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1
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Al-Shami A, Spolski R, Kelly J, Keane-Myers A, Leonard WJ.
A role for TSLP in the development of inflammation in an asthma model.
J Exp Med 202(6): 829-39, 2005.
[Text Abstract on PubMed]
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2
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Ettinger R, Sims GP, Fairhurst AM, Robbins R, da Silva YS, Spolski R, Leonard WJ, Lipsky PE.
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.
J Immunol 175(12): 7867-79, 2005.
[Text Abstract on PubMed]
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3
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Kim HP, Kim BG, Letterio J, Leonard WJ.
Smad-dependent cooperative regulation of interleukin 2 receptor alpha chain gene expression by T cell receptor and transforming growth factor-beta.
J Biol Chem 280(40): 34042-7, 2005.
[Text Abstract on PubMed]
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4
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Kim HP, Korn LL, Gamero AM, Leonard WJ.
Calcium-dependent activation of interleukin-21 gene expression in T cells.
J Biol Chem 280(26): 25291-7, 2005.
[Text Abstract on PubMed]
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5
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Kovanen PE, Young L, Al-Shami A, Rovella V, Pise-Masison CA, Radonovich MF, Powell J, Fu J, Brady JN, Munson PJ, Leonard WJ.
Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.
Int Immunol 17(8): 1009-21, 2005.
[Text Abstract on PubMed]
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6
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Leonard WJ, Spolski R.
Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation.
Nat Rev Immunol 5(9): 688-98, 2005.
[Text Abstract on PubMed]
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7
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Leonard WJ.
Interleukin-7 deficiency in rheumatoid arthritis.
Arthritis Res Ther 7(1): 42-3, 2005.
[Text Abstract on PubMed]
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8
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Morra M, Barrington RA, Abadia-Molina AC, Okamoto S, Julien A, Gullo C, Kalsy A, Edwards MJ, Chen G, Spolski R, Leonard WJ, Huber BT, Borrow P, Biron CA, Satoskar AR, Carroll MC, Terhorst C.
Defective B cell responses in the absence of SH2D1A.
Proc Natl Acad Sci U S A 102(13): 4819-23, 2005.
[Text Abstract on PubMed]
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9
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Wu Z, Kim HP, Xue HH, Liu H, Zhao K, Leonard WJ.
Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity.
Mol Cell Biol 25(22): 9741-52, 2005.
[Text Abstract on PubMed]
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10
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Zeng R, Spolski R, Finkelstein SE, Oh S, Kovanen PE, Hinrichs CS, Pise-Masison CA, Radonovich MF, Brady JN, Restifo NP, Berzofsky JA, Leonard WJ.
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.
J Exp Med 201(1): 139-48, 2005.
[Text Abstract on PubMed]
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11
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Al-Shami A, Spolski R, Kelly J, Fry T, Schwartzberg PL, Pandey A, Mackall CL, Leonard WJ.
A role for thymic stromal lymphopoietin in CD4(+) T cell development.
J Exp Med 200(2): 159-68, 2004.
[Text Abstract on PubMed]
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12
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Kovanen PE, Leonard WJ.
Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways.
Immunol Rev 202: 67-83, 2004.
[Text Abstract on PubMed]
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13
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Ozaki K, Spolski R, Ettinger R, Kim HP, Wang G, Qi CF, Hwu P, Shaffer DJ, Akilesh S, Roopenian DC, Morse HC, Lipsky PE, Leonard WJ.
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6.
J Immunol 173(9): 5361-71, 2004.
[Text Abstract on PubMed]
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14
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Xue HH, Bollenbacher J, Rovella V, Tripuraneni R, Du YB, Liu CY, Williams A, McCoy JP, Leonard WJ.
GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells.
Nat Immunol 5(10): 1036-44, 2004.
[Text Abstract on PubMed]
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15
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Kelly J, Leonard WJ.
Immune deficiencies due to defects in cytokine signaling.
Curr Allergy Asthma Rep 3(5): 396-401, 2003.
[Text Abstract on PubMed]
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16
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Kelly J, Spolski R, Imada K, Bollenbacher J, Lee S, Leonard WJ.
A role for Stat5 in CD8+ T cell homeostasis.
J Immunol 170(1): 210-7, 2003.
[Text Abstract on PubMed]
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17
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Kelly JA, Spolski R, Kovanen PE, Suzuki T, Bollenbacher J, Pise-Masison CA, Radonovich MF, Lee S, Jenkins NA, Copeland NG, Morse HC, Leonard WJ.
Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.
J Exp Med 198(1): 79-89, 2003.
[Text Abstract on PubMed]
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18
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Kovanen PE, Rosenwald A, Fu J, Hurt EM, Lam LT, Giltnane JM, Wright G, Staudt LM, Leonard WJ.
Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling.
J Biol Chem 278(7): 5205-13, 2003.
[Text Abstract on PubMed]
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19
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Wang G, Tschoi M, Spolski R, Lou Y, Ozaki K, Feng C, Kim G, Leonard WJ, Hwu P.
In vivo antitumor activity of interleukin 21 mediated by natural killer cells.
Cancer Res 63(24): 9016-22, 2003.
[Text Abstract on PubMed]
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20
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Kim HP, Leonard WJ.
The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements.
EMBO J 21(12): 3051-9, 2002.
[Text Abstract on PubMed]
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21
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Leonard WJ.
TSLP: finally in the limelight.
Nat Immunol 3(7): 605-7, 2002.
[Text Abstract on PubMed]
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22
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Ozaki K, Leonard WJ.
Cytokine and cytokine receptor pleiotropy and redundancy.
J Biol Chem 277(33): 29355-8, 2002.
[Text Abstract on PubMed]
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23
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Ozaki K, Spolski R, Feng CG, Qi CF, Cheng J, Sher A, Morse HC, Liu C, Schwartzberg PL, Leonard WJ.
A critical role for IL-21 in regulating immunoglobulin production.
Science 298(5598): 1630-4, 2002.
[Text Abstract on PubMed]
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24
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Xue HH, Fink DW, Zhang X, Qin J, Turck CW, Leonard WJ.
Serine phosphorylation of Stat5 proteins in lymphocytes stimulated with IL-2.
Int Immunol 14(11): 1263-71, 2002.
[Text Abstract on PubMed]
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25
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Xue HH, Kovanen PE, Pise-Masison CA, Berg M, Radovich MF, Brady JN, Leonard WJ.
IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.
Proc Natl Acad Sci U S A 99(21): 13759-64, 2002.
[Text Abstract on PubMed]
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26
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Kim HP, Kelly J, Leonard WJ.
The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements.
Immunity 15(1): 159-72, 2001.
[Text Abstract on PubMed]
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27
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Leonard WJ.
Cytokines and immunodeficiency diseases.
Nat Rev Immunol 1(3): 200-8, 2001.
[Text Abstract on PubMed]
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28
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Leonard WJ.
Role of Jak kinases and STATs in cytokine signal transduction.
Int J Hematol 73(3): 271-7, 2001.
[Text Abstract on PubMed]
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29
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Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G.
HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
Blood 98(3): 823-9, 2001.
[Text Abstract on PubMed]
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30
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Sporri B, Kovanen PE, Sasaki A, Yoshimura A, Leonard WJ.
JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling.
Blood 97(1): 221-6, 2001.
[Text Abstract on PubMed]
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31
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Kagami S, Nakajima H, Kumano K, Suzuki K, Suto A, Imada K, Davey HW, Saito Y, Takatsu K, Leonard WJ, Iwamoto I.
Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue.
Blood 95(4): 1370-7, 2000.
[Text Abstract on PubMed]
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32
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Leonard WJ, Lin JX.
Cytokine receptor signaling pathways.
J Allergy Clin Immunol 105(5): 877-88, 2000.
[Text Abstract on PubMed]
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33
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Leonard WJ.
Use of chimeric receptor molecules to dissect signal transduction mechanisms.
Methods Enzymol 327: 228-39, 2000.
[Text Abstract on PubMed]
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34
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Leonard WJ.
X-linked severe combined immunodeficiency: from molecular cause to gene therapy within seven years.
Mol Med Today 6(10): 403-7, 2000.
[Text Abstract on PubMed]
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35
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Lin JX, Leonard WJ.
The role of Stat5a and Stat5b in signaling by IL-2 family cytokines.
Oncogene 19(21): 2566-76, 2000.
[Text Abstract on PubMed]
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36
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Nakajima H, Noguchi M, Leonard WJ.
Role of the common cytokine receptor gamma chain (gammac) in thymocyte selection.
Immunol Today 21(2): 88-94, 2000.
[Text Abstract on PubMed]
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37
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Ozaki K, Kikly K, Michalovich D, Young PR, Leonard WJ.
Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain.
Proc Natl Acad Sci U S A 97(21): 11439-44, 2000.
[Text Abstract on PubMed]
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38
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Pandey A, Ozaki K, Baumann H, Levin SD, Puel A, Farr AG, Ziegler SF, Leonard WJ, Lodish HF.
Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin.
Nat Immunol 1(1): 59-64, 2000.
[Text Abstract on PubMed]
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39
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Puel A, Leonard WJ.
Mutations in the gene for the IL-7 receptor result in T(-)B(+)NK(+) severe combined immunodeficiency disease.
Curr Opin Immunol 12(4): 468-73, 2000.
[Text Abstract on PubMed]
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40
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Reeves R, Leonard WJ, Nissen MS.
Binding of HMG-I(Y) imparts architectural specificity to a positioned nucleosome on the promoter of the human interleukin-2 receptor alpha gene.
Mol Cell Biol 20(13): 4666-79, 2000.
[Text Abstract on PubMed]
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41
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Soldaini E, John S, Moro S, Bollenbacher J, Schindler U, Leonard WJ.
DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.
Mol Cell Biol 20(1): 389-401, 2000.
[Text Abstract on PubMed]
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42
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Suzuki K, Nakajima H, Saito Y, Saito T, Leonard WJ, Iwamoto I.
Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice.
Int Immunol 12(2): 123-32, 2000.
[Text Abstract on PubMed]
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43
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Zhang S, Fukuda S, Lee Y, Hangoc G, Cooper S, Spolski R, Leonard WJ, Broxmeyer HE.
Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling.
J Exp Med 192(5): 719-28, 2000.
[Text Abstract on PubMed]
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44
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Aman MJ, Migone TS, Sasaki A, Ascherman DP, Zhu M, Soldaini E, Imada K, Miyajima A, Yoshimura A, Leonard WJ.
CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling.
J Biol Chem 274(42): 30266-72, 1999.
[Text Abstract on PubMed]
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45
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John S, Vinkemeier U, Soldaini E, Darnell JE, Leonard WJ.
The significance of tetramerization in promoter recruitment by Stat5.
Mol Cell Biol 19(3): 1910-8, 1999.
[Text Abstract on PubMed]
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46
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Kovanen PE, Leonard WJ.
Inhibitors keep cytokines in check.
Curr Biol 9(23): R899-902, 1999.
[Text Abstract on PubMed]
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47
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Leonard WJ, Imada K, Nakajima H, Puel A, Soldaini E, John S.
Signaling via the IL-2 and IL-7 receptors from the membrane to the nucleus.
Cold Spring Harb Symp Quant Biol 64: 417-24, 1999.
[Text Abstract on PubMed]
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48
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Lo M, Bloom ML, Imada K, Berg M, Bollenbacher JM, Bloom ET, Kelsall BL, Leonard WJ.
Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach.
Blood 94(9): 3027-36, 1999.
[Text Abstract on PubMed]
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49
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Nakajima H, Leonard WJ.
Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity.
J Immunol 162(2): 782-90, 1999.
[Text Abstract on PubMed]
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50
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Zhu M, John S, Berg M, Leonard WJ.
Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
Cell 96(1): 121-30, 1999.
[Text Abstract on PubMed]
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51
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Durum SK, Candèias S, Nakajima H, Leonard WJ, Baird AM, Berg LJ, Muegge K.
Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility.
J Exp Med 188(12): 2233-41, 1998.
[Text Abstract on PubMed]
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52
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Imada K, Bloom ET, Nakajima H, Horvath-Arcidiacono JA, Udy GB, Davey HW, Leonard WJ.
Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity.
J Exp Med 188(11): 2067-74, 1998.
[Text Abstract on PubMed]
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53
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Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ.
Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation.
Mol Cell Biol 18(11): 6416-22, 1998.
[Text Abstract on PubMed]
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54
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Mulloy JC, Migone TS, Ross TM, Ton N, Green PL, Leonard WJ, Franchini G.
Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2(pan-p)) transform T cells independently of Jak/STAT activation.
J Virol 72(5): 4408-12, 1998.
[Text Abstract on PubMed]
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55
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Puel A, Ziegler SF, Buckley RH, Leonard WJ.
Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency.
Nat Genet 20(4): 394-7, 1998.
[Text Abstract on PubMed]
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56
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Scharton-Kersten T, Nakajima H, Yap G, Sher A, Leonard WJ.
Infection of mice lacking the common cytokine receptor gamma-chain (gamma(c)) reveals an unexpected role for CD4+ T lymphocytes in early IFN-gamma-dependent resistance to Toxoplasma gondii.
J Immunol 160(6): 2565-9, 1998.
[Text Abstract on PubMed]
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57
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Zhu MH, Berry JA, Russell SM, Leonard WJ.
Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.
J Biol Chem 273(17): 10719-25, 1998.
[Text Abstract on PubMed]
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58
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Aman MJ, Leonard WJ.
Cytokine signaling: cytokine-inducible signaling inhibitors.
Curr Biol 7(12): R784-8, 1997.
[Text Abstract on PubMed]
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59
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Ascherman DP, Migone TS, Friedmann MC, Leonard WJ.
Interleukin-2 (IL-2)-mediated induction of the IL-2 receptor alpha chain gene. Critical role of two functionally redundant tyrosine residues in the IL-2 receptor beta chain cytoplasmic domain and suggestion that these residues mediate more than Stat5 activation.
J Biol Chem 272(13): 8704-9, 1997.
[Text Abstract on PubMed]
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60
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Boesteanu A, Silva AD, Nakajima H, Leonard WJ, Peschon JJ, Joyce S.
Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development.
J Exp Med 186(2): 331-6, 1997.
[Text Abstract on PubMed]
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61
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Feldman GM, Rosenthal LA, Liu X, Hayes MP, Wynshaw-Boris A, Leonard WJ, Hennighausen L, Finbloom DS.
STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression.
Blood 90(5): 1768-76, 1997.
[Text Abstract on PubMed]
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62
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He YW, Nakajima H, Leonard WJ, Adkins B, Malek TR.
The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.
J Immunol 158(6): 2592-9, 1997.
[Text Abstract on PubMed]
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63
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Leonard WJ.
Genetic effects on immunity. Protein tyrosine kinases: disease loci for inherited immunodeficiencies.
Curr Opin Immunol 9(4): 525-7, 1997.
[Text Abstract on PubMed]
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64
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Lin JX, Leonard WJ.
Signaling from the IL-2 receptor to the nucleus.
Cytokine Growth Factor Rev 8(4): 313-32, 1997.
[Text Abstract on PubMed]
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65
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Lin JX, Leonard WJ.
The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sites.
Mol Cell Biol 17(7): 3714-22, 1997.
[Text Abstract on PubMed]
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66
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Nakajima H, Leonard WJ.
Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice.
J Immunol 159(10): 4737-44, 1997.
[Text Abstract on PubMed]
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67
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Nakajima H, Liu XW, Wynshaw-Boris A, Rosenthal LA, Imada K, Finbloom DS, Hennighausen L, Leonard WJ.
An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction.
Immunity 7(5): 691-701, 1997.
[Text Abstract on PubMed]
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68
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Nakajima H, Shores EW, Noguchi M, Leonard WJ.
The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis.
J Exp Med 185(2): 189-95, 1997.
[Text Abstract on PubMed]
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69
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Noguchi M, Sarin A, Aman MJ, Nakajima H, Shores EW, Henkart PA, Leonard WJ.
Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain.
Proc Natl Acad Sci U S A 94(21): 11534-9, 1997.
[Text Abstract on PubMed]
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70
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Takemoto S, Mulloy JC, Cereseto A, Migone TS, Patel BK, Matsuoka M, Yamaguchi K, Takatsuki K, Kamihira S, White JD, Leonard WJ, Waldmann T, Franchini G.
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins.
Proc Natl Acad Sci U S A 94(25): 13897-902, 1997.
[Text Abstract on PubMed]
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71
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Aman MJ, Tayebi N, Obiri NI, Puri RK, Modi WS, Leonard WJ.
cDNA cloning and characterization of the human interleukin 13 receptor alpha chain.
J Biol Chem 271(46): 29265-70, 1996.
[Text Abstract on PubMed]
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72
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Friedmann MC, Migone TS, Russell SM, Leonard WJ.
Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.
Proc Natl Acad Sci U S A 93(5): 2077-82, 1996.
[Text Abstract on PubMed]
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73
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Hilbert DM, Migone TS, Kopf M, Leonard WJ, Rudikoff S.
Distinct tumorigenic potential of abl and raf in B cell neoplasia: abl activates the IL-6 signaling pathway.
Immunity 5(1): 81-9, 1996.
[Text Abstract on PubMed]
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74
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John S, Marais R, Child R, Light Y, Leonard WJ.
Importance of low affinity Elf-1 sites in the regulation of lymphoid-specific inducible gene expression.
J Exp Med 183(3): 743-50, 1996.
[Text Abstract on PubMed]
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75
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John S, Robbins CM, Leonard WJ.
An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.
EMBO J 15(20): 5627-35, 1996.
[Text Abstract on PubMed]
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76
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Leonard WJ.
Dysfunctional cytokine receptor signaling in severe combined immunodeficiency.
J Investig Med 44(6): 304-11, 1996.
[Text Abstract on PubMed]
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77
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Leonard WJ.
STATs and cytokine specificity.
Nat Med 2(9): 968-9, 1996.
[Text Abstract on PubMed]
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78
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Leonard WJ.
The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling.
Annu Rev Med 47: 229-39, 1996.
[Text Abstract on PubMed]
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79
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Lin JX, Mietz J, Modi WS, John S, Leonard WJ.
Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.
J Biol Chem 271(18): 10738-44, 1996.
[Text Abstract on PubMed]
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80
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Mulloy JC, Crownley RW, Fullen J, Leonard WJ, Franchini G.
The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.
J Virol 70(6): 3599-605, 1996.
[Text Abstract on PubMed]
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81
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Epling-Burnette PK, Wei S, Liu JH, Pericle F, Ussery D, Russell SM, Leonard WJ, Djeu JY.
Expression of interleukin-2 receptor gamma on human monocytes: characterization of lineage specific post-translational modifications.
Eur J Immunol 25(1): 291-4, 1995.
[Text Abstract on PubMed]
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82
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John S, Reeves RB, Lin JX, Child R, Leiden JM, Thompson CB, Leonard WJ.
Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.
Mol Cell Biol 15(3): 1786-96, 1995.
[Text Abstract on PubMed]
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83
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Kozak CA, Leonard WJ.
Genetic mapping of the interleukin 1 receptor alpha and beta chain genes in the mouse.
Mamm Genome 6(11): 823-4, 1995.
[Text Abstract on PubMed]
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84
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Leonard WJ, Shores EW, Love PE.
Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development.
Immunol Rev 148: 97-114, 1995.
[Text Abstract on PubMed]
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85
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Obiri NI, Debinski W, Leonard WJ, Puri RK.
Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15.
J Biol Chem 270(15): 8797-804, 1995.
[Text Abstract on PubMed]
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86
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Qazilbash MH, Walsh CE, Russell SM, Noguchi M, Mann MM, Leonard WJ, Liu JM.
Retroviral vector for gene therapy of X-linked severe combined immunodeficiency syndrome.
J Hematother 4(2): 91-8, 1995.
[Text Abstract on PubMed]
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87
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Schmalstieg FC, Leonard WJ, Noguchi M, Berg M, Rudloff HE, Denney RM, Dave SK, Brooks EG, Goldman AS.
Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency.
J Clin Invest 95(3): 1169-73, 1995.
[Text Abstract on PubMed]
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88
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Sugie K, Nakamura K, Teshigawara K, Diamond MS, Springer TA, Nakamura Y, Leonard WJ, Uchida A, Yodoi J.
Activation of natural killer cells by the mAb YTA-1 that recognizes leukocyte function-associated antigen-1.
Int Immunol 7(5): 763-9, 1995.
[Text Abstract on PubMed]
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89
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Ziegler SE, Morella KK, Anderson D, Kumaki N, Leonard WJ, Cosman D, Baumann H.
Reconstitution of a functional interleukin (IL)-7 receptor demonstrates that the IL-2 receptor gamma chain is required for IL-7 signal transduction.
Eur J Immunol 25(2): 399-404, 1995.
[Text Abstract on PubMed]
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90
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Bosco MC, Espinoza-Delgado I, Schwabe M, Russell SM, Leonard WJ, Longo DL, Varesio L.
The gamma subunit of the interleukin-2 receptor is expressed in human monocytes and modulated by interleukin-2, interferon gamma, and transforming growth factor beta 1.
Blood 83(12): 3462-7, 1994.
[Text Abstract on PubMed]
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91
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Leonard WJ, Noguchi M, Russell SM, McBride OW.
The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.
Immunol Rev 138: 61-86, 1994.
[Text Abstract on PubMed]
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92
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Leonard WJ, Noguchi M, Russell SM.
Sharing of a common gamma chain, gamma c, by the IL-2, IL-4, and IL-7 receptors: implications for X-linked severe combined immunodeficiency (XSCID).
Adv Exp Med Biol 365: 225-32, 1994.
[Text Abstract on PubMed]
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93
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Leonard WJ.
The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: implications for cytokine pleiotropy and redundancy.
Curr Opin Immunol 6(4): 631-5, 1994.
[Text Abstract on PubMed]
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94
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Liu JH, Wei S, Ussery D, Epling-Burnette PK, Leonard WJ, Djeu JY.
Expression of interleukin-2 receptor gamma chain on human neutrophils.
Blood 84(11): 3870-5, 1994.
[Text Abstract on PubMed]
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95
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Lodi PJ, Garrett DS, Kuszewski J, Tsang ML, Weatherbee JA, Leonard WJ, Gronenborn AM, Clore GM.
High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR.
Science 263(5154): 1762-7, 1994.
[Text Abstract on PubMed]
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96
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Nakamura Y, Russell SM, Mess SA, Friedmann M, Erdos M, Francois C, Jacques Y, Adelstein S, Leonard WJ.
Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling.
Nature 369(6478): 330-3, 1994.
[Text Abstract on PubMed]
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97
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Djeu JY, Liu JH, Wei S, Rui H, Pearson CA, Leonard WJ, Blanchard DK.
Function associated with IL-2 receptor-beta on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2.
J Immunol 150(3): 960-70, 1993.
[Text Abstract on PubMed]
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98
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Graham GJ, Zhou L, Weatherbee JA, Tsang ML, Napolitano M, Leonard WJ, Pragnell IB.
Characterization of a receptor for macrophage inflammatory protein 1 alpha and related proteins on human and murine cells.
Cell Growth Differ 4(3): 137-46, 1993.
[Text Abstract on PubMed]
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99
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Lin JX, Bhat NK, John S, Queale WS, Leonard WJ.
Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.
Mol Cell Biol 13(10): 6201-10, 1993.
[Text Abstract on PubMed]
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100
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Noguchi M, Adelstein S, Cao X, Leonard WJ.
Characterization of the human interleukin-2 receptor gamma chain gene.
J Biol Chem 268(18): 13601-8, 1993.
[Text Abstract on PubMed]
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101
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Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ.
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.
Science 262(5141): 1877-80, 1993.
[Text Abstract on PubMed]
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102
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Noguchi M, Yi H, Rosenblatt HM, Filipovich AH, Adelstein S, Modi WS, McBride OW, Leonard WJ.
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans.
Cell 73(1): 147-57, 1993.
[Text Abstract on PubMed]
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103
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Otani H, Erdos M, Leonard WJ.
Tyrosine kinase(s) regulate apoptosis and bcl-2 expression in a growth factor-dependent cell line.
J Biol Chem 268(30): 22733-6, 1993.
[Text Abstract on PubMed]
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104
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Toledano MB, Ghosh D, Trinh F, Leonard WJ.
N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65.
Mol Cell Biol 13(2): 852-60, 1993.
[Text Abstract on PubMed]
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105
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Wei S, Blanchard DK, Liu JH, Leonard WJ, Djeu JY.
Activation of tumor necrosis factor-alpha production from human neutrophils by IL-2 via IL-2-R beta.
J Immunol 150(5): 1979-87, 1993.
[Text Abstract on PubMed]
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106
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Izquierdo M, Downward J, Otani H, Leonard WJ, Cantrell DA.
Interleukin (IL)-2 activation of p21ras in murine myeloid cells transfected with human IL-2 receptor beta chain.
Eur J Immunol 22(3): 817-21, 1992.
[Text Abstract on PubMed]
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107
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Otani H, Siegel JP, Erdos M, Gnarra JR, Toledano MB, Sharon M, Mostowski H, Feinberg MB, Pierce JH, Leonard WJ.
Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.
Proc Natl Acad Sci U S A 89(7): 2789-93, 1992.
[Text Abstract on PubMed]
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108
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Toledano MB, Leonard WJ.
Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.
Proc Natl Acad Sci U S A 88(10): 4328-32, 1991.
[Text Abstract on PubMed]
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109
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Leonard WJ, Gerace WJ.
Quark-meson coupling model for baryon wave functions and properties.
PHYSICAL REVIEW D. PARTICLES AND FIELDS 41(3): 924-936, 1990.
[Text Abstract on PubMed]
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110
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Leonard WJ, Gnarra JR, Napolitano M, Sharon M.
Structure, function, and regulation of the interleukin-2 receptor and identification of a novel immune activation gene.
Philos Trans R Soc Lond B Biol Sci 327(1239): 187-92, 1990.
[Text Abstract on PubMed]
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111
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Leonard WJ, Gnarra JR, Sharon M.
The multisubunit interleukin-2 receptor.
Ann N Y Acad Sci 594: 200-6, 1990.
[Text Abstract on PubMed]
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112
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Leonard WJ, Sharon M, Gnarra JR.
Structure and function of interleukin-2 receptors.
Prog Clin Biol Res 352: 179-87, 1990.
[Text Abstract on PubMed]
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113
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Lin BB, Cross SL, Halden NF, Roman DG, Toledano MB, Leonard WJ.
Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene.
Mol Cell Biol 10(2): 850-3, 1990.
[Text Abstract on PubMed]
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114
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Napolitano M, Seamon KB, Leonard WJ.
Identification of cell surface receptors for the Act-2 cytokine.
J Exp Med 172(1): 285-9, 1990.
[Text Abstract on PubMed]
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115
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Roman DG, Toledano MB, Leonard WJ.
Sp1 represses IL-2 receptor alpha chain gene expression.
New Biol 2(7): 642-7, 1990.
[Text Abstract on PubMed]
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116
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Sharon M, Gnarra JR, Leonard WJ.
A 100-kilodalton protein is associated with the murine interleukin 2 receptor: biochemical evidence that p100 is distinct from the alpha and beta chains.
Proc Natl Acad Sci U S A 87(12): 4869-73, 1990.
[Text Abstract on PubMed]
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117
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Toledano MB, Roman DG, Halden NF, Lin BB, Leonard WJ.
The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines.
Proc Natl Acad Sci U S A 87(5): 1830-4, 1990.
[Text Abstract on PubMed]
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118
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Cross SL, Halden NF, Lenardo MJ, Leonard WJ.
Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes.
Science 244(4903): 466-9, 1989.
[Text Abstract on PubMed]
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119
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Halden NF, Wolf JB, Leonard WJ.
Identification of a novel site specific endonuclease produced by Mycoplasma fermentans: discovery while characterizing DNA binding proteins in T lymphocyte cell lines.
Nucleic Acids Res 17(9): 3491-9, 1989.
[Text Abstract on PubMed]
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120
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Leonard WJ, Sharon M, Cross SL.
The human interleukin-2 receptor. Structure and molecular regulation.
Year Immunol 5: 46-58, 1989.
[Text Abstract on PubMed]
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121
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Sharon M, Gnarra JR, Leonard WJ.
The beta-chain of the IL-2 receptor (p70) is tyrosine-phosphorylated on YT and HUT-102B2 cells.
J Immunol 143(8): 2530-3, 1989.
[Text Abstract on PubMed]
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122
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Lipes MA, Napolitano M, Jeang KT, Chang NT, Leonard WJ.
Identification, cloning, and characterization of an immune activation gene.
Proc Natl Acad Sci U S A 85(24): 9704-8, 1988.
[Text Abstract on PubMed]
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123
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Sharon M, Gnarra JR, Baniyash M, Leonard WJ.
Possible association between IL-2 receptors and class I HLA molecules on T cells.
J Immunol 141(10): 3512-5, 1988.
[Text Abstract on PubMed]
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124
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Sharon M, Siegel JP, Tosato G, Yodoi J, Gerrard TL, Leonard WJ.
The human interleukin 2 receptor beta chain (p70). Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells.
J Exp Med 167(3): 1265-70, 1988.
[Text Abstract on PubMed]
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125
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Cross SL, Feinberg MB, Wolf JB, Holbrook NJ, Wong-Staal F, Leonard WJ.
Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I.
Cell 49(1): 47-56, 1987.
[Text Abstract on PubMed]
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126
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Greene WC, Leonard WJ, Wano Y, Svetlik PB, Peffer NJ, Sodroski JG, Rosen CA, Goh WC, Haseltine WA.
Trans-activator gene of HTLV-II: interpretation.
Science 235(4792): 1073, 1987.
[Text Abstract on PubMed]
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127
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Greene WC, Leonard WJ.
Human interleukin 2 receptor (Tac antigen).
Methods Enzymol 150: 682-700, 1987.
[Text Abstract on PubMed]
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128
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Siegel JP, Sharon M, Smith PL, Leonard WJ.
The IL-2 receptor beta chain (p70): role in mediating signals for LAK, NK, and proliferative activities.
Science 238(4823): 75-8, 1987.
[Text Abstract on PubMed]
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129
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Chanda PK, Chen GF, Baine Y, Leonard WJ, Greene WC, Chang TW, Chang NT.
Expression of human interleukin-2 receptor cDNA in E. coli.
Biochem Biophys Res Commun 141(2): 804-11, 1986.
[Text Abstract on PubMed]
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130
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Gerace WJ, Leonard WJ, Sparrow DA.
Importance of quadrupole coupling for low energy pion charge exchange reactions.
PHYSICAL REVIEW C. NUCLEAR PHYSICS 34(1): 353-356, 1986.
[Text Abstract on PubMed]
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131
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Greene WC, Depper JM, Krönke M, Leonard WJ.
The human interleukin-2 receptor: analysis of structure and function.
Immunol Rev 92: 29-48, 1986.
[Text Abstract on PubMed]
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132
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Greene WC, Depper JM, Krönke M, Leonard WJ.
The human interleukin-2 receptor: role in normal T-cell growth and association with HTLV-I-induced T-cell leukemia.
Cold Spring Harb Symp Quant Biol 51 Pt 2: 731-7, 1986.
[Text Abstract on PubMed]
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133
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Greene WC, Leonard WJ, Depper JM, Nelson DL, Waldmann TA.
The human interleukin-2 receptor: normal and abnormal expression in T cells and in leukemias induced by the human T-lymphotropic retroviruses.
Ann Intern Med 105(4): 560-72, 1986.
[Text Abstract on PubMed]
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134
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Greene WC, Leonard WJ, Depper JM.
Growth of human T lymphocytes: an analysis of interleukin 2 and its cellular receptor.
Prog Hematol 14: 283-301, 1986.
[Text Abstract on PubMed]
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135
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Greene WC, Leonard WJ, Wano Y, Svetlik PB, Peffer NJ, Sodroski JG, Rosen CA, Goh WC, Haseltine WA.
Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
Science 232(4752): 877-80, 1986.
[Text Abstract on PubMed]
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136
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Greene WC, Leonard WJ.
The human interleukin-2 receptor.
Annu Rev Immunol 4: 69-95, 1986.
[Text Abstract on PubMed]
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137
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Sharon M, Klausner RD, Cullen BR, Chizzonite R, Leonard WJ.
Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions.
Science 234(4778): 859-63, 1986.
[Text Abstract on PubMed]
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138
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Treiger BF, Leonard WJ, Svetlik P, Rubin LA, Nelson DL, Greene WC.
A secreted form of the human interleukin 2 receptor encoded by an "anchor minus" cDNA.
J Immunol 136(11): 4099-105, 1986.
[Text Abstract on PubMed]
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139
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Depper JM, Leonard WJ, Drogula C, Krönke M, Waldmann TA, Greene WC.
Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.
Proc Natl Acad Sci U S A 82(12): 4230-4, 1985.
[Text Abstract on PubMed]
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140
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Depper JM, Leonard WJ, Drogula CL, Krönke M, Waldmann TA, Greene WC.
Activators of protein kinase C and 5-azacytidine induce IL-2 receptor expression on human T lymphocytes.
J Cell Biochem 27(3): 267-76, 1985.
[Text Abstract on PubMed]
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141
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Greene WC, Depper JM, Krönke M, Leonard WJ.
The human interleukin-2 receptor.
J Cell Sci Suppl 3: 97-106, 1985.
[Text Abstract on PubMed]
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142
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Greene WC, Robb RJ, Svetlik PB, Rusk CM, Depper JM, Leonard WJ.
Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.
J Exp Med 162(1): 363-8, 1985.
[Text Abstract on PubMed]
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143
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Krönke M, Depper JM, Leonard WJ, Vitetta ES, Waldmann TA, Greene WC.
Adult T cell leukemia: a potential target for ricin A chain immunotoxins.
Blood 65(6): 1416-21, 1985.
[Text Abstract on PubMed]
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144
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Krönke M, Leonard WJ, Depper JM, Greene WC.
Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia.
Science 228(4704): 1215-7, 1985.
[Text Abstract on PubMed]
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145
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Krönke M, Leonard WJ, Depper JM, Greene WC.
Sequential expression of genes involved in human T lymphocyte growth and differentiation.
J Exp Med 161(6): 1593-8, 1985.
[Text Abstract on PubMed]
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146
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Leonard WJ, Depper JM, Kanehisa M, Krönke M, Peffer NJ, Svetlik PB, Sullivan M, Greene WC.
Structure of the human interleukin-2 receptor gene.
Science 230(4726): 633-9, 1985.
[Text Abstract on PubMed]
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147
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Leonard WJ, Depper JM, Krönke M, Robb RJ, Waldmann TA, Greene WC.
The human receptor for T-cell growth factor. Evidence for variable post-translational processing, phosphorylation, sulfation, and the ability of precursor forms of the receptor to bind T-cell growth factor.
J Biol Chem 260(3): 1872-80, 1985.
[Text Abstract on PubMed]
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148
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Leonard WJ, Donlon TA, Lebo RV, Greene WC.
Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.
Science 228(4707): 1547-9, 1985.
[Text Abstract on PubMed]
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149
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Leonard WJ, Krönke M, Peffer NJ, Depper JM, Greene WC.
Interleukin 2 receptor gene expression in normal human T lymphocytes.
Proc Natl Acad Sci U S A 82(18): 6281-5, 1985.
[Text Abstract on PubMed]
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150
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Miller J, Malek TR, Leonard WJ, Greene WC, Shevach EM, Germain RN.
Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA.
J Immunol 134(6): 4212-7, 1985.
[Text Abstract on PubMed]
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151
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Waldmann TA, Longo DL, Leonard WJ, Depper JM, Thompson CB, Krönke M, Goldman CK, Sharrow S, Bongiovanni K, Greene WC.
Interleukin 2 receptor (Tac antigen) expression in HTLV-I-associated adult T-cell leukemia.
Cancer Res 45(9 Suppl): 4559s-4562s, 1985.
[Text Abstract on PubMed]
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152
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Depper JM, Leonard WJ, Krönke M, Noguchi PD, Cunningham RE, Waldmann TA, Greene WC.
Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen.
J Immunol 133(6): 3054-61, 1984.
[Text Abstract on PubMed]
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153
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Depper JM, Leonard WJ, Krönke M, Waldmann TA, Greene WC.
Augmented T cell growth factor receptor expression in HTLV-1-infected human leukemic T cells.
J Immunol 133(4): 1691-5, 1984.
[Text Abstract on PubMed]
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154
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Greene WC, Robb RJ, Depper JM, Leonard WJ, Drogula C, Svetlik PB, Wong-Staal F, Gallo RC, Waldmann TA.
Phorbol diester induces expression of Tac antigen on human acute T lymphocytic leukemic cells.
J Immunol 133(2): 1042-7, 1984.
[Text Abstract on PubMed]
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155
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Krönke M, Leonard WJ, Depper JM, Arya SK, Wong-Staal F, Gallo RC, Waldmann TA, Greene WC.
Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.
Proc Natl Acad Sci U S A 81(16): 5214-8, 1984.
[Text Abstract on PubMed]
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156
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Leonard WJ, Strauss AW, Go MF, Alpers DH, Gordon JI.
Biosynthesis and compartmentalization of rat-intestinal vitamin-D-dependent calcium-binding protein.
Eur J Biochem 139(3): 561-71, 1984.
[Text Abstract on PubMed]
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157
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Waldmann TA, Goldman CK, Leonard WJ, Depper JM, Robb RJ, Korsmeyer SJ, Greene WC.
Interleukin-2 receptors on activated malignant and normal B-cells.
Curr Top Microbiol Immunol 113: 96-101, 1984.
[Text Abstract on PubMed]
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158
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Waldmann TA, Goldman CK, Robb RJ, Depper JM, Leonard WJ, Sharrow SO, Bongiovanni KF, Korsmeyer SJ, Greene WC.
Expression of interleukin 2 receptors on activated human B cells.
J Exp Med 160(5): 1450-66, 1984.
[Text Abstract on PubMed]
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159
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Waldmann TA, Leonard WJ, Depper JM, Krönke M, Goldman CK, Oh T, Greene WC.
Interleukin-2 receptor expression in retrovirus associated adult T-cell leukemia.
Princess Takamatsu Symp 15: 259-68, 1984.
[Text Abstract on PubMed]
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160
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Cossman J, Neckers LM, Leonard WJ, Greene WC.
Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen.
J Exp Med 157(3): 1064-9, 1983.
[Text Abstract on PubMed]
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161
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Depper JM, Leonard WJ, Robb RJ, Waldmann TA, Greene WC.
Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation.
J Immunol 131(2): 690-6, 1983.
[Text Abstract on PubMed]
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162
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Greene WC, Depper JM, Leonard WJ, Fleisher TA, Waldmann TA.
Construction of human suppressor T cell hybridomas.
Lymphokine Res 2(2): 53-60, 1983.
[Text Abstract on PubMed]
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163
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Korsmeyer SJ, Greene WC, Cossman J, Hsu SM, Jensen JP, Neckers LM, Marshall SL, Bakhshi A, Depper JM, Leonard WJ, Jaffe ES, Waldmann TA.
Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia.
Proc Natl Acad Sci U S A 80(14): 4522-6, 1983.
[Text Abstract on PubMed]
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164
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Leonard WJ, Depper JM, Robb RJ, Waldmann TA, Greene WC.
Characterization of the human receptor for T-cell growth factor.
Proc Natl Acad Sci U S A 80(22): 6957-61, 1983.
[Text Abstract on PubMed]
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165
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Greene WC, Fleisher TA, Depper JM, Leonard WJ, Stanton GJ, Waldmann TA.
Characterization of a soluble suppressor of human B cell function produced by a continuous human suppressor T cell line. II. Evidence for suppression through a direct action of CTC-SISS-B on human B cells.
J Immunol 129(3): 1120-3, 1982.
[Text Abstract on PubMed]
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166
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Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC.
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.
Nature 300(5889): 267-9, 1982.
[Text Abstract on PubMed]
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167
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FOSTER JF, SOGAMI M, PETERSEN HA, LEONARD WJ.
THE MICROHETEROGENEITY OF PLASMA ALBUMINS. I. CRITICAL EVIDENCE FOR AND DESCRIPTION OF THE MICROHETEROGENEITY MODEL.
J Biol Chem 240: 2495-502, 1965.
[Text Abstract on PubMed]
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168
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LEONARD WJ, FOSTER JF.
INFLUENCE OF HELIX CONTENT AND SOLVENT ENVIRONMENT ON THE OPTICAL ROTATORY DISPERSION PARAMETERS OF POLYPEPTIDES.
J Mol Biol 62: 590-8, 1963.
[Text Abstract on PubMed]
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169
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LEONARD WJ, VIJAI KK, FOSTER JF.
A structural transformation in bovine and human plasma albumins in alkaline solution as revealed by rotatory dispersion studies.
J Biol Chem 238: 1984-8, 1963.
[Text Abstract on PubMed]
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170
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SOGAMI M, LEONARD WJ, FOSTER JF.
Statistical evaluation of the rotatory dispersion parameters for helical polymers and proteins: two proposed methods and their application to data on polyglutamic acid and plasma albumin.
Arch Biochem Biophys 100: 260-9, 1963.
[Text Abstract on PubMed]
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171
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LEONARD WJ, FOSTER JF.
Changes in optical rotation in the acid transformations of plasma albumin. Evidence for the contribution of tertiary structure to rotatory behavior.
J Biol Chem 236: 2662-9, 1961.
[Text Abstract on PubMed]
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172
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LEONARD WJ, FOSTER JF.
The N-F transition as the basis for cooperative detergent binding of bovine plasma albumin.
J Biol Chem 236: PC73-PC75, 1961.
[Text Abstract on PubMed]
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173
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Imada K, Leonard WJ.
The Jak-STAT pathway.
Mol Immunol 37(1-2): 1-11,
[Text Abstract on PubMed]
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174
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Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Krönke M, Svetlik PB, Peffer NJ, Waldmann TA.
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.
Nature 311(5987): 626-31,
[Text Abstract on PubMed]
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