Projects and Investigators

FY 2004 Projects

Dartmouth Medical School

Objective

Bulk synthesis of a new triterpenoid, ethyl 2-carboxy-3,12-dioxooleana-1,9(11)-dien-28-oate (NSC #D722320, TP-222).

Program Description

Several new synthetic triterpenoids have shown chemopreventive and chemotherapeutic activities including growth inhibition of leukemia and carcinoma cells, induction of tumor cell differentiation, and suppression of de novo synthesis of COX-2 and iNOS. TP-222 has been synthesized to overcome pharmacokinetic limitations of previous triterpenoids and has shown a promising in vivo activity. The RAPID support will include bulk synthesis of 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) for further evaluation of chemopreventive activity.

Contact Information:

Dr. Michael B. Sporn
Dartmouth Medical School
Dartmouth, NH
Tel: 603-650-6557
Fax: 603-650-1129
E-mail: Michael.B.Sporn@Dartmouth.edu

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