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1
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Seggewiss R, Loré K, Greiner E, Magnusson MK, Price DA, Douek DC, Dunbar CE, Wiestner A.
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner.
Blood 105(6): 2473-9, 2005.
[Text Abstract on PubMed]
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2
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Dunbar CE.
Stem and progenitor cell therapies: insights from non-human primate models.
Cytotherapy 6(6): 586-8, 2004.
[Text Abstract on PubMed]
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3
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Hanawa H, Hematti P, Keyvanfar K, Metzger ME, Krouse A, Donahue RE, Kepes S, Gray J, Dunbar CE, Persons DA, Nienhuis AW.
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system.
Blood 103(11): 4062-9, 2004.
[Text Abstract on PubMed]
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4
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Hematti P, Hong BK, Ferguson C, Adler R, Hanawa H, Sellers S, Holt IE, Eckfeldt CE, Sharma Y, Schmidt M, von Kalle C, Persons DA, Billings EM, Verfaillie CM, Nienhuis AW, Wolfsberg TG, Dunbar CE, Calmels B.
Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.
PLoS Biol 2(12): e423, 2004.
[Text Abstract on PubMed]
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5
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Kiem HP, Sellers S, Thomasson B, Morris JC, Tisdale JF, Horn PA, Hematti P, Adler R, Kuramoto K, Calmels B, Bonifacino A, Hu J, von Kalle C, Schmidt M, Sorrentino B, Nienhuis A, Blau CA, Andrews RG, Donahue RE, Dunbar CE.
Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia.
Mol Ther 9(3): 389-95, 2004.
[Text Abstract on PubMed]
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6
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Kuramoto K, Follmann DA, Hematti P, Sellers S, Agricola BA, Metzger ME, Donahue RE, von Kalle C, Dunbar CE.
Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates.
Blood 103(11): 4070-7, 2004.
[Text Abstract on PubMed]
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7
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Shi PA, De Angioletti M, Donahue RE, Notaro R, Luzzatto L, Dunbar CE.
In vivo gene marking of rhesus macaque long-term repopulating hematopoietic cells using a VSV-G pseudotyped versus amphotropic oncoretroviral vector.
J Gene Med 6(4): 367-73, 2004.
[Text Abstract on PubMed]
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8
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Hinds KA, Hill JM, Shapiro EM, Laukkanen MO, Silva AC, Combs CA, Varney TR, Balaban RS, Koretsky AP, Dunbar CE.
Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells.
Blood 102(3): 867-72, 2003.
[Text Abstract on PubMed]
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9
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Huhn RD, Fogarty PF, Nakamura R, Read EJ, Leitman SF, Rick ME, Kimball J, Greene A, Hansmann K, Gratwohl A, Young N, Barrett AJ, Dunbar CE.
High-dose cyclophosphamide with autologous lymphocyte-depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia.
Blood 101(1): 71-7, 2003.
[Text Abstract on PubMed]
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10
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Hematti P, Sloand EM, Carvallo CA, Albert MR, Yee CL, Fuehrer MM, Blancato JK, Kearns WG, Barrett JA, Childs RW, Vogel JC, Dunbar CE.
Absence of donor-derived keratinocyte stem cells in skin tissues cultured from patients after mobilized peripheral blood hematopoietic stem cell transplantation.
Exp Hematol 30(8): 943-9, 2002.
[Text Abstract on PubMed]
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11
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Hu J, Dunbar CE.
Update on hematopoietic stem cell gene transfer using non-human primate models.
Curr Opin Mol Ther 4(5): 482-90, 2002.
[Text Abstract on PubMed]
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12
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Hu J, Takatoku M, Sellers SE, Agricola BA, Metzger ME, Donahue RE, Dunbar CE.
Analysis of origin and optimization of expansion and transduction of circulating peripheral blood endothelial progenitor cells in the rhesus macaque model.
Hum Gene Ther 13(17): 2041-50, 2002.
[Text Abstract on PubMed]
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13
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Kluge KA, Bonifacino AC, Sellers S, Agricola BA, Donahue RE, Dunbar CE.
Retroviral transduction and engraftment ability of primate hematopoietic progenitor and stem cells transduced under serum-free versus serum-containing conditions.
Mol Ther 5(3): 316-22, 2002.
[Text Abstract on PubMed]
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14
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Schmidt M, Zickler P, Hoffmann G, Haas S, Wissler M, Muessig A, Tisdale JF, Kuramoto K, Andrews RG, Wu T, Kiem HP, Dunbar CE, von Kalle C.
Polyclonal long-term repopulating stem cell clones in a primate model.
Blood 100(8): 2737-43, 2002.
[Text Abstract on PubMed]
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15
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Shi PA, Hematti P, von Kalle C, Dunbar CE.
Genetic marking as an approach to studying in vivo hematopoiesis: progress in the non-human primate model.
Oncogene 21(21): 3274-83, 2002.
[Text Abstract on PubMed]
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16
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Burt RK, Fassas A, Snowden J, van Laar JM, Kozak T, Wulffraat NM, Nash RA, Dunbar CE, Arnold R, Prentice G, Bingham S, Marmont AM, McSweeney PA.
Collection of hematopoietic stem cells from patients with autoimmune diseases.
Bone Marrow Transplant 28(1): 1-12, 2001.
[Text Abstract on PubMed]
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17
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Donahue RE, Dunbar CE.
Update on the use of nonhuman primate models for preclinical testing of gene therapy approaches targeting hematopoietic cells.
Hum Gene Ther 12(6): 607-17, 2001.
[Text Abstract on PubMed]
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18
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Dunbar CE.
The use of nonhuman primate models to improve gene transfer into haematopoietic stem cells.
J Intern Med 249(4): 329-38, 2001.
[Text Abstract on PubMed]
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19
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Russell SJ, Dunbar CE.
Gene therapy approaches for multiple myeloma.
Semin Hematol 38(3): 268-75, 2001.
[Text Abstract on PubMed]
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20
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Sellers SE, Tisdale JF, Agricola BA, Metzger ME, Donahue RE, Dunbar CE, Sorrentino BP.
The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells.
Blood 97(6): 1888-91, 2001.
[Text Abstract on PubMed]
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21
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Shi PA, Pomper GJ, Metzger ME, Donahue RE, Leitman SF, Dunbar CE.
Assessment of rapid remobilization intervals with G-CSF and SCF in murine and rhesus macaque models.
Transfusion 41(11): 1438-44, 2001.
[Text Abstract on PubMed]
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22
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Takatoku M, Sellers S, Agricola BA, Metzger ME, Kato I, Donahue RE, Dunbar CE.
Avoidance of stimulation improves engraftment of cultured and retrovirally transduced hematopoietic cells in primates.
J Clin Invest 108(3): 447-55, 2001.
[Text Abstract on PubMed]
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23
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Giri N, Kang E, Tisdale JF, Follman D, Rivera M, Schwartz GN, Kim S, Young NS, Rick ME, Dunbar CE.
Clinical and laboratory evidence for a trilineage haematopoietic defect in patients with refractory Diamond-Blackfan anaemia.
Br J Haematol 108(1): 167-75, 2000.
[Text Abstract on PubMed]
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24
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Heim DA, Hanazono Y, Giri N, Wu T, Childs R, Sellers SE, Muul L, Agricola BA, Metzger ME, Donahue RE, Tisdale JF, Dunbar CE.
Introduction of a xenogeneic gene via hematopoietic stem cells leads to specific tolerance in a rhesus monkey model.
Mol Ther 1(6): 533-44, 2000.
[Text Abstract on PubMed]
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25
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Tisdale JF, Dunn DE, Geller N, Plante M, Nunez O, Dunbar CE, Barrett AJ, Walsh TJ, Rosenfeld SJ, Young NS.
High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial.
Lancet 356(9241): 1554-9, 2000.
[Text Abstract on PubMed]
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26
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Wu T, Kim HJ, Sellers SE, Meade KE, Agricola BA, Metzger ME, Kato I, Donahue RE, Dunbar CE, Tisdale JF.
Prolonged high-level detection of retrovirally marked hematopoietic cells in nonhuman primates after transduction of CD34+ progenitors using clinically feasible methods.
Mol Ther 1(3): 285-93, 2000.
[Text Abstract on PubMed]
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27
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Hanazono Y, Brown KE, Handa A, Metzger ME, Heim D, Kurtzman GJ, Donahue RE, Dunbar CE.
In vivo marking of rhesus monkey lymphocytes by adeno-associated viral vectors: direct comparison with retroviral vectors.
Blood 94(7): 2263-70, 1999.
[Text Abstract on PubMed]
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28
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Yu JM, Emmons RV, Hanazono Y, Sellers S, Young NS, Dunbar CE.
Expression of interferon-gamma by stromal cells inhibits murine long-term repopulating hematopoietic stem cell activity.
Exp Hematol 27(5): 895-903, 1999.
[Text Abstract on PubMed]
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29
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Bodine DM, Dunbar CE, Girard LJ, Seidel NE, Cline AP, Donahue RE, Orlic D.
Improved amphotropic retrovirus-mediated gene transfer into hematopoietic stem cells.
Ann N Y Acad Sci 850: 139-50, 1998.
[Text Abstract on PubMed]
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30
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Mavroudis DA, Read EJ, Molldrem J, Raptis A, Plante M, Carter CS, Phang S, Dunbar CE, Barrett AJ.
T cell-depleted granulocyte colony-stimulating factor (G-CSF) modified allogenic bone marrow transplantation for hematological malignancy improves graft CD34+ cell content but is associated with delayed pancytopenia.
Bone Marrow Transplant 21(5): 431-40, 1998.
[Text Abstract on PubMed]
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31
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Tisdale JF, Hanazono Y, Sellers SE, Agricola BA, Metzger ME, Donahue RE, Dunbar CE.
Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability.
Blood 92(4): 1131-41, 1998.
[Text Abstract on PubMed]
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32
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Brown KE, Tisdale J, Barrett AJ, Dunbar CE, Young NS.
Hepatitis-associated aplastic anemia.
N Engl J Med 336(15): 1059-64, 1997.
[Text Abstract on PubMed]
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33
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Sekhar M, Yu JM, Soma T, Dunbar CE.
Murine long-term repopulating ability is compromised by ex vivo culture in serum-free medium despite preservation of committed progenitors.
J Hematother 6(6): 543-9, 1997.
[Text Abstract on PubMed]
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34
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Dunbar CE, Seidel NE, Doren S, Sellers S, Cline AP, Metzger ME, Agricola BA, Donahue RE, Bodine DM.
Improved retroviral gene transfer into murine and Rhesus peripheral blood or bone marrow repopulating cells primed in vivo with stem cell factor and granulocyte colony-stimulating factor.
Proc Natl Acad Sci U S A 93(21): 11871-6, 1996.
[Text Abstract on PubMed]
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35
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Dunbar CE.
Gene transfer to hematopoietic stem cells: implications for gene therapy of human disease.
Annu Rev Med 47: 11-20, 1996.
[Text Abstract on PubMed]
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36
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Emmons RV, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR.
Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction.
Blood 87(10): 4068-71, 1996.
[Text Abstract on PubMed]
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37
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Soma T, Yu JM, Dunbar CE.
Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-beta but not macrophage inflammatory protein-1 alpha activities.
Blood 87(11): 4561-7, 1996.
[Text Abstract on PubMed]
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38
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Bock TA, Orlic D, Dunbar CE, Broxmeyer HE, Bodine DM.
Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes.
J Exp Med 182(6): 2037-43, 1995.
[Text Abstract on PubMed]
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39
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Dunbar CE, Stewart FM.
Separating the wheat from the chaff: selection of benign hematopoietic cells in chronic myeloid leukemia.
Blood 79(5): 1107-10, 1992.
[Text Abstract on PubMed]
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40
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Dunbar CE, Crosier PS, Nienhuis AW.
Introduction of an activated RAS oncogene into murine bone marrow lymphoid progenitors via retroviral gene transfer results in thymic lymphomas.
Oncogene Res 6(1): 39-51, 1991.
[Text Abstract on PubMed]
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41
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Dunbar CE, Smith DA, Kimball J, Garrison L, Nienhuis AW, Young NS.
Treatment of Diamond-Blackfan anaemia with haematopoietic growth factors, granulocyte-macrophage colony stimulating factor and interleukin 3: sustained remissions following IL-3.
Br J Haematol 79(2): 316-21, 1991.
[Text Abstract on PubMed]
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42
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Browder TM, Dunbar CE, Nienhuis AW.
Private and public autocrine loops in neoplastic cells.
Cancer Cells 1(1): 9-17, 1989.
[Text Abstract on PubMed]
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43
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Dunbar CE, Browder TM, Abrams JS, Nienhuis AW.
COOH-terminal-modified interleukin-3 is retained intracellularly and stimulates autocrine growth.
Science 245(4925): 1493-6, 1989.
[Text Abstract on PubMed]
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44
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Wong PM, Chung SW, Dunbar CE, Bodine DM, Ruscetti S, Nienhuis AW.
Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells result in a myeloproliferative disorder.
Mol Cell Biol 9(2): 798-808, 1989.
[Text Abstract on PubMed]
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45
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Kelly PF, Donahue RE, Vandergriff JA, Takatoku M, Bonifacino AC, Agricola BA, Metzger ME, Dunbar CE, Nienhuis AW, Vanin EF.
Prolonged multilineage clonal hematopoiesis in a rhesus recipient of CD34 positive cells marked with a RD114 pseudotyped oncoretroviral vector.
Blood Cells Mol Dis 30(1): 132-43,
[Text Abstract on PubMed]
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