Federal Register Notice August 5, 1999 |
---|
[Federal Register: August 5, 1999 (Volume 64, Number 150)] [Notices] [Page 42707-42708] From the Federal Register Online via GPO Access [wais.access.gpo.gov] [DOCID:fr05au99-108] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Toxicology Program, National Institute of Environmental Health Sciences, Center for the Evaluation of Risks to Human Reproduction; Announces an Expert Panel Review of Phthalates, August 17-19, 1999 in Alexandria, VA Background The National Toxicology Program (NTP) and the National Institute of Environmental Health Sciences have established the NTP Center for the Evaluation of Risks to Human Reproduction (63 FR 68782, No 239). The purpose of the Center is to provide timely and unbiased, scientifically sound evaluations of human and experimental evidence for adverse effects on reproduction, including development, caused by agents to which humans may be exposed. The evaluations produced through the Center will be published as monographs in Environmental Health Perspectives; a special effort will be made to summarize the reports in terms that can be understood by those who are not scientifically trained. Expert Panel Review of Phthalates Seven phthalate esters will be evaluated by an expert panel under the auspices of the NTP Center (64 FR 18921-18922, No 73). These were selected based on their high production volume, extent of human exposures, use in children's products, or published evidence of reproductive or developmental toxicity. The chemicals to be evaluated are listed below with their Chemical Abstract Service registry numbers. butyl benzyl phthalate (85-68-7) di(2-ethylhexyl) phthalate (117-81-7) di-isodecyl phthalate (26761-40-0, 68515-49-1) di-isononyl phthalate (28553-12-0, 68515-48-0) di-n-butyl phthalate (84-74-2) di-n-hexyl phthalate (84-75-3) di-n-octyl phthalate (117-84-0) Review Panel and Charge to Panel To date, a panel of 14 scientists have been selected for their expertise in various aspects of reproductive toxicology and other relevant areas to conduct the review. The roster of these experts follows: Phthalates Expert Panel Name and Affiliation Kim Boekelheide, MD, PhD--Brown University, Providence, RI Bob Chapin, PhD--NIEHS, Research Triangle Park, NC Mike Cunningham, PhD--NIEHS, Research Triangle Park, NC Elaine Faustman, PhD--University of Washington, Seattle, WA Paul Foster, PhD--Chemical Industry Institute of Toxicology, Research Triangle Park, NC Mari Golub, PhD--Cal/EPA, Davis, CA Rogene Henderson, PhD--Inhalation Toxicology Research Institute, Albuquerque, NM Irwin Hinberg, PhD--Health Canada, Ottawa, Ontario, Canada Bob Kavlock, PhD--EPA/ORD, Research Triangle Park, NC Jennifer Seed, PhD--EPA/OPPT, Washington, DC Katherine Shea, MD--North Carolina State University, Raleigh, NC Shelly Tyl, PhD--Research Triangle Institute, Research Triangle Park, NC Paige Williams, PhD--Harvard University, Cambridge, MA Tim Zacharewski, PhD--Michigan State University, East Lansing, MI Charge to Expert Panel Rigorously evaluate all relevant data and reach a conclusion regarding the strength of scientific evidence that exposure to a chemical may or may not present a risk to human reproduction or development. 1. Evaluate all reproductive and developmental toxicity
studies--in humans and animals--for quality, completeness, and sufficiency. Determine
consistency of reported effects within and among species. Briefly summarize relevant
individual studies. The review will take place from August 17-19 at the Embassy Suites Hotel, 1900 Diagonal
Road, Alexandria, VA with some workgroup sessions at Sciences, International, Inc., 1800
Diagonal Road, Suite 500, Alexandria, VA (limited seating availability). The meeting will
commence at 8:30 AM on August 17 in the Virginia Ballroom of the Embassy Suites Hotel. The
review will be open to the public with an opportunity scheduled for oral public comment.
Attendance will be limited only by the availability of space. For registration information
please contact: Ms. Harriet McCollum, CERHR, 1800 Diagonal Road, Suite 500, Alexandria, VA
22314-2808, Phone: (703) 838-9440, e-mail: hmccollum@sciences.com.
This page last updated: September 14, 2004 |