Protein Function in Disease Section
Rodney L Levine, MD, PhD, Principal Investigator
Our section focuses on oxidative modifications of specific proteins and the physiological and pathological
effects of those modifications. We study the mechanisms by which proteins are oxidatively modified, how
the proteasome distinguishes native from modified, factors which control susceptibility to oxidative
modification, and pathways for reversal of those modifications.
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Front and back views of alpha-1-antitrypsin showing oxidizable methionines.
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Questions, comments and suggestions about this page may be addressed to
Rodney L Levine.
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