1: Cancer Res. 2002 Jun 15;62(12):3335-9.
Related Articles, Links
Click here to read
Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.

Lal A, Glazer CA, Martinson HM, Friedman HS, Archer GE, Sampson JH, Riggins GJ.

Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.

The gene most commonly altered in human glioblastomas is the epidermalgrowth factor receptor (EGFR). We profiled transcripts induced by mutantEGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did make glioblastoma cells both more motile and invasive using in vitro assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) selectively down-regulated these molecular effectors in glioblastoma cells, eliminating enhanced invasion.

Publication Types:
PMID: 12067969 [PubMed - indexed for MEDLINE]