Biosketch

Dr. Christine Grady’s research focuses on research subject recruitment, incentives, vulnerability, and international research ethics. Dr. Grady has written widely in books and scholarly journals on such topics as bioethics, HIV disease, and nursing. She also is the author of the book, The Search for an AIDS Vaccine: Ethical Issues in the Development and Testing of a Preventive HIV Vaccine.

Dr. Grady received a bachelor’s degree in nursing and biology from Georgetown University, a master’s degree in community health nursing from Boston College, and a doctoral degree in philosophy and bioethics from Georgetown University.

She is a senior research fellow at the Kennedy Institute of Ethics and was elected as a fellow at both the American Academy of Nursing and the Hastings Center. She is a member of an institutional review board for the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

She has participated in numerous intergovernmental task forces and is the recipient of several awards, including the NIH Director's Award in 2007 and 1997 and 1999 and the Assistant Secretary of Health Award in 1988.

She currently serves on three editorial boards of professional journals in bioethics and nursing; she has lectured widely at national and international conferences, professional societies, universities, and healthcare institutions on ethical issues in clinical research and clinical care. She was formerly assistant director for clinical science at the National Institute of Nursing Research.

Honors and Awards

Elected fellow, 2002, Fellows Council 2005, and vice chair of the Council of the Hastings Center, 2006; NIH Director’s Award, 1999, 1997 and 2007; Elected fellow in the American Academy of Nursing, 1997; Outstanding Research Article Award, Journal of the Association of Nurses in AIDS Care, 1997; U.S. Public Health Service First Annual Faye G. Abdellah Publication Award, 1993; DHHS Assistant Secretary of Health Award, 1988; Nursing Research Award, NIH Clinical Center Nursing Department, 1987; Distinguished Alumna Award, Georgetown University School of Nursing, 1987; Distinguished Nurse Award, NIH Clinical Center Nursing Department, 1986; Sigma Theta Tau Honor Society

Publications

BOOKS

Lavery J, Grady C, Wahl E, Emanuel E. (eds)  Ethical Issues in International Biomedical Research: A Casebook.  New York: Oxford University Press.  2007

BOOKS AND BOOK CHAPTERS

Grady C and Levine R. Shared responsibility for treatment in the South African phase 1 HIV preventive vaccine trials. Chapter 13.2 in J. Lavery, C. Grady, E. Wahl, E. Emanuel Ethical Issues in International Biomedical Research: A Casebook.  New York: Oxford University Press.  2007: 225-230.

Grady C.  Ethics of vaccine research.  Chapter 2 in A.S. Iltis (ed) Research Ethics, New York/London: Routledge Taylor and Francis Group.  2006: 22-31.

Grady C. Ethical Principles in Clinical Research. Chapter 2 in J. Gallin and F. Ognibene (eds) 2nd Edition, Principles and Practice of Clinical Research. New York: Elsevier, Academic Press; 2007: 15-26.

Lavery J, Grady C, Wahl E, Emanuel E. (eds) Ethical Issues in International Biomedical Research: A Casebook. New York: Oxford University Press. 2007

Emanuel EJ, Crouch RA, Grady C, Lie R, Miller FG, Wendler D, editors The Oxford Textbook of Clinical Research Ethics (New York: Oxford University Press. In press

Emanuel E, Crouch R, Arras J, Moreno J, Grady C. (eds) Ethical and Regulatory Aspects of Clinical Research: Readings and Commentary. Baltimore and London: The Johns Hopkins University Press. 2003

Grady, C. The Search for an AIDS Vaccine: Ethical Issues in the Development and Testing of a Preventive HIV Vaccine. Bloomington, Indiana: Indiana University Press. 1995

Grady C. Ethics of vaccine research. Chapter 2 in A.S. Iltis (ed) Research Ethics, New York/London: Routledge Taylor and Francis Group. 2006.

Grady C. Ethical Issues in Critical Care, Chapter 7 in P Morton, D Fontaine, C Hudak, & B. Gallo (eds). Critical Care Nursing: A Holistic Approach, 8th edition. Philadelphia: Lippincott, Williams and Wilkins; 2005; 9th edition, in press

Grady C. Ethical Principles in Clinical Research. Chapter 2 in J. Gallin (ed) Principles and Practice of Clinical Research. New York: Academic Press; 2002: 15-26. 2nd Edition, in press

Wiener L., Septimus A. and Grady C. Psychosocial support and ethical issues for the child and family. Chapter 40 in P. Pizzo and C. Wilfert (eds) Pediatric AIDS, 3rd Edition. Baltimore, MD: Lippincott, Williams and Wilkins; 1998: 703-727.

Grady C. Ethics, Genetics, and Nursing Practice. Chapter 9 in D. Lea, J. Jenkins, and C. Francomano (eds). Genetics in Clinical Practice. Boston: Jones and Bartlett Publishers; 1998: 221-252.

Grady C. HIV Disease: Ethical Considerations for clinicians. Chapter 34 in V. DeVita, S. Hellman, S. Rosenberg, J. Curran, M. Essex, and A. Fauci (eds). AIDS: Etiology, Diagnosis, Prevention, and Treatment, 4th edition, Philadelphia: J.B. Lippincott Co.; 1997: 633-642.

JOURNAL ARTICLES

Persad G, Little R, Grady C. Including Persons with HIV Infection in Cancer Clinical Trials. J Clin Oncology, 2008, (in press)

Seidenfeld J, Horstmann E, Emanuel E, Grady C. Participants in phase 1 oncology research:  Are they vulnerable?” Archives of Internal Medicine, 2008; 168(1): 16-20

Henderson GE, Churchill LR, Davis AM, Easter MM, Grady C, et al. Clinical trials and medical care: Defining the therapeutic misconception. PLoS Med 2007 4(11): e32

Hardy NM, Grady C, Pentz R, Stetler-Stevenson M, Raffeld M, Fontaine LS, Babb R, Bishop MR, Caporaso N, Marti GE.  Bioethical considerations of monoclonal B-cell lymphocytosis: donor transfer after haematopoetic stem cell transfer.  Br. J. Haemotology 2007 Dec 13; 9(5): 824-831.

Thiessen C, Ssekugugu R, Wagman J,  Kiddugavu M, Wawer M, Emanuel E, Gray R, Serwadda D, Grady C. Personal and Community Benefits and Harms of Research: Views from Rakai, Uganda.  AIDS, 2007 Nov. 30; 21(18): 2493-2501

Danis M, Farrar A, Grady C, Taylor C, O’Donnell P, Soeken K, Ulrich C.  Does fear of retaliation deter requests for ethics consultation?  Medicine, Health Care and Philosophy, 2007

Ulrich C, O’Donnell P, Taylor C, Farrar A, Danis M, Grady C. Ethical climate, ethics stress, and the job satisfaction of nurses and social workers in the United States.  Social Science & Medicine, 2007.  65:1708-1719.

Denny C and Grady C. Clinical research with economically disadvantaged populations. J Med Ethics. 2007 Jul; 33(7):382-5.

Grady C. Quality Improvement and Ethical Oversight. Annals of Internal Medicine.  2007; 146(9): 680-681.

Slutsman J, Buchanan D, Grady C.  Ethical Issues in Chemoprevention Trials: Considerations for IRBs and Investigators.  IRB: Ethics and Human Research.  2007; 29(2):

Emanuel E and Grady C.  Four Paradigms of Clinical Research and Research Oversight.  Cambridge Quarterly of Health Care Ethics.  2006; 16(1): 82-96.

Ulrich, C., Danis, M., Ratcliffe, S., Garrett-Mayer, E., Koziol, D., Soeken, K., & Grady, C.   Ethical Conflict in Nurse Practitioners and Physician Assistants in Managed Care. Nursing Research. 2006; 55(6): 3

Merritt M and Grady C, “Reciprocity and Post-trial Access for Participants in Antiretroviral Therapy Trials” AIDS 20 (2006): 1791-1794

Grady C, Horstmann E, Sussman J, Hull S.  The Limits of Disclosure:  What Research Subjects Want to Know About Investigator Financial Interests. Journal of Law, Medicine, and Ethics 2006; 34(3): 592-599

Grady C, Hampson L, Wallen G, Rivera-Goba M, Carrington K, Mittleman B. Exploring Perceptions about the Ethics of Clinical Research in an Urban Community.  American Journal of Public Health 2006; 96(11): 1996-2001.

Pace C, Grady C, Wendler D, Bebchuk J, Tavel J, McNay L, Forster H, Killen J,  and Emanuel E. for the ESPRIT Group.  Post Trial Access to Tested Interventions: The Views of IRB/REC Chairs, Investigators and Research Participants in a Multinational HIV/AIDS Study.  AIDS Research and Human Retroviruses Sep 2006, Vol. 22, No. 9: 837-841

Agrawal M, Grady C, Fairclough DL, Meropol NJ, Maynard K, Emanuel EJ.  Patients’ decision-making process regarding participation in phase 1 oncology research.  Journal of Clinical Oncology 2006; 24 (27): 4479-4484

Lie RK, Grady C, Emanuel EJ. Circumcision and HIV prevention research. An ethical analysis Lancet 2006; 368: 522-25

Grady C. Ethics of international research: what does responsiveness mean? Virtual Mentor. April 2006;8:235-240. Available at: http://www.ama-assn.org/ama/pub/category/3040.html

Grady C, Horstmann E, Sussman J, Hull S. The Limits of Disclosure: What Research Subjects Want to Know About Investigator Financial Interests. Journal of Law, Medicine, and Ethics 2006; 34(3): 592-59

Pace C, Talisuna A, Wendler D, Maiso F, Wabwire-Mangen F, Bakyaita N, Okiria E, Garrett-Mayer E, Emanuel E, and Grady C. Quality of Parental Consent in a Ugandan Malaria Study. American Journal of Public Health 2005; 95 1184-1189

Horstmann E, McCabe M, Grochow L, Yamamoto S, Rubinstein L, Budd T, Shoemaker D, Emanuel E, Grady C. Risks and Benefits of Phase I Oncology Trials 1991-2002. New England Journal of Medicine. 2005; 352(9): 895-904.

Grady C. Payment of clinical research subjects. Journal of Clinical Investigation. 2005; 115 1681-1687

Emanuel E, Wendler D, Killen J, Grady C. What Makes Clinical Research In Developing Countries Ethical? The Benchmarks of Ethical Research Journal of Infectious Diseases 2004; 189:930-7.

Horng S and Grady C. Misunderstanding in clinical research: distinguishing therapeutic misconception, therapeutic misestimation, and therapeutic optimism. IRB: Ethics and Human Research, 2003: 25(1): 11-16

Horng S, Emanuel E, Wilfond B, Rackoff J, Martz K, Grady C., Descriptions of benefits and risks in consent forms for Phase I Oncology Trials. New England Journal of Medicine, 2002; 347(26):2134-2140.

Dickert N, Emanuel E, Grady C. Decisions about paying research subjects: analysis of current policies. Annals of Internal Medicine, 2002; 136(5): 368-373.

Emanuel E, Wendler D, Grady C. What makes clinical research ethical? Journal of the American Medical Association, 2000; 283(20):2701-11

Dickert N and Grady C. What’s the price of a research subject? Approaches to payment for research participation. New England Journal of Medicine, 1999; 341(3):198-203