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1
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Hiragun T, Peng Z, Beaven MA.
Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells.
Mol Pharmacol 67(3): 598-603, 2005.
[Text Abstract on PubMed]
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2
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Iwaki S, Tkaczyk C, Satterthwaite AB, Halcomb K, Beaven MA, Metcalfe DD, Gilfillan AM.
Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit.
J Biol Chem 280(48): 40261-70, 2005.
[Text Abstract on PubMed]
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3
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Peng Z, Beaven MA.
An essential role for phospholipase D in the activation of protein kinase C and degranulation in mast cells.
J Immunol 174(9): 5201-8, 2005.
[Text Abstract on PubMed]
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4
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Qiao H, Andrade MV, Lisboa FA, Morgan K, Beaven MA.
Fc{epsilon}RI and Toll-Like Receptors Mediate Synergistic Signals to Markedly Augment Production of Inflammatory Cytokines in Murine Mast Cells.
Blood: 2005.
[Text Abstract on PubMed]
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5
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Andrade MV, Hiragun T, Beaven MA.
Dexamethasone suppresses antigen-induced activation of phosphatidylinositol 3-kinase and downstream responses in mast cells.
J Immunol 172(12): 7254-62, 2004.
[Text Abstract on PubMed]
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6
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Choi WS, Hiragun T, Lee JH, Kim YM, Kim HP, Chahdi A, Her E, Han JW, Beaven MA.
Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr.
Mol Cell Biol 24(16): 6980-92, 2004.
[Text Abstract on PubMed]
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7
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Hundley TR, Gilfillan AM, Tkaczyk C, Andrade MV, Metcalfe DD, Beaven MA.
Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells.
Blood 104(8): 2410-7, 2004.
[Text Abstract on PubMed]
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8
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Chahdi A, Choi WS, Kim YM, Beaven MA.
Mastoparan selectively activates phospholipase D2 in cell membranes.
J Biol Chem 278(14): 12039-45, 2003.
[Text Abstract on PubMed]
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9
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Kirshenbaum AS, Akin C, Wu Y, Rottem M, Goff JP, Beaven MA, Rao VK, Metcalfe DD.
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI.
Leuk Res 27(8): 677-82, 2003.
[Text Abstract on PubMed]
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10
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Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM.
The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase.
J Biol Chem 278(48): 48474-84, 2003.
[Text Abstract on PubMed]
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11
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Chahdi A, Choi WS, Kim YM, Fraundorfer PF, Beaven MA.
Serine/threonine protein kinases synergistically regulate phospholipase D1 and 2 and secretion in RBL-2H3 mast cells.
Mol Immunol 38(16-18): 1269-76, 2002.
[Text Abstract on PubMed]
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12
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Choi WS, Chahdi A, Kim YM, Fraundorfer PF, Beaven MA.
Regulation of phospholipase D and secretion in mast cells by protein kinase A and other protein kinases.
Ann N Y Acad Sci 968: 198-212, 2002.
[Text Abstract on PubMed]
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13
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Choi WS, Kim YM, Combs C, Frohman MA, Beaven MA.
Phospholipases D1 and D2 regulate different phases of exocytosis in mast cells.
J Immunol 168(11): 5682-9, 2002.
[Text Abstract on PubMed]
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14
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Chaves-Dias C, Hundley TR, Gilfillan AM, Kirshenbaum AS, Cunha-Melo JR, Metcalfe DD, Beaven MA.
Induction of telomerase activity during development of human mast cells from peripheral blood CD34+ cells: comparisons with tumor mast-cell lines.
J Immunol 166(11): 6647-56, 2001.
[Text Abstract on PubMed]
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15
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Hundley TR, Prasad AR, Beaven MA.
Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase.
J Immunol 167(3): 1629-36, 2001.
[Text Abstract on PubMed]
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16
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Chahdi A, Fraundorfer PF, Beaven MA.
Compound 48/80 activates mast cell phospholipase D via heterotrimeric GTP-binding proteins.
J Pharmacol Exp Ther 292(1): 122-30, 2000.
[Text Abstract on PubMed]
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17
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Cissel DS, Beaven MA.
Disruption of Raf-1/heat shock protein 90 complex and Raf signaling by dexamethasone in mast cells.
J Biol Chem 275(10): 7066-70, 2000.
[Text Abstract on PubMed]
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18
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Holbrook PG, Geetha V, Beaven MA, Munson PJ.
Recognizing the pleckstrin homology domain fold in mammalian phospholipase D using hidden Markov models.
FEBS Lett 448(2-3): 269-72, 1999.
[Text Abstract on PubMed]
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19
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Cissel DS, Fraundorfer PF, Beaven MA.
Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and phosphatidylinositol-3-kinase-regulated phospholipase D in a mast cell line.
J Pharmacol Exp Ther 285(1): 110-8, 1998.
[Text Abstract on PubMed]
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20
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Kassessinoff TA, Gabet A, Beaven MA, Sagi-Eisenberg R.
Inositol polyphosphates regulate the membrane interactions of the endosomal p100, G-protein-related protein.
Biochim Biophys Acta 1394(1): 111-20, 1998.
[Text Abstract on PubMed]
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21
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Senyshyn J, Baumgartner RA, Beaven MA.
Quercetin sensitizes RBL-2H3 cells to polybasic mast cell secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway.
J Immunol 160(10): 5136-44, 1998.
[Text Abstract on PubMed]
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22
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Zhang C, Baumgartner RA, Yamada K, Beaven MA.
Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-alpha and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinases.
J Biol Chem 272(20): 13397-402, 1997.
[Text Abstract on PubMed]
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23
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Zhang C, Hirasawa N, Beaven MA.
Antigen activation of mitogen-activated protein kinase in mast cells through protein kinase C-dependent and independent pathways.
J Immunol 158(10): 4968-75, 1997.
[Text Abstract on PubMed]
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24
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Ali H, Choi OH, Fraundorfer PF, Yamada K, Gonzaga HM, Beaven MA.
Sustained activation of phospholipase D via adenosine A3 receptors is associated with enhancement of antigen- and Ca(2+)-ionophore-induced secretion in a rat mast cell line.
J Pharmacol Exp Ther 276(2): 837-45, 1996.
[Text Abstract on PubMed]
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25
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Baumgartner RA, Deramo VA, Beaven MA.
Constitutive and inducible mechanisms for synthesis and release of cytokines in immune cell lines.
J Immunol 157(9): 4087-93, 1996.
[Text Abstract on PubMed]
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26
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Baumgartner RA, Hirasawa N, Ozawa K, Gusovsky F, Beaven MA.
Enhancement of TNF-alpha synthesis by overexpression of G alpha z in a mast cell line.
J Immunol 157(4): 1625-9, 1996.
[Text Abstract on PubMed]
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27
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Beaven MA, Baumgartner RA.
Downstream signals initiated in mast cells by Fc epsilon RI and other receptors.
Curr Opin Immunol 8(6): 766-72, 1996.
[Text Abstract on PubMed]
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28
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Beaven MA.
Calcium signalling: sphingosine kinase versus phospholipase C?
Curr Biol 6(7): 798-801, 1996.
[Text Abstract on PubMed]
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29
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Choi OH, Park CS, Itoh K, Adelstein RS, Beaven MA.
Cloning of the cDNA encoding rat myosin heavy chain-A and evidence for the absence of myosin heavy chain-B in cultured rat mast (RBL-2H3) cells.
J Muscle Res Cell Motil 17(1): 69-77, 1996.
[Text Abstract on PubMed]
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30
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Jabril-Cuenod B, Zhang C, Scharenberg AM, Paolini R, Numerof R, Beaven MA, Kinet JP.
Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2.
J Biol Chem 271(27): 16268-72, 1996.
[Text Abstract on PubMed]
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31
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Rider LG, Hirasawa N, Santini F, Beaven MA.
Activation of the mitogen-activated protein kinase cascade is suppressed by low concentrations of dexamethasone in mast cells.
J Immunol 157(6): 2374-80, 1996.
[Text Abstract on PubMed]
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32
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Hirasawa N, Santini F, Beaven MA.
Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules.
J Immunol 154(10): 5391-402, 1995.
[Text Abstract on PubMed]
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33
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Hirasawa N, Scharenberg A, Yamamura H, Beaven MA, Kinet JP.
A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by Fc epsilon R1 is not shared by a G protein-coupled receptor.
J Biol Chem 270(18): 10960-7, 1995.
[Text Abstract on PubMed]
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34
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Ali H, Maeyama K, Sagi-Eisenberg R, Beaven MA.
Antigen and thapsigargin promote influx of Ca2+ in rat basophilic RBL-2H3 cells by ostensibly similar mechanisms that allow filling of inositol 1,4,5-trisphosphate-sensitive and mitochondrial Ca2+ stores.
Biochem J 304 ( Pt 2): 431-40, 1994.
[Text Abstract on PubMed]
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35
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Baumgartner RA, Ozawa K, Cunha-Melo JR, Yamada K, Gusovsky F, Beaven MA.
Studies with transfected and permeabilized RBL-2H3 cells reveal unique inhibitory properties of protein kinase C gamma.
Mol Biol Cell 5(4): 475-84, 1994.
[Text Abstract on PubMed]
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36
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Baumgartner RA, Yamada K, Deramo VA, Beaven MA.
Secretion of TNF from a rat mast cell line is a brefeldin A-sensitive and a calcium/protein kinase C-regulated process.
J Immunol 153(6): 2609-17, 1994.
[Text Abstract on PubMed]
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37
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Beaven MA, Ramkumar V, Ali H.
Adenosine A3 receptors in mast cells.
Trends Pharmacol Sci 15(1): 13-4, 1994.
[Text Abstract on PubMed]
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38
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Choi OH, Adelstein RS, Beaven MA.
Secretion from rat basophilic RBL-2H3 cells is associated with diphosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by protein kinase C.
J Biol Chem 269(1): 536-41, 1994.
[Text Abstract on PubMed]
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39
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Aridor M, Rajmilevich G, Beaven MA, Sagi-Eisenberg R.
Activation of exocytosis by the heterotrimeric G protein Gi3.
Science 262(5139): 1569-72, 1993.
[Text Abstract on PubMed]
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40
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Beaven MA, Metzger H.
Signal transduction by Fc receptors: the Fc epsilon RI case.
Immunol Today 14(5): 222-6, 1993.
[Text Abstract on PubMed]
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41
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Choi OH, Lee JH, Kassessinoff T, Cunha-Melo JR, Jones SV, Beaven MA.
Antigen and carbachol mobilize calcium by similar mechanisms in a transfected mast cell line (RBL-2H3 cells) that expresses ml muscarinic receptors.
J Immunol 151(10): 5586-95, 1993.
[Text Abstract on PubMed]
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42
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Ozawa K, Szallasi Z, Kazanietz MG, Blumberg PM, Mischak H, Mushinski JF, Beaven MA.
Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.
J Biol Chem 268(3): 1749-56, 1993.
[Text Abstract on PubMed]
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43
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Ozawa K, Yamada K, Kazanietz MG, Blumberg PM, Beaven MA.
Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells.
J Biol Chem 268(4): 2280-3, 1993.
[Text Abstract on PubMed]
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44
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Ramkumar V, Stiles GL, Beaven MA, Ali H.
The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells.
J Biol Chem 268(23): 16887-90, 1993.
[Text Abstract on PubMed]
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45
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Santini F, Beaven MA.
Nonselective actions of herbimycin A.
Immunol Today 14(7): 369-70, 1993.
[Text Abstract on PubMed]
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46
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Santini F, Beaven MA.
Tyrosine phosphorylation of a mitogen-activated protein kinase-like protein occurs at a late step in exocytosis. Studies with tyrosine phosphatase inhibitors and various secretagogues in rat RBL-2H3 cells.
J Biol Chem 268(30): 22716-22, 1993.
[Text Abstract on PubMed]
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47
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Peleg I, Ludowyke RI, Beaven MA, Adelstein RS.
The role of myosin phosphorylation in RBL-2H3 cell secretion.
J Lab Clin Med 120(5): 675-80, 1992.
[Text Abstract on PubMed]
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48
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Yamada K, Jelsema CL, Beaven MA.
Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells.
J Immunol 149(3): 1031-7, 1992.
[Text Abstract on PubMed]
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49
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Ali H, Müller CE, Daly JW, Beaven MA.
Methylxanthines block antigen-induced responses in RBL-2H3 cells independently of adenosine receptors or cyclic AMP: evidence for inhibition of antigen binding to IgE.
J Pharmacol Exp Ther 258(3): 954-62, 1991.
[Text Abstract on PubMed]
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50
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Hide M, Ali H, Price SR, Moss J, Beaven MA.
GTP-binding protein G alpha Z: its down-regulation by dexamethasone and its credentials as a mediator of antigen-induced responses in RBL-2H3 cells.
Mol Pharmacol 40(4): 473-9, 1991.
[Text Abstract on PubMed]
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51
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Hide M, Beaven MA.
Calcium influx in a rat mast cell (RBL-2H3) line. Use of multivalent metal ions to define its characteristics and role in exocytosis.
J Biol Chem 266(23): 15221-9, 1991.
[Text Abstract on PubMed]
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52
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Jones SV, Choi OH, Beaven MA.
Carbachol induces secretion in a mast cell line (RBL-2H3) transfected with the ml muscarinic receptor gene.
FEBS Lett 289(1): 47-50, 1991.
[Text Abstract on PubMed]
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53
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Martin JL, Pumford NR, LaRosa AC, Martin BM, Gonzaga HM, Beaven MA, Pohl LR.
A metabolite of halothane covalently binds to an endoplasmic reticulum protein that is highly homologous to phosphatidylinositol-specific phospholipase C-alpha but has no activity.
Biochem Biophys Res Commun 178(2): 679-85, 1991.
[Text Abstract on PubMed]
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54
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Ali H, Cunha-Melo JR, Saul WF, Beaven MA.
Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor.
J Biol Chem 265(2): 745-53, 1990.
[Text Abstract on PubMed]
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55
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Beaven MA, Gonzaga HM.
Stimulatory signals for secretion in a cultured mast cell line: evidence for activation of phospholipase C through more than one G-protein.
Adv Second Messenger Phosphoprotein Res 24: 387-92, 1990.
[Text Abstract on PubMed]
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56
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Collado-Escobar D, Ali H, Beaven MA.
On the mechanism of action of dexamethasone in a rat mast cell line (RBL-2H3 cells). Evidence for altered coupling of receptors and G-proteins.
J Immunol 144(9): 3449-57, 1990.
[Text Abstract on PubMed]
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57
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Collado-Escobar D, Cunha-Melo JR, Beaven MA.
Treatment with dexamethasone down-regulates IgE-receptor-mediated signals and up-regulates adenosine-receptor-mediated signals in a rat mast cell (RBL-2H3) line.
J Immunol 144(1): 244-50, 1990.
[Text Abstract on PubMed]
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58
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Rowley WH, Sato S, Huang SC, Collado-Escobar DM, Beaven MA, Wang LH, Martinez J, Gardner JD, Jensen RT.
Cholecystokinin-induced formation of inositol phosphates in pancreatic acini.
Am J Physiol 259(4 Pt 1): G655-65, 1990.
[Text Abstract on PubMed]
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59
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Adelstein RS, Beaven MA, Bengur AR, Kawamoto S, Ludowyke RI, Peleg I, Sellers JR.
In situ phosphorylation of human platelet and rat basophilic leukemia cell (RBL-2H3) myosin heavy chain and light chain.
Adv Exp Med Biol 255: 289-97, 1989.
[Text Abstract on PubMed]
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60
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Ali H, Collado-Escobar DM, Beaven MA.
The rise in concentration of free Ca2+ and of pH provides sequential, synergistic signals for secretion in antigen-stimulated rat basophilic leukemia (RBL-2H3) cells.
J Immunol 143(8): 2626-33, 1989.
[Text Abstract on PubMed]
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61
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Ali H, Cunha-Melo JR, Beaven MA.
Receptor-mediated release of inositol 1,4,5-trisphosphate and inositol 1,4-bisphosphate in rat basophilic leukemia RBL-2H3 cells permeabilized with streptolysin O.
Biochim Biophys Acta 1010(1): 88-99, 1989.
[Text Abstract on PubMed]
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62
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Cunha-Melo JR, Gonzaga HM, Ali H, Huang FL, Huang KP, Beaven MA.
Studies of protein kinase C in the rat basophilic leukemia (RBL-2H3) cell reveal that antigen-induced signals are not mimicked by the actions of phorbol myristate acetate and Ca2+ ionophore.
J Immunol 143(8): 2617-25, 1989.
[Text Abstract on PubMed]
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63
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Dean NM, Beaven MA.
Methods for the analysis of inositol phosphates.
Anal Biochem 183(2): 199-209, 1989.
[Text Abstract on PubMed]
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64
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Huang FL, Yoshida Y, Cunha-Melo JR, Beaven MA, Huang KP.
Differential down-regulation of protein kinase C isozymes.
J Biol Chem 264(7): 4238-43, 1989.
[Text Abstract on PubMed]
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65
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Ludowyke RI, Peleg I, Beaven MA, Adelstein RS.
Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells.
J Biol Chem 264(21): 12492-501, 1989.
[Text Abstract on PubMed]
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66
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Sato S, Stark HA, Martinez J, Beaven MA, Jensen RT, Gardner JD.
Receptor occupation, calcium mobilization, and amylase release in pancreatic acini: effect of CCK-JMV-180.
Am J Physiol 257(2 Pt 1): G202-9, 1989.
[Text Abstract on PubMed]
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67
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Beaven MA, Cunha-Melo JR.
Membrane phosphoinositide-activated signals in mast cells and basophils.
Prog Allergy 42: 123-84, 1988.
[Text Abstract on PubMed]
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68
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Cunha-Melo JR, Dean NM, Ali H, Beaven MA.
Formation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate from inositol 1,3,4,5-tetrakisphosphate and their pathways of degradation in RBL-2H3 cells.
J Biol Chem 263(28): 14245-50, 1988.
[Text Abstract on PubMed]
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69
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Lo TN, Eng SP, Jaseph LA, Beaven MA, Lo CS.
Cardiotoxin from cobra venom increases the level of phosphatidylinositol 4-monophosphate and phosphatidylinositol kinase activity in two cell lines.
Biochim Biophys Acta 970(1): 51-60, 1988.
[Text Abstract on PubMed]
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70
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Maeyama K, Hohman RJ, Ali H, Cunha-Melo JR, Beaven MA.
Assessment of IgE-receptor function through measurement of hydrolysis of membrane inositol phospholipids. New insights on the phenomena of biphasic antigen concentration-response curves and desensitization.
J Immunol 140(11): 3919-27, 1988.
[Text Abstract on PubMed]
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71
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Maeyama K, Taguchi Y, Sasaki M, Wada H, Beaven MA, Watanabe T.
Induction of histidine decarboxylase of rat basophilic leukemia (2H3) cells stimulated by higher oligomeric IgE or phorbol myristate acetate.
Biochem Biophys Res Commun 151(3): 1402-7, 1988.
[Text Abstract on PubMed]
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72
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Soll AH, Toomey M, Culp D, Shanahan F, Beaven MA.
Modulation of histamine release from canine fundic mucosal mast cells.
Am J Physiol 254(1 Pt 1): G40-8, 1988.
[Text Abstract on PubMed]
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73
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Beaven MA, Guthrie DF, Moore JP, Smith GA, Hesketh TR, Metcalfe JC.
Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release.
J Cell Biol 105(3): 1129-36, 1987.
[Text Abstract on PubMed]
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74
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Beaven MA, Maeyama K, Wolde-Mussie E, Lo TN, Ali H, Cunha-Melo JR.
Mechanism of signal transduction in mast cells and basophils: studies with RBL-2H3 cells.
Agents Actions 20(3-4): 137-45, 1987.
[Text Abstract on PubMed]
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75
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Cunha-Melo JR, Dean NM, Moyer JD, Maeyama K, Beaven MA.
The kinetics of phosphoinositide hydrolysis in rat basophilic leukemia (RBL-2H3) cells varies with the type of IgE receptor cross-linking agent used.
J Biol Chem 262(24): 11455-63, 1987.
[Text Abstract on PubMed]
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76
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Lo TN, Saul W, Beaven MA.
The actions of Ca2+ ionophores on rat basophilic (2H3) cells are dependent on cellular ATP and hydrolysis of inositol phospholipids. A comparison with antigen stimulation.
J Biol Chem 262(9): 4141-5, 1987.
[Text Abstract on PubMed]
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77
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Mizuguchi J, Ji YY, Nakabayaschi H, Huang KP, Beaven MA, Chused T, Paul WE.
Protein kinase C activation blocks anti-IgM-mediated signaling BAL17 B lymphoma cells.
J Immunol 139(4): 1054-9, 1987.
[Text Abstract on PubMed]
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78
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Paul WE, Mizuguchi J, Beaven MA, Hornbeck P, Tsang W, Ohara J.
B lymphocyte activation. The roles of receptor cross-linkage and BSF-1.
Adv Exp Med Biol 213: 207-14, 1987.
[Text Abstract on PubMed]
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79
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Maeyama K, Hohman RJ, Metzger H, Beaven MA.
Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy water.
J Biol Chem 261(6): 2583-92, 1986.
[Text Abstract on PubMed]
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80
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Mizuguchi J, Beaven MA, Li JH, Paul WE.
Phorbol myristate acetate inhibits anti-IgM-mediated signaling in resting B cells.
Proc Natl Acad Sci U S A 83(12): 4474-8, 1986.
[Text Abstract on PubMed]
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81
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Mizuguchi J, Beaven MA, Ohara J, Paul WE.
BSF-1 action on resting B cells does not require elevation of inositol phospholipid metabolism or increased [Ca2+]i.
J Immunol 137(7): 2215-9, 1986.
[Text Abstract on PubMed]
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82
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Mizuguchi J, Tsang W, Morrison SL, Beaven MA, Paul WE.
Membrane IgM, IgD, and IgG act as signal transmission molecules in a series of B lymphomas.
J Immunol 137(7): 2162-7, 1986.
[Text Abstract on PubMed]
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83
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WoldeMussie E, Aiken D, Beaven MA.
Evidence for rapid histamine turnover and loss of histamine from immature rat mast cells.
Biochem Pharmacol 35(6): 903-9, 1986.
[Text Abstract on PubMed]
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84
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WoldeMussie E, Maeyama K, Beaven MA.
Loss of secretory response of rat basophilic leukemia (2H3) cells at 40 degrees C is associated with reversible suppression of inositol phospholipid breakdown and calcium signals.
J Immunol 137(5): 1674-80, 1986.
[Text Abstract on PubMed]
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85
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Lo TN, WoldeMussie E, Wilson N, Wu D, Beaven MA.
Inflammatory response induced by intrapleural injection of antiserum to IgE in rat. An evaluation of the role of histamine.
Biochem Pharmacol 34(21): 3901-7, 1985.
[Text Abstract on PubMed]
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86
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Nabika T, Velletri PA, Beaven MA, Endo J, Lovenberg W.
Vasopressin-induced calcium increases in smooth muscle cells from spontaneously hypertensive rats.
Life Sci 37(6): 579-84, 1985.
[Text Abstract on PubMed]
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87
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Nabika T, Velletri PA, Lovenberg W, Beaven MA.
Increase in cytosolic calcium and phosphoinositide metabolism induced by angiotensin II and [Arg]vasopressin in vascular smooth muscle cells.
J Biol Chem 260(8): 4661-70, 1985.
[Text Abstract on PubMed]
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88
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Robinson-White A, Baylin SB, Olivecrona T, Beaven MA.
Binding of diamine oxidase activity to rat and guinea pig microvascular endothelial cells. Comparisons with lipoprotein lipase binding.
J Clin Invest 76(1): 93-100, 1985.
[Text Abstract on PubMed]
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89
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Woldemussie E, Aiken DL, Beaven MA.
Changes in histidine uptake and histamine synthesis during the growth cycle of rat basophilic leukemia (2H3) cells.
J Pharmacol Exp Ther 232(1): 20-6, 1985.
[Text Abstract on PubMed]
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90
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WoldeMussie E, Beaven MA.
alpha-Fluoromethylhistidine. Kinetics of uptake and inhibition of histamine synthesis in basophil (2H3) cell cultures.
Mol Pharmacol 28(2): 191-9, 1985.
[Text Abstract on PubMed]
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91
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Beaven MA, Moore JP, Smith GA, Hesketh TR, Metcalfe JC.
The calcium signal and phosphatidylinositol breakdown in 2H3 cells.
J Biol Chem 259(11): 7137-42, 1984.
[Text Abstract on PubMed]
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92
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Beaven MA, Rogers J, Moore JP, Hesketh TR, Smith GA, Metcalfe JC.
The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.
J Biol Chem 259(11): 7129-36, 1984.
[Text Abstract on PubMed]
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93
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Hesketh TR, Beaven MA, Rogers J, Burke B, Warren GB.
Stimulated release of histamine by a rat mast cell line is inhibited during mitosis.
J Cell Biol 98(6): 2250-4, 1984.
[Text Abstract on PubMed]
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94
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Lo TN, Almeida AP, Beaven MA.
Effect of indomethacin on generation of chemotactic activity in inflammatory exudates induced by carrageenan.
Eur J Pharmacol 99(1): 31-43, 1984.
[Text Abstract on PubMed]
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95
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Soll AH, Amirian DA, Thomas LP, Park J, Elashoff JD, Beaven MA, Yamada T.
Gastrin receptors on nonparietal cells isolated from canine fundic mucosa.
Am J Physiol 247(6 Pt 1): G715-23, 1984.
[Text Abstract on PubMed]
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96
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Beaven MA, Aiken DL, Woldemussie E, Soll AH.
Changes in histamine synthetic activity, histamine content and responsiveness to compound 48/80 with maturation of rat peritoneal mast cells.
J Pharmacol Exp Ther 224(3): 620-6, 1983.
[Text Abstract on PubMed]
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97
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Rogers J, Hesketh TR, Smith GA, Beaven MA, Metcalfe JC, Johnson P, Garland PB.
Intracellular pH and free calcium changes in single cells using quene 1 and quin 2 probes and fluorescence microscopy.
FEBS Lett 161(1): 21-7, 1983.
[Text Abstract on PubMed]
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98
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Beaven MA, Robinson-White A, Roderick NB, Kauffman GL.
The demonstration of histamine release in clinical conditions: a review of past and present assay procedures.
Klin Wochenschr 60(17): 873-81, 1982.
[Text Abstract on PubMed]
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99
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Beaven MA, Roderick NB, Shaff RE, Soll AH.
Histamine synthesis in intact and disrupted rat mast cells.
Biochem Pharmacol 31(7): 1189-95, 1982.
[Text Abstract on PubMed]
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100
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Beaven MA, Soll AH, Lewin KJ.
Histamine synthesis by intact mast cells from canine fundic mucosa and liver.
Gastroenterology 82(2): 254-62, 1982.
[Text Abstract on PubMed]
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101
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Lo TN, Almeida AP, Beaven MA.
Dextran and carrageenan evoke different inflammatory responses in rat with respect to composition of infiltrates and effect of indomethacin.
J Pharmacol Exp Ther 221(1): 261-7, 1982.
[Text Abstract on PubMed]
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102
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Robinson-White A, Beaven MA.
Presence of histamine and histamine-metabolizing enzyme in rat and guinea-pig microvascular endothelial cells.
J Pharmacol Exp Ther 223(2): 440-5, 1982.
[Text Abstract on PubMed]
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103
|
Almeida AP, Beaven MA.
Phylogeny of histamine in vertebrate brain.
Brain Res 208(1): 244-50, 1981.
[Text Abstract on PubMed]
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104
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Bayer BM, Almeida AP, Beaven MA.
Inhibition of the expression of the "A" system of amino acid transport by anti-inflammatory drugs during cell culture growth and mitogenic stimulation of thymus lymphocytes.
J Pharmacol Exp Ther 219(3): 752-9, 1981.
[Text Abstract on PubMed]
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105
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Bayer BM, Beaven MA.
Cytostatic activity of pharmacological concentrations of indomethacin in cell cultures and inactivity of closely related compounds.
Biochem Pharmacol 30(7): 807-9, 1981.
[Text Abstract on PubMed]
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106
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Beaven MA.
Anaphylactoid reactions to anesthetic drugs.
Anesthesiology 55(1): 3-5, 1981.
[Text Abstract on PubMed]
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107
|
Moss J, Fahmy NR, Sunder N, Beaven MA.
Hormonal and hemodynamic profile of an anaphylactic reaction in man.
Circulation 63(1): 210-3, 1981.
[Text Abstract on PubMed]
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108
|
Soll AH, Lewin KJ, Beaven MA.
Isolation of histamine-containing cells from rat gastric mucosa: biochemical and morphologic differences from mast cells.
Gastroenterology 80(4): 717-27, 1981.
[Text Abstract on PubMed]
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109
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Almeida AP, Bayer BM, Horakova Z, Beaven MA.
Influence of indomethacin and other anti-inflammatory drugs on mobilization and production of neutrophils: studies with carrageenan-induced inflammation in rats.
J Pharmacol Exp Ther 214(1): 74-9, 1980.
[Text Abstract on PubMed]
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110
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Almeida AP, Beaven MA.
Gel formation with leucocytes and heparin.
Life Sci 26(7): 549-55, 1980.
[Text Abstract on PubMed]
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111
|
Almeida AP, Flye W, Deveraux D, Horakova Z, Beaven MA.
Distribution of histamine and histaminase (diamine oxidase)d in blood of various species.
Comp Biochem Physiol C 67C(2): 187-90, 1980.
[Text Abstract on PubMed]
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112
|
Bayer BM, Lo TN, Beaven MA.
Anti-inflammatory drugs alter amino acid transport in HTC cells.
J Biol Chem 255(18): 8784-90, 1980.
[Text Abstract on PubMed]
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113
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Beaven MA, Bayer BM.
Factors influencing the uptake and disposition of indomethacin-[14C] in cell cultures.
Biochem Pharmacol 29(14): 2055-61, 1980.
[Text Abstract on PubMed]
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114
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Beaven MA, Roderick NB.
Impromidine, a potent inhibitor of histamine methyltransferase (HMT) and diamine oxidase (DAO).
Biochem Pharmacol 29(20): 2897-900, 1980.
[Text Abstract on PubMed]
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115
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de Mello MC, Bayer BM, Beaven MA.
Evidence that prostaglandins do not have a role in the cytostatic action of anti-inflammatory drugs.
Biochem Pharmacol 29(3): 311-8, 1980.
[Text Abstract on PubMed]
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116
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Horakova Z, Bayer BM, Almeida AP, Beaven MA.
Evidence that histamine does not participate in carrageenan-induced pleurisy in rat.
Eur J Pharmacol 62(1): 17-25, 1980.
[Text Abstract on PubMed]
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117
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Bayer BM, Beaven MA.
Evidence that indomethacin reversibly inhibits cell growth in the G1 phase of the cell cycle.
Biochem Pharmacol 28(3): 441-3, 1979.
[Text Abstract on PubMed]
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118
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Bayer BM, Kruth HS, Vaughan M, Beaven MA.
Arrest of cultured cells in the G1 phase of the cell cycle by indomethacin.
J Pharmacol Exp Ther 210(1): 106-11, 1979.
[Text Abstract on PubMed]
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119
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Baylin SB, Hsu TH, Stevens SA, Kallman CH, Trump DL, Beaven MA.
The effects of L-dopa on in vitro and in vivo calcitonin release from medullary thyroid carcinoma.
J Clin Endocrinol Metab 48(3): 408-14, 1979.
[Text Abstract on PubMed]
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120
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Beaven MA, Shaff RE.
Inhibition of histamine methylation in vivo by the dimaprit analog, SKF Compound 91488.
Agents Actions 9(5-6): 455-60, 1979.
[Text Abstract on PubMed]
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121
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Beaven MA, Shaff RE.
New inhibitors of histamine-N-methyltransferase.
Biochem Pharmacol 28(2): 183-8, 1979.
[Text Abstract on PubMed]
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122
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Ottesen EA, Neva FA, Paranjape RS, Tripathy SP, Thiruvengadam KV, Beaven MA.
Specific allergic sensitsation to filarial antigens in tropical eosinophilia syndrome.
Lancet 1(8127): 1158-61, 1979.
[Text Abstract on PubMed]
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123
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Shaff RE, Beaven MA.
Increased sensitivity of the enzymatic isotopic assay of histamine: measurement of histamine in plasma and serum.
Anal Biochem 94(2): 425-30, 1979.
[Text Abstract on PubMed]
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124
|
Soll AH, Lewin K, Beaven MA.
Isolation of histamine-containing cells from canine fundic mucosa.
Gastroenterology 77(6): 1283-90, 1979.
[Text Abstract on PubMed]
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125
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Baylin SB, Weisburger WR, Eggleston JC, Mendelsohn G, Beaven MA, Abeloff MD, Ettinger DS.
Variable content of histaminase, L-dopa decarboxylase and calcitonin in small-cell carcinoma of the lung. Biologic and clinical implications.
N Engl J Med 299(3): 105-10, 1978.
[Text Abstract on PubMed]
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126
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Beaven MA, Wilcox G, Terpstra GK.
A microprocedure for the measurement of 14CO2 release from [14C]carboxyl-labeled amino acids.
Anal Biochem 84(2): 638-41, 1978.
[Text Abstract on PubMed]
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127
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Beaven MA.
Histamine: its role in physiological and pathological processes.
Monogr Allergy 13: 1-113, 1978.
[Text Abstract on PubMed]
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128
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Hial V, De Mello MC, Horakova Z, Beaven MA.
Antiproliferative activity of anti-inflammatory drugs in two mammalian cell culture lines.
J Pharmacol Exp Ther 202(2): 446-54, 1977.
[Text Abstract on PubMed]
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129
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Horakova Z, Keiser HR, Beaven MA.
Blood and urine histamine levels in normal and pathological states as measured by a radiochemical assay.
Clin Chim Acta 79(2): 447-56, 1977.
[Text Abstract on PubMed]
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130
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Shaff RE, Beaven MA.
Inhibition of histamine-N-methyltransferase and histaminase (diamine oxidase) by a new histamine H2-receptor agonist, Dimaprit.
Biochem Pharmacol 26(21): 2075-8, 1977.
[Text Abstract on PubMed]
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131
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Beaven MA, Horakova Z, Keiser HR.
Interference with histamine and imidazole acetic acid metabolism by salicylates: a possible contribution to salicylate analgesic activity?
Experientia 32(9): 1180-2, 1976.
[Text Abstract on PubMed]
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132
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Beaven MA.
Histamine (first of two parts).
N Engl J Med 294(1): 30-6, 1976.
[Text Abstract on PubMed]
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133
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Beaven MA.
Histamine (second of two parts).
N Engl J Med 294(6): 320-5, 1976.
[Text Abstract on PubMed]
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134
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Geller RG, Yoshida H, Beaven MA, Horakova Z, Atkins FL, Yamabe H, Pisano JJ.
Pharmacologically active substances in venoms of the bald-faced hornet, Vespula (Dolichovespula) maculata, and the yellow jacket, Vespula (Vespula) maculifrons.
Toxicon 14(1): 27-33, 1976.
[Text Abstract on PubMed]
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135
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Hial V, Horakova Z, Shaff FE, Beaven MA.
Alteration of tumor growth by aspirin and indomethacin: studies with two transplantable tumors in mouse.
Eur J Pharmacol 37(2): 367-76, 1976.
[Text Abstract on PubMed]
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136
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Kaplan AP, Beaven MA.
In vivo studies of the pathogenesis of cold urticaria, cholinergic urticaria, and vibration-induced swelling.
J Invest Dermatol 67(3): 327-32, 1976.
[Text Abstract on PubMed]
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137
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Metzger WJ, Kaplan AP, Beaven MA, Irons JS, Patterson R.
Hereditary vibratory angioedema: confirmation of histamine release in a type of physical hypersensitivity.
J Allergy Clin Immunol 57(6): 605-8, 1976.
[Text Abstract on PubMed]
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138
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Moss J, De Mello MC, Vaughan M, Beaven MA.
Effect of salicylates on histamine and L-histidine metabolism. Inhibition of imidazoleacetate phosphoribosyl transferase.
J Clin Invest 58(1): 137-41, 1976.
[Text Abstract on PubMed]
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139
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Shaff RE, Beaven MA.
Turnover and synthesis of diamine oxidase (DAO) in rat tissues. Studies with heparin and cycloheximide.
Biochem Pharmacol 25(9): 1057-62, 1976.
[Text Abstract on PubMed]
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140
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Wilcox G, Beaven MA.
A sensitive and specific tritium release assay for dopamine-beta-hydroxylase (DbetaH) in serum.
Anal Biochem 75(2): 484-97, 1976.
[Text Abstract on PubMed]
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141
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Atkins FL, Beaven MA.
Ornithine decarboxylase and histaminase (diamine oxidase) activities in rat thymus and their relationship to the thymus lymphocyte.
Biochem Pharmacol 24(7): 763-8, 1975.
[Text Abstract on PubMed]
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142
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Baylin S, Horakova Z, Beaven MA.
Increase in food consumption and growth after treatment with aminoguanidine.
Experientia 31(5): 562-4, 1975.
[Text Abstract on PubMed]
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143
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Beaven MA, Marshall JR, Baylin SB, Sjoerdsma A.
Changes in plasma histaminase activity during normal early human pregnancy and pregnancy disorders.
Am J Obstet Gynecol 123(6): 605-9, 1975.
[Text Abstract on PubMed]
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144
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Beaven MA, Shaff RE.
Study of the relationship of histaminase and diamine oxidase activities in various rat tissues and plasma by sensitive isotopic assay procedures.
Biochem Pharmacol 24(9): 979-84, 1975.
[Text Abstract on PubMed]
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145
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Kaplan AP, Gray L, Shaff RE, Horakova Z, Beaven MA.
In vivo studies of mediator release in cold urticaria and cholinergic urticaria.
J Allergy Clin Immunol 55(6): 394-402, 1975.
[Text Abstract on PubMed]
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146
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Baxter JH, Beaven MA, Horáková Z.
Effects of adrenergic agents, theophylline and other drugs on dextran edema and histamine release in rats.
Biochem Pharmacol 23(7): 1211-7, 1974.
[Text Abstract on PubMed]
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147
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Beaven MA, Horakova Z, Keiser H.
Inhibition by aspirin of ribose conjugation in the metabolism of histamine.
Eur J Pharmacol 29(1): 138-46, 1974.
[Text Abstract on PubMed]
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148
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Horakova Z, Beaven MA.
Time course of histamine release and edema formation in the rat paw after thermal injury.
Eur J Pharmacol 27(3): 305-12, 1974.
[Text Abstract on PubMed]
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149
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Atkins FL, Beaven MA, Keiser HR.
Dopa decarboxylase in medullary carcinoma of the thyroid.
N Engl J Med 289(11): 545-8, 1973.
[Text Abstract on PubMed]
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150
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Baylin SB, Beaven MA, Krauss RM, Keiser HR.
Response of plasma histaminase activity to small doses of heparin in normal subjects and patients with hyperlipoproteinemia.
J Clin Invest 52(8): 1985-93, 1973.
[Text Abstract on PubMed]
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151
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Beaven MA, de Jong W.
Presence of histaminase and ornithine decarboxylase activities in rat thymus.
Biochem Pharmacol 22(2): 257-65, 1973.
[Text Abstract on PubMed]
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152
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Baylin SB, Beaven MA, Buja LM, Keiser HR.
Histaminase activity: a biochemical marker for medullary carcinoma of the thyroid.
Am J Med 53(6): 723-33, 1972.
[Text Abstract on PubMed]
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153
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Baylin SB, Beaven MA, Keiser HR, Tashjian AH, Melvin KE.
Serum histaminase and calcitonin levels in medullary carcinoma of the thyroid.
Lancet 1(7748): 455-8, 1972.
[Text Abstract on PubMed]
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154
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Beaven MA, Jacobsen S, Horáková Z.
Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues, serum and urine.
Clin Chim Acta 37: 91-103, 1972.
[Text Abstract on PubMed]
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155
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Cohen IK, Beaven MA, Horáková Z, Keiser HR.
Histamine and collagen synthesis in keloid and hypertrophic scar.
Surg Forum 23(0): 509-10, 1972.
[Text Abstract on PubMed]
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156
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Beaven MA, Jacobsen S.
A new assay for histaminase activity: measurement of tritiated water from beta (side chain label)-H 3-histamine.
J Pharmacol Exp Ther 176(1): 52-64, 1971.
[Text Abstract on PubMed]
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157
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Horáková Z, Zierdt CH, Beaven MA.
Identification of lactobacillus as the source of bacterial histidine decarboxylase in rat stomach.
Eur J Pharmacol 16(1): 67-77, 1971.
[Text Abstract on PubMed]
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158
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Isaac L, Cho AK, Beaven MA.
Decline of histidine decarboxylase activity and histamine levels in rat stomach after reserpine.
Biochem Pharmacol 20(7): 1453-61, 1971.
[Text Abstract on PubMed]
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159
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Isaac L, Cho AK, Beaven MA.
Decline of histidine decarboxylase activity and histamine levels in rat stomach after reserpine.
Biochem Pharmacol 20(7): 1453-61, 1971.
[Text Abstract on PubMed]
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160
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Lovenberg W, Beaven MA.
The release of tritium upon deamination of 3,4-dihydroxy (2-3H) phenylethylamine by plasma amine oxidase.
Biochim Biophys Acta 250(2): 452-5, 1971.
[Text Abstract on PubMed]
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161
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Baylin SB, Beaven MA, Engelman K, Sjoerdsma A.
Elevated histaminase activity in medullary carcinoma of the thyroid gland.
N Engl J Med 283(23): 1239-44, 1970.
[Text Abstract on PubMed]
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162
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Beaven MA, Horáková Z, Severs WB.
Bacterial histidine decarboxylase in rat stomach.
Eur J Pharmacol 11(2): 233-40, 1970.
[Text Abstract on PubMed]
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163
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Severs WB, Gordon JW, Beaven MA, Jacobsen S.
Some observations on aminoguanidine pharmacology.
Pharmacology 3(4): 201-8, 1970.
[Text Abstract on PubMed]
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164
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Volicer L, Beaven MA, Reid WD.
The accumulation of H3-serotonin in platelet-free rats.
Pharmacology 4(4): 203-8, 1970.
[Text Abstract on PubMed]
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165
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Beaven MA, Gordon JW, Jacobsen S, Severs WB.
A specific and sensitive assay for aminoguanidine: its application to a study of the disposition of aminoguanidine in animal tissues.
J Pharmacol Exp Ther 165(1): 14-22, 1969.
[Text Abstract on PubMed]
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166
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Beaven MA, Horakova Z, Severs WB, Brodie BB.
Selective labeling of histamine in rat gastric mucosa: application to measurement of turnover rate.
J Pharmacol Exp Ther 161(2): 320-8, 1968.
[Text Abstract on PubMed]
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167
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Beaven MA.
Discussion of the distribution of serotonin in the nervous system of various animal species.
Adv Pharmacol 6(Pt A): 189-90, 1968.
[Text Abstract on PubMed]
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168
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Reid WD, Volicer L, Smookler H, Beaven MA, Brodie BB.
Brain amines and temperature regulation.
Pharmacology 1(6): 329-44, 1968.
[Text Abstract on PubMed]
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169
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Johnson HL, Beaven MA, Erjavec F, Brodie BB.
Selective labeling and release of nonmast-cell histamine.
Life Sci 5(2): 115-23, 1966.
[Text Abstract on PubMed]
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170
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Beaven MA.
Use of tracers in the study of biogenic amine compartments.
Adv Tracer Methodol 2: 243-52, 1965.
[Text Abstract on PubMed]
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171
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Beaven MA, Maickel RP.
Stereoselectivity of norepinephrine storage sites in heart.
Biochem Biophys Res Commun 14: 509-13, 1964.
[Text Abstract on PubMed]
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172
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BEAVEN MA, COSTA E, BRODIE BB.
The turnover of norepinephrine in thyrotoxic and nonthyrotoxic mice.
Life Sci 4: 241-6, 1963.
[Text Abstract on PubMed]
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173
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BECKETT AH, BEAVEN MA, ROBINSON AE.
METABOLISM OF CHLORPROMAZINE IN HUMANS.
Biochem Pharmacol 12: 779-94, 1963.
[Text Abstract on PubMed]
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174
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BRODIE B, BEAVEN MA.
NEUROCHEMICAL TRANSDUCER SYSTEMS.
Med Exp Int J Exp Med 20: 320-51, 1963.
[Text Abstract on PubMed]
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175
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MAICKEL RP, BEAVEN MA, BRODIE BB.
IMPLICATIONS OF UPTAKE AND STORAGE OF NOREPINEPHRINE BY SYMPATHETIC NERVE ENDINGS.
Life Sci 12: 953-8, 1963.
[Text Abstract on PubMed]
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176
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BECKETT AH, BEAVEN MA, ROBINSON AE.
Metabolism of chlorpromazine.
Psychopharmacol Serv Cent Bull 2: 42-4, 1962.
[Text Abstract on PubMed]
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177
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BECKETT AH, BEAVEN MA, ROBINSON AE.
Paper chromatography: multiple spot formation by pure substances.
Nature 186: 775-6, 1960.
[Text Abstract on PubMed]
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178
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BECKETT AH, BEAVEN MA, ROBINSON AE.
Some factors involved in multiple spot formation in the paper chromatography of sympathomimetic amines in the presence of acids.
J Pharm Pharmacol 12(Suppl): 203-16, 1960.
[Text Abstract on PubMed]
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179
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Beaven MA, Horakova Z, Johnson HL, Erjavec F, Brodie BB.
Selective labeling of histamine in rat gastric mucosa.
Fed Proc 26(1): 233-6,
[Text Abstract on PubMed]
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180
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Erjavec F, Beaven MA, Brodie BB.
Uptake and release of 3-H-histamine in cat submaxillary gland.
Fed Proc 26(1): 237-40,
[Text Abstract on PubMed]
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181
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Markley K, Horakova Z, Smallman ET, Beaven MA.
The role of histamine in burn, tourniquet and endotoxin shock in mice.
Eur J Pharmacol 33(2): 255-65,
[Text Abstract on PubMed]
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