Teams

Project

Investigators

NHLBI
CC, INOVA Fairfax Hospital

"Antiproliferative Therapy for Severe Pulmonary Arterial Hypertension"

PI: R. Machado, MD, NHLBI
PI: M. Boehm, MD, NHLBI
AIs: M.J. Cuttica, MD, A. Cochard, and C. Barnett, MD, CC Critical Care Medicine Department; M. Gladwin, MD, NHLBI; S. Nathan, MD, INOVA Fairfax Hospital

NICHD
University of Oxford (UK)

"Characterization of Glycosphingolipid Accumulation in Smith-Lemli-Opitz Syndrome and Treatment with N-butyldsoxynojirimycin"

PI: F. Porter, MD, PhD, NICHD
PI: F. Platt, PhD, Oxford

NHLBI
CC, University of Maryland

"Life-Threatening Pulmonary Complications of Organ Transplantation: An Investigation of the Pathogenesis of Bronchiolitis Obliterans and Its Novel Treatment with Aerosolized Liposomal Cyclosporine A"

PI: R. Childs, MD, NHLBI; A.T. Iacono, MD, University of Maryland
PI: A. Suffredini, MD, CC Critical Care Medicine Department; M.L. Terrin, MD, University of Maryland
AIs: R. Danner, MD, CC Critical Care Medicine Department; B. Griffith, MD, University of Maryland

NIAID
Uniformed Services University of the Health Sciences NCI, NHGRI, CC, University of California, San Francisco

"Role of Pathogen-specific IgE and histamine release in the hyper-IgE syndrome"

PI: A. Freeman, MD, S. Holland, MD, NIAID
PI: E. Mitre, MD, USUHS
AIs: from NCI, NHGRI, NIAID, CC, USUHS and UCSF

NICHD, NEI, NIDCR, NIMH, NIDDK Georgetown University Medical Center Uniformed Services University of the Health Sciences

"WAGR Syndrome: Clinical Characterization and Correlation with Geneotype"

PI: J. Han, MD, and B. Lu, PhD, NICHD
PI: F. Lacbawan, MD, Georgetown University Medical Center
AIs: O. Rennert, MD, PhD, NICHD; B. Brooks, MD, PhD, NEI; D. Domingo, DDS, MS, NIDCR; J. Kopp, MD, NIDDK; S. Swedo, MD, NIMH; S. Sharp, MD, USUHS

NHLBI
NCI, University of Virginia

"Sensitivity and resistance to Rituximab therapy in SLL/CLL: the role of antigenic modulation, immune effector mechanisms and direct pro-apoptotic signaling"

PI: A. Wiestner, MD, PhD, NHLBI
PI: W. Wilson, MD, PhD, NCI
PIs: G. Weiss, MD, R. Taylor, PhD, University of Virginia

NINDS
University of Pennsylvania

"Quantification of urinary oxidized lipids, 8-hydroxyguanine, and 8-hydroxy-2'-deoxyguanosine in Friedreich ataxia patients undergoing idebenone treatment in a phase II double-blind placebo-controlled study"

PI: K. Fischbeck, MD, NINDS
AI: N. DiProspero, MD, PhD, NINDS
PI: R. Wilson, MD, PhD, University of Pennsylvania
AI: I. Blair, PhD, University of Pennsylvania

NINDS
NIDDK

"Translational Studies of Hereditary Spastic Paraplegias types SPG4 and SPG20"

PI: C. Blackstone, MD, PhD, NINDS
PI: J. Hurley, PhD, NIDDK
AIs: J. Bakowska, PhD, NINDS, and D. Yang, PhD, NIDDK

NICHD
Cleveland Clinic Genomic Medicine Institute

"Genetics of inherited paragangliomas and gastric stromal tumors associated with adrenal and other tumors"

PI: C. Stratakis, MD, DMSc, NICHD
PI: C. Eng, MD, PhD, Cleveland Clinic

Teams

Project

Investigators

NCI
Hackensack University Medical Center

"Dynamic Measurement and modeling of Immune Homeostasis and Reconstitution in Pre-clinical and Clinical Studies of Cytokine Therapy and Allogeneic Hematopoietic Stem Cell Transplantation (AHSCT)".

PIs: R. Gress, MD, and Y. Chu, MD, NCI
PI: R. Korngold, PhD, Hackensack University Medical Center
AIs: F. Hakim, PhD, W. Telford, PhD, I. Sidorov, PhD, D. Dimitrov, PhD, ScD, NCI

Teams

Project

Investigators

NIAID
CC, University of Toronto George Washington University

"Intensification of Antiretroviral Therapy Using HIV Integrase Inhibitor (MK-0518) to Assess Decay of Viral Reservoirs in Peripheral Blood and Gut-Associated Lymphoid Tissue of Chronically Infected Patients"

PI: L. Healey, MD, CC Critical Care Medicine Department
PI: T.W. Chun, PhD, NIAID
AIs: S.R. Penzak, Pharm.D., CC Pharmacy Department; S. Moir, PhD., & S. Kottilil, MD, PhD, NIAID; C. Kovacs, MD & M. Loufty, MD, University, of Toronto, D. Ward, MD, George Washington University

NIDCR
CC

"Humoral Response Profiling of Viral and Cellular Tumor Antigens for Predicting, Diagnosing, and Monitoring HIV Malignancies"

PI: Kovacs, MD, CC Critical Care Medicine Department
PI: P. Burbelo, MD, NIDCR
AIs: L. Healey, MD, CC Critical Care Medicine Department; M. Iadarola, PhD, NIDCR

NIAID
CC, Massachusetts General Hospital

"1H Magnetic Resonance Spectroscopy for Quantification of Hepatic Triglyceride Content: Validation and Application in HIV-infected Patients"

PI: C. Hadigan MD, MPH, NIAID
PI: M. Torriani, MD, Mass. Gen. Hosp.
AIs: A. Louie, MD, & D. Thomasson, PhD, CC Diagnostic Radiology Department; C. Morse, MD, MPH, CC Critical Care Medicine Department; S. Kottilil, MD, NIAID; D. Sahani, MD, Massachusetts General Hospital

NIAID
University of Washington

"Development of Immunotoxins against Kaposi’s Sarcoma Associated Herpesvirus for Treatment of Multicentric Castleman’s Disease (MCD)"

PI: E. Berger, PhD, NIAID
PI: C. Casper, MD, MPH, University of Washington

Teams

Project

Investigators

NIDDK
UCLA

"Effects of Beta Cell Rest in Young Individuals with Type 2 Diabetes and in Relevant Animal Model"

PI: K. Rother, MD, NIDDK
PI: P. Butler, MD, UCLA
AI: R. Brown, MD, NIDDK

NHLBI
Johns Hopkins University

"Identification of Predictive Biomarkers of Asthma Exacerbations in Exhaled Breath Condensates from High Risk Patients"

PI: Stewart Levine, MD, NHLBI
AI: M. Kaler, CRNP, NHLBI
PIs: J. Jackman, PhD, & R. Rothman, MD, PhD, JHU

NIDDK
NHLBI, Harvard School of Public Health

"Ethnic Differences in Triglyceride Levels and Vascular Disease: A Study of Premenopausal African American and Caucasian Women"

PI: A. Sumner, MD, NIDDK
PI: Frank M. Sacks, MD, Harvard
AIs: V. Sachdev, MD, NHLBI; B. Denkinger, RD, CC Nutrition Department; M. Ricks, RN, NIDDK; M. Aikawa, MD, PhD, Brigham & Women’s Hospital

NHLBI
CC

"Contribution of Stromal Free Hemoglobin, Red Cell Membranes, and Red Cell Lysate on Nitric Oxide Inactivation in the Chronic Hemolytic State"

PI: M.T. Gladwin, MD, NHLBI
PI: S. Solomon, PhD, CCMD/CC
AIs: H. Klein, MD, CC Department of Transfusion Medicine; C. Natanson, MD, & D. Sweeney, MD, CC Critical Care Medicine Department; R. Machado, MD, NHLBI

Teams

Project

Investigators

NCI
Gynecologic Oncology Group, University of Miami, University of Oklahoma

"Targeting HPV E2 as a vaccine against HPV mediated CIN1 and CIN2"

PI: S. Khleif, MD, NCI
AIs: J. Berzofsky, MD, PhD; J. Qian, PhD, NCI
Extramural: Gynecologic Oncology Group; J. Lucci III, MD, University of Miami; J. Walker, MD, University of Oklahoma