National Institute on Aging
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Laboratory of Clinical Investigation
1997 - 1998 Publications

  1. Beamer, B. A., Yen, C. J., Andersen, R. E., Muller, D., Elahi, D., Cheskin, L. J., Andres, R., Roth, J., and Shuldiner, A. R.: Association of the Pro12Ala variant in the peroxisome proliferator- activated receptor-gamma2 gene with obesity in two Caucasian populations. Diabetes 47: 1806-8, 1998.

  2. Conwit, R. A., Tracy, B., Cowl, A., McHugh, M., Stashuk, D., Brown, W. F., and Metter, E. J.: Firing rate analysis using decompostion-enhanced spike triggered averaging in the quadriceps femoris. Muscle Nerve 21: 1338-40, 1998.

  3. Fozard, J.L.: Contributions of longitudinal studies to epidemiology and disease prevention: An overview. Aust J of Ageing 17: 22-24, 1998.

  4. Harik-Khan, R. I., Wise, R. A., and Fozard, J. L.: Determinants of maximal inspiratory pressure. The Baltimore Longitudinal Study of Aging. Am J Respir Crit Care Med 158: 1459-64, 1998.

  5. Hirsch, R., Lethbridge-Cejku, M., Hanson, R., Scott, W. W., Jr., Reichle, R., Plato, C. C., Tobin, J. D., and Hochberg, M. C.: Familial aggregation of osteoarthritis: data from the Baltimore Longitudinal Study on Aging. Arthritis Rheum 41: 1227-32, 1998.

  6. Lee-Kwon, W., Park, D., and Bernier, M.: Nucleotide excision repair is not required for the antiapoptotic function of insulin-like growth factor 1. Exp Cell Res 241: 458-66, 1998.

  7. Lee-Kwon, W., Park, D., Baskar, P. V., Kole, S., and Bernier, M.: Antiapoptotic signaling by the insulin receptor in chinese hamster ovary cells. Biochemistry 37: 15747-57, 1998.

  8. Lee-Kwon, W., Park, D., and Bernier, M.: Involvement of the Ras/extracellular signal-regulated kinase signalling pathway in the regulation of ERCC-1 mRNA levels by insulin. Biochem J 331: 591-7, 1998.

  9. Nagai, Y., Metter, E. J., Earley, C. J., Kemper, M. K., Becker, L. C., Lakatta, E. G., and Fleg, J. L.: Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia. Circulation 98: 1504-9, 1998.

  10. Nagai, Y., Kemper, M. K., Earley, C. J., and Metter, E. J.: Blood-flow velocities and their relationships in carotid and middle cerebral arteries. Ultrasound Med Biol 24: 1131-6, 1998.

  11. O'Connor, K. G., Tobin, J. D., Harman, S. M., Plato, C. C., Roy, T. A., Sherman, S. S., and Blackman, M. R.: Serum levels of insulin-like growth factor-I are related to age and not to body composition in healthy women and men. J Gerontol A Biol Sci Med Sci 53: M176-82, 1998.

  12. Pearson, J.D., S.Y., Kao., Brant, L.J., Metter, E.J., Tockman, M.S., and Fozard, J.L.: Longitudinal change in forced expiratory volume in healthy, non-smoking men and women: The Baltimore Longitudinal Study of Aging. Am J Hum Biol 10: 471-481, 1998.

  13. Perfetti, R., Barnett, P. S., Mathur, R., and Egan, J. M.: Novel therapeutic strategies for the treatment of type 2 diabetes. Diabetes Metab Rev 14: 207-25, 1998.

  14. Ryan, A. S., Egan, J. M., Habener, J. F., and Elahi, D.: Insulinotropic hormone glucagon-like peptide-1-(7-37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia. J Clin Endocrinol Metab 83: 2399-404, 1998.

  15. Yang, H., Egan, J. M., Wang, Y., Moyes, C. D., Roth, J., Montrose, M. H., and Montrose-Rafizadeh, C.: GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor. Am J Physiol 275: C675-83, 1998.

  16. Carter, H. B., Epstein, J. I., Chan, D. W., Fozard, J. L., and Pearson, J. D.: Recommended prostate-specific antigen testing intervals for the detection of curable prostate cancer. Jama 277: 1456-60, 1997.

  17. Carter, H. B., Partin, A. W., Luderer, A. A., Metter, E. J., Landis, P., Chan, D. W., Fozard, J. L., and Pearson, J. D.: Percentage of free prostate-specific antigen in sera predicts aggressiveness of prostate cancer a decade before diagnosis. Urology 49: 379-84, 1997.

  18. Carter, H.B. and Pearson, J.D.: PSA and the natural course of prostate cancer. In: Schroder, F. (Ed.) Advances in Prostate Cancer and BPH: Proceedings of the IV Congress on Progress and Controversies in Oncological Urology, Parthenon Publishing, New York, 187-193, 1997.

  19. Conwit, R. A., Tracy, B., Jamison, C., McHugh, M., Stashuk, D., Brown, W. F., and Metter, E. J.: Decomposition-enhanced spike-triggered averaging: contraction level effects. Muscle Nerve 20: 976-82, 1997.

  20. De Ore, K., Greig, N. H., Holloway, H. W., Wang, Y., Perfetti, R., and Egan, J. M.: The effects of GLP-1 on insulin release in young and old rats in the fasting state and during an intravenous glucose tolerance test. J Gerontol A Biol Sci Med Sci 52: B245-9, 1997.

  21. Edelstein, S. L., Knowler, W. C., Bain, R. P., Andres, R., Barrett-Connor, E. L., Dowse, G. K., Haffner, S. M., Pettitt, D. J., Sorkin, J. D., Muller, D. C., Collins, V. R., and Hamman, R. F.: Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes 46: 701-10, 1997.

  22. Ershler, W. B., Harman, S. M., and Keller, E. T.: Immunologic aspects of osteoporosis. Dev Comp Immunol 21: 487-99, 1997.

  23. Fozard, J.L., Graafmans, J.A.M., Bouma, H., Rietsema, J., and van Berlo, A.: Aging and ergonomics: The challenge of environmental changes and individual differences. In: Brookhuis, K., �Weikurt, C., �Moraal, J., and �de Waard, D. (Eds.) Aging and Human Factors: Proceedings of the tenth anniversary meeting of the Human Factors and Ergonomics Society, TNO Press, Soesterberg, 51-60, 1997.

  24. Graafmans, J.A.M., Fozard, J.L., Rietsema, J., van Berlo, A., and Bouma, H.: Gerontechnology: Matching the technological environment to the needs and capacities of the elderly. In: Brookhuis, K., �Weikert, C., �Moraal, J., and �de Waard, D. (Eds.) Aging and Human Factors: Proceedings of the tenth anniversary meeting of the Human Factors and Ergonomics Society, TNO Press, Soesterberg, 19-30, 1997.

  25. Kole, H. K., Liotta, A. S., Garant, M. J., Kole, S., and Bernier, M.: Specific inhibition of insulin receptor dephosphorylation by a synthetic dodecapeptide containing sulfotyrosyl residues as phosphotyrosyl mimetic. Indian J Biochem Biophys 34: 50-5, 1997.

  26. Korrapati, M. R., Sorkin, J. D., Andres, R., Muller, D. C., Loi, C. M., Vesell, E. S., and Vestal, R. E.: Acetylator phenotype in relation to age and gender in the Baltimore Longitudinal Study of Aging. J Clin Pharmacol 37: 83-91, 1997.

  27. Lindle, R. S., Metter, E. J., Lynch, N. A., Fleg, J. L., Fozard, J. L., Tobin, J., Roy, T. A., and Hurley, B. F.: Age and gender comparisons of muscle strength in 654 women and men aged 20-93 yr. J Appl Physiol 83: 1581-7, 1997.

  28. Martin, K., Lethbridge-Cejku, M., Muller, D. C., Elahi, D., Andres, R., Tobin, J. D., and Hochberg, M. C.: Metabolic correlates of obesity and radiographic features of knee osteoarthritis: data from the Baltimore Longitudinal Study of Aging. J Rheumatol 24: 702-7, 1997.

  29. Metter, E. J., Conwit, R., Tobin, J., and Fozard, J. L.: Age-associated loss of power and strength in the upper extremities in women and men. J Gerontol A Biol Sci Med Sci 52: B267-76, 1997.

  30. Montrose-Rafizadeh, C., Wang, Y., Janczewski, A. M., Henderson, T. E., and Egan, J. M.: Overexpression of glucagon-like peptide-1 receptor in an insulin- secreting cell line enhances glucose responsiveness. Mol Cell Endocrinol 130: 109-17, 1997.

  31. Montrose-Rafizadeh, C., Yang, H., Rodgers, B. D., Beday, A., Pritchette, L. A., and Eng, J.: High potency antagonists of the pancreatic glucagon-like peptide-1 receptor. J Biol Chem 272: 21201-6, 1997.

  32. Montrose-Rafizadeh, C., Yang, H., Wang, Y., Roth, J., Montrose, M. H., and Adams, L. G.: Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. J Cell Physiol 172: 275-83, 1997.

  33. Montrose-Rafizadeh, C., Kole, J., Bartkowski, L. M., Lee, L. H., Blackmon, D. L., Behnken, S. E., Gearhart, J. D., Cohn, J. A., and Montrose, M. H.: Gene targeting of a CFTR allele in HT29 human epithelial cells. J Cell Physiol 170: 299-308, 1997.

  34. Morita, T., Hanaoka, K., Morales, M. M., Montrose-Rafizadeh, C., and Guggino, W. B.: Cloning and characterization of maxi K+ channel alpha-subunit in rabbit kidney. Am J Physiol 273: F615-24, 1997.

  35. Perfetti, R., Lee-Kwon, W., Montrose-Rafizadeh, C., and Bernier, M.: Overexpression and activation of the insulin receptor enhances expression of ERCC-1 messenger ribonucleic acid in cultured cells. Endocrinology 138: 1829-35, 1997.

  36. Resnick, S. M., Metter, E. J., and Zonderman, A. B.: Estrogen replacement therapy and longitudinal decline in visual memory. A possible protective effect? Neurology 49: 1491-7, 1997.

  37. Silver, K., Walston, J., Chung, W. K., Yao, F., Parikh, V. V., Andersen, R., Cheskin, L. J., Elahi, D., Muller, D., Leibel, R. L., and Shuldiner, A. R.: The Gln223Arg and Lys656Asn polymorphisms in the human leptin receptor do not associate with traits related to obesity. Diabetes 46: 1898-900, 1997.

  38. Stewart, W. F., Kawas, C., Corrada, M., and Metter, E. J.: Risk of Alzheimer's disease and duration of NSAID use. Neurology 48: 626-32, 1997.

  39. Vittone, J., Blackman, M. R., Busby-Whitehead, J., Tsiao, C., Stewart, K. J., Tobin, J., Stevens, T., Bellantoni, M. F., Rogers, M. A., Baumann, G., Roth, J., Harman, S. M., and Spencer, R. G.: Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism 46: 89-96, 1997.

  40. Wallace, W. C., Akar, C. A., Lyons, W. E., Kole, H. K., Egan, J. M., and Wolozin, B.: Amyloid precursor protein requires the insulin signaling pathway for neurotrophic activity. Brain Res Mol Brain Res 52: 213-27, 1997.

  41. Wang, Y., Kole, H. K., Montrose-Rafizadeh, C., Perfetti, R., Bernier, M., and Egan, J. M.: Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions. J Mol Endocrinol 19: 241-8, 1997.

  42. Wang, Y., Perfetti, R., Greig, N. H., Holloway, H. W., DeOre, K. A., Montrose-Rafizadeh, C., Elahi, D., and Egan, J. M.: Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats. J Clin Invest 99: 2883-9, 1997.

  43. Zenilman, M. E., Magnuson, T. H., Perfetti, R., Chen, J., and Shuldiner, A. R.: Pancreatic reg gene expression is inhibited during cellular differentiation. Ann Surg 225: 327-32, 1997.

  44. Zhou, J. and Egan, J. M.: SNAP-25 is phosphorylated by glucose and GLP-1 in RIN 1046-38 cells. Biochem Biophys Res Commun 238: 297-300, 1997.

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