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Links to NCI Materials
The body's 30,000 or so genes carry the blueprint for making proteins, of which all living matter is made. Each protein has a particular shape and function that determine its role in the body. Cancer researchers are turning to "proteomics" - the study of protein shape, function, and patterns of expression - in hopes of developing better prevention, screening, and treatment options.
Following is a list of links to NCI-related material about proteomics.
Clinical Proteomic Technologies Initiative for Cancer
This initiative seeks to build the foundation of technologies, data, reagents and standards, systems, and infrastructure needed to systematically advance our understanding of protein biology in cancer and accelerate discovery research and clinical applications.
Proteomics and Cancer: Fact Sheet
(Posted: 04/30/2004, Updated: 09/29/2005) - The term "proteome" was first coined in 1994 and refers to all the proteins in a cell, tissue, or organism. Proteomics refers to the study of the proteome. Because proteins are involved in almost all biological activities, the proteome is a rich source of biological information.
New Method to Identify Blood Proteins May Spur Novel Disease Marker Discoveries
(Posted: 06/03/2004) - Using conventional technologies, researchers have developed a new method for identifying proteins found in trace quantities in the blood. The method offers hope for detecting tiny amounts of these blood-borne molecules that signal the presence of diseases such as cancer.
Proteomics Shows Promise in Colon Cancer Chemoprevention Study
(Posted: 04/15/2004) - Using new technology associated with the study of proteins, or proteomics, scientists at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and their colleagues have made a step toward predicting which people with familial adenomatous polyposis (FAP), an inherited condition that often leads to colon cancer, will respond to the prevention drug celecoxib.
The NCI/FDA Proteomics Research Program, Its Research, and Diagnostic Tests by Private Industry (e.g., OvaCheck™): Fact Sheet
(Posted: 03/22/2004, Updated: 09/29/2005) - The former NCI/FDA proteomics program was not involved with the development of OvaCheck™. It was independently developed by Correlogic Systems in conjunction with Quest Diagnostics and LabCorp, two non-governmental, private companies.
Proteomics Research Aids Cancer Diagnosis and Treatment
(Posted: 04/09/2003) - A new technique may allow physicians to monitor patients' responses to molecularly targeted drugs, according to researchers from the National Cancer Institute and the Food and Drug Administration.
Protein Patterns in Blood May Predict Prostate Cancer Diagnosis
(Posted: 10/15/2002) - Patterns of proteins found in patients' blood serum may help distinguish between prostate cancer and benign conditions, scientists from the NCI and FDA report today in the Journal of the National Cancer Institute.
New Bioinformatics Tool Will Help Design Cancer Drugs
(Posted: 08/22/2002) - A new method that allows researchers to link genomic and proteomic information from cancer cells to information about drug structure will be a powerful tool in the design and discovery of new drugs, researchers report in the August issue of the Nature publication The Pharmacogenomics Journal.
Protein Patterns May Identify Ovarian Cancer
(Posted: 02/07/2002) - Scientists from the FDA and the NCI report today, in a special fast-tracked release in The Lancet, that patterns of proteins found in patients' blood serum may reflect the presence of disease.
Proteomics: Research for the 21st Century
(Posted: 02/07/2002) - A fast-tracked paper on a possible new ovarian cancer screening tool by Lance Liotta , M.D., Ph.D., National Cancer Institute (NCI), and Emanuel Petricoin, M.D., Food and Drug Administration (FDA), appeared electronically in The Lancet on February 7, 2002. Read about the latest proteomics research.
New Joint Program Announced by FDA and NCI Holds Promise for Cancer
(Posted: 07/20/2001) - The Food and Drug Administration (FDA) and the National Cancer Institute (NCI) announced today a new joint research and clinical program that holds great promise for developing better and more targeted treatments for cancer.
NCI Visuals Online: Proteomics Images
From the National Cancer Institute's Visuals Online database. All images are in the public domain and may be freely used.
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