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Protein Function in Disease Section

Rodney L Levine, MD, PhD, Principal Investigator

Our section focuses on oxidative modifications of specific proteins and the physiological and pathological effects of those modifications. We study the mechanisms by which proteins are oxidatively modified, how the proteasome distinguishes native from modified, factors which control susceptibility to oxidative modification, and pathways for reversal of those modifications.

alpha-1-antitrypsin image
Front and back views of alpha-1-antitrypsin showing oxidizable methionines. Read more.PDF file

 

Questions, comments and suggestions about this page may be addressed to Rodney L Levine.

 

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