The Protein Structure Initiative (PSI) is a federal, university, and industry effort aimed at dramatically reducing the costs and lessening the time it takes to determine a three-dimensional protein structure. The long-range goal of the PSI is to make the three-dimensional, atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences.
Expected benefits from the PSI include: structural descriptions to help researchers discover the functions of proteins, design experiments, and solve other key biomedical problems; faster identification of promising new structure-based medicines; better therapeutics for treating both genetic and infectious diseases; and development of technology and methodology for protein production and crystallography.
The PSI actively engages the scientific community in the selection of proteins for structure determination and is increasing its outreach, accessibility, and impact on biomedical research via the PSI-Nature Structural Genomics Knowledgebase, a continually updated portal to PSI data, resources, and latest developments.
For more details about the PSI's goals, organization, and benefits, see the PSI Mission Statement. Additional information about the PSI can be found under the links listed below.
