Laboratory of Molecular
Robert S Adelstein, MD, Principal Investigator
The Laboratory of Molecular Cardiology investigates the regulation,
expression and function of contractile proteins with an emphasis
on myosin. We are particularly interested in the mechanisms
responsible for regulating the contractile proteins in nonmuscle
and smooth muscle cells as well as the factors that govern
the transcription and expression of the genes encoding the
contractile proteins. We focus on vertebrate nonmuscle myosin
II, the conventional form of myosin present in all eukaryotic
cells as well as other classes of myosin such as myosin I,
III, V, X and XV from a variety of sources. By studying the
genes, mRNA, and proteins active in the contractile process
during embryonic development and maturity, we hope to understand
the mechanisms by which cells differentiate, alter their phenotype,
migrate, change shape, move membrane receptors, secrete cellular
products, and proliferate. We are using this information to
understand both normal and disease processes.
The laboratory is presently staffed by two tenured investigators
who are all section heads. Bob Adelstein (the Lab Chief) is
Head of the Section on Muscle Molecular Biology. Sachiyo
Kawamoto, a Staff Scientist, is studying nonmuscle myosin
gene regulation including the regulation of cell-specific
alternative splicing of nonmuscle myosin II-B.
There are on average 20 to 30 people working in the lab.
We are particularly proud of our summer program, in which
we train students (high school, college, medical, veterinary,
pharmacy and graduate school) for 2-3 months during the year.
Many of these students go on to earn advanced degrees.
We hold a lab meeting once a week at which time one of the
lab members presents their recent work. We have a journal
club at which time one lab member presents and discusses recent
journal article(s) distributed to all earlier in the week.
We meet once a month with the Laboratory of Cell Biology (NHLBI)
and many lab members participate in one or more of the NIH