National Institute on Aging
National Institutes of Health 		NIA Home
Research Programs
Intramural
Laboratory of Neurosciences
1999 - 2001 Publications

  1. Chan SL, Pedersen WA, Zhu H., Mattson MP. Numb modifies neuronal vulnerabililty to amyloid b-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease. NeuroMolecular Med. 2001;1:55-67.

  2. Cheng A, Chan SL, Milhavet O, Wang S, Mattson MP. p38 MAP kinase mediates nitric oxide-induced apoptosis of neural progenitor cells. J Biol Chem. 2001;276(46):43320-43327. [Abs]

  3. Culmsee C, Bondada S, Mattson MP. Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain Res Mol Brain Res. 2001;87(2):257-262. [Abs]

  4. Culmsee C, Monnig J, Kemp BE, Mattson MP. AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci. 2001;17(1):45-58. [Abs]

  5. Culmsee C, Zhu X, Yu QS, Chan SL, Camandola S, Guo Z, Greig NH, Mattson MP. A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J Neurochem. 2001;77(1):220-228. [Abs]

  6. Culmsee C, Zhu Y, Krieglstein J, Mattson MP. Evidence for the involvement of Par-4 in ischemic neuron cell death. J Cereb Blood Flow Metab. 2001;21(4):334-343. [Abs]

  7. Cutler RG, Mattson MP. Sphingomyelin and ceramide as regulators of development and lifespan. Mech Ageing Dev. 2001;122(9):895-908. [Abs]

  8. Doyle ME, Greig NH, Holloway HW, Betkey JA, Bernier M, Egan JM. Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent. Endocrinology. 2001;142(10):4462-4468. [Abs]

  9. Duan W, Guo Z, Mattson MP. Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice. J Neurochem. 2001;76(2):619-626. [Abs]

  10. Duan W, Lee J, Guo Z, Mattson MP. Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury. J Mol Neurosci. 2001;16(1):1-12. [Abs]

  11. Gary DS, Mattson MP. Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis. J Neurochem. 2001;76(5):1485-1496. [Abs]

  12. Glazner GW, Camandola S, Geiger JD, Mattson MP. Endoplasmic reticulum D-myo-inositol 1,4,5-trisphosphate-sensitive stores regulate nuclear factor-kappaB binding activity in a calcium-independent manner. J Biol Chem. 2001;276(25):22461-22467. [Abs]

  13. Greig NH, Utsuki T, Yu Q, Zhu X, Holloway HW, Perry T, Lee B, Ingram DK, Lahiri DK. A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase. Curr Med Res Opin. 2001;17(3):159-165. [Abs]

  14. Guo Z, Lee J, Lane M, Mattson M. Iodoacetate protects hippocampal neurons against excitotoxic and oxidative injury: involvement of heat-shock proteins and Bcl-2. J Neurochem. 2001;79(2):361-370. [Abs]

  15. Haughey NJ, Nath A, Mattson MP, Slevin JT, Geiger JD. HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. J Neurochem. 2001;78(3):457-467. [Abs]

  16. Klapper W, Shin T, Mattson MP. Differential regulation of telomerase activity and TERT expression during brain development in mice. J Neurosci Res. 2001;64(3):252-260. [Abs]

  17. Lahiri DK, Farlow MR, Sambamurti K, Greig NH, Giacobini E, Schneider LS. A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease. Curr Drug Targets. 2003;4(2):97-112. [Abs]

  18. Lu C, Chan SL, Haughey N, Lee WT, Mattson MP. Selective and biphasic effect of the membrane lipid peroxidation product 4-hydroxy-2,3-nonenal on N-methyl-D-aspartate channels. J Neurochem. 2001;78(3):577-589. [Abs]

  19. Lu C, Fu W, Mattson MP. Caspase-mediated suppression of glutamate (AMPA) receptor channel activity in hippocampal neurons in response to DNA damage promotes apoptosis and prevents necrosis: implications for neurological side effects of cancer therapy and neurodegenerative disorders. Neurobiol Dis. 2001;8(2):194-206. [Abs]

  20. Lu C, Fu W, Mattson MP. Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death. NeuroMolecular Med. 2001;1:69-79.

  21. Lu C, Fu W, Mattson MP. Telomerase protects developing neurons against DNA damage-induced cell death. Brain Res Dev Brain Res. 2001;131(1-2):167-171. [Abs]

  22. Lu C, Mattson MP. Dimethyl sulfoxide suppresses NMDA- and AMPA-induced ion currents and calcium influx and protects against excitotoxic death in hippocampal neurons. Exp Neurol. 2001;170(1):180-185. [Abs]

  23. Mattson MP. A cholesterol shuttle and dementia. Trends Neurosci. 2001;24: 691-692.

  24. Mattson MP. Amino acid signaling removes and then replaces brain cells. Trends Neurosci. 2001;24:565-566.

  25. Mattson MP. A multi-talented secreted protein. Trends Neurosci. 2001;24(8):441-442.

  26. Mattson MP. Does DNA damage sculpt the developing brain? Trends Neurosci. 2001;24(2):77.

  27. Mattson MP. Involvement of superoxide in the pathogenic action of mutations that cause Alzheimer's disease. Meth. Enzymol. 2001;352:455-474.

  28. Mattson MP. Lose weight STAT: CNTF tops leptin. Trends Neurosci. 2001;24(6):313-314.

  29. Mattson MP. New blood cells help an overburdened brain. Trends Neurosci. 2001;24(1):5.

  30. Mattson MP. Neuronal death and GSK-3b: a tau fetish? Trends Neurosci. 2001;24(5):255-256.

  31. Mattson MP, Camandola S. NF-kB in neuronal plasticity and neurodegenerative disorders. J Clin Invest. 2001;107(3):247-254.

  32. Mattson MP. Stem cells as therapeutics for neurodegenerative disorders? Expert Rev. Neurotherapeutics 2001;1:89-95.

  33. Mattson MP, Chan SL. Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits. J Mol Neurosci. 2001;17(2):205-224. [Abs]

  34. Mattson MP, Chan SL, Camandola S. Presenilin mutations and calcium signaling defects in the nervous and immune systems. Bioessays. 2001;23(8):733-744. [Abs]

  35. Mattson MP, Duan W, Lee J, Guo Z. Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms. Mech Ageing Dev. 2001;122(7):757-778. [Abs]

  36. Mattson MP, Duan W, Lee J, Guo Z, Roth GS, Ingram DK, Lane MA. Progress in the development of caloric restriction mimetic dietary supplements. J Anti-aging Med. 2001;4:225-232.

  37. Mattson MP, Duan W, Pedersen WA, Culmsee C. Neurodegenerative disorders and ischemic brain diseases. Apoptosis. 2001;6(1-2):69-81. [Abs]

  38. Mattson MP, Gary DS, Chan SL, Duan W. Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease. Biochem Soc Symp. 2001;(67):151-162. [Abs]

  39. Mattson MP, Fu W, Zhang P. Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. Mech Ageing Dev. 2001;122(7):659-671. [Abs]

  40. Mattson MP, Klapper W. Emerging roles for telomerase in neuronal development and apoptosis. J Neurosci Res. 2001;63(1):1-9. [Abs]

  41. Pedersen WA, McCullers D, Culmsee C, Haughey NJ, Herman JP, Mattson MP. Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease. Neurobiol Dis. 2001;8(3):492-503. [Abs]

  42. Pedersen WA, Wan R, Mattson MP. Impact of aging on stress-responsive neuroendocrine systems. Mech Ageing Dev. 2001;122(9):963-983. [Abs]

  43. Prolla TA, Mattson MP. Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction. Trends Neurosci. 2001;24(11 Suppl):S21-31. [Abs]

  44. Rao MS, Mattson MP. Stem cells and aging: expanding the possibilities. Mech Ageing Dev. 2001;122(7):713-734. [Abs]

  45. Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, Ge YW, Lahiri DK, Greig NH. Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci USA. 2001;98(13):7605-7610. [Abs]

  46. Turchan J, Anderson C, Hauser KF, Sun Q, Zhang J, Liu Y, Wise PM, Kruman I, Maragos W, Mattson MP, Booze R, Nath A. Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine. BMC Neurosci. 2001;2(1):3. [Abs]

  47. Warren GW, van Ess PJ, Watson AM, Mattson MP, Blouin RA. Cytochrome P450 and antioxidant activity in interleukin-6 knockout mice after induction of the acute-phase response. J Interferon Cytokine Res. 2001;21(10):821-826. [Abs]

  48. Yu Q, Holloway HW, Flippen-Anderson JL, Hoffman B, Brossi A, Greig NH. Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action. J Med Chem. 2001;44(24):4062-4071. [Abs]

  49. Zhou D, Yu T, Chen G, Brown SA, Yu Z, Mattson MP, Thompson JS. Effects of NF-kappaB1 (p50) targeted gene disruption on ionizing radiation-induced NF-kappaB activation and TNFalpha, IL-1alpha, IL-1beta and IL-6 mRNA expression in vivo. Int J Radiat Biol. 2001;77(7):763-772. [Abs]

  50. Camandola S, Poli G, Mattson MP (2000) The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappaB in neurons. Mol. Brain Res. 85: 53-60.[Abs]

  51. Chan SL, Mayne M, Holden CP, Geiger JD, Mattson MP (2000) Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J. Biol. Chem. 275: 18195-18200. [Abs]

  52. Duan W, Guo Z, Mattson MP (2000) Participation of par-4 in the degeneration of striatal neurons induced by metabolic compromise with 3-nitropropionic acid. Exp. Neurol. 165:1-11. [Abs]

  53. Fu W, Killen M, Culmsee C, Dhar S, Pandita TK, Mattson MP (2000) The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function. J. Mol. Neurosci. 14: 3-15. [Abs]

  54. Furey ML, Pietrini P, Alexander GE, Mentis MJ, Szczepanik J, Shetty U, Greig NH, Holloway HW, Schapiro MB, Freo U (2000) Time course of pharmacodynamic and pharmacokinetic effects of physostigmine assessed by functional brain imaging in humans. Pharmacol. Biochem. Behav. 66: 475-481.[Abs]

  55. Furukawa K, D'Souza I, Crudder CH, Onodera H, Itoyama Y, Poorkaj P, Bird TD, Schellenberg GD (2000) Pro-apoptotic effects of tau mutations in chromosome 17 frontotemporal dementia and parkinsonism. Neuroreport. 11: 57-60. [Abs]

  56. Glazner GW, Chan SL, Lu C, Mattson MP (2000) Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic and ensuring apoptosis. J. Neurosci. 20: 3641-3649.[Abs]

  57. Guo Z, Ersoz A, Butterfield DA, Mattson MP (2000) Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid. J. Neurochem. 75: 314-320.[Abs]

  58. Guo Z, Kindy MS, Kruman I, Mattson MP (2000) ALS-linked Cu/Zn-SOD mutation impairs cerebral synaptic glucose and glutamate transport and exacerbates ischemic brain injury. J. Cereb. Blood Flow Metab. 20: 463-468. [Abs]

  59. Guo ZH, Mattson MP (2000) In vivo 2-deoxyglucose administration preserves glucose and glutamate transport and mitochondrial function in cortical synaptic terminals after exposure to amyloid beta-peptide and iron: evidence for a stress response. Exp. Neurol. 166:173-179.[Abs]

  60. Ingram DK, Roth GS, Umegaki H, Ikari H (2000) Development of an adenoviral vector for intracerebral delivery of the dopamine D(2) receptor. Mech. Ageing Dev. 116: 77-93.[Abs]

  61. Jucker M, Bondolfi L, Calhoun ME, Long JM, Ingram DK (2000) Structural brain aging in inbred mice: potential for genetic linkage. Exp. Gerontol. 35:1383-1388.[Abs]

  62. Kalehua AN, Taub DD, Baskar PV, Hengemihle J, Munoz J, Trambadia M, Speer DL, De Simoni MG (2000) Aged mice exhibit greater mortality concomitant to increased brain and plasma TNF-a levels following intracerebroventricular injection of lipopolysaccharide. Gerontology. 46: 115-128.[Abs]

  63. Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, Mattson MP (2000) Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci. 20: 6920-6926.[Abs]

  64. Lane MA (2000) Nonhuman primate models in biogerontology. Exp. Gerontol. 35: 533-541. [Abs]

  65. Lane MA, Tilmont EM, De Angelis H, Handy A, Ingram DK, Kemnitz JW, Roth GS (2000) Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta). Mech. Ageing Dev. 112:185-196.[Abs]

  66. Lee J, Duan W, Long JM, Ingram DK, Mattson MP (2000) Dietary restriction increases survival of newly-generated neural cells and induces BDNF expression in the dentate gyrus of rats. J. Mol. Neurosci. 15: 99-108.

  67. Lee J, Herman JP, Mattson MP (2000) Dietary restriction selectively decreases glucocorticoid receptor expression in the hippocampus and cerebral cortex of rats. Exp. Neurol. 166: 435-441.[Abs]

  68. Mattson MP (2000) Apoptosis and neurodegenerative disorders. Nat. Rev. Mol. Cell. Biol 1: 120-129.

  69. Mattson MP, Culmsee C, Yu ZF (2000) Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res. 301:173-187.[Abs]

  70. Mattson MP, LaFerla FM, Chan SL, Leissring MA, Shepel PN, Geiger JD (2000) Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 23: 222-229.[Abs]

  71. Mattson MP, Zhu H, Yu J, Kindy MS (2000) Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J. Neurosci. 20: 1358-1364. [Abs]

  72. Pedersen WA, Chan SL, Mattson MP (2000) A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. J. Neurochem. 74: 1426-1433. [Abs]

  73. Pedersen WA, Luo H, Kruman I, Kasarskis E, Mattson MP (2000) The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic sclerosis. FASEB J. 14: 913-924. [Abs]

  74. Piper D, Mujtaba J, Rao MS, Lucerno M (2000) Immunocytochemical and physiological characterization of human neural precursors. J. Neurophysiology 84: 534-548.[Abs]

  75. Sullivan PG, Geiger JD, Mattson MP, Scheff SW (2000) Dietary supplement creatine protects against traumatic brain injury. Ann. Neurol. 48: 723-729.[Abs]

  76. Szayna M, Doyle ME, Betkey JA, Holloway HW, Spencer RG, Greig NH, Egan JM (2000) Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats. Endocrinology. 141:1936-1941.[Abs]

  77. Yu Z, Nikolova-Karakashian M, Zhou D, Cheng G, Schuchman EH, Mattson MP (2000) Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis. J. Mol. Neurosci. 15: 85-98.

  78. Yang T, Mujtaba T, Venkatraman G, Yuan W, Rao MS, Luskin M (2000) Region-specific differentiation of neural-tube derived neuronal restricted progenitor cells after heterotopic transplantation. Proc. Natl. Acad. Sci. U.S.A. 97: 13366-13371.[Abs]

  79. Zhu H, Fu W, Mattson MP (2000) The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis. J. Neurochem. 75:117-124.[Abs]

  80. Bruce-Keller AJ, Umberger G, McFall R, Mattson MP (1999) Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann. Neurol. 45: 8-15. [Abs]

  81. Duan W, Mattson MP (1999) Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J. Neurosci. Res. 57: 185-206. [Abs]

  82. Duan W, Zhang Z, Gash DM, Mattson MP (1999) Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease. Ann. Neurol. 46: 587-597. [Abs]

  83. Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP (1999) Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knockin mice. Nature Med. 5: 101-107. [Abs]

  84. Ingram DK, Jucker M (1999) Developing mouse models of aging: a consideration of strain differences in age-related behavioral and neural parameters. Neurobiol. Aging. 20: 137-145. [Abs]

  85. Lane MA, Ingram DK, Roth GS (1999) Nutritional modulation of aging in nonhuman primates.J. Nutr. Health Aging. 3: 69-76.

  86. Long JM, Mouton PR, Jucker M, Ingram DK (1999) What counts in brain aging? Design-based stereological analysis of cell number. J. Gerontol. A. Biol. Sci. Med. Sci. 54: B407-B417. [Abs]

  87. Mujtaba T, Piper D, Groves A, Kalyani A, Lucero M, Rao MS (1999) Lineage restricted precursors can be isolated from both the mouse neural tube and cultured ES cells. Dev. Biol. 214: 113-127. [Abs]

  88. Shaw KT, Greig NH (1999) Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection. Neuroreport 10: 53-56. [Abs]

  89. Yu Q, Holloway HW, Utsuki T, Brossi A, Greig NH (1999) Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease. J. Med. Chem. 42:1855-1861. [Abs]

  90. Yu ZF, Zhou D, Bruce-Keller AJ, Kindy MS, Mattson MP (1999) Lack of the p50 subunit of NF-kB increases the vulnerability of hippocampal neurons to excitotoxic injury. J. Neurosci. 19: 8856-8865. [Abs]

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