The following is a compilation of abstracts of NIH grants directly related to CFS. Abstracts are taken from the CRISP database. Most NIH grants are funded for more than one year. Thus, a particular abstract usually appears more than once in this list.
CFS-related grants for the years 1999 - 2004 primarily involve the following topics:
- CFS and the cardiovascular system, including neurally mediated hypotension and orthostatic intolerance, as well as clinical trials of medications to treat these conditions. Grants in this category also cover other aspects of potential circulatory dysfunction in CFS, such as muscle blood flow and venous dysfunction.
- The epidemiology of CFS, including incidence in community samples, twin studies and CFS in adolescents.
- Immunology of CFS, including mechanisms of immunologically mediated fatigue, and involvement of natural killer cells and inflammatory factors.
- Neurobiology of CFS, including pathophysiology.
- Psychological aspects of CFS, including studies of psychiatric co morbidities and efficacy of cognitive behavior therapy.
- CFS Cooperative Research Centers, emphasizing integrated multi-faceted research programs, including studies of the immunology, neurophysiology and genetics of CFS.
- Other aspects of CFS, including studies of physiological parameters, virology and sleep disturbance.
- Microarrays and Proteomics in MZ Twins discordant for CFS
In addition to the grants specifically listed here, the NIH funds many studies of the physiological systems that appear to be affected by CFS, for example the nervous and cardiovascular systems, the HPA axis and systems influencing sleep. In addition, the NIH funds many studies of conditions that have some symptoms in common with CFS, and therefore may have some similar underlying pathologies. These include, among others, fibromyalgia, Lyme disease, sleep disturbances, and cancer-related fatigue. Information on some of these conditions can be found on the Internet: Search NIH web site
Peer Reviewed Publications
The grants listed here have resulted in a number of peer-reviewed publications. To find publications written
by the Principal Investigator of a given grant, first find that individual's name in the grant listing and then
search MEDLINE using the name. Because
MEDLINE will often contain entries from more than one individual having the same name, it will usually be
useful to use the term "chronic fatigue" (or another relevant term) as a second search term, along with the name.
In addition, this web site provides a direct link to MEDLINE using "chronic fatigue" as a search term, to find
papers that reference this term, regardless of the author.
CFS Pubmed Search