Laboratory of Biochemical Genetics (LBG)
![](https://webarchive.library.unt.edu/eot2008/20090113172022im_/http://dir.nhlbi.nih.gov/images/1x1pix.gif) |
![Central and Peripheral Nervous system of Drosophila stage 16 embryo stained with mAb 22C10 antibody and Fluorescent Dye Alexa 488.](images/image002.jpg)
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Central
and Peripheral Nervous system of Drosophila stage 16 embryo
stained with mAb 22C10 antibody and Fluorescent Dye Alexa
488.
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Marshall Nirenberg, MD, Principal Investigator
Welcome to the Laboratory of Biochemical Genetics. The Laboratory
is an intramural research program within the National Heart Lung
and Blood Institute in Bethesda Maryland. The Chief of the Laboratory
is Marshall Nirenberg, Ph.D.
Basic problems in molecular biology and biochemistry are studied,
especially molecular mechanisms that regulate gene expression during
embryonic development. Current research focuses on:
- Characterizing DNA clones that correspond to novel mouse or
Drosophila homeobox genes,
- Defining neuron specific enhancer nucleotide sequences and corresponding
DNA binding proteins in DNA cloned from transgenic Drosophila
lines that were generated by P element transposition,
- Defining mouse genomic DNA sequences that regulate gene transcription,
- Identifying regulatory sequences in cloned DNA that correspond
to a gene for an a-subunit of an L-type voltage- sensitive calcium
channel from rat brain, and
- Studying mechanisms that regulate DNA replication and cell
division in mouse cells
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