Revised PHS 398 (DHHS Public Health Service Grant Application) Now Available

Notice Number: NOT-OD-08-028

Key Dates
Release Date: January 4, 2008

Issued by
National Institutes of Health (NIH), (

EFFECTIVE DATE: The newly revised “Application for a DHHS Public Health Service Grant” (PHS 398, rev. 11/07) instructions and forms are now available and will be accepted for due dates on or after January 25, 2008. All applications received for May 25, 2008 and subsequent due dates must use the new instructions and forms. During the transition period the previous version (interim revision 04/2006) will continue to be available, and applications using the previous version will be accepted.  However, applications submitted using instructions and forms other than the PHS 398 (rev 11/07) for May 25, 2008 and subsequent due dates will be returned to the applicant. 

NIH continues to transition grant mechanisms from the PHS 398 to the SF424 (R&R) and electronic submission through The paper PHS 398 is required for all grant mechanisms that have not transitioned to the SF424 (R&R), including New, Resubmission, Renewal, and Revision applications.  Mechanisms that have not yet transitioned to electronic submission include research training grants, research career development awards, changes of grantee institution, and complex mechanisms such as cooperative agreements, program project and centers. Once a mechanism has transitioned to electronic submission the applicant must apply through using the SF424 (R&R) and electronic PHS 398 components that are provided as part of the electronic application forms. For more information on NIH's transition plans, including a timeline for the transition of various mechanisms, see the website for Electronic Submission of Grant Applications:

The newly revised instructions and forms are available at The forms available on the website continue to be provided in two formats—MS Word and PDF-fillable using Adobe Acrobat Reader Software. Free Adobe Software may be accessed at Applicants are strongly encouraged to access the instructions and forms via the Internet because they provide valuable links to current policy documents and allow easy navigation of the instructions. For further information, contact

Notable Changes to the PHS 398 Instructions (rev. 11/07):

This edition of the PHS 398 implements a number of important policy changes, including NIH Policy for Sharing of Data Obtained in NIH-Supported or Conducted Genome-Wide Association Studies, and registration of clinical trials in as required by Public Law 110-85.  The Foreword of the instructions includes a Summary of Changes (see Page I-1).  Additional changes are highlighted as follows:

Implementation of Grants.Gov Terminology

As part of the ongoing effort to keep the PHS 398 and the SF424 (R&R) synchronized, new terminology is implemented in the PHS 398:



Competing continuation application

Renewal application

Revision or amendment [to application]

Resubmission application

Competing supplement

Revision application

Principal Investigator

Program Director/Principal Investigator (PD/PI)

Key Personnel

Senior/key Personnel

Performance site

Project/performance site

Duly authorized representative

Authorized Organizational Representative





Definition of New Investigator

Structure of Document

Suggested Cover Letter Format

Budget Justification

Indefinite Plans for Involvement of Human Subjects or Use of Vertebrate Animals

Instructions for Career Development Award Applications

Institutional Research Training Application Including Ruth L. Kirschstein-NRSA Applications

Appendix Format

Part II, Instructions for Preparing the Protection of Human Subjects Section of the Research Plan

Changes of Note to Specific PHS 398 Form and Format Pages:

398 Face Page

398 Form Page 2 and Project/Performance Site Format Page

Modular Budget Form Page

Checklist Form Page

Institutional Training Grant Data Tables


Inquiries on any changes to the forms and instructions may be directed to:

Grants Info
Office of Extramural Research
National Institutes of Health
Telephone: 301-435-0714
TTY: 301-451-5936

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, RealPlayer, Video or Flash files, see Help Downloading Files.