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Cartoon: R34.NIAID uses a two-step approach to funding investigator-initiated clinical trials: a Clinical Trial Planning Grant (R34) followed by a Clinical Trial Implementation Cooperative Agreement (U01).

R34s provide funding for the preparation of 1) materials NIAID staff need to determine a project's feasibility and 2) documentation necessary for implementing the clinical trial in the U01.

This two-step process does not apply to applications responding to requests for applications (RFA). If you're applying for a clinical trial through an RFA, make sure you follow instructions in the RFA.

If you plan to apply for an investigator-initiated clinical trial, you'll need to consider many details in addition to the information we highlight on this tutorial page.

For more information, go to Investigator-Initiated Clinical Trial Planning and Implementation Grants. Also, follow NIAID Clinical Terms of Award instructions, and visit Investigator-Initiated Clinical Trial Planning and Implementation Grants questions and answers.

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