Summaries & Associations of Study Results
TR-424 o-Benzyl-p-Chlorophenol
Target Organs and Levels of Evidence
NTP Technical Report Number 424
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| O-BENZYL-P-CHLOROPHENOL 120-32-1 |
12/01/92 | GERMICIDE IN DISINFECTANT SOLUTIONS AND SOAP. (TDB) | Gavage MR: 0,30,60,120, FR: 0,60,120,240, M: 0,120,240,480 MG/KG/50 PER GROUP | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INCREASED SEVERITY OF NEPHROPATHY | |||
| PARATHYROID GLAND: HYPERPLASIA | ||||
| BONE: CRANIAL FIBROUS OSTEODYSTROPHY; FEMUR FIBROUS OSTEODYSTROPHY | ||||
| GLANDULAR STOMACH: MINERALIZATION | ||||
| FR: EQUIVOCAL EVIDENCE | KIDNEY TRANSITIONAL CELL: CARCINOMA 0/50 0/50 1/51 1/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INCREASED SEVERITY OF NEPHROPATHY | |||
| MM: SOME EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA 0/50 2/50 2/50 2/50 OR CARCINOMA 0/50 0/50 2/50 1/50 COMBINED 0/50 2/50 4/50 3/50; (STEP SECTIONS) ADENOMA 0/50 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 1/50 0/50 COMBINED 0/50 1/50 3/50 3/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INCREASED INCIDENCE AND SEVERITY OF NEPHROPATHY | |||
| BONE: FIBROUS OSTEODYSTROPHY | ||||
| GLANDULAR STOMACH: MINERALIZATION | ||||
| FM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INCREASED INCIDENCE AND SEVERITY OF NEPHROPATHY | |||
| BONE: FIBROUS OSTEODYSTROPHY | ||||
| GLANDULAR STOMACH: MINERALIZATION | ||||
Web page last updated on February 10, 2006
