VITAL Vitamins and Lifestyle Study: Cohort Study of Dietary Supplements and Cancer Risk
Emily White, Ph.D.
University of Washington,
Fred Hutchinson Cancer Research Center
Cancer Prevention Research Program,
Seattle, Wash.
Funded since 1999
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Vitamin and mineral supplements are among the most commonly used drugs
in the United States. Manufacturers market and consumers use supplements
to prevent chronic diseases such as cancer, but with the exception of
beta-carotene, there is sparse evidence for either their benefits or risks.
The overall aim of this research is to investigate the associations of
supplement use with cancer risk. Specific aims focus on the associations
of vitamin C, vitamin E, calcium and multivitamins with prostate, female
breast, lung, colorectal, and total cancer incidence.
In the initial 5 years of this cohort study, 77,700 men and women, aged
50 to 76 and living in a 13-county area of western Washington State were
recruited into the cohort. Cohort members completed a baseline questionnaire
covering detailed information on supplement use over the past 10 years,
diet (using a food frequency questionnaire), health history, and cancer
risk factors. Seventy percent of participants provided DNA by self-collected
buccal brushes.
Supplement users were targeted in recruitment, therefore supplement use
by cohort members is both high and of long duration. Cancer endpoint information
is ascertained by linkage to the western Washington (Seattle-Puget Sound)
cancer registry, which is part of the NCI-funded Surveillance,
Epidemiology, and End Results (SEER) Program, and deaths by linkage
to the Washington State death file. Out-migration from the SEER catchment
area is monitored by linkage to the National Change of Address file. If
the study continues for an additional 5 years, approximately 6,000 cancers
are expected to be diagnosed, allowing completion of the analyses to address
the specific aims.
If supplements are harmful or of no use in relation to cancer, this information
is important for the large number of Americans taking supplements. If
beneficial effects are found, these could be translated into highly cost-effective
cancer control measures.
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