Summaries & Associations of Study Results
TR-402 Furan
Target Organs and Levels of Evidence
NTP Technical Report Number 402
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| FURAN 110-00-9 |
03/11/91 | CHEMICAL INTERMEDIATE. SOLVENT FOR RESINS. IN LACQUER FORMATION. ORGANIC SYNTHESIS. (TDB) | Gavage R: 0,2,4,8, M: 0,8,15 MG/KG/50 PER GROUP | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | LIVER: ADENOMA 1/50 4/50 18/50 27/50, CARCINOMA 0/50 1/50 6/50 18/50, COMBINED 1/50 5/50 22/50 35/50; CHOLANGIOCARCINOMA 0/50 43/50 48/50 49/50 | |||
| HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 8/50 11/50 17/50 25/50 | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: NEPHROPATHY | |||
| LIVER: (BILIARY TRACT) DILATATION, FIBROSIS, HYPERPLASIA, AND INFLAMMATION, CHRONIC; (HEPATOCYTE) CYTOMEGALY, DEGENERATION, NECROSIS | ||||
| PARATHYROID GLAND: HYPERPLASIA | ||||
| FR: CLEAR EVIDENCE | LIVER: ADENOMA 0/50 2/50 4/50 7/50, CARCINOMA 0/50 0/50 0/50 1/50, COMBINED 0/50 2/50 4/50 8/50; CHOLANGIOCARCINOMA 0/50 49/50 50/50 48/50 | |||
| HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 8/50 9/50 17/50 21/50 | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: NEPHROPATHY | |||
| LIVER: (BILIARY TRACT) CHRONIC FOCAL INFLAMMATION, CYST, FOCAL FIBROSIS, FOCAL HYPERPLASIA, METAPLASIA; (HEPATOCYTE) CYTOMEGALY, CYTOPLASMIC VACUOLIZATION, FOCAL DEGENERATION, FOCAL HYPERPLASIA, FOCAL NECROSIS | ||||
| PARATHYROID GLAND: HYPERPLASIA | ||||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 20/50 33/50 42/50, CARCINOMA 7/50 32/50 34/50, COMBINED 26/50 44/50 50/50 | |||
| ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 1/49 6/50 10/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: (BILIARY TRACT) CHRONIC FOCAL INFLAMMATION, CYST, FOCAL FIBROSIS, FOCAL HYPERPLASIA, METAPLASIA; (HEPATOCYTE) CYTOMEGALY, CYTOPLASMIC VACUOLIZATION, FOCAL DEGENERATION, FOCAL HYPERPLASIA, FOCAL NECROSIS | |||
| FM: CLEAR EVIDENCE | LIVER: ADENOMA 5/50 31/50 48/50, CARCINOMA 2/50 7/50 27/50, COMBINED 7/50 34/50 50/50 | |||
| ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 2/50 1/50 6/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: (BILIARY TRACT) DILATATION, CHRONIC INFLAMMATION, FIBROSIS, HYPERPLASIA; (HEPATOCYTE) CYTOMEGALY, DEGENERATION, NECROSIS | |||
Web page last updated on February 10, 2006
