The Staurosporin Nucleus, a Molecule(!) for All Diseases |
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| Launch in standalone player | |
| Air date: | Tuesday, May 14, 2002, 2:00:00 PM |
| Category: | Mass Spectrometry Interest Group of the NCI at Frederick |
| Description: | Mass Spectrometry Interest Group at the NCI-Frederick
Although staurosporin was originally identified as a PKC inhibitor, the more targets that this molecular scaffold has been exposed to, the more interesting it has become. Currently there are staurosporin "lookalikes" in clinical trials as drug candidates for topoisomerase I and II inhibition and Cyclin-dependent kinase inhibition. Not areas that one would assume, a priori, that the same basic molecule would be involved. Some thoughts that come to mind involve the possibilities for using such molecules as probes for targets and then the use of sensitive mass spectrometric techniques might well be able to show commonalities in binding sites, thus leading to improved designs for both screens and molecules. These areas will be discussed from both a natural product and also a synthetic perspective. For more information, visit http://msig.ncifcrf.gov |
| Author: | David Newman, Natural Products Branch, NCI-Frederick |
| Runtime: | 00:39:30 |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| CIT File ID: | 10744 |
| CIT Live ID: | 1652 |
| Permanent link: | http://videocast.nih.gov/launch.asp?10744 |