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1
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Zmuda-Trzebiatowska E, Oknianska A, Manganiello V, Degerman E.
Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.
Cell Signal 18(3): 382-90, 2006.
[Text Abstract on PubMed]
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2
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Adler-Wailes DC, Liu H, Ahmad F, Feng N, Londos C, Manganiello V, Yanovski JA.
Effects of the human immunodeficiency virus-protease inhibitor, ritonavir, on basal and catecholamine-stimulated lipolysis.
J Clin Endocrinol Metab 90(6): 3251-61, 2005.
[Text Abstract on PubMed]
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3
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Ahmad F, Härndahl L, Tang Y, Holst LS, Manganiello VC.
Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B.
Methods Mol Biol 307: 93-107, 2005.
[Text Abstract on PubMed]
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4
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Hambleton R, Krall J, Tikishvili E, Honeggar M, Ahmad F, Manganiello VC, Movsesian MA.
Isoforms of cyclic nucleotide phosphodiesterase PDE3 and their contribution to camp hydrolytic activity in subcellular fractions of human myocardium.
J Biol Chem 280(47): 39168-74, 2005.
[Text Abstract on PubMed]
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5
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Shimizu K, Murata T, Hiramoto K, Sugiyama T, Nakagawa T, Manganiello VC, Tagawa T.
Expression of cyclic nucleotide phosphodiesterase 3A in isolated rat submandibular acini.
Arch Oral Biol: 2005.
[Text Abstract on PubMed]
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6
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Degerman E, Manganiello V, Holst JJ, Ahrén B.
Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice.
Eur J Pharmacol 498(1-3): 319-23, 2004.
[Text Abstract on PubMed]
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7
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Härndahl L, Wierup N, Enerbäck S, Mulder H, Manganiello VC, Sundler F, Degerman E, Ahrén B, Holst LS.
Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.
J Biol Chem 279(15): 15214-22, 2004.
[Text Abstract on PubMed]
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8
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Manganiello V.
Emergence and success of PDE5 inhibitors as effective therapy for erectile dysfunction.
Int J Impot Res 16 Suppl 1: S1-3, 2004.
[Text Abstract on PubMed]
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9
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Masciarelli S, Horner K, Liu C, Park SH, Hinckley M, Hockman S, Nedachi T, Jin C, Conti M, Manganiello V.
Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility.
J Clin Invest 114(2): 196-205, 2004.
[Text Abstract on PubMed]
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10
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Akesson L, Ahrén B, Manganiello VC, Holst LS, Edgren G, Degerman E.
Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes.
Endocrinology 144(12): 5293-9, 2003.
[Text Abstract on PubMed]
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11
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Manganiello V.
Cyclic nucleotide phosphodiesterase 5 and sildenafil: promises realized.
Mol Pharmacol 63(6): 1209-11, 2003.
[Text Abstract on PubMed]
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12
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Murata T, Sugatani T, Shimizu K, Manganiello VC, Tagawa T.
Effect of the phosphodiesterase 4 inhibitor, rolipram, on retinoic acid-increased alkaline phosphatase activity in the mouse fibroblastic C3H10T1/2 cell line.
Arch Oral Biol 48(1): 63-7, 2003.
[Text Abstract on PubMed]
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13
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Narita M, Murata T, Shimizu K, Sugiyama T, Nakagawa T, Manganiello VC, Tagawa T.
Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition.
Anticancer Drugs 14(5): 377-81, 2003.
[Text Abstract on PubMed]
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14
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Piscione F, Manganiello V, Viola O, Chiariello M.
[Morphologic and functional abnormalities of the cardiovascular system in patients with hepatic cirrhosis]
Ital Heart J Suppl 4(2): 85-95, 2003.
[Text Abstract on PubMed]
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15
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Göransson O, Resjö S, Rönnstrand L, Manganiello V, Degerman E.
Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes.
Cell Signal 14(2): 175-82, 2002.
[Text Abstract on PubMed]
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16
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Härndahl L, Jing XJ, Ivarsson R, Degerman E, Ahrén B, Manganiello VC, Renström E, Holst LS.
Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin.
J Biol Chem 277(40): 37446-55, 2002.
[Text Abstract on PubMed]
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17
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Manganiello V.
Short-term regulation of PDE4 activity.
Br J Pharmacol 136(3): 339-40, 2002.
[Text Abstract on PubMed]
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18
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Mei J, Holst LS, Landström TR, Holm C, Brindley D, Manganiello V, Degerman E.
C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.
Diabetes 51(3): 631-7, 2002.
[Text Abstract on PubMed]
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19
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Resjö S, Göransson O, Härndahl L, Zolnierowicz S, Manganiello V, Degerman E.
Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes.
Cell Signal 14(3): 231-8, 2002.
[Text Abstract on PubMed]
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20
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Shimizu K, Murata T, Okumura K, Manganiello VC, Tagawa T.
Expression and role of phosphodiesterase 3 in human squamous cell carcinoma KB cells.
Anticancer Drugs 13(8): 875-80, 2002.
[Text Abstract on PubMed]
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21
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Wechsler J, Choi YH, Krall J, Ahmad F, Manganiello VC, Movsesian MA.
Isoforms of cyclic nucleotide phosphodiesterase PDE3A in cardiac myocytes.
J Biol Chem 277(41): 38072-8, 2002.
[Text Abstract on PubMed]
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22
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Zhang HH, Halbleib M, Ahmad F, Manganiello VC, Greenberg AS.
Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP.
Diabetes 51(10): 2929-35, 2002.
[Text Abstract on PubMed]
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23
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Choi YH, Ekholm D, Krall J, Ahmad F, Degerman E, Manganiello VC, Movsesian MA.
Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes.
Biochem J 353(Pt 1): 41-50, 2001.
[Text Abstract on PubMed]
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24
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Degerman E, Resjö S, Landström TR, Manganiello V.
Methods to study phosphorylation and activation of the hormone-sensitive adipocyte phosphodiesterase type 3B in rat adipocytes.
Methods Mol Biol 155: 167-80, 2001.
[Text Abstract on PubMed]
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25
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Murata T, Sugatani T, Manganiello VC, Shimizu K, Tagawa T.
Expression of phosphodiesterase 3 in rat submandibular gland cell lines.
Arch Oral Biol 46(5): 453-7, 2001.
[Text Abstract on PubMed]
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26
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Murata T, Sugatani T, Shimizu K, Manganiello VC, Tagawa T.
Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland.
Anticancer Drugs 12(1): 79-83, 2001.
[Text Abstract on PubMed]
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27
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Shakur Y, Holst LS, Landstrom TR, Movsesian M, Degerman E, Manganiello V.
Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family.
Prog Nucleic Acid Res Mol Biol 66: 241-77, 2001.
[Text Abstract on PubMed]
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28
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Ahmad F, Cong LN, Stenson Holst L, Wang LM, Rahn Landstrom T, Pierce JH, Quon MJ, Degerman E, Manganiello VC.
Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells.
J Immunol 164(9): 4678-88, 2000.
[Text Abstract on PubMed]
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29
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Kasuya J, Liang SJ, Goko H, Park SH, Kato K, Xu ZD, Hockman S, Manganiello VC, Fujita-Yamaguchi Y.
Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B gene.
Biochem Biophys Res Commun 268(3): 827-34, 2000.
[Text Abstract on PubMed]
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30
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Kenan Y, Murata T, Shakur Y, Degerman E, Manganiello VC.
Functions of the N-terminal region of cyclic nucleotide phosphodiesterase 3 (PDE 3) isoforms.
J Biol Chem 275(16): 12331-8, 2000.
[Text Abstract on PubMed]
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31
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Rahn Landström T, Mei J, Karlsson M, Manganiello V, Degerman E.
Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor alpha and cAMP.
Biochem J 346 Pt 2: 337-43, 2000.
[Text Abstract on PubMed]
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32
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Rondinone CM, Carvalho E, Rahn T, Manganiello VC, Degerman E, Smith UP.
Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor.
J Biol Chem 275(14): 10093-8, 2000.
[Text Abstract on PubMed]
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33
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Shakur Y, Takeda K, Kenan Y, Yu ZX, Rena G, Brandt D, Houslay MD, Degerman E, Ferrans VJ, Manganiello VC.
Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum.
J Biol Chem 275(49): 38749-61, 2000.
[Text Abstract on PubMed]
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34
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Ahmad F, Gao G, Wang LM, Landstrom TR, Degerman E, Pierce JH, Manganiello VC.
IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells.
J Immunol 162(8): 4864-75, 1999.
[Text Abstract on PubMed]
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35
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Castan I, Wijkander J, Manganiello V, Degerman E.
Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes.
Biochem J 339 ( Pt 2): 281-9, 1999.
[Text Abstract on PubMed]
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36
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Coudray C, Charon C, Komas N, Mory G, Diot-Dupuy F, Manganiello V, Ferre P, Bazin R.
Evidence for the presence of several phosphodiesterase isoforms in brown adipose tissue of Zucker rats: modulation of PDE2 by the fa gene expression.
FEBS Lett 456(1): 207-10, 1999.
[Text Abstract on PubMed]
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37
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Ekholm D, Mulloy JC, Gao G, Degerman E, Franchini G, Manganiello VC.
Cyclic nucleotide phosphodiesterases (PDE) 3 and 4 in normal, malignant, and HTLV-I transformed human lymphocytes.
Biochem Pharmacol 58(6): 935-50, 1999.
[Text Abstract on PubMed]
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38
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Manganiello VC, Degerman E.
Cyclic nucleotide phosphodiesterases (PDEs): diverse regulators of cyclic nucleotide signals and inviting molecular targets for novel therapeutic agents.
Thromb Haemost 82(2): 407-11, 1999.
[Text Abstract on PubMed]
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39
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Resjö S, Oknianska A, Zolnierowicz S, Manganiello V, Degerman E.
Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A.
Biochem J 341 ( Pt 3): 839-45, 1999.
[Text Abstract on PubMed]
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40
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Degerman E, Landstr¿m TR, Wijkander J, Holst LS, Ahmad F, Belfrage P, Manganiello V.
Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B.
Methods 14(1): 43-53, 1998.
[Text Abstract on PubMed]
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41
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Göransson O, Wijkander J, Manganiello V, Degerman E.
Insulin-induced translocation of protein kinase B to the plasma membrane in rat adipocytes.
Biochem Biophys Res Commun 246(1): 249-54, 1998.
[Text Abstract on PubMed]
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42
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He R, Komas N, Ekholm D, Murata T, Taira M, Hockman S, Degerman E, Manganiello VC.
Expression and characterization of deletion recombinants of two cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3).
Cell Biochem Biophys 29(1-2): 89-111, 1998.
[Text Abstract on PubMed]
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43
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Holst LS, Mulder H, Manganiello V, Sundler F, Ahrén B, Holm C, Degerman E.
Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I.
Biochem Biophys Res Commun 250(1): 181-6, 1998.
[Text Abstract on PubMed]
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44
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Nagaoka T, Shirakawa T, Kasuya J, Balon TW, Manganiello VC, Fujita-Yamaguchi Y.
Cyclic nucleotide PDE-3. Quantitation of PDE-3A and -3B mRNAs in rat tissues by RNase protection assay.
Cell Biochem Biophys 29(1-2): 49-66, 1998.
[Text Abstract on PubMed]
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45
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Wijkander J, Landström TR, Manganiello V, Belfrage P, Degerman E.
Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase.
Endocrinology 139(1): 219-27, 1998.
[Text Abstract on PubMed]
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46
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Degerman E, Belfrage P, Manganiello VC.
Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3).
J Biol Chem 272(11): 6823-6, 1997.
[Text Abstract on PubMed]
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47
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Ekholm D, Belfrage P, Manganiello V, Degerman E.
Protein kinase A-dependent activation of PDE4 (cAMP-specific cyclic nucleotide phosphodiesterase) in cultured bovine vascular smooth muscle cells.
Biochim Biophys Acta 1356(1): 64-70, 1997.
[Text Abstract on PubMed]
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48
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Ekholm D, Hemmer B, Gao G, Vergelli M, Martin R, Manganiello V.
Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein.
J Immunol 159(3): 1520-9, 1997.
[Text Abstract on PubMed]
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49
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Holm C, Langin D, Manganiello V, Belfrage P, Degerman E.
Regulation of hormone-sensitive lipase activity in adipose tissue.
Methods Enzymol 286: 45-67, 1997.
[Text Abstract on PubMed]
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50
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Wijkander J, Holst LS, Rahn T, Resjö S, Castan I, Manganiello V, Belfrage P, Degerman E.
Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. Membrane translocation in response to peroxovanadate.
J Biol Chem 272(34): 21520-6, 1997.
[Text Abstract on PubMed]
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51
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Degerman E, Belfrage P, Manganiello VC.
cGMP-inhibited phosphodiesterases (PDE3 gene family).
Biochem Soc Trans 24(4): 1010-4, 1996.
[Text Abstract on PubMed]
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52
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Leroy MJ, Degerman E, Taira M, Murata T, Wang LH, Movsesian MA, Meacci E, Manganiello VC.
Characterization of two recombinant PDE3 (cGMP-inhibited cyclic nucleotide phosphodiesterase) isoforms, RcGIP1 and HcGIP2, expressed in NIH 3006 murine fibroblasts and Sf9 insect cells.
Biochemistry 35(31): 10194-202, 1996.
[Text Abstract on PubMed]
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53
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Manganiello VC, Degerman E, Taira M, Kono T, Belfrage P.
Type III cyclic nucleotide phosphodiesterases and insulin action.
Curr Top Cell Regul 34: 63-100, 1996.
[Text Abstract on PubMed]
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54
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Miki T, Taira M, Hockman S, Shimada F, Lieman J, Napolitano M, Ward D, Taira M, Makino H, Manganiello VC.
Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family.
Genomics 36(3): 476-85, 1996.
[Text Abstract on PubMed]
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55
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Movsesian MA, Komas N, Krall J, Manganiello VC.
Expression and activity of low Km, cGMP-inhibited cAMP phosphodiesterase in cardiac and skeletal muscle.
Biochem Biophys Res Commun 225(3): 1058-62, 1996.
[Text Abstract on PubMed]
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56
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Murata T, Taira M, Manganiello VC.
Differential expression of cGMP-inhibited cyclic nucleotide phosphodiesterases in human hepatoma cell lines.
FEBS Lett 390(1): 29-33, 1996.
[Text Abstract on PubMed]
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57
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Rahn T, Rönnstrand L, Leroy MJ, Wernstedt C, Tornqvist H, Manganiello VC, Belfrage P, Degerman E.
Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol.
J Biol Chem 271(19): 11575-80, 1996.
[Text Abstract on PubMed]
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58
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Eriksson H, Ridderstråle M, Degerman E, Ekholm D, Smith CJ, Manganiello VC, Belfrage P, Tornqvist H.
Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the antilipolytic action of insulin.
Biochim Biophys Acta 1266(1): 101-7, 1995.
[Text Abstract on PubMed]
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59
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Leibowitz MD, Biswas C, Brady EJ, Conti M, Cullinan CA, Hayes NS, Manganiello VC, Saperstein R, Wang LH, Zafian PT.
A novel insulin secretagogue is a phosphodiesterase inhibitor.
Diabetes 44(1): 67-74, 1995.
[Text Abstract on PubMed]
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60
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Manganiello VC, Murata T, Taira M, Belfrage P, Degerman E.
Diversity in cyclic nucleotide phosphodiesterase isoenzyme families.
Arch Biochem Biophys 322(1): 1-13, 1995.
[Text Abstract on PubMed]
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61
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Manganiello VC, Taira M, Degerman E, Belfrage P.
Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family).
Cell Signal 7(5): 445-55, 1995.
[Text Abstract on PubMed]
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62
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Omatsu-Kanbe M, Cushman SW, Manganiello VC, Taira M.
Insulin stimulates hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase in rat brown adipose cells.
FEBS Lett 374(2): 187-91, 1995.
[Text Abstract on PubMed]
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63
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Reinhardt RR, Chin E, Zhou J, Taira M, Murata T, Manganiello VC, Bondy CA.
Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases.
J Clin Invest 95(4): 1528-38, 1995.
[Text Abstract on PubMed]
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64
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Degerman E, Moos M, Rascón A, Vasta V, Meacci E, Smith CJ, Lindgren S, Andersson KE, Belfrage P, Manganiello V.
Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase.
Biochim Biophys Acta 1205(2): 189-98, 1994.
[Text Abstract on PubMed]
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65
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Makino H, Manganiello VC, Kono T.
Roles of ATP in insulin actions.
Annu Rev Physiol 56: 273-95, 1994.
[Text Abstract on PubMed]
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66
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Rahn T, Ridderstråle M, Tornqvist H, Manganiello V, Fredrikson G, Belfrage P, Degerman E.
Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. Studies using the selective inhibitor wortmannin.
FEBS Lett 350(2-3): 314-8, 1994.
[Text Abstract on PubMed]
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67
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Rascón A, Degerman E, Taira M, Meacci E, Smith CJ, Manganiello V, Belfrage P, Tornqvist H.
Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase.
J Biol Chem 269(16): 11962-6, 1994.
[Text Abstract on PubMed]
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68
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López-Aparicio P, Belfrage P, Manganiello VC, Kono T, Degerman E.
Stimulation by insulin of a serine kinase in human platelets that phosphorylates and activates the cGMP-inhibited cAMP phosphodiesterase.
Biochem Biophys Res Commun 193(3): 1137-44, 1993.
[Text Abstract on PubMed]
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69
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Smith CJ, Krall J, Manganiello VC, Movsesian MA.
Cytosolic and sarcoplasmic reticulum-associated low Km, cGMP-inhibited cAMP phosphodiesterase in mammalian myocardium.
Biochem Biophys Res Commun 190(2): 516-21, 1993.
[Text Abstract on PubMed]
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70
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Taira M, Hockman SC, Calvo JC, Taira M, Belfrage P, Manganiello VC.
Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.
J Biol Chem 268(25): 18573-9, 1993.
[Text Abstract on PubMed]
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71
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López-Aparicio P, Rascón A, Manganiello VC, Andersson KE, Belfrage P, Degerman E.
Insulin induced phosphorylation and activation of the cGMP-inhibited cAMP phosphodiesterase in human platelets.
Biochem Biophys Res Commun 186(1): 517-23, 1992.
[Text Abstract on PubMed]
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72
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Manganiello VC, Degerman E, Smith CJ, Vasta V, Tornqvist H, Belfrage P.
Mechanisms for activation of the rat adipocyte particulate cyclic-GMP-inhibited cyclic AMP phosphodiesterase and its importance in the antilipolytic action of insulin.
Adv Second Messenger Phosphoprotein Res 25: 147-64, 1992.
[Text Abstract on PubMed]
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73
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Meacci E, Taira M, Moos M, Smith CJ, Movsesian MA, Degerman E, Belfrage P, Manganiello V.
Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.
Proc Natl Acad Sci U S A 89(9): 3721-5, 1992.
[Text Abstract on PubMed]
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74
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Rascón A, Lindgren S, Stavenow L, Belfrage P, Andersson KE, Manganiello VC, Degerman E.
Purification and properties of the cGMP-inhibited cAMP phosphodiesterase from bovine aortic smooth muscle.
Biochim Biophys Acta 1134(2): 149-56, 1992.
[Text Abstract on PubMed]
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75
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Vasta V, Smith CJ, Calvo J, Belfrage P, Manganiello VC.
Insulin and isoproterenol induce phosphorylation of the particulate cyclic GMP-inhibited, low Km cyclic AMP phosphodiesterase (cGI PDE) in 3T3-L1 adipocytes.
Biochem Biophys Res Commun 183(3): 1070-5, 1992.
[Text Abstract on PubMed]
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76
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Lindgren S, Rascón A, Andersson KE, Manganiello V, Degerman E.
Selective inhibition of cGMP-inhibited and cGMP-noninhibited cyclic nucleotide phosphodiesterases and relaxation of rat aorta.
Biochem Pharmacol 42(3): 545-52, 1991.
[Text Abstract on PubMed]
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77
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Manganiello VC, Smith CJ, Degerman E, Vasta V, Tornqvist H, Belfrage P.
Molecular mechanisms involved in the antilipolytic action of insulin: phosphorylation and activation of a particulate adipocyte cAMP phosphodiesterase.
Adv Exp Med Biol 293: 239-48, 1991.
[Text Abstract on PubMed]
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78
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Smith CJ, Vasta V, Degerman E, Belfrage P, Manganiello VC.
Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation.
J Biol Chem 266(20): 13385-90, 1991.
[Text Abstract on PubMed]
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79
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Tanaka T, Hockman S, Moos M, Taira M, Meacci E, Murashima S, Manganiello VC.
Comparison of putative cGMP-binding regions in bovine brain and cardiac cGMP-stimulated phosphodiesterases.
Second Messengers Phosphoproteins 13(2-3): 87-98, 1991.
[Text Abstract on PubMed]
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80
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Degerman E, Smith CJ, Tornqvist H, Vasta V, Belfrage P, Manganiello VC.
Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation.
Proc Natl Acad Sci U S A 87(2): 533-7, 1990.
[Text Abstract on PubMed]
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81
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Murashima S, Tanaka T, Hockman S, Manganiello V.
Characterization of particulate cyclic nucleotide phosphodiesterases from bovine brain: purification of a distinct cGMP-stimulated isoenzyme.
Biochemistry 29(22): 5285-92, 1990.
[Text Abstract on PubMed]
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82
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Lindgren S, Andersson KE, Belfrage P, Degerman E, Manganiello VC.
Relaxant effects of the selective phosphodiesterase inhibitors milrinone and OPC 3911 on isolated human mesenteric vessels.
Pharmacol Toxicol 64(5): 440-5, 1989.
[Text Abstract on PubMed]
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83
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Smith CJ, Manganiello VC.
Role of hormone-sensitive low Km cAMP phosphodiesterase in regulation of cAMP-dependent protein kinase and lipolysis in rat adipocytes.
Mol Pharmacol 35(3): 381-6, 1989.
[Text Abstract on PubMed]
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84
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Tsai SC, Adamik R, Manganiello VC, Moss J.
Effects of nitroprusside and nitroglycerin on cGMP content and PGI2 formation in aorta and vena cava.
Biochem Pharmacol 38(1): 61-5, 1989.
[Text Abstract on PubMed]
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85
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Degerman E, Manganiello VC, Newman AH, Rice KC, Belfrage P.
Purification, properties and polyclonal antibodies for the particulate, low Km cAMP phosphodiesterase from bovine adipose tissue.
Second Messengers Phosphoproteins 12(4): 171-82, 1988.
[Text Abstract on PubMed]
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86
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Kincaid RL, Manganiello VC.
Assay of cyclic nucleotide phosphodiesterase using radiolabeled and fluorescent substrates.
Methods Enzymol 159: 457-70, 1988.
[Text Abstract on PubMed]
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87
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Manganiello V, Degerman E, Elks M.
Selective inhibitors of specific phosphodiesterases in intact adipocytes.
Methods Enzymol 159: 504-20, 1988.
[Text Abstract on PubMed]
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88
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Moss J, Hom BE, Hewlett EL, Tsai SC, Adamik R, Halpern JL, Price SR, Manganiello VC.
Mechanism of enhanced sensitivity to bradykinin in pertussis toxin-treated fibroblasts: toxin increases bradykinin-stimulated prostaglandin formation.
Mol Pharmacol 34(3): 279-85, 1988.
[Text Abstract on PubMed]
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89
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Abou-Samra AB, Harwood JP, Manganiello VC, Catt KJ, Aguilera G.
Phorbol 12-myristate 13-acetate and vasopressin potentiate the effect of corticotropin-releasing factor on cyclic AMP production in rat anterior pituitary cells. Mechanisms of action.
J Biol Chem 262(3): 1129-36, 1987.
[Text Abstract on PubMed]
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90
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Degerman E, Belfrage P, Newman AH, Rice KC, Manganiello VC.
Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand.
J Biol Chem 262(12): 5797-807, 1987.
[Text Abstract on PubMed]
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91
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Elks ML, Jackson M, Manganiello VC, Vaughan M.
Effect of N6-(L-2-phenylisopropyl)adenosine and insulin on cAMP metabolism in 3T3-L1 adipocytes.
Am J Physiol 252(3 Pt 1): C342-8, 1987.
[Text Abstract on PubMed]
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92
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Manganiello VC.
Subcellular localization and biological function of specific cyclic nucleotide phosphodiesterases.
J Mol Cell Cardiol 19(10): 1037-40, 1987.
[Text Abstract on PubMed]
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93
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Nonoguchi H, Knepper MA, Manganiello VC.
Effects of atrial natriuretic factor on cyclic guanosine monophosphate and cyclic adenosine monophosphate accumulation in microdissected nephron segments from rats.
J Clin Invest 79(2): 500-7, 1987.
[Text Abstract on PubMed]
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94
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Wada H, Manganiello VC, Osborne JC.
Analysis of the kinetics of cyclic AMP hydrolysis by the cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.
J Biol Chem 262(29): 13938-45, 1987.
[Text Abstract on PubMed]
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95
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Wada H, Osborne JC, Manganiello VC.
Effects of temperature on allosteric and catalytic properties of the cGMP-stimulated cyclic nucleotide phosphodiesterase from calf liver.
J Biol Chem 262(11): 5139-44, 1987.
[Text Abstract on PubMed]
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96
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Tsai SC, Adamik R, Hom BE, Manganiello VC, Moss J.
Effects of nitroprusside on the bradykinin responsiveness of human fibroblasts.
Mol Pharmacol 30(3): 274-8, 1986.
[Text Abstract on PubMed]
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97
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Elks ML, Manganiello VC.
A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1 adipocytes.
J Cell Physiol 124(2): 191-8, 1985.
[Text Abstract on PubMed]
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98
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Elks ML, Manganiello VC.
Antilipolytic action of insulin: role of cAMP phosphodiesterase activation.
Endocrinology 116(5): 2119-21, 1985.
[Text Abstract on PubMed]
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99
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Jelsema CL, Moss J, Manganiello VC.
Effect of bradykinin on prostaglandin production by human skin fibroblasts in culture.
Methods Enzymol 109: 480-503, 1985.
[Text Abstract on PubMed]
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100
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Kincaid RL, Manganiello VC, Odya CE, Osborne JC, Stith-Coleman IE, Danello MA, Vaughan M.
Purification and properties of calmodulin-stimulated phosphodiesterase from mammalian brain.
J Biol Chem 259(8): 5158-66, 1984.
[Text Abstract on PubMed]
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101
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Manganiello VC, Yamamoto T, Elks M, Lin MC, Vaughan M.
Regulation of specific forms of cyclic nucleotide phosphodiesterases in cultured cells.
Adv Cyclic Nucleotide Protein Phosphorylation Res 16: 291-301, 1984.
[Text Abstract on PubMed]
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102
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Roscher AA, Manganiello VC, Jelsema CL, Moss J.
Autoregulation of bradykinin receptors and bradykinin-induced prostacyclin formation in human fibroblasts.
J Clin Invest 74(2): 552-8, 1984.
[Text Abstract on PubMed]
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103
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Yamamoto T, Yamamoto S, Manganiello VC, Vaughan M.
Effects of fatty acids on activity of cGMP-stimulated cyclic nucleotide phosphodiesterase from calf liver.
Arch Biochem Biophys 229(1): 81-9, 1984.
[Text Abstract on PubMed]
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104
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Bareis DL, Manganiello VC, Hirata F, Vaughan M, Axelrod J.
Bradykinin stimulates phospholipid methylation, calcium influx, prostaglandin formation, and cAMP accumulation in human fibroblasts.
Proc Natl Acad Sci U S A 80(9): 2514-8, 1983.
[Text Abstract on PubMed]
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105
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Elks ML, Manganiello VC, Vaughan M.
Hormone-sensitive particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes. Regulation of responsiveness by dexamethasone.
J Biol Chem 258(14): 8582-7, 1983.
[Text Abstract on PubMed]
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106
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Elks ML, Watkins PA, Manganiello VC, Moss J, Hewlett E, Vaughan M.
Selective regulation by pertussis toxin of insulin-induced activation of particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes.
Biochem Biophys Res Commun 116(2): 593-8, 1983.
[Text Abstract on PubMed]
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107
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Manganiello VC, Reed BC, Lieberman FS, Moss J, Lane MD, Vaughan M.
Alterations in cyclic AMP phosphodiesterase activities during differentiation of 3T3-L1 cells.
J Cyclic Nucleotide Protein Phosphor Res 9(2): 143-54, 1983.
[Text Abstract on PubMed]
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108
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Roscher AA, Manganiello VC, Jelsema CL, Moss J, Vaughan M.
Regulation by bradykinin of its receptor and of receptor-mediated prostacyclin formation in cultured human fibroblasts.
Trans Assoc Am Physicians 96: 175-81, 1983.
[Text Abstract on PubMed]
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109
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Roscher AA, Manganiello VC, Jelsema CL, Moss J.
Receptors for bradykinin in intact cultured human fibroblasts. Identification and characterization by direct binding study.
J Clin Invest 72(2): 626-35, 1983.
[Text Abstract on PubMed]
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110
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Strewler GJ, Danello MA, Manganiello VC, Vaughan M.
Ca2+-independent cyclic GMP phosphodiesterases from rat liver and HTC hepatoma cells.
Biochem J 213(2): 379-86, 1983.
[Text Abstract on PubMed]
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111
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Tsai SC, Adamik R, Manganiello VC, Vaughan M.
Regulation of activity of purified guanylate cyclase from liver that is unresponsive to nitric oxide.
Biochem J 215(3): 447-55, 1983.
[Text Abstract on PubMed]
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112
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Yamamoto T, Manganiello VC, Vaughan M.
Purification and characterization of cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from calf liver. Effects of divalent cations on activity.
J Biol Chem 258(20): 12526-33, 1983.
[Text Abstract on PubMed]
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113
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Yamamoto T, Yamamoto S, Osborne JC, Manganiello VC, Vaughan M, Hidaka H.
Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.
J Biol Chem 258(23): 14173-7, 1983.
[Text Abstract on PubMed]
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114
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Gagnon C, Kelly S, Manganiello V, Vaughan M, Odya C, Strittmatter W, Hoffman A, Hirata F.
Modification of calmodulin function by enzymatic carboxylic methylation.
Nature 291(5815): 515-6, 1981.
[Text Abstract on PubMed]
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115
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Hirata F, del Carmine R, Nelson CA, Axelrod J, Schiffmann E, Warabi A, De Blas AL, Nirenberg M, Manganiello V, Vaughan M, Kumagai S, Green I, Decker JL, Steinberg AD.
Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases.
Proc Natl Acad Sci U S A 78(5): 3190-4, 1981.
[Text Abstract on PubMed]
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116
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Kincaid RL, Kempner E, Manganiello VC, Osborne JC, Vaughan M.
Calmodulin-activated cyclic nucleotide phosphodiesterase from brain. Relationship of subunit structure to activity assessed by radiation inactivation.
J Biol Chem 256(21): 11351-5, 1981.
[Text Abstract on PubMed]
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117
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Kincaid RL, Manganiello VC, Vaughan M.
Calmodulin-activated cyclic nucleotide phosphodiesterase from brain. Changes in molecular size assessed by gel filtration and electrophoresis.
J Biol Chem 256(21): 11345-50, 1981.
[Text Abstract on PubMed]
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118
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Moss J, Manganiello VC, Hom BE, Nakaya S, Vaughan M.
Effects of d- and l-propranolol on the responsiveness of human fibroblasts to choleragen and prostaglandin E1.
Biochem Pharmacol 30(11): 1263-9, 1981.
[Text Abstract on PubMed]
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119
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Tsai SC, Adamik R, Manganiello VC, Vaughan M.
Reversible inactivation of soluble liver guanylate cyclase by disulfides.
Biochem Biophys Res Commun 100(2): 637-43, 1981.
[Text Abstract on PubMed]
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120
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Vaughan M, Danello MA, Manganiello VC, Strewler GJ.
Regulation of cyclic nucleotide phosphodiesterase activity.
Adv Cyclic Nucleotide Res 14: 263-71, 1981.
[Text Abstract on PubMed]
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121
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Gagnon C, Kelly S, Manganiello V, Vaughn M, Strittmatter W, Hoffman A, Hirata F.
Protein carboxyl-methylase modifies calmodulin function.
Ann N Y Acad Sci 356: 385-6, 1980.
[Text Abstract on PubMed]
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122
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Tsai SC, Shindo H, Manganiello VC, Adamik R, Vaughan M.
Products of reaction catalyzed by purified rat liver guanylate cyclase determined by 31p NMR spectroscopy.
Proc Natl Acad Sci U S A 77(10): 5734-7, 1980.
[Text Abstract on PubMed]
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123
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Strewler GJ, Manganiello VC.
Purification and characterization of phosphodiesterase activator from kidney. A lysosomal protease.
J Biol Chem 254(23): 11891-8, 1979.
[Text Abstract on PubMed]
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124
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Fishman PH, Bradley RM, Moss J, Manganiello VC.
Effect of serum on ganglioside uptake and choleragen responsiveness of transformed mouse fibroblasts.
J Lipid Res 19(1): 77-81, 1978.
[Text Abstract on PubMed]
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125
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Gallin JI, Sandler JA, Clyman RI, Manganiello VC, Vaughan M.
Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion.
J Immunol 120(2): 492-6, 1978.
[Text Abstract on PubMed]
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126
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Strewler GJ, Manganiello VC, Vaughan M.
Phosphodiesterase activator from rat kidney cortex.
J Biol Chem 253(2): 390-4, 1978.
[Text Abstract on PubMed]
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127
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Tsai SC, Manganiello VC, Vaughan M.
Activation of kidney guanylate cyclase by cobalt.
Arch Biochem Biophys 189(1): 155-60, 1978.
[Text Abstract on PubMed]
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128
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Tsai SC, Manganiello VC, Vaughan M.
Purification of guanylate cyclase from rat liver supernatant.
J Biol Chem 253(23): 8542-7, 1978.
[Text Abstract on PubMed]
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129
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Clyman RI, Manganiello VC, Vaughan M.
Oxygen: influence on cyclic nucleotides and calcium sequestration in the human umbilical artery.
Chest 71(2 suppl): 247-9, 1977.
[Text Abstract on PubMed]
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130
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Fishman PH, Moss J, Manganiello VC.
Synthesis and uptake of gangliosides by choleragen-responsive human fibroblasts.
Biochemistry 16(9): 1871-5, 1977.
[Text Abstract on PubMed]
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131
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Lovell-Smith CJ, Manganiello VC, Vaughan M.
Solubilization and characterization of hormone- responsive phosphodiesterase activity of rat fat cells.
Biochim Biophys Acta 497(2): 447-58, 1977.
[Text Abstract on PubMed]
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132
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Moss J, Manganiello VC, Fishman PH.
Enzymatic and chemical oxidation of gangliosides in cultured cells: effects of choleragen.
Biochemistry 16(9): 1876-81, 1977.
[Text Abstract on PubMed]
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133
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Clyman RI, Manganiello VC, Lovell-Smith CJ, Vaughan M.
Calcium uptake by subcellular fractions of human umbilical artery.
Am J Physiol 231(4): 1074-81, 1976.
[Text Abstract on PubMed]
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134
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Manganiello VC, Lovell-Smith CJ, Vaughan M.
Effects of choleragen on hormonal responsiveness of adenylate cyclase in human fibroblasts and rat fat cells.
Biochim Biophys Acta 451(1): 62-71, 1976.
[Text Abstract on PubMed]
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135
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Manganiello VC, Vaughan M.
Activation and inhibition of fat cell adenylate cyclase by fluoride.
J Biol Chem 251(20): 6205-9, 1976.
[Text Abstract on PubMed]
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136
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Moss J, Fishman PH, Manganiello VC, Vaughan M, Brady RO.
Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness.
Proc Natl Acad Sci U S A 73(4): 1034-7, 1976.
[Text Abstract on PubMed]
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137
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Moss J, Manganiello VC, Vaughan M.
Hydrolysis of nicotinamide adenine dinucleotide by choleragen and its A protomer: possible role in the activation of adenylate cyclase.
Proc Natl Acad Sci U S A 73(12): 4424-7, 1976.
[Text Abstract on PubMed]
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138
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Clyman RI, Blacksin AS, Manganiello VC, Vaughan M.
Oxygen and cyclic nucleotides in human umbilical artery.
Proc Natl Acad Sci U S A 72(10): 3883-7, 1975.
[Text Abstract on PubMed]
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139
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Clyman RI, Blacksin AS, Sandler JA, Manganiello VC, Vaughan M.
The role of calcium in regulation of cyclic nucleotide content in human umbilical artery.
J Biol Chem 250(12): 4718-21, 1975.
[Text Abstract on PubMed]
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140
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Sandler JA, Smith TK, Manganiello VC, Kirkpatrick CH.
Stimulation of monocyte cGMP by leukocyte dialysates. An antigen-independent property of dialyzable transfer factor.
J Clin Invest 56(5): 1271-9, 1975.
[Text Abstract on PubMed]
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141
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Manganiello VC, Breslow J.
Effects of prostaglandin E1 and isoproterenol on cyclic AMP content of human fibroblasts modified by time and cell density in subculture.
Biochim Biophys Acta 362(3): 509-20, 1974.
[Text Abstract on PubMed]
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142
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Stoner J, Manganiello VC, Vaughan M.
Effects of bradykinin and indomethacin on cyclic GMP and cyclic AMP in lung slices.
Proc Natl Acad Sci U S A 70(12): 3830-3, 1973.
[Text Abstract on PubMed]
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143
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Manganiello V, Vaughan M.
Selective loss of adipose cell responsiveness to glucagon with growth in the rat.
J Lipid Res 13(1): 12-6, 1972.
[Text Abstract on PubMed]
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144
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Mason RJ, Manganiello V, Vaughan M.
Effect of thyroxine on the disaturated lecithin content of lung.
Am Rev Respir Dis 106(5): 767-8, 1972.
[Text Abstract on PubMed]
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145
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Weihing RR, Manganiello VC, Chiu R, Phillips AH.
Purification of hepatic microsomal membranes.
Biochemistry 11(16): 3128-35, 1972.
[Text Abstract on PubMed]
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146
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Manganiello VC, Phillips AH.
The relationship between ribosomes and the endoplasmic reticulum during protein synthesis.
J Biol Chem 240(10): 3951-9, 1965.
[Text Abstract on PubMed]
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147
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Manganiello VC, Smith CJ, Newman AH, Rice K, Degerman E, Belfrage P.
Hormonal regulation of adipocyte particulate "low Km" cAMP phosphodiesterase.
J Cyclic Nucleotide Protein Phosphor Res 11(7): 497-511,
[Text Abstract on PubMed]
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148
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Murata T, Shimizu K, Narita M, Manganiello VC, Tagawa T.
Characterization of phosphodiesterase 3 in human malignant melanoma cell line.
Anticancer Res 22(6A): 3171-4,
[Text Abstract on PubMed]
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