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You may apply for a multiproject grant in one of the following two ways:
P01 grants support multidisciplinary, long-term research programs headed by an investigator who brings in a group of other investigators to support the project and share resources. This is the only option that allows you to submit an investigator-initiated application.
P50 grants are research center grants where a multidisciplinary group of investigators share a common research topic.
U19 grants are cooperative agreements, requiring substantial involvement from agency staff. See the Cooperative Agreements (U) SOP.
To help you decide the best way to go, read Application Approach: What Are Your Choices? and Compare FOAs in our NIH Grant Cycle: Application to Renewal.
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