Clinical and Quality-of-life Outcomes in Older Men Diagnosed with Prostate Cancer
Objectives:
Describe clinical and socio-demographic characteristics, quality
of life, and treatment decisions of men 75 years and older diagnosed with
prostate cancer; correlate comorbidity, baseline disease-specific and
general health-related quality of life and treatment selection with
long-term survival and quality of life.
Rationale:
Decisions for screening and aggressively treating prostate cancer
in elderly men are controversial given the uncertain benefits and likely
harms. The effect of screening and aggressive treatment on survival and
health-related quality of life in elderly men is not well characterized.
Data: Baseline data on socio-demographics, comorbidity, disease- specific
and general HRQOL, tumor characteristics, and treatments. Follow-up data on
survival, cancer recurrence/progression, disease- specific and general
HRQOL.
Methods:
Compare baseline characteristics of men undergoing aggressive
(radical prostatectomy/radiation) vs. conservative (androgen
deprivation/watchful waiting) management. Model disease-free and overall
survival and changes in HRQOL to compare differences between treatment
groups. Propensity score analyses will be used to adjust for potential
selection bias; multivariate analyses will further adjust for baseline
differences between the treatment groups.
Collaborators:
Michael Barry, MD; Mary McNaughton Collins, MD
Contact Information:
Richard Hoffman, MD, MPH
New Mexico VA Health Care System
111GIM
1501 San Pedro Drive SE
Albuquerque, NM 87108
Phone: 505-256-2727
Fax: 505-256-2888
E-mail: rhoffman@unm.edu
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