of the University of Washington and at the Western Facility Annex in Seattle.

Wisconsin National Primate Research Center

Research Emphasis/Objectives

The WNPRC's mission is to increase our understanding of basic primate biology and to improve human health and quality of life through research. To accomplish this, the WNPRC:

• Helps discover treatments, preventions and cures for human disease.
• Generates new knowledge of primate biology, from the molecular and whole animal levels to the understanding of primate ecosystems.
• Facilitates research progress by providing expertise, resources and training to scientists worldwide.
• Collects primate information and disseminates to the research community and to the public.

2008 Quick Facts:

• Personnel: The WNPRC supports research by more than 250 core and affiliate scientists from the UW-Madison, across the U.S. and around the world. Many graduate students and post-doctoral trainees also conduct research through the Center.
• Funding: $91 million including core and affiliate scientists' total funding. Of that, $38.5 million supporting subprojects using Primate Center resources. Of that, $4.2 million in non-federal funding, primarily foundations and industry.
• Colony: 1,411 animals: 1,106 rhesus macaques, 260 common marmosets, 45 cynomolgus macaques.
• Publications: 119 published and in press journal articles citing the WNPRC.

Current Research

The WNPRC supports three areas of major emphasis and a diverse affiliate program.

Aging and Metabolic Diseases

• Effects of caloric restriction on aging
• Obesity
• Diabetes mellitus
• Osteoporosis
• Ocular aging (glaucoma, presbyopia)
• Neurodegeneration
• Gene expression profiling
• Parkinson's Disease

Immunogenetics and Virology

• Simian immunodeficiency virus
• HIV vaccines
• Simian immunodeficiency virus
• MHC-defined animals
• Cytotoxic T-cells
• Molecular MHC analysis

Reproduction and Development

• Embryonic stem cell biology
• Fertility regulation
• Embryonic differentiation
• Maternal-fetal health
• Reproductive neuroendocrinology
• Polycystic ovarian syndrome
• Endometriosis
• Reproductive tract gene therapy

Services Provided

To Outside Investigators

Researchers interested in conducting research through the WNPRC and using one of the below services or resources should first contact our Centralized Protocol Implementation Unit (CPI).
 

CPI integrates and utilizes research service and animal service personnel and their talents to make research programs function in a precise and efficient manner. This integration serves as a gateway for the use of the NPRC and all its service units in research projects for both local and extramural principal investigators.
 

Research Services:

• Assay Services
• Genetics
• Immunology
• Virology

Research Resources:

• Aging Resource
• Stem Cell Resource

Animal Services:

• Behavioral Management Unit
• Colony Management Unit
• Compliance and Training Unit
• Veterinary Services Unit
• Pathology Services (tissue specimens, organs, other biological materials.)

To Collaborating Scientists

The center actively encourages researchers from the Midwest region and as well as national and international to use its facilities and services and to conduct collaborative studies. Scientists wishing to conduct research must have their projects reviewed and approved by the center director and advisory committees and have independent funding to cover costs. Most of the center's services are available on a fee-for-service basis.

Contact Information

Wisconsin National Primate Research Center
1220 Capitol Court
Madison, WI 53715-1299

Web site: www.primate.wisc.edu

Grant No.: P51 RR000167

Center Director and Contact
Joseph W. Kemnitz, Ph.D.
608-263-3500; Fax: 608-265-2067
E-mail: kemnitz@primate.wisc.edu

Additional Contacts
Jordana Lenon
Public Information and Outreach
608-263-7024
jlenon@primate.wisc.edu

Ray Hamel, M.L.S.
Library and Information Services
608-263-3512
E-mail: hamel@primate.wisc.edu
refdesk@primate.wisc.edu

Principal Investigator
Martin T. Cadwallader, Ph.D.

The center has approximately 120,000 square feet of laboratory, animal, office, and related support space on and near the University of Wisconsin-Madison campus. The UW-Madison Graduate School provides center's administrative support and academic setting.

Yerkes National Primate Research Center

Research Emphasis/Objectives

The Yerkes National Primate Research Center conducts biomedical and biobehavioral research to improve the health and well-being of human and nonhuman primates.

Current Research

Microbiology and Immunology

Primate models for research on AIDS pathogenesis, treatment, and vaccines; and for other infectious diseases including malaria.

Neuroscience

Molecular, cellular, and behavioral studies of drugs of abuse, especially cocaine; cognitive neuroscience and brain function.

Psychobiology

Endocrine and behavioral studies of primates living in complex social groups.

Visual Science

Developmental studies of visual function.

Services Provided

To Outside Investigators

Research proposals by investigators from other institutions are encouraged. Proposals should be submitted for review by the research advisory committee to ensure that resources are available. All proposals are reviewed by the Institutional Animal Care and Use Committee. Services available to outside investigators at approved rates include veterinary medicine, pathology, and biomedical engineering.

Animals

Rhesus macaque ( Macaca mulatta ), pigtailed macaque ( M. nemestrina ), cynomolgus macaque ( M. fascicularis ), sooty mangabey ( Cercocebus atys ), baboon ( Papio ) species, squirrel monkey ( Saimiri sciureus ), chimpanzees ( Pan troglodytes ), tufted brown capuchins ( Cebus apella ).

Service Cores

Brain imaging, DNA microarray, molecular pathology, virology, and radioimmunoassay.

Contact Information

Yerkes National Primate Research Center
Emory University
954 North Gatewood Road, N.E.
Atlanta, GA 30322

Web site: www.yerkes.emory.edu

Grant No.: P51 RR000165

Center Director and Contact
Stuart Zola, Ph.D.
404-727-7707; Fax: 404-727-0623
E-mail: szola@rmy.emory.edu

Principal Investigator
Michael M. E. Johns, M.D.

Center facilities include the Main Station on 25 acres of the Emory University campus in Atlanta and the 117-acre Field Station for psychobiology research in nearby Lawrenceville.

Baboon Research Resources

Research Emphasis/Objectives

The Baboon Research Resource conducts multidisciplinary studies on captive baboons and provides a resource of laboratory-born and laboratory-reared baboons for NIH-sponsored research programs. Additional objectives are to: maintain and provide available research facilities accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International; serve as a ready source of baboons ( Papio spp. ) of mixed ages and sex for use in biomedical and behavioral sciences; and provide professional staff necessary to support investigators' research needs.

Current Research

Current research activities involve characterizing the endogenous microorganisms of the conventional research baboon, improving methods for production of baboons in a captive environment, developing a specific-pathogen-free colony of baboons, developing vaccines, and testing genetic diversity among the baboon breeding population.

Services Provided

To Outside Investigators

The mission of the Oklahoma University Health Sciences Center (OUHSC) Baboon Research Resource is to support biomedical and behavioral research requiring the baboon as the animal model. The resource supports research investigators at the OUHSC and also serves as a national resource by supporting numerous investigators located at institutions across the United States. This resource enables NIH-funded investigators to purchase baboons for their research programs, subcontract with the resource to conduct the study on location at the OUHSC, or lease the baboons for conducting their studies and then return the baboons to the breeding colony. Together with the Oklahoma State University College of Veterinary Medicine, the Oklahoma State University Center for Health Sciences, and the Texas Tech University Health Sciences Center, the resource continues to further develop and improve the usefulness of the baboon as an animal model.

To Collaborating Scientists

Individuals interested in collaborative studies must provide a protocol to the principal investigator of the Baboon Research Resource. Approval of collaborative projects depends on the relevance of the proposed project to the objectives of the Baboon Research Resource, with preference given to NIH-funded studies. Complete animal husbandry, veterinary medical care, technical assistance, and pathology services are available to investigators who have approval from the principal investigator to use resource colony animals.

Animals

Adult, infant, and juvenile baboons are available.

Contact Information

Baboon Research Resources
University of Oklahoma Health Sciences Center
Division of Animal Resources
940 S. L. Young Boulevard, BMSB 203
Oklahoma City, OK 73190

Grant No.: P40 RR012317

Principal Investigator and Contact
Gary L. White, D.V.M., M.M.S.
405-271-5185; Fax: 405-271-2660
E-mail: gary-white@ouhsc.edu

Additional Contact
Richard W. Eberle, Ph.D.
405-744-8169; Fax: 405-744-5275
E-mail: reberle@okstate.edu

Caribbean Primate Research Center Program

Research Emphasis/Objectives

Cayo Santiago

Short- and long-term studies of social and sexual behavior, population genetics, demography, reproductive biology, psychopharmacology, functional morphological and spontaneous diseases (arthritis, osteoporosis, adult-onset macular degeneration, glaucoma, diabetes, obesity, hypertension), and parasitoses of rhesus monkeys maintained under seminatural conditions. Colony size: 900.

Sabana Seca Field Station

Headquarters of the Caribbean Primate Research Center (CPRC), specific-pathogen-free (SPF) rhesus breeding colony and biomedical research on spontaneous diseases (see above), reproductive biology and embryology, social behavior, endocrinology, medical genetics, vaccine development, and husbandry of Cayo Santiago-derived rhesus macaques maintained under a variety of housing configurations (individual cages, pens, and large corrals). Colony size: 800.

Laboratory for Primate Morphology and Genetics (formerly known as CPRC museum)

Anthropological and biomedical osteological research on 2,500 complete skeletons from 10 species of nonhuman primates, including more than 1,000 from Cayo Santiago rhesus monkeys of known identity, age, sex, matriline, and parity, and 175 skeletons from patas monkeys.

Virology Laboratories

Research on simian immunodeficiency virus (SIV, as a model for AIDS in rhesus monkeys) and on strategies for the development of vaccines against SIV and dengue viruses. This BL2/3 fully equipped laboratory also supports the SPF grants by performing serological testing of herpes, STLV-1, SRV, and SIV in rhesus macaques.

Services Provided

To Collaborating Scientists

CPRC welcomes collaborative research with established behavioral and biomedical investigators and encourages the use of its animal and osteological resources for dissertation research. Investigators are charged modest use fees for access to the animals, computerized database, and office space. All proposals receive rigorous peer review and are judged on scientific merit, feasibility, and potential overlap with ongoing studies. Protocols using live monkeys must be approved by the Institutional Animal Care and Use Committee (IACUC) of the home institution, as well as the University of Puerto Rico Medical Sciences Campus IACUC.

Contact Information

Caribbean Primate Research Center Program
University of Puerto Rico Medical Sciences Campus
P.O. Box 1053
Sabana Seca, PR 00952-1053

Web site: ucm.rcm.upr.edu/cprc.html

Grant No.: P40 RR003640

Principal Investigator and Contact
Edmundo N. Kraiselburd, Ph.D.
787-764-4325; Fax: 787-764-4325
E-mail: ekraiselburd@rcm.upr.edu

Mailing Address
Unit of Comparative Medicine
Office B-315
University of Puerto Rico School of Medicine
Medical Sciences Campus
P.O. Box 365067
San Juan, PR 00936-5067

Development of a Specific-Pathogen-Free Baboon Colony

Research Emphasis/Objectives

The baboon has long been used in biomedical research and for certain applications has considerable advantages over other primate species. Despite their widespread use in research, there is currently an acute shortage of baboons available for use. As is well appreciated for macaques, viruses constituting the normal flora of research animals can have a considerable effect on research results and their validity. Baboons are known to harbor analogs of many of the herpesviruses and retroviruses known to infect humans and other primates. Despite many years of successful breeding of baboons by various institutions, no colonies of specific-pathogen-free (SPF) baboons exist that are free of even one specific virus. The center is developing the beginning of a self-sustaining colony of baboons free of all known herpesviruses, four retroviruses, and SV40.

Current Research

To accomplish this goal, the center has established—in collaboration with co-investigators and consultants—serological and PCR tests for each of the 11 target viruses. These baboon viruses include six herpesviruses (analogs of human HSV, VZV, CMV, HHV6, EBV, and HHV8), four retroviruses (simian foamy virus, SRV/D, SIV, and STLV), and SV40. Twenty-four infant baboons are being recruited into the SPF program in each of the first five years, for a final total of at least 66 SPF baboons. All infants will be repeatedly tested for each of the target viruses. At one month of age, larger social groups of 4-6 SPF animals are formed. Beginning at 2-3 years of age, SPF animals will be integrated into larger socially compatible groups. These groups will eventually mature into breeding harems of SPF animals. This approach provides infants with age-matched companions for socialization during their early period of development, minimizes opportunities for transmission of viruses to the infants from adult animals, and allows for the simultaneous elimination of many different viruses from SPF animals.

Services Provided

When the program is fully developed, the goal is to provide healthy, behaviorally normal, SPF baboons that are free of all known herpesviruses, four retroviruses, and SV40.

Contact Information

Development of a Specific-Pathogen-Free Baboon Colony
University of Oklahoma Health Sciences Center
BMSB 203
940 S. L. Young Boulevard
Oklahoma City, OK 73190

Grant No.: R24 RR016556

Principal Investigator
Gary L. White, D.V.M.
405-271-5185; Fax: 405-271-2660
E-mail: gary-white@ouhsc.edu

Owl Monkey Breeding and Research Resource

Research Emphasis/Objectives

Research objectives are to carry out multidisciplinary studies of reproduction in owl monkeys (Aotus spp.), to search for models relevant to human health, and to provide a resource of laboratory-born and -reared animals for NIH-sponsored research programs.

Current Research

Research projects aim to characterize factors that influence captive reproduction, with emphasis on developing methods to improve reproductive potential. Additional studies aim to optimize the usefulness of owl monkeys in malaria research. A multidisciplinary approach—including behavioral science, reproductive endocrinology, medical primatology, pathology, and genetics—is used to meet research goals.

Services Provided

To Outside Investigators

Tissues and body fluids are available. Such specimens are provided on a priority basis to NIH-sponsored research studies that are related to the objectives of this project. Costs of packaging and shipping are negotiated on an individual basis, to be determined by the nature of the collaboration.

To Collaborating Scientists

Individuals interested in collaborative studies must provide a protocol to the principal investigator. Approval of collaborative projects depends on the relevance of the proposed project to the objectives of the ongoing research effort. Complete animal husbandry, medical care, and pathology services are available without charge to investigators who have received approval from the principal investigator to use resource colony animals.

Animals

The breeding colony currently contains approximately 300 owl monkeys of varying ages. Some offspring and reproductive culls are available.

Core Staff

Investigators conducting studies of medical primatology, reproductive endocrinology, data management, primate management and husbandry, primate behavioral psychology, veterinary pathology, and genetics are included within the research team.

Guest Investigators and Graduate Students

Guest investigators and graduate students interested in studies of factors influencing reproduction of owl monkeys and their usefulness in studies of human malaria are invited to send letters of interest. These letters will be considered based on the relevance of the applicant's interests to the ongoing research effort and the availability of resources to meet the needs of the guest investigator.

Contact Information

Owl Monkey Breeding and Research Resource
Center for Neotropical Primate Research Resources
College of Medicine
University of South Alabama
Mobile, AL 36688

Web site: www.CNPRR.org

Grant No.: R24 RR20052

Principal Investigator and Contact
Christian R. Abee, D.V.M.
251-460-6239; Fax: 251-460-7783
E-mail: cabee@mdandeerson.org

Squirrel Monkey Breeding and Research Resource

Research Emphasis/Objectives

Research objectives are to carry out multidisciplinary studies of reproduction in squirrel monkeys, to search for models relevant to human health, and to provide a resource of laboratory-born and -reared animals for NIH-sponsored research programs.

Current Research

Characterizing factors that influence captive reproduction with emphasis on developing methods to improve reproductive potential. A multidisciplinary approach—including behavioral studies, reproductive endocrinology, medical primatology, and genetics—is ongoing

Services Provided

To Outside Investigators

Tissues and body fluids are available. Such specimens are provided on a priority basis to NIH-sponsored research studies that are related to the objectives of this project. Costs of packaging and shipping are negotiated on an individual basis to be determined by the nature of the collaboration.

To Collaborating Scientists

Individuals interested in collaborative studies must provide a protocol to the principal investigator. Approval of collaborative projects depends on the relevance of the proposed project to the objectives of the ongoing research effort. Complete animal husbandry, medical care, and pathology services are available without charge to investigators who have received approval from the principal investigator to use resource colony animals.

Animals

The breeding colony currently contains approximately 450 squirrel monkeys of varying ages. Some offspring and reproductive culls are available.

Core Staff

Investigators conducting studies of medical primatology, reproductive endocrinology, data management, primate management and husbandry, primate behavioral psychology, and genetics.

Guest Investigators and Graduate Students

Guest investigators and graduate students interested in studies of factors influencing reproduction of squirrel monkeys in captivity are invited to send letters of interest. These letters will be considered based on the relevance of the applicant's interests to the ongoing research effort and the availability of resources to meet the needs of the guest investigator.

Contact Information

Squirrel Monkey Breeding and Research Resource
Center for Neotropical Primate Research and Resources
College of Medicine
University of South Alabama
Mobile, AL 36688

Web site: www.cnprr.org

Grant No.: P40 RR001254

Principal Investigator and Contact
Christian R. Abee, D.V.M.
251-460-6239; Fax: 251-460-7783
E-mail: cabee@mdanderson.org

Vervet Research Colony

Research Emphasis/Objectives

The colony emphasizes development of the vervet as an alternative to the rhesus monkey for biomedical research applications. The objectives are to provide SPF animals, husbandry information, access to the pedigreed and genotyped colony for research manipulations, and access to the repository for hypothesis testing and pilot data generation.

Current Research

Current research includes assessment of: 1) genetic, neurobiological, and behavioral correlates of obesity, insulin resistance, diabetes, osteoporosis, and osteoarthritis; 2) genetic, developmental, and neurobiological influences on traits related to vulnerability for psychopathology; and 3) social, endocrine, and dietary effects on pregnancy outcomes and individual development across the lifespan.

Services Provided

This resource will provide approximately 100 animals per year for biomedical research, including some selected for particular traits (e.g., old age, insulin resistance, and impulsivity) or genotypes. Individuals wishing to collaborate on site can be provided with access to the colony for phenotypic or genetic assessment or for the conduct of discrete experiments. Technical support and complete anatomic and clinical pathology services are available. There is also scientific support for statistical genetic analyses.

Contact Information

Wake Forest University Primate Center
Wake Forest University School of Medicine
Medical Center Blvd.
Winston-Salem NC 27157-1040

E-mail: wfupc@wfubmc.edu

Web Site: http://www.wfubmc.edu/wfupc

Grant No.: P40 RR019963

Principal Investigator and Contact
Jay R. Kaplan, Ph.D.
336-716-1522; Fax: 336-716-1515
E-mail: jkaplan@wfubmc.edu

Additional Contact
Matthew J. Jorgensen, Ph.D.
336-716-6935; Fax 336-716-1515

Alamogordo Primate Facility

Research Emphasis/Objectives

The Alamogordo Primate Facility (APF) houses chimpanzees that have been used in biomedical research, but no active, invasive research is conducted on the site.

Services Provided

The APF provides for the long-term care and husbandry of chimpanzees that have been used in biomedical research. Charles River Laboratories Inc. operates the facility under contract with the National Institutes of Health. To be used in continuing virological research, the animals must be transferred to active chimpanzee research settings.

Animals

All chimpanzees at the APF have been exposed to various microorganisms, such as hepatitis C virus and HIV. For this reason, they may be candidates for studies related to these diseases. The National Center for Research Resources (NCRR) may remove infected animals from the APF to other accredited chimpanzee facilities for research purposes. Investigators interested in the chimpanzees at the APF should contact Dr. Harold Watson in NCRR's Division of Comparative Medicine to discuss research requirements. Dr. Watson can be reached at 301-435-0744.

Contact Information

Alamogordo Primate Facility
Holloman Air Force Base
Alamogordo, NM 88330

Contact
Harold Watson, Ph.D.
301-435-0744; Fax: 301-480-3819
E-mail: watsonh@mail.nih.gov

University of Louisiana at Lafayette

Research Emphasis/Objectives

The center maintains and provides available research facilities accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International; a ready source of chimpanzees of mixed ages and sex for use in biomedical and behavioral sciences, and also provides professional staff necessary to support investigators with their research needs.

Current Research

Vaccine development and testing; pharmacokinetic, pharmacodynamic, preclinical safety, and efficacy studies.

Services Provided

The University of Louisiana at Lafayette-New Iberia Research Center (UL Lafayette-NIRC) is an AAALAC-International-accredited nonhuman primate research facility dedicated to the support of basic and applied biomedical and behavioral research. All proposed programs must be approved by the presenting institution and the UL Lafayette-NIRC animal care and use committees. State-of-the-art biomedical support facilities are available that include access to ultrasound, radiography with automatic processor and computer imagery for diagnostic enhancement, and endoscopy and laparoscopy with video monitors, camera and color photo imagery.

Diagnostic Laboratory

A 12,000-square-foot laboratory is available for investigators' research support requirements. Capabilities within the laboratory include—but are not limited to—hematology, chemistry, microbiology, urinalysis, parasitology, and histology. Among the investigator support procedures are Ficoll gradient isolation of peripheral blood mononuclear cells, platelet aggregation profiles, nonhuman primate lymphocyte proliferation assay, and flow cytometry (lymphocyte enumeration). Emergency generator power is accessible in each laboratory unit and for all major instrumentation and critical freezers.

Animals

The center cares for approximately 360 chimpanzees and 5,500 New and Old World species of nonhuman primates. In addition to chimpanzees, the following species of nonhuman primates are being bred at the center: Vervet monkey ( Chlorocebus aethiops ), cynomolgus macaque ( Macaca fascicularis ), pigtailed macaque ( M. nemestrina ), rhesus macaque ( M. mulatta ).

Contact Information

University of Louisiana at Lafayette
New Iberia Research Center
4401 West Admiral Doyle Drive
New Iberia, LA 70560

Web site: nirc.louisiana.edu

Grant No.: U42 RR015087

Principal Investigator and Contact
Thomas J. Rowell, D.V.M.
337-482-0225; Fax: 337-373-0057
E-mail: tjr7173@louisiana.edu

University of Texas

Research Emphasis/Objectives

Research objectives are to provide physically and behaviorally healthy chimpanzees for critical biomedical research and testing; to conduct relevant research projects of benefit to chimpanzee health, productivity, and well-being.

Current Research

Develop and improve techniques of captive management; investigate behavioral factors influencing improvements in the husbandry and well-being of chimpanzees; support collaborative programs in genetic management.

Services Provided

A demographically balanced group of approximately 100 physically and behaviorally healthy chimpanzees to meet current and future research and testing needs in the United States. The colony is housed in eight 4,500-square-foot outdoor corrals in multiple-male family groups. Complete facilities and services are available for visiting scientists. Chimpanzees are available to investigators supported by NIH grants and contracts.

Biological Materials

Tissues and body fluids are available when coordinated with preventive health care procedures.

Contact Information

University of Texas
M. D. Anderson Cancer Center
Department of Veterinary Sciences
650 Cool Water Drive
Bastrop, TX 78602

Web site: http://mdanderson.org

Grant No.: U42 RR015090

Contact
William Satterfield, D.V.M.
512-321-3991; Fax: 512-332-5208
E-mail: wsatterf@mdanderson.org

Principal Investigator
Christian R. Abee, D.V.M.

Chimpanzee Management Program

Description

The NIH Chimpanzee Management Program (ChiMP) supports long-term, cost-effective housing and maintenance at NCRR-supported facilities for chimpanzees. NCRR provides programmatic oversight of the facilities and ensures they comply with the Animal Welfare Act, and policies concerning laboratory animal care and use. READ MORE >>

Contact Information
National Center for Research Resources
National Institutes of Health
One Democracy Plaza
6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874

Contact
William T. Watson, D.V.M., M.S.
301-435-0744; Fax: 301-480-3819
E-mail: WatsonWm@mail.nih.gov

Caribbean Primate Research Center SPF Rhesus Monkey Program

Research Emphasis/Objectives

The objective of this program is to establish, and maintain, a specific-pathogen-free (SPF) rhesus macaque supply and breeding colony program at the Sabana Seca Field Station of the Caribbean Primate Research Center (CPRC). The CPRC program will make a significant contribution to advancing AIDS research by providing high-quality and healthy SPF rhesus monkeys to NIH-sponsored research programs. The CPRC program uses genetically characterized, MHC-typed, Indian-origin monkeys from the CPRC's free-ranging colony on the island of Cayo Santiago. The CPPC will donate the founding stock for the colony from its Cayo Santiago and Cayo Santiago-derived populations. Previous surveys have shown that the Cayo Santiago macaques are free of several important viruses, including retroviruses and simian virus 40 (SV-40), and that the majority of immature animals are negative for B-virus (Herpesvirus simiae or Cercopithecine herpesvirus type 1. About 20-25 percent of these monkeys are also Mamu-A*01 positive. Currently, there is a shortage of SPF rhesus monkeys for biomedical research, and the demand for these animals is expected to increase dramatically in the future. The establishment and maintenance of this program at the Sabana Seca Field Station will help meet the increased demand for both SPF (B-virus, SRV-D, SIV, STLV-1, and SV-40-free) and Mamu-A*01 positive rhesus monkeys. Forty-five SPF females and nine SPF males (nine breeding groups) will be added to the colony each year through internal recruitment from Cayo Santiago and the Sabana Seca Field Station. MHC-typing and selective breeding will be used to increase the production of SPF Mamu-A*01 positive offspring. By year five, the program will have supplied 106 offspring including about 30 Mamu-A*01 positive animals.

Current Research

The virology laboratory conducts research on recombinant DNA vaccines using rhesus macaques and performs viral tests for herpes B-virus, STLV, and SIV. The BL 2/3 Virology Laboratory has allowed CPRC to establish the SPF program under the sponsorship of NCRR, and one of its major objectives is to support ongoing SPF programs. The laboratory serves as a platform of research in vaccine development (SHIV, SIV, dengue) and in genetics. This laboratory provides services to the conventional and SPF CPRC colonies (viral serology) and is collaborating with mainland investigators (Centers for Disease Control and Prevention) in SHIV vaccine protocols involving rhesus macaques.

Services Provided

CPRC welcomes collaborative research with established behavioral and biomedical investigators and encourages the use of its animal and osteological resources for dissertation research. Investigators are charged modest use fees for access to the animals, computerized database, and office space. All proposals receive rigorous peer review and are judged on scientific merit, feasibility, and potential overlap with ongoing studies. Protocols using live monkeys must be approved by the Institutional Animal Care and Use Committee (IACUC) of the home institution, as well as the University of Puerto Rico Medical Sciences Campus IACUC.

Contact Information

University of Puerto Rico
Medical Sciences Campus
P.O. Box 1053
Sabana Seca, PR 00952-1053

Web site: ucm.rcm.upr.edu/cprc.html

Grant No.: U42 RR16021

Principal Investigator and Contact
Edmundo N. Kraiselburd, Ph.D.
787-764-4325; Fax: 787-764-4325
E-mail: ekraiselburd@rcm.upr.edu

Mailing Address
Unit of Comparative Medicine
Office B-315
University of Puerto Rico School of Medicine
Medical Sciences Campus
P.O. Box 365067
San Juan, PR 00936-5067

Enhancement of the CPRC SPF Rhesus Monkey Program

Research Emphasis/Objectives

The objective of this program is to enhance the existing specific-pathogen-free (SPF) rhesus macaque supply and breeding colony program at the Sabana Seca Field Station of the Caribbean Primate Research Center (CPRC). This program uses genetically characterized, MHC-typed, Indian-origin monkeys from established social groups obtained from the CPRC's free-ranging colony on the island of Cayo Santiago. The CPRC will donate the founding stock for the colony, which consists of 102 adult and 21 juvenile females and a minimum of 20 sires. The establishment and maintenance of this expanded program at the Sabana Seca Field Station will help meet the increased demand for both SPF (B-virus, SRV-D, SIV, and STLV-1-free) and Mamu-A*01 positive rhesus monkeys. The founding cohort is expected to produce a minimum of 70 infants during the first year and an estimated total offspring of about 400 SPF animals in five years. The CPRC's program provides high-quality and healthy SPF rhesus monkeys to NIH-sponsored research programs.

Current Research

The virology laboratory conducts research on recombinant DNA vaccines using rhesus macaques and performs viral tests for herpes B-virus, STLV, and SIV. The BL 2/3 Virology Laboratory has allowed CPRC to establish the specific-pathogen-free program under the sponsorship of NCRR, and one of its major objectives is to support ongoing SPF programs. The laboratory serves as a platform of research in vaccine development (SHIV, SIV, dengue) and in genetics. This laboratory provides services to the conventional and to the SPF CPRC colonies (viral serology) and is collaborating with mainland investigators (Centers for Disease Control and Prevention) in SHIV vaccine protocols involving rhesus macaques.

Services Provided

CPRC welcomes collaborative research with established behavioral and biomedical investigators and encourages the use of its animal and osteological resources for dissertation research. Investigators are charged modest use fees for access to the animals, computerized database, and office space. All proposals receive rigorous peer review and are judged on scientific merit, feasibility, and potential overlap with ongoing studies. Protocols using live monkeys must be approved by the Institutional Animal Care and Use Committee (IACUC) of the home institution, as well as the University of Puerto Rico Medical Sciences Campus IACUC.

Contact Information

University of Puerto Rico
Medical Sciences Campus
P.O. Box 1053
Sabana Seca, PR 00952-1053

Web site: ucm.rcm.upr.edu/cprc.html

Grant No.: U24 RR18108

Principal Investigator and Contact
Edmundo N. Kraiselburd, Ph.D.
787-764-4325; Fax: 787-764-4325
E-mail: ekraiselburd@rcm.upr.edu

Mailing Address
Unit of Comparative Medicine
Office B-315
University of Puerto Rico School of Medicine
Medical Sciences Campus
P.O. Box 365067
San Juan, PR 00936-5067

Establishment of a SPF Rhesus Macaque Colony in Texas

Research Emphasis/Objectives

This project will produce Indian-origin rhesus monkeys ( Macaca mulatta ) that are specific-pathogen-free (SPF) for herpes B virus, SIV, SRV, and STLV-1. The proposed colony will produce high quality genetically characterized animals for use in AIDS-related research by NIH grantees.

Contact Information

Southwest Foundation for Biomedical Research
Department of Comparative Medicine
P.O. Box 760549
San Antonio, TX 78245-0549

Grant No.: U24 RR18108

Principal Investigator
Larry B. Cummins, D.V.M.
210-258-9549; Fax: 210-670-3305
E-mail: bcummins@icarus.sfbr.org

Expansion of a SPF Rhesus Colony in Louisiana

Research Emphasis/Objectives

The center's objective is development of a specific-pathogen-free (SPF) rhesus monkey (Macaca mulatta) breeding colony. Animals derived from the colony are limited to use for AIDS research. Nonhuman primates derived from the colony are seronegative for simian immunodeficiency virus (SIV), simian T -lymphotrophic virus (STLV-1), type D retrovirus (SRV), and cercopithecine herpesvirus 1 (CHV1 or B-virus). The retroviruses (SIV, STLV-1 and SRV), when present in animals used for AIDS studies, may confound research data. B-virus is hazardous to humans and is being eliminated to protect personnel coming in contact with infected animals or their tissues.

Services Provided

SPF rhesus monkeys may be requested for AIDS research by contacting the principal investigator. The Tulane Resource Allocation Committee has responsibility for allocating animal resources to NIH-funded investigators. To apply for allocation of SPF rhesus monkeys, investigators must first complete an application form, which is available from the principal investigator.

Contact Information

Tulane National Primate Research Center
18703 Three Rivers Road
Covington, LA 70433

Grant No.:U24 RR18111

Principal Investigator
Rudolf P. Bohm, Jr., D.V.M.
985-671-6266; Fax: 985-871-6388
E-mail: bohm@tulane.edu

Additional Contact
James L. Blanchard, D.V.M., Ph.D.
985-871-6285
E-mail: jblanch1@tulane.edu

Production of Pedigreed SPF Rhesus Macaques in California

Research Emphasis/Objectives

The objective of this program is to produce pedigreed rhesus macaques of Indian origin that are free of selected viral pathogens. These agents include: Cercopithecine herpesvirus 1 (herpes B), simian immunodeficiency virus (SIV), simian T-lymphotropic virus 1, type D retrovirus, and simian foamy virus (SFV). These animals are of known pedigrees confirmed by microsatellite testing and are also typed for Mamu-A*01 alleles by the UC Davis Veterinary Genetics Laboratory. Colony status is confirmed by frequent viral screening through the Simian Retroviral Core Laboratory.

Current Research

Research programs are in place to use assisted reproductive technology strategies to expand numbers of Mamu-A*01 positive animals and other genotypes that may be of specific research interest. The center is also identifying additional viral pathogens to be excluded from the specific-pathogen-free (SPF) population. Genetic studies are under way to determine whether A*01 positive individuals are heterozygous or homozygous.

Services Provided

Animals

Scientists wishing to use pedigreed Indian origin rhesus macaques should contact the principal investigator. Scientists wishing to conduct research at the California National Primate Research Center should contact the director. Information for research access to the primate center is available on the center's Web site .

Other Services

Pedigree analysis and MHC typing for rhesus macaque is available through the UC Davis Veterinary Genetics Laboratory.

Contact Information

California National Primate Research Center
University of California, Davis
One Shields Avenue
Davis, CA 95616-8542

Web site: www.cNPRC.ucdavis.edu

Grant No.: U42 RR016023
U24 RR018144

Principal Investigator and Contact
Nicholas Lerche, D.V.M.
530-752-6490; Fax: 530-752-2880
E-mail: nwlerche@ucdavis.edu

SPF Indian Rhesus Monkey Colony in Louisiana

Research Emphasis/Objectives

The center's objective is development of a specific-pathogen-free (SPF) rhesus monkey ( Macaca mulatta ) breeding colony. Animals derived from the colony are limited to use for AIDS research. Nonhuman primates derived from the colony are seronegative for simian immunodeficiency virus (SIV), simian T-lymphotrophic virus (STLV-1), type D retrovirus (SRV), and Cercopithecine herpesvirus 1 (CHV1 or B-virus). The retroviruses (SIV, STLV-1, and SRV), when present in animals used for AIDS studies, may confound research data. B-virus is hazardous to humans and is being eliminated to protect personnel from coming in contact with infected animals or their tissues.

Services Provided

SPF rhesus monkeys may be requested for AIDS research by contacting the principal investigator. The Tulane Resource Allocation Committee has responsibility for allocating the animals to NIH-funded investigators. To apply for allocation of SPF rhesus monkeys must first complete an application form, which is available through the principal investigator.

Contact Information

Tulane National Primate Research Center
18703 Three Rivers Road
Covington, LA 70433

Grant No.: U42 RR016026

Principal Investigator
James L. Blanchard, D.V.M., Ph.D.
985-871-6285
E-mail: blanch1@tulane.edu

Additional Contact
Rudolf P. Bohm, Jr., D.V.M.
985-871-6266; Fax:985-871-6388
E-mail: bohm@tulane.edu

Specific-Pathogen-Free Rhesus Monkeys in Oregon

Research Emphasis/Objectives

Research objectives are to: Enhance the Oregon National Primate Research Center's specific-pathogen-free (SPF) Indian-origin rhesus macaque breeding resource to support AIDS research by increasing the number of pedigreed, genetically diverse females in the breeding colony. Manage the resource for the production of major histocompatibility complex (MHC)-defined offspring of known parentage for use in AIDS-related research through the use of breeder males that are homozygous for MHC alleles that are important for assessing cell-mediated immune function in vaccine development.

Current Research

The center's SPF Indian-origin rhesus macaque breeding programs have target female breeder populations of 250 and 125, respectively. All adults and juveniles are free of simian immunodeficiency virus, T-lymphotrophic virus 1, type D simian retroviruses, and Herpesvirus simiae. Frequent microbiologic monitoring is performed to ensure SPF status. Research objectives focus on maintaining pedigreed, genetically diverse female breeders and production of offspring with defined MHC class 1 haplotypes. Polymorphic microsatellite analyses are used to verify parentage, select appropriate males, and monitor genetic diversity in the colonies. Selective breeding of MHC-typed animals and assisted reproductive technology are used to enhance production of offspring with desired MHC haplotypes. The SPF definition is being expanded in the U24-supported colony to include additional viral agents that are useful as models of opportunistic infections in AIDS research or as vectors for vaccine development such as cytomegalovirus, rhadinovirus, spumaretrovirus, and simian virus 40.

Services Provided

Animals

SPF juvenile Indian-origin rhesus macaques, primarily males, are available for sale to NIH grantees and other qualifying investigators for AIDS-related research. Blood samples and other tissues and body fluids obtainable using routine, noninvasive clinical procedures are available to qualifying investigators with appropriate institutional approvals for research animal use. Cost estimates for collection, packaging, and shipping are available upon request. Allocation of animals produced under this cooperative agreement will be determined by a coordinating committee in consultation with the NCRR program administrator to ensure equitable distribution.

Other Services

The center's resources are available to collaborative NIH grantees with appropriate animal care and use approval and institutional contractual agreements. Resources include veterinary clinical services, biological safety level 3 laboratory and animal containment facilities, anatomic pathology, clinical pathology, microbiology, and flow cytometry. Further information on the collaboration research program is available from the associate director's office. Contact P. Michael Conn, Ph.D., 503-690-5297, e-mail: connm@ohsu.edu

Contact Information

Oregon National Primate Research Center
Oregon Health Sciences University, West Campus
Division of Pathobiology and Immunology
505 N.W. 185th Avenue
Beaverton, OR 97006-3499

Web site: onprc.ohsu.edu

Grant No.: U42 RR16025
U24 RR18107

Principal Investigator and Contact
Michael K. Axthelm, D.V.M.
503-690-5236; Fax: 503-690-5524
E-mail: axthelmm@ohsu.edu

Additional Contact
Gary S. Heckman, D.V.M.
503-690-5516; Fax: 503-614-3736
E-mail: heckmang@ohsu.edu

Washington M. nemestrina SPF Breeding Colony

Research Emphasis/Objectives

Nonhuman primate species have proven to be invaluable resources for AIDS research in several fields, including vaccine development, therapeutic agent discovery, and pathogenesis. Well-defined models of AIDS currently exist in Macaca nemestrina, utilizing a large number of primate lentiviruses and other infectious agents. Washington NPRC plans to expand the size of a small colony of SPF M. nemestrina breeding animals to provide a significant increase in the long-term availability of appropriate nonhuman primates. In addition, the center will expand a similar colony located in Indonesia. Access to feral animals is not limited in this country of origin, and the center will take advantage of this to quickly expand the existing SPF M. nemestrina colony to breed SPF offspring that will be transferred to the United States.

Current Research

Create an M. nemestrina breeding colony free of Mycobacterium tuberculosis (TB); simian immunodeficiency virus; simian retrovirus, all subtypes; simian T-lymphoptrophic virus, and Cercopithecine herpesvirus 1 for application to AIDS-related NIH research projects. Expand the M. nemestrina breeding colony in Bogor, Indonesia, to provide SPF juveniles negative for the same five agents above.

Contact Information

Washington National Primate Research Center
University of Washington
Box 357330; Health Sciences Center, Room I-421
Seattle, WA 98195-7330

Web site: www.wanprc.org/wanprc

Grant No.: U24 RR018114

Principal Investigator
David M. Anderson, D.V.M.
206-616-4583; Fax: 206-616-1710
E-mail: danderson@u.washington.edu

Yerkes National Primate Research Center SPF Breeding Colonies

Research Emphasis/Objectives

The objective of this program is to manage and breed a colony of rhesus macaques of Indian origin that are free of selected viral pathogens. These agents include: Cercopithecine herpesvirus 1 (herpes B), simian immunodeficiency virus (SIV), simian T-lymphotrophic virus 1; and type D retrovirus. These animals are pedigreed by microsatellite testing and are also typed for Mamu-A*01 alleles.

Current Research

The central objective of this project is to maintain and expand specific-pathogen-free (SPF) breeding colonies of macaque monkeys at the Yerkes National Primate Research Center (NPRC). As a conservative projection, if production in the SPF colony remains equal to or exceeds its present production of some 125 animals per year (with all females retained), the combination of retained births from the SPF colony and identification of virus-free infants from the non-SPF colony will provide for growth of 150-175 animals per year in the SPF colony. Other significant results include beginning the genetic characterization of the entire SPF colony for pedigree analysis in the laboratory of Dr. Jeff Rogers at the Southwest NPRC.

Services Provided

SPF juvenile Indian-origin rhesus macaques, primarily males, are available to NIH grantees and other qualifying investigators for AIDS-related research. Blood samples and other tissues and body fluids that can be collected via noninvasive clinical procedures are available to qualifying investigators with appropriate institutional approvals for research animal use. Costs to services are set by NIH policy and are posted on the Yerkes NPRC Web site .

Contact Information

Emory University
954 North Gatewood Road, NE
Atlanta, GA 30322

Web site: www.yerkes.emory.edu

Grant No.: U24 RR018109

Principal Investigator and Contact
Thomas P. Gordon, D.V.M.
404-727-7844; Fax: 404-727-8061
E-mail: gordon@rmy.emory.edu

Additional Contact
James Else, D.V.M.
404-727-9710; Fax: 404-727-9401
E-mail: jelse@rmy.emory.edu

Construction of a Targeted Rhesus Macaque Microarray

Research Emphasis/Objectives

The objective is to obtain nonhuman primate sequences for the purposes of producing NHP expression arrays, SNP discovery and genotyping.

Current Research

Various methods were used to determine the 3' end of all human genes. This information was then used to select human primers that amplified the 3' end of rhesus orthologs of human genes from rhesus macaque genomic DNA. Sequences were deposited in GenBank's Sequence Tagged Site database and were used by Affymetrix to construct a whole-genome rhesus macaque GeneChip, which became available for purchase in June 2005. The resource Web site includes information on the genes represented on the GeneChip, plus links to GenBank records for sequences of those genes. The primers developed for the rhesus project are now being applied to two additional projects. First, 3' UTR sequences are being obtained for the vervet monkey, toward the goal of developing a vervet expression array. Second, the primers are being used in a SNP discovery project that will aid the genotyping of rhesus macaques.

Services Provided

NHP sequences, expression arrays, SNP discovery, genotyping.

Contact Information

Department of Genetics, Cell Biology & Anatomy
University of Nebraska Medical Center
Omaha, NE 68198-6395

Web site: rhesusgenechip.unomaha.edu

Grant No.: R24 RR017444

Principal Investigator and Contact
Robert Norgren, Ph.D.
402-559-8891; Fax: 402-559-7328
E-mail: rnorgren@unmc.edu

Additional Contact
Eliot Spindel
503-690-5512; Fax: 503-690-5384
E-mail: spindele@ohsu.edu

Creation of a Nonhuman Embryo Gene Expression Resource

Research Emphasis/Objectives

The Primate Embryo Gene Expression Resource (PREGER) contains a collection of nearly 200 amplified cDNA libraries from rhesus monkey oocytes and embryos representing a wide variety of experimental conditions. The purpose of PREGER is to provide interested investigators with access to molecular reagents needed for gene expression analysis in nonhuman primate embryos, at vastly reduced cost and labor.

Current Research

The resource is being expanded to incorporate samples of stem cells for studies related to stem cell biology. Determinants of oocyte quality are being sought through a novel suppression-subtraction hybridization method developed for application to the cDNA libraries contained in the resource.

Services Provided

The resource can produce and distribute amplified cDNA libraries in solution, phage libraries, dot blot hybridization membranes for gene expression analysis, primer sequences, and available human or rhesus monkey cDNA probes. The resource also houses an online searchable gene expression database, and a Web site containing methods, contacts, bibliography, and other tools. Registered users also receive a periodic newsletter about relevant advances in primate embryology. Collaborative arrangements in which gene expression patterns of specific genes are examined, or users contribute new experimentally manipulated samples that can then be analyzed in conjunction with a broader core set of samples, thereby reducing investigator expense, are also welcomed.

Contact Information

The Fels Institute for Cancer Research and Molecular Biology
Temple University School of Medicine
3307 North Broad Street
Philadelphia, PA 19140

Web site: www.preger.org

Grant No.: R24 RR15253

Principal Investigator and Contact
Keith Latham, Ph.D.
215-707-7577; Fax: 215-707-1454
E-mail: klatham@temple.edu

Genetic Typing Laboratory

Research Emphasis/Objectives

Objectives of the laboratory are to: Identify and characterize previously unknown polymorphisms (including PCR-amplified mitochondrial DNA, Y-chromosome, and microsatellite DNA or STR loci); study the effectiveness of alternative genetic management strategies and the effect of demographic factors on the population/genetic structure of captive groups of primates; identify marker loci for genes that influence susceptibility to retroviral, B-virus, and other infections; and employ both ancient and contemporary mitochondrial DNA and microsatellite DNA loci for studies of ancestor-descendant relationships.

Services Provided

To Collaborating Scientists and Graduate Students

All principal investigators of NIH-supported specific-pathogen-free (SPF) breeding programs or their designees are eligible to request genetic marker analysis on rhesus macaques ( Macaca mulatta ), crab-eating macaques ( M. fascicularis ), pigtailed macaques ( M. nemestrina ), and other species of Macaca and Papio in SPF colonies; identify paternity; calculate kinship and inbreeding coefficients; determine country of origin; estimate parameters of genetic diversity, genetic subdivision, and founder representation within the colony; collaborate with principal investigators on colony management strategies and on research involving those data; and amplify and sequence noncoding control region of mitochondrial DNA extracted from modern and prehistoric (e.g., skeletal) material.

Contact Information

University of California, Davis
Department of Anthropology
209 Young Hall
Davis, CA 95616

Web site: www.anthro.ucdavis

Grant No.: R24 RR05090

Principal Investigator
David Glenn Smith, Ph.D.
530-752-6343, 8570, or 6665; Fax: 530-752-8885
Message: 530-752-0745
E-mail: dgsmith@ucdavis.edu

Additional Contacts
John W. McDonough
530-752-8570
E-mail: jwmed@ucdavis.edu

Debra George
530-752-8570
E-mail: dageorge@ucdavis.edu

Herpes B-Virus Diagnosis: National Resource Laboratory

Research Emphasis/Objectives

To identify B-virus infections in humans and macaques and study basic pathogenesis mechanisms of this and other neurotropic herpesviruses; to develop control and prevention strategies for B-virus infections in both humans and macaques. All samples evaluated by the resource can be used in ongoing research studies.

Current Research

Assessment of evolutionary conservation among alpha-herpesviruses by biochemical, immunological, and molecular biological approaches; development of recombinant reagents; identification of effective antiviral strategies and design of putative vaccines; elucidation of host-virus interactions during pathogenesis; collaborative identification/exploration of putative alpha-herpesviruses not previously described.

Services Provided

Diagnostic Services

This laboratory resource is designed to provide rapid virological and serological analyses to identify Herpesvirus simiae (B virus) infections in humans and nonhuman primates, particularly macaques. Virological analyses are performed by virus isolation, polypeptide analysis, DNA restriction endonuclease analyses, and experimental polymerase chain reaction. Serological analyses include enzyme-linked immunosorbent assay (ELISA), competition ELISA, and Western blot analyses. The laboratory also provides telephone and mail information to requestors seeking assistance for identifying infections, and/or CDC-derived information for handling human or macaque cases of B-virus infection. Staff are available for collaboration in investigating cases of B-virus infection in humans and nonhuman primates. Resource staff perform all diagnostic services adjacent to the herpesvirus research laboratory of the principal investigator. This proximity permits consultation with and additional assistance from staff members when required.

Other Services

Specialized biocontainment laboratory (BCL-4) facilities, investigation of new animal models of herpesvirus disease, antiviral testing, epidemiological analyses of alpha-herpesvirus outbreaks, necropsy and autopsy assistance for virological analyses of B-virus infections, assistance in developing specific-pathogen-free SPF primate colonies, and isolation/characterization of nonhuman primate alpha-herpesvirus.

Fees

Cost reimbursement for procedures performed to identify potential B-virus infections in humans and nonhuman primates is requested to maintain the resource.

Contact Information

Georgia State University
Viral Immunology Center
Department of Biology
50 Decatur Street
Atlanta, GA 30302-4118

Web site: www.gsu.edu/bvirus

Grant No.: P40 RR005062

Principal Investigator and Contact
Julia K. Hilliard, Ph.D.
404-651-0808; Fax: 404-651-0821
Emergency: 404-358-8168
E-mail: biojkh@panther.gsu.edu

Additional Contact
Richard Henkel, Ph.D.
404-651-0813; Fax: 404-651-0821
E-mail: biordh@panther.gsu.edu

Nete Priest
404-651-0808; Fax: 404-651-0814
E-mail: bioyyp@panther.gsu.edu

Luminex Reagents for NHP Research

Research Emphasis/Objectives

The research objective of this resource is to facilitate and expand the use of the Luminex technology for the detection of multiple NHP cytokines in small sample volumes.

Current Research

We have tested a large number of mono- and polyclonal antibodies against human cytokines in order to improve the breadth and analytical power of our 23-plex NHP Luminex panel by increasing the number of detectable molecules in Old World monkey species. We have also cloned, sequenced and expressed IFN-a, IL-4, IL-6, IL-10, IL-18, and TNF-a from marmoset in order to generate recombinant antibodies that will be used as Luminex reagents for this NHP specie.

Services Provided

Diagnostic Services

Website with NHP crossreactivity for antibodies. Novel antibodies will be distributed to scientists who justify their need on cost-recovery bases. Detection of cytokines in body fluids and cell culture supernatant from Old World Monkeys in a fee-for-service basis.

Contact Information

Southwest National Primate Research Center
Southwest Foundation for Biomedical Research
7620 NW Loop 410
San Antonio, TX 78227

Web site: http://www.sfbr.org/pages/snprc_projects.php?p=60

Grant No.: R24 RR023345

Principal Investigator and Director
Luis D. Giavedoni, Ph.D.
210-258-9603; Fax: 210-670-3310
E-mail: Lgiavedo@sfbr.org

Additional Contact
Vida L. Hodara
210-258-9683; Fax: 210-670-3310
E-mail: vhodara@sfbr.org

NIH Nonhuman Primate Reagent Resource

Research Emphasis/Objectives

The objective of the NIH Nonhuman Primate Reagent Resource is to facilitate the use of nonhuman primate models of disease by providing reagents for targeting cell subsets or immune pathways in vivo. This is accomplished by developing new reagents specific for nonhuman primate proteins and by optimizing existing reagents for in vivo use in the nonhuman primate species.

Current Research

Current research is exploring the in vivo effectiveness of mouse/human, mouse/rhesus, fully-human and fully-rhesus recombinant monoclonal antibodies directed against cell targets. The goal is to develop reagents for administration to nonhuman primates that provide the optimal efficiency and duration of effect.

Services Provided

The resource provides antibodies for in vivo administration and for in vitro diagnostics in nonhuman primates. A database of commercial reagents that cross react with 12 different nonhuman primate species is maintained on the website. The resource also provides nonhuman primate recombinant proteins, reference reagents and cell lines.

Contact Information

Beth Israel Deaconess Medical Center
Division of Viral Pathogenesis
Center for Life Sciences 1038
3 Blackfan Circle
Boston, MA 02115

Web site: http://NHPReagents.bidmc.harvard.edu

Grant No.: R24 RR016001

Principal Investigator and Director
Keith A. Reimann, D.V.M.
617-735-4476; Fax: 617-735-4527
E-mail: kreimann@bidmc.harvard.edu

Additional Contact
Kristine Regione, Adm. Asst.
617-667-4583; Fax: 617-667-8210
E-mail: kregione@bidmc.harvard.edu

Primate Genomics

Research Emphasis/Objectives

The center's objective is to develop the resources necessary to apply the technologies of functional genomics to nonhuman primate research. Central to this effort is the construction of macaque cDNA libraries, large-scale expressed sequence tag (EST) sequencing, and the production of macaque oligonucleotide microarrays.

Current Research

The resources being developed are tested in the context of integrated model systems, with particular emphasis on SIV infection of the rhesus macaque. The goal is to develop and make available physical and informational genomic resources to foster hypothesis-driven research using nonhuman primates and to increase understanding of a primary model for AIDS research.

Services Provided

cDNA libraries or clones from a variety of macaque tissues, macaque EST database, macaque oligonucleotide microarray.

Contact Information

Washington National Primate Research Center
University of Washington
Box 358070
Seattle, WA 98195-8070

Web site: www.macaque.org

Grant No.: R24 RR16354

Principal Investigator
Michael G. Katze, Ph.D.
206-732-6136; Fax: 206-732-6056
E-mail: honey@u.washington.edu

Additional Contact
Shawn Iadonato, Ph.D.
206-378-0400; Fax: 206-378-0408
E-mail: siadonato@illumigen.com

Resource for Nonhuman Primate Immune Reagents

Research Emphasis/Objectives

Research objectives include characterizing, cloning, and quality testing nonhuman primate cytokines and immune cell-associated molecules in vitro and in vivo. Derivation of cytokines with extended bioavailability.

Current Research

Ongoing preparation of recombinant rhesus IL-2, IL-4, IL-7, IL-10, IL-12, IL-15, and Ig fusion cytokines. Custom preparation of cytokine- and cell-associated molecule expression vectors. Testing of adjuvant effect of defined immune enhancers in nonhuman primates. Cloning of new cytokines, receptors, and signaling molecules (IL-17, 21, 23, IL-7Ra, IL-15Ra, TIM3, FoxP3, etc.).

Services Provided

Distribution of nonhuman primate cytokine/immune molecule cDNAs for analysis and expression. Custom preparation of cytokine- and cell-associated molecule expression vectors. Custom preparation of recombinant cytokines. Custom cloning of new molecules from nonhuman primates. Expertise in cytokine analysis.

Contact Information

Department of Pathology and Laboratory Medicine
Emory University School of Medicine
1639 Pierce Drive, WMRB Room 2339
Atlanta, GA 30322

Web site: pathology.emory.edu/Villinger/index.htm

Grant No.: R24 RR016988

Principal Investigator
François Villinger, D.V.M., Ph.D.
404-712-2838; Fax: 404-712-1771
E-mail: fvillin@emory.edu

Additional Contact
Chadi Filfili
404-712-1767; Fax: 404-712-1771
E-mail: rnhpir@emory.edu