NIBIB - LBPS Selected Publications

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LBPS Selected Publications

Drug Delivery and Kinetics (DDK)

Amaral J, Fariss RN, Campos M, Robison WG, Jr., Kim H, Lutz R and Becerra SP. Transscleral-RPE Permeability of Pigment Epithelium-derived Factor (PEDF) and Ovalbumin Proteins: Implications for Subconjunctival Protein Delivery. Invest Ophthalmol Vis Sci, 46(12):4383-92, 2005.

Chen MY, Hoffer A, Morrison PF, Hamilton JF, Hughes J, Schlageter KS, Lee J, Kelly BR and Oldfield EH. Surface Properties, more than size, limiting distribution of virus-sized particles and viruses in the central nervous system. J. Neurosurgery, 103: 311-319, 2005.

Croteau D, Walbridge S, Morrison PF, Butman JA, Vortmeyer AO, Johnson D, Oldfield EH and Lonser RR. Real-time, in vivo, computed tomographic imaging of convection-enhanced delivery of a low molecular weight tracer. J. Neurosurgery, 102: 90-97, 2005.

Galban CJ, Maderwald S, Uffmann K and Ladd ME. A diffusion tensor imaging analysis of gender differences in water diffusivity within human skeletal muscle. NMR Biomed., 18(8): p. 489-498, 2005.

Ghose S, Fujita M, Morrison PF, Uhl G, Murphy DL, Mozley PD, Halldin C and Innis R. Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters. Synapse, 56: 100-104, 2005.

Heiss JD, Walbridge S, Morrison PF, Hampton R, Sato S, Vortmeyer A, Butman JA, O'Malley J, Vidwan P, Dedrick RL and Oldfield EH. Local distribution and toxicity of prolonged intracerebral infusion of muscimol. In press, J. Neurosurgery, for Dec. 2005.

Kim H, Csaky KG, Chan C-C, Bungay PM, Lutz RJ, Dedrick RL, Yuan P, Rosenberg J, Grillo-Lopez AJ, Wilson WH and Robinson MR. The pharmacokinetics of rituximab following an intravitreal injection. (available on-line) (This technology was transferred to human testing with the FDA approval, IND 67,755) (Annual Report 1 Z01 OD 010324: Physical and Mathematical Models for Drug Delivery), Experimental Eye Research, Nov. 2005.

Kim H, Csaky KG, Gilger BC, Dunn JP, Tremblay M, de Monasterio FM, Tansey G, Yuan P, Bungay P, Lutz RJ and Robinson MR. The preclinical evaluation of a novel episcleral cyclosporine implant for ocular Graft-vs-Host disease, Invest. Ophth. Vis. Sci., Vol. 46, No. 2, 655 – 662, 2005. (This work was transferred to human testing with the FDA approval, IND 69,171)

Kim H, Csaky KG, Gravlin L, Yuan P, Lutz RJ, Bungay PM, Dedrick RL, Tansey G, de Monasterio F, Tremblay M, Potti GK, Grimes G and Robinson MR. The safety and pharmacokinetics of a preservative-free triamcinoline acetonide formulation for intravitreal administration. Retina (re-submitted). (This technology was transferred to human testing with the FDA approval, IND 67,755) (Annual Report 1 Z01 OD 010324: Physical and Mathematical Models for Drug Delivery)

Kim H, Lizak MJ, Tansey G, Csaky KG, Robinson MR, Wang NS and Lutz RJ. Study of ocular transport of drugs released from an intravitreal implant using magnetic resonance imaging. Annals of Biomedical Engineering, 33 (2): 150 – 164, 2005.

Morrison PF. Distributed models of drug kinetics. In Principles of Clinical Pharmacology, Second Edition, Atkinson AJ, Abernethy DR, Daniels CE, Dedrick RL and Markey SP (eds). (Annual Report 1 Z01 OD 011082: Development of Finite Element and Imaging Methods for Drug Delivery) Elsevier New York, in press, 2005.

Park J, Bungay PM, Lutz RJ, Augsburger JJ, Millard RW, Sinha Roy A and Banerjee RK. Evaluation of coupled convective-diffusive transport of drugs administered by intravitreal injection and controlled release implant. (Annual Report 1 Z01 OD 010324: Physical and Mathematical Models for Drug Delivery) J Control Release, 105:279-95, 2005.

Robinson MR, Lee SS, Kim H, Kim S, Lutz RJ, Galban C, Bungay PM, Yuan P, Wang NS, Kim J and Csaky KG. A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide. (available on-line) (Annual Report 1 Z01 OD 010324: Physical and Mathematical Models for Drug Delivery) Experimental Eye Research, Sept 2005.

Benjamin RK, Hochberg FH, Fox E, Bungay PM, Elmquist WF, Stewart CF, Gallo JM, Collins JM, Pelletier RP, de Groot JF, Hickner RC, Cavus I, Grossman SA and Colvin OM. Review of microdialysis in brain tumors, from concept to application: first annual Carolyn Frye-Halloran symposium. (Annual Report 1 Z01 OD 010276: Microdialysis Studies) Neuro-Oncol, 6: 65-74, 2004.

Kim H, Robinson MR, Lizak MJ, Tansey G, Lutz RJ, Yuan P, Wang NS and Csaky KG. Controlled drug release from an ocular implant: An evaluation using dynamic 3-dimensional magnetic resonance imaging. (Annual Report 1 Z01 OD 010324: Physical and Mathematical Models for Drug Delivery) Invest Ophthalmol Vis Sci, 45:2722-31, 2004.

Morrison PF and Chattoraj DK. Replication of a unit-copy plasmid F in the bacterial cell cycle: A replication rate function analysis. (Annual Report 1 Z01 OD 010484: Replication Dynamics of Low Copy Number Plasmids) Plasmid 52: 15-30, 2004.

Yim PJ, Cebral JR, Weaver A, Lutz RJ, Soto O, Vasbinder GB, Ho VB and Choyke PL. Estimation of the differential pressure at renal artery stenoses. (Annual Report 1 Z01 OD 010324: Physical and Mathematical Models for Drug Delivery) Magn Reson Med, 51:969-77, 2004.

Bungay PM, Newton-Vinson P, Isele W, Garris PA and Justice JB. Microdialysis of dopamine interpreted with quantitative model incorporating probe implantation trauma. (Annual Report 1 Z01 OD 010276: Microdialysis Studies) J Neurochem, 86:932-46, 2003.

Guedez L, Rivera AM, Salloum R, Miller ML, Diegmueller JJ, Bungay PM and Stetler-Stevenson WG. Quantitative assessment of angiogenic responses by the directed in vivo angiogenesis assay. (Annual Report 1 Z01 OD 011015: Implantable Capsule for Angiogenesis Studies) Am J Pathol, 162:1431-9, 2003.

Nguyen TT, Pannu YS, Sung C, Dedrick RL, Walbridge S, Brechbiel MW, Garmestani K, Beitzel M, Yordanov AT and Oldfield EH. Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging. J. Neurosurg., 98: 584-590, 2003.

Sarntinoranont M, Banerjee RK, Lonser RR and Morrison PF. A computational model of direct interstitial infusion of macromolecules into the spinal cord. (Annual Report 1 Z01 OD 010353: (Annual Report 1 Z01 OD 010353: Characterization/Optimization of Drug Delivery to CNS Target Tissues) Ann Biomed Eng, 31: 448-461, 2003.

Sarntinoranont M, Iadarola MJ, Lonser RR and Morrison PF Direct interstitial infusion of NK1-targeted neurotoxin into the spinal cord a computational model. (Annual Report 1 Z01 OD 010353: Characterization/Optimization of Drug Delivery to CNS Target Tissues) Am J Physiol Regul Integr Comp Physiol, 285:R243-54, 2003.

Sarntinoranont M, Iadarola MJ and Morrison PF. A kinetic analysis of substance P trafficking. (Annual Report 1 Z01 OD 011050: Substance P Conjugates in Pain) J Pharm Sci, 92: 232-243, 2003.

Sarntinoranont M, Rooney F and Ferrari M. Interstitial stress and fluid pressure within a growing tumor. Ann. Biomed. Eng., 31: 327-335, 2003.

Tang A, Bungay PM and Gonzales RA. Characterization of probe and tissue factors that influence interpretation of quantitative microdialysis experiments for dopamine. (Annual Report 1 Z01 OD 010276: Microdialysis Studies) J Neurosci Methods, 126:1-11, 2003.

Wiener SM, Hoyt RF Jr, Deleonardis JR, Clevenger RR, Lutz RJ, Christini, DV and Safer B. Method for pressure mediated selective delivery of therapeutic substances and cannula. (Annual Report 1 Z01 OD 010324: Physical and Mathematical Models for Drug Delivery) US Patent application No. 09/700,999, 2001.

Biomedical Instrumentation and Multiscale Imaging (BIMI)

Forbes J, Jin AJ, Ma K, Gutierrez-Cruz G, Tsai W and Wang K. Titan PEVK segment: Charge-driven elasticity of the open and flexible polyampholyte. J. Muscle Res. Cell Motil. 27, 2006.

Jin AJ, Prasad K, Smith PD, Lafer E M and Nossal RJ. Measuring the elasticity of clathrin coated vesicles via atomic force microscopy. Biophys. J. 90:3333-44, 2006.

Chen W, Joly A and Morgan NY. Optical Physics and Applications of Luminescent Nanoparticles, In Handbook of Semiconductor Nanostructures and Devices, Balandin AA, Wang KL (eds.), (Annual Report 1 Z01 OD 011011: Propagation of Light in Tissue and Imaging) American Scientific Publishers, (Stevenson Ranch, CA), 2005.

Gorbach A, Ntziachristos V and Perelman L. Advances in Optical Imaging of Cancer. In New Techniques in Oncologic Imaging, Padhani, Choyke (eds.), (Annual Report 1 Z01 OD 022005: IR and Near-IR Image-Guided Assessment of Renal Perfusion during Nephrectomies), Taylor and Francis Books, 2005.

Gorbach A, Perelman L and Ntziachristos V. Advances in Optical Imaging. Invited Chapter. Accepted for publication in Recent Advances in Cancer Imaging, Marcel Dekker Inc.

Gorbach AM, Elster E and Kirk A. Infrared Image Guided Assessment and Resuscitation of Cadaveric Kidney. U.S. Patent Application, submitted. (Annual Report 1 Z01 OD 022006-01: Multi-spectral Imaging of Cadaveric Organ Viability During Organ Resuscitation), 2005.

Morgan NY, English S, Chen W, Chernomordik V, Russo A, Smith PD and Gandjbakhche A. Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots. (Annual Report 1 Z01 OD 011011: Propagation of Light in Tissue and Imaging) Acad Radiol. 12:313-23, 2005.

Morgan NY, Smith PD and Wellner E. Spatially Selective Fixed-Optics Multicolor Fluorescence Detection System For Microfluidic Device. Patent number: 60/693,780. Pending. (Annual Report 1 Z01 OD 022008: Single-use, Multichannel Microfluidic Chips for Capillary Electrophoresis), 2005.

Morgan NY, Wellner E, Talbot T, Smith PD and Phillips TM. Development of a two-color laser fluorescence detector: On-line detection of internal standards and unknowns by capillary electrophoresis within the same sample. (Annual Report 1 Z01 OD 022010: Improved Laser-Induced Fluorescence Detection for Capillary Electrophoresis) J Chromatography A, 2005.

Roy S, Dimitriadis EK, Kar S, Geanacopoulos M, Lewis MS and Adhya S. Gal repressor-operator-HU ternary complex: pathway of repressosome formation. (Annual Report 1 Z01 OD 011054: The Molecular Interactions Involved in Gal Repression and 010184: Physical Biochemistry of Macromolecules) Biochemistry, 44:5373-80, 2005.

Smith PD, Morgan NY, Wellner E and Phillips TM. Miniature Laser-Induced Fluorescence Detector. Patent number: 60/682,847. (Annual Report 1 Z01 OD 022009: Miniature In-line Microfluidic LIF Detector for Assessment of Peptides in LC-MS) Pending, 2005.

Sviridov A, Chernomordik V, Hassan M, Russo A, Eidsath A, Smith P and Gandjbakhche AH. Intensity profiles of linearly polarized light backscattered from skin and tissue-like phantoms. (Annual Report 1 Z01 OD 011011: Propagation of Light in Tissue and Imaging) J Biomed Opt. 10:14012, 2005.

Choi EJ and Dimitriadis EK. Cytochrome c adsorption to supported, anionic lipid bilayers studied via atomic force microscopy. (Annual Report 1 Z01 OD 011079: Kinetics of Protein Absorption on Lipid Bilayers; Atomic Force Microscopy Study) Biophys J. 87:3234-41, 2004.

Choi EJ, Jin AJ, Niu S-L, Smith PD and Litman BJ. Visualizing individual rhodopsin (a G-protein coupled receptor) molecules in native disk and reconstructed membranes via atomic force microscopy. Tech. Proc. 2004 Nanotech. & Trade Show, 1, 63-66, 2004.

Gorbach AM, Heiss JD, Kopylev L and Oldfield EH. Intraoperative infrared imaging of brain tumors. J Neurosurg 101: 960-9, 2004.

Shoelson B, Dimitriadis EK, Cai H, Kachar B and Chadwick RS. Evidence and implications of inhomogeneity in tectorial membrane elasticity. (Annual Report 1 Z01 OD 011036: Probing the Elasticity of Biological Samples with the Atomic Force Microscope) Biophys J, 87:2768-77, 2004.

Gerdelman DH, Hekmat F, Chernomordik V, Smith P, Eidsath A, Pursley R, Atkinson J, Mulshine J, and Gandjbakhche A. "Diffuse Reflectance spectroscopy to quantify inflammation of the oral epithelium in vivo," in Progress in Biomedical Optics and Imaging: Optical Biopsy IV, RR Alfano (ed.), 3(5) 50-70 SPIE, 2003.

Gorbach A, Simonton D, Hale DA, Swanson SJ, and Kirk AD. Objective, real-time, intraoperative assessment of renal perfusion using infrared imaging. Am J Transplant, 3:988-93, 2003.

Gorbach AM, Heiss J, Kufta C, Sato S, Fedio P, Kammerer WA, Solomon J, Oldfield EH. Intraoperative infrared functional imaging of human brain. Ann Neurol, 54:297-309 ,2003.

Leuba SH, Karymov MA, Tomschik M, Ramjit R, Smith P and Zlatanova J. Assembly of single chromatin fibers depends on the tension in the DNA molecule: Magnetic tweezers study. (Annual Report 1 Z01 OD 011007: System for Laser/Mechanical Dissection of Chromosomes) Proc Natl Acad Sci USA, 100: 495-500 2003.

Morgan NY, Gaitan M, Locascio LE, Smith PD, Phillips TM, and Pohida T. “A microfluidic flow-through immunoassay for simultaneous detection of multiple proteins in a sub-microliter biological sample”, US Provisional Application No. 60/509,285 for patent, filed Oct. 2003.

Phillips TM and Smith P. Analysis of intracellular regulatory proteins by immunoaffinity capillary electrophoresis coupled with laser-induced fluorescence detection. (Annual Report 1 Z01 OD 011059: Development of an Ultrasensitive Capillary Electrophoresis Detection System) Biomed Chromatogr 17:182-7, 2003.

Sinz A, Jin AJ and Zschornig, O. Evaluation of the metal binding properties of a histidine-rich fusogenic peptide by electrospray ionization fourier transform ion cyclotron resonance mass spectroscopy. Journal of Mass Spectrometry, 38: 1150-1159, 2003.

Tokumasu F, Jin AJ, Feigenson GW and Dvorak JA. Atomic Force Microscopy of Nanometric Liposome Adsorption and Nanoscopic Membrane Domain Formation, Ultramicroscopy, 97: 217-227, 2003.

Tokumasu F, Jin AJ, Feigenson GW and Dvorak JA. Nanoscopic lipid domain dynamics revealed by atomic force microscopy. Biophys J, 84: 2609-2618, 2003.

Wood B, Gorbach A, Perelman L, Hvizda J and Neeman Z. Apparatus for Multifocal Energy Deposition and Methods for its Use. US Provisional Application for patent (Patent Application 60/403,875), filed Oct. 2003.

Bonner RF, Goldstein S, Smith PD and Pohida T. Designs for non-contact laser capture microdissection. Patent number: 6,420,132. Accepted. Annual Report 1 Z01 OD 011006: Engineering Development of Laser Capture Microdissection, 2002.

Bonner RF, Goldstein S, Smith PD and Pohida T. Precision laser capture microdissection utilizing short pulse length. Patent number: 6,420,132 B1. Accepted. (Annual Report 1 Z01 OD 011006: Engineering Devel opment of Laser Capture Microdissection), 2002.

Tokumasu F, Jin AJ and Dvorak JA. Lipid membrane phase behaviour elucidated in real time by controlled environment atomic force microscopy. Lipid membrane phase behaviour elucidated in real time by controlled environment atomic force microscopy. (Annual Report 1Z01OD011040: Biological Membranes and Atomic Force Microscopy) J. Electron Microsc, 51: 1-9, 2002.

Wang K, Forbes JG and Jin AJ. Single molecule measurements of titin elasticity. Single molecule measurements of titin elasticity. Prog Biophys Mol Biol, 77: 1-44, 2002.

Molecular Interactions (MI)

Aldaz-Carroll L, Whitbeck CJ, Ponce de Leon M, Lou H, Pannell LK, Lebowitz J, Fogg C, White C, Moss B, Cohen GH, and Eisenberg RJ. Physical and immunological characterization of a recombinant secreted form of the membrane protein encoded by the vaccinia virus L1R gene. (Annual Report 1 Z01 OD 011081: Characterizing Viral Protein Interactions and Other Protein Interacting Systems) Virology, 341:59-71, 2005.

Cole NB, Murphy DD, Lebowitz J, Di Noto L, Levine RL, Nussbaum RL. Metal-catalyzed oxidation of alpha-synuclein: helping to define the relationship between oligomers, protofibrils, and filaments. (Annual Report 1 Z01 OD 011081: Characterizing Viral Protein Interactions and Other Protein Interacting Systems) J Biol Chem, 280:9678-90, 2005.

Lebowitz J. Through the looking glass: the discovery of supercoiled DNA. In The Inside Story: DNA to RNA to Protein. Reprints from TIBS. Witkowski J, (ed.), Cold Spring Harbor Press (Cold Spring Harbor, NY), 147-160, 2005.

Lewis MS and Reily MM. Application of weighted robust regression to equilibrium ultracentrifugation. In Analytical Ultracentrifugation: Techniques and Methods, Scott DJ, Harding SE, Rowe AT, (eds), Royal Society of Chemistry, London, 151-162. (Annual Report 1 Z01 OD 010039: Biophysical Instrumentation and Methodology), 2005.

Lewis MS, Reily MM, Holladay LA (2005) Fitting of Thermodynamic Data from Equilibrium Ultracentrifugation by Robust Least-Squares with Reduced Parameter Cross-Correlation Coefficients. In Analytical Ultracentrifugation: Techniques and Methods. Scott DJ, Harding SE, Rowe AT, Eds. Royal Society of Chemistry, London 372-388. (Annual Report 1 Z01 OD 010039: Biophysical Instrumentation and Methodology)

Pancera M, Lebowitz J, Schn A, Zhu P, Freire E, Kwong PD, Roux KH, Sodroski J, Wyatt R (2005) Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replacement of the native trimerization domain with a heterologous trimerization motif: characterization and ligand binding analysis. J Virol 79:9954-69. (Annual Report 1 Z01 OD 011081: Characterizing Viral Protein Interactions and Other Protein Interacting Systems)

Roy S, Dimitriadis EK, Kar S, Geanacopoulos M, Lewis MS, Adhya S (2005) Gal repressor-operator-HU ternary complex: pathway of repressosome formation. Biochemistry. 44:5373-80. (Annual Report 1 Z01 OD 011054: The Molecular Interactions Involved in Gal Repression and 010184: Physical Biochemistry of Macromolecules)

Szajner P, Weisberg A, Lebowitz J, Heuser J, and Moss B (2005) External scaffold of immature poxvirus particles is made of trimers of a 63-kDa protein that form a honeycomb lattice. J Cell Biol 170:971-81.

Center RJ, Lebowitz J, Leapman RD, Moss B (2004) Promoting the trimerization of soluble HIV-1 Env through the use of HIV-1SIV chimeras. J Virol 78:2265-76. (Annual Report 1 Z01 OD 011038: STEM Mass Analysis of HIV and SIV Proteins)

Goldin E, Stahl S, Cooney AM, Kaneski CR, Gupta S, Brady RO, Ellis JR, Schiffmann R (2004) Transfer of a Mitochondrial DNA Fragment to MCOLN1 Causes an Inherited Case of Mucolipidosis IV. Human Mutation 24(6):460-465. (Annual Report OD 011084: Information Analysis of DNA, RNA and Protein Sequences)

Lewis MS, Reily MM (2004) Estimation of weights for various methods of the fitting of equilibrium data from the analytical ultracentrifuge. Methods in Enzymol, Johnson M and Brand L, Eds, Academic Press, San Diego, 384:232-242. (Annual Report 1 Z01 OD 010039: Biophysical Instrumentation and Methodology)

Budge PJ, Lebowitz J, Graham BS (2003) Antiviral activity of RhoA-derived peptides against respiratory syncytial virus is dependent on formation of peptide dimers. Antimicrobial Agents Chemother, 47:3470-77. (Annual Report 1 Z01 OD 011081: Characterizing Viral Protein Interactions and Other Protein Interacting Systems)

Cleaver JE, Collins C, Ellis J, Volik S (2003) Genome sequence and splice site analysis of the low fidelity polymerases H & I that are associated with replication of UV damaged DNA. Genomics, 82 : pp. 561-570. (Annual Report OD 011084: Information Analysis of Splice Site Mutations)

Hellerud C, Adamowicz M, Jurkiewicz D, Taybert J, Kubalska J, Ciara E, Popowska E, Ellis JR, Lindstedt S, and Pronicka E (2003) Clinical Heterogeneity and Molecular Findings in Five Polish Patients with Glycerol Kinase Deficiency; Investigation of Two Splice Site Mutations with Computerized Splice Junction Analysis and Xp21 Gene Specific mRNA Analysis. Molecular Genetics and Metabolism, 79(3): pp. 149-159. (Annual Report OD 011084: Information Analysis of Splice Site Mutations)

Hellerud C, Burlina A, Gabelli C, Ellis JR, Nyholm P-G, Lindstedt S ( 2003) Glycerol Metabolism and Determination of Triglycerides – Clinical, Biochemical, and Molecular Findings in Six Subjects Clinical Chemistry and Laboratory Medicine, 41(1): pp. 46-55. (Annual Report OD 011084: Information Analysis of Splice Site Mutations)

Lebowitz J, Lewis MS, Schuck P (2003) Back to the Future: A rebuttal to Henryk Eisenberg. Protein Sci, 12: 2649-2650. (Annual Reports 1 Z01 OD 010039: Biophysical Instrumentation and Methodology and 010485: Biophysical Characterization of Macromolecules)

Dynamics of Macromolecular Assembly (DMA)

P. Schuck "Analytical Ultracentrifugation." In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer. (in press) (2006)

Balbo A, Minor KH, Velikovsky CA, Mariuzza RA, Peterson CB, Schuck P "Studying multi-protein complexes by multi-signal sedimentation velocity analytical ultracentrifugation." Proceedings of the National Academy of Sciences 102:81-86 (2005)

Balbo A, Schuck P. "Ultracentrifugation in the analysis of protein-protein interactions." In: Protein-Protein Interactions, Cold Spring Harbor Laboratory Press ( E. Golemis, P.D. Adams, Edts) Cold Spring Harbor, New York (2005)

Budihas SR, Gorshkova I, Gaidamakov S, Wamiru A, Bona MK, Parniak MA, Crouch RJ, McMahon JB, Beutler JA, Le Grice SF, "Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones." Nucleic Acids Res., 2005 Mar 1;33(4):1249-56 (2005)

Burgess BR, Schuck P, Garboczi DN. "Dissection of the merozoite surface protein 3, a representative of plasmodium falciparum surface proteins, reveals an oligomeric and highly elongated molecule." Journal of Biological Chemistry 280:37236-37245 (2005)

Che MM, Boja ES, Yoon H-Y, Gruschus J, Jaffe H, Stauffer S, Schuck P, Fales HM, Randazzo PA. "Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and arf GAP domains." Cellular Signalling 17:1276-1288 (2005)

Chen Z, Earl P, Damon I, Zhou Y-H, Yu F, Sebrell A, Emerson S, Americo J, Cohen G, Svitel J, Schuck P, Satterfield W, Moss B, Purcell R. "A chimpanzee monoclonal antibody to vaccinia virus B5R protein protects mice against virulent vaccinia virus and neutralizes vaccinia and smallpox viruses in vitro." Proceedings of the National Academy of Sciences USA (in press) (2005)

Chen Z, Moayeri M, Zhou Y-H, Leppla S, Emerson S, Sebrell A, Yu F, Svitel J, Schuck P, Purcell P. Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen. Journal of Infectious Diseases (in press) (2005)

D.J. Scott and P. Schuck. "A brief introduction to the analytical ultracentrifugation of proteins for beginners." In: Modern Analytical Ultracentrifugation: Techniques and Methods (D.J. Scott, S.E. Harding, A.J. Rowe, Editors) The Royal Society of Chemistry, Cambridge (in press) (2005)

Dam J, Schuck P. "Sedimentation velocity analysis of heterogeneous protein-protein interactions: Sedimentation coefficient distributions c(s) and asymptotic boundary profiles from Gilbert-Jenkins theory." Biophysical Journal 89:651-666 (2005)

Dam J, Velikovsky CA, Mariuzza RA, Urbanke C, Schuck P. "Sedimentation velocity analysis of heterogeneous protein-protein interactions: Lamm equation modeling and sedimentation coefficient distributions c(s)." Biophysical Journal 89:619-634 (2005)

Gaidamakov SA, Gorshkova II, Schuck P, Haruki M, Yamada H, Cerritelli SM, Crouch RJ. "Eukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domain." Nucleic Acids Research 33:2166-2175 (2005)

Gonzales JM, Velez M, Jimenez M, Alfonso C, Schuck P, Mingorance J, Vicente M, Minton AP, Rivas G. "The cooperative behavior of E. Coli cell division protein FtsZ assembly involves the preferential cyclization of long single-stranded fibrils." Proceedings of the National Academy of Sciences USA 102:1895-1900 (2005)

Gupta N, Steenbeke TD, Khazanie P, Censoplano NM, Chung EA, Cruz CC, Chaikin MA, Daucher M, Kottilil S, Mavilio D, Schuck P, Sun P, Rabin PL, Radaev S, Van Ryk D, Cicala C, Arthos JA, Fauci AS. "Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: Implications for immunotherapy." Virology 332:491-497 (2005)

Heeb MJ, Griffin JH, Schuck P, Xu X. "Protein S multimers and monomers each have different anticoagulant activity." Journal of Thrombosis and Haemostasis (in press) (2005)

Kornblatt JA, Schuck P. "The influence of temperature on the conformation of canine plasminogen: an analytical ultracentrifugation and dynamic light scattering study." Biochemistry 44:13122-13131 (2005)

Minor KH, Schar CR, Blouse GE, Shore JD, Lawrence DA, Schuck P, Peterson CB. "A mechanism for assembly of complexes of vitronectin and plasminogen activator inhibitor-1 from sedimentation velocity analysis." Journal of Biological Chemistry 280:28711-28720 (2005)

Schuck P. "Diffusion-deconvoluted sedimentation coefficient distributions for the analysis of interacting and non-interacting protein mixtures." In: Modern Analytical Ultracentrifugation: Techniques and Methods (D.J. Scott, S.E. Harding, A.J. Rowe, Editors) The Royal Society of Chemistry, Cambridge (2005)

Snyder GA, Torabi-Parizi P, Ford JM, Arthos JA, Schuck P, Colonna M, Sun PD. "The DC-SIGN and DC-SIGNR repeat oligomerizes the receptor and increases gp120 binding affinity." Journal of Virology 79:4589-4598. (2005)

Vorup-Jensen T, Carman CV, Shimaoka M, Schuck P, Svitel J, Springer TA. "Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin {alpha}X{beta}2." Proceedings of the National Academy of Sciences USA 102:161401619 (2005)

Yikilmaz E, Rouault TA, Schuck P. "Self-association and ligand-induced conformational changes of iron-regulatory proteins 1 and 2." Biochemistry 44:8470-8478 (2005)

Boukari H, Nossal R, Sackett DL, Schuck P. "Hydrodynamics of nanoscopic tubulin rings in dilute solution." Physical Review Letters 93:098106 (2004)

Dam J, Schuck P. "Determination of sedimentation coefficient distributions by direct modeling of the sedimentation boundary with Lamm equation solutions." Methods in Enzymology 384:185-212 (2004)

Gonzales NR, Padlan EA, DePascalis R, Schuck P, Schlom J, Kashmiri SV. "SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity." Molecular Immunology 41:863-872 (2004)

Guan R, Malchiodi EL, Wang Q, Schuck P, Mariuzza RA. "Crystal structure of the c-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein I-alpha reveals sodium-mediated receptor dimerization." Journal of Biological Chemistry 279:31873-31882 (2004)

Houtman JCD, Higashimoto Y, Dimasi N, Cho S, Yamaguchi H, Bowden B, Regan C, Malchiodi EL, Mariuzza RA, Schuck P, Appella E, Samelson LE. "Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences." Biochemistry 43:4170-4178 (2004)

Schuck P "A model for sedimentation in inhomogeneous media. I. Dynamic density gradients from sedimenting co-solutes." Biophysical Chemistry 108:187-200 (2004)

Schuck P "A model for sedimentation in inhomogeneous media. II. Compressibility of aqueous and organic solvents." Biophysical Chemistry 108:201-214 (2004)

Schuck, P. "Sample Delivery System with Laminar Mixing for Microvolume Biosensing", Patent Pending (DHHS E-143-2000/0-EP-04)

Tziatzios C, Schubert D, Schuck P, Lancaster CRD, Gennis RB, Barquera B. The state of association of the Na+ -translocating NADH: quinon oxidoreductase in detergent solution. An ultracentrifugation study. Journal of Colloid and Polymer Science 127:48-53 (2004)

Vistica J, Dam J, Balbo A, Yikilmaz E, Mariuzza RA, Rouault TA, Schuck P. "Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition." Analytical Biochemistry 326:234-256 (2004)

Ali SA, Iwabuchi N, Matsui T, Hirota K, Kidokoro S, Arai M, Kuwajima K, Schuck P, Arisaka F, "Reversible and fast association of a molecular chaperone, gp57A, of bacteriophage T4." Biophysical Journal 85:2606-2618 (2003)

Andersen JF, Francischetti IMB, Valenzuela JG, Schuck P, Ribeiro JMC. "Inhibition of hemostasis by a high-affinity biogenic amine-binding protein from the saliva of a blood feeding insect." Journal of Biological Chemistry 278:4611-4617 (2003)

Dam J, Guan R, Natarajan K, Dimasi N, Chlewicki LK, Kranz DM, Schuck P, Margulies DH, Mariuzza RA. "Variable MHC class I engagement by Ly49 NK cell receptors revealed by the crystal structure of Ly49C bound to H-2K b." Nature Immunology 4:1213-1222 (2003)

DePascalis R, Gonzales NR, Padlan EA, Schuck P, Batra SK, Schlom J, Kashmiri SVS. "In vitro affinity maturation of an SDR-grafted humanized anti-carcinoma antibody (HuCC49V10): Isolation and characterization of minimally immunogenic high affinity variants." Clinical Cancer Research 9:5521-5531 (2003)

Gonzales NR, Padlan EA, DePascalis R, Schuck P, Schlom J, Kashmiri SVS. "Minimizing immunogenicity of the SDR-grafted humanized antibody CC49 by genetic manipulation of the framework residues." Molecular Immunology 40:337-349 (2003)

Lebowitz J, Lewis MS, Schuck P. "Back to the Future: A rebuttal to Henryk Eisenberg." Protein Science 12:2649-2650 (2003)

Rosovitz MJ, Schuck P, Varughese M, Chopra AP, Singh Y, McGinnis LM, Leppla SH. "Alanine scanning mutations in anthrax toxin protective antigen domain 4 reveal residues important for binding to the cellular receptor and to a neutralizing monoclonal antibody." Journal of Biological Chemistry 278:30936-30944 (2003)

Schuck P "On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation." Analytical Biochemistry 320:104-124 (2003)

Svitel J, Balbo A, Mariuzza R, Gonzales NE, Schuck P. "Combined affinity and rate constant distributions of analyte or ligand populations from experimental surface-binding kinetics and equilibria." Biophysical Journal 84:4063-4077 (2003)

Andersen PS, Schuck P, Sundberg EJ, Geisler C, Karjalainen K, Mariuzza RA. "Quantifying the energetics of cooperativity in a ternary protein complex." Biochemistry 41:5177-5184 (2002)

Arthos J, Cicala C, Steenbeke TD, Chun T-W, Dela Cruz C, Hanback DB, Khazanie P, Nam D, Schuck P, Selig SM, VanRyk D, Chaikin M, Fauci AS. "Efficient inhibition of HIV-1 viral replication by a novel modification of sCD4." Journal of Biological Chemistry 277:11456-11464 (2002)

De Pascalis R, Iwahashi M, Tamura M, Padlan EA, Gonzales NR, Santos AD, Giuliano M, Schuck P, Schlom J, Kashmiri SVS. "Grafting of abbreviated complementarity-determining regions containing specificity-determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody." Journal of Immunology 169:3076-3084 (2002)

Gilligan JJ, Schuck P, Yergey AL. "Mass spectrometry after capture and small-volume elution of analyte from a surface plasmon resonance biosensor." Analytical Chemistry 74:2041-2047 (2002)

Lebowitz J, Lewis MS, Schuck P. "Modern analytical ultracentrifugation in protein science - a tutorial review." Protein Science 11:2067-2079 (2002)

Perugini MA, Schuck P, Howlett GJ. "Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions." European Journal of Biochemistry 269:5939-5949 (2002)

Rebois V, Schuck P, Northup J. "Elucidating kinetic and thermodynamic constants for the interaction of G protein subunits and receptors by surface plasmon resonance spectroscopy.(2002) Methods in Enzymology 344:15-42 (2002)

Schuck P, Perugini MA, Gonzales NR, Howlett GJ, and Schubert D. "Size-distribution analysis of proteins by analytical ultracentrifugation: Strategies and application to model systems." Biophysical Journal 82:1096-1111 (2002)

Taraporewala ZF, Schuck P, Ramig RF, Patton JT. "Analysis of a rotavirus temperature-sensitive mutant indicates that NSP2 octamers are the functional form of the protein." Journal of Virology 76:7082-93 (2002)

Abrantes M, Magone MT, Boyd LF, Schuck P. "Adaptation of a surface plasmon resonance biosensor with microfluidics for use with small sample volumes and long contact times." Analytical Chemistry 73:2828-2835 (2001)

Center RJ, Schuck P, Leapman RD, Earl PL, Moss B, Arthur LO, Lebowitz J. "Oligomeric structure of soluble and virion-associated forms of the simian immunodeficiency virus envelope proteins in the pre-fusion activated conformation." Proceedings of the National Academy of Sciences USA 98:14877-14882 (2001)

Li Y, Li H, Dimasi N, McCormick JK, Martin R, Schuck P, Schlievert PM, Mariuzza RA: "Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II." Immunity 14:93-104 (2001)

Solovyova A, Schuck P, Costenaro L, Ebel C. "Non-ideality by sedimentation velocity of halophilic malate dehydrogenase in complex solvents." Biophysical Journal 81:1868-1880 (2001)

Boyington JC, Motyka SA, Schuck P, Brooks AG, Sun PD: "Structure of an Ig-like NK cell receptor in complex with a class I MHC ligand: Peptide recognition and allotype specificity." Nature 405, 537-543 (2000)

Center RJ, Earl PL, Lebowitz J, Schuck P, Moss B: "The HIV-1 gp120 V2 domain mediates gp41-independent inter-subunit contacts." Journal of Virology 74:4448-4455 (2000)

Huang K-P, Huang FL, Li J, Schuck P, and McPhie P: "Calcium-sensitive interaction between calmodulin and modified forms of rat brain neurogranin/RC3." Biochemistry 29, 7291-7299 (2000)

Perugini MA, Schuck P, Howlett GJ: "Self-association of human apolipoprotein E3 and E4 in the presence and absence of phospholipid." Journal of Biological Chemistry 275, 36758-36765 (2000)

Schuck P, Braswell EH: Current Protocols in Immunology (Section 18.8.1 - 18.8.22) (2000) "Measurement of protein interactions by equilibrium ultracentrifugation." Kar SR, Kinsbury JS, Lewis MS, Laue RM, and Schuck P. " Analysis of transport experiments using pseudo-absorbance data." Analytical Biochemistry 285:135-142 (2000)

Schuck P, Rossmanith P: "Determination of the sedimentation coefficient distribution by least-squares boundary modeling" Biopolymers 54, 328-341 (2000)

Schuck P, Taraporewala Z, McPhee P, Patton JT: "Rotavirus nonstructural protein NSP2 is an octamer and undergoes ligand-induced conformational changes." Journal of Biological Chemistry (2000)

Schuck P: "Size distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and Lamm equation modeling." Biophysical Journal 78, 1606-1619 (2000)

Natarajan K, Boyd LF, Schuck P, Yokoyama WM, Eilat D, Margulies DH: "Interaction of NK cell inhibitory receptor Ly-49A with H-2Dd. Identification of a site distinct from the TCR site." Immunity 11, 591-601 (1999)

Reiter Y, Schuck P, Boyd LF, and Plaksin D: "Antibody single-domain phage display library of a native heavy chain variable region: isolation of functional single-domain VH molecules and their characterization." Journal of Molecular Biology 290, 685-698 (1999)

Schuck P, Boyd LF, Andersen PS: Current Protocols in Protein Science (Section 20.2.1-20.2.21) (1999) "Measuring protein interactions by optical biosensors."

Schuck P, Demeler B: "Direct sedimentation analysis of interference-optical data in analytical ultracentrifugation." Biophysical Journal 76, 2288-2296 (1999)

Schuck P, Radu CG, Ward ES: "Sedimentation equilibrium analysis of recombinant mouse FcRn with murine IgG1" Molecular Immunology 36, 1117-1125 (1999)

Wibbenmeyer JA, Schuck P, Smith-Gill SJ, Willson RC: "Salt links dominate affinity of antibody HyHEL-5 for lysozyme through enthalpic contributions" Journal of Biological Chemistry 274, 26838-26842 (1999)

Schuck P and Millar, DB:. Rapid determination of molar mass in Archibald experiments by direct analysis using the Lamm equation. Analytical Biochemistry. 259:48-53 (1998)

Schuck P: "Sedimentation analysis of non-interacting and self-associating solutes using numerical solutions to the Lamm equation." Biophysical Journal 75:1503-1512 (1998)

Schuck P, CE McPhee, GJ Howlett. Determination of sedimentation coefficients for small peptides. Biophysical Journal 74:466-474 (1998)

Lebowitz J, Teale M, Schuck PW: "Analytical band centrifugation of proteins and protein complexes." Biochemical Society Transactions 26, 745-749 (1998)

Sayers CI, Cain SA, Swan J, Pickett M, Watt PJ, Holgate ST, Padlan EA, Schuck P and Helm BA. "Amino acid residues that influence Fc e RI-mediated effector functions of human immunoglobulin E." Biochemistry, 37:16152-16164, 1998.

Schuck P, Millar DB and Kortt AA. Determination of binding constants by equilibrium titration with circulating sample in a surface plasmon resonance biosensor. Analytical Biochemistry 265:79-91, 1998.

Schuck P: "Use of Surface Plasmon Resonance to Probe the Equilibrium and Dynamic Aspects of Interactions Between Biological Macromolecules." Annual Reviews of Biophysics and Biomolecular Structure, 26: 541-566, 1997.

Publications, continued

Last reviewed on: 09/12/2008

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