Figure 2: Model of Edg-1 functions in blood vessel development
Edg-1 knockout mice demonstrate that Edg-1 is essential for vascular maturation by impairing the recruitment of smooth muscle cells (SMCs) to vessel walls. SPP, found in blood, may directly stimulate Edg-1 on SMCs, facilitating their migration to vessels walls. In a second mechanism, which does not exclude the first, SPP could stimulate Edg-1 expressed on endothelial cells (ECs), which in turn recruit SMCs.
For details, see Liu Y, Wada R, Yamashita T, Mi Y, Deng CX, Hobson JP, Rosenfeldt HM, Nava VE, Chae SS, Lee MJ, Liu CH, Hla T, Spiegel S, Proia RL. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. Journal of Clinical Investigation 106(8):951-961, 2000. [Entrez].
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