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Computerized databases linking chemical structures with preclinical antiviral and antimicrobial efficacy data are maintained to assist DAIDS staff in tracking compounds for further preclinical study. Upon request by academic, government, and private sector investigators, DAIDS staff can search these databases and provide nonproprietary information (obtained from the literature, patents, and public conferences) regarding specific compounds to help guide the investigators' drug development efforts.

Resource Descriptions

• Separate databases are maintained for HIV, OI, and TB therapies
  
• Both in vitro and in vivo biological data are maintained within the databases
  
• Databases contain chemical structure information and can be searched by chemical substructure features
  
• OI databases contain information for Candida albicans, Cryptococcus neoformans, Cryptosporidium parvum, Histoplasma capsulatum, Mycobacterium avium, Pneumocystis carinii, and Toxoplasma gondii
  
• TB databases contain information for both wild type and drug-resistant strains of Mycobacterium tuberculosis

Accessing These Resources

• For further information please contact Dr. Mohamed Nasr (phone: 301-496-0636; e-mail: mn12p@nih.gov).
  
• Internet access to portions of these databases is available at Database for Anti-HIV Compounds.