Press Center
Recommendations of the ICCEC - Request for Comments
[Federal Register: January 8, 1998 (Volume 63, Number 5)]
[Notices]
[Page 1118 - 1119]
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Institute of Environmental Health Sciences (NIEHS)
Announcement of Nominated Chemicals Under Consideration for Toxicological Studies by the National Toxicology Program (NTP) -- Recommendations by the Interagency Committee for Chemical Evaluation and Coordination (ICCEC) -- Request for Comments
Background
As part of an effort to earlier
inform and obtain public input into the selection of chemicals
for evaluation, the National Toxicology Program (NTP) routinely
seeks public input on (1) chemicals nominated to the Program for
toxicological studies, and (2) the testing recommendations made
by the Interagency Committee for Chemical Evaluation and Coordination
(ICCEC). Summaries of the ICCEC's recommendations and public comments
received are next presented to the NTP Board of Scientific Counselors
for their review and comment in an open public session. ICCEC
recommendations, Board recommendations, and public comments are
incorporated into recommendations that are then submitted to the
NTP Executive Committee. The Executive Committee reviews and approves
action to move forward to test, defer, or delete each of the nominated
chemicals, classes or mixtures for the various types of study,
and recommends priorities.
Request for Comment
Interested parties are encouraged
to comment and provide information on chemicals under consideration
for study listed in the Table. The Program would welcome receiving
toxicology and carcinogenesis information from completed, ongoing,
or planned studies by others, as well as current production data,
human exposure information, use patterns, and environmental occurrence
for any of the chemicals listed in this announcement. To provide
comments or information, please contact Dr. William Eastin at
the address given below within 60 days of the appearance of this
announcement.
At their meeting on December 11, 1997, the ICCEC reviewed and recommended 9 chemicals or chemical classes for metabolism, toxicity, or carcinogenicity studies. It was also recommended that testing not be performed on one chemical, trans--1,4-dichloro-2-butene (CAS Number 110-57-6), because industry studies showed it to be a potent carcinogen. Chemicals with CAS numbers, nomination source, types of studies under consideration, and other information are given in the Table.
Contact may be made by mail to: Dr. William Eastin, NIEHS/NTP, P. O. Box 12233, Research Triangle Park, North Carolina 27709; by telephone at (919) 541-7941; by FAX at (919) 541-3687; or by email at Eastin@NIEHS.NIH.GOV.
Dated: December 23, 1997
______________________
Kenneth Olden, Ph. D.
Director
National Toxicology Program
Attachment
Chemicals Recommended for Study by the
NTP Interagency Committee for Chemical
Evaluation and Coordination
(ICCEC) on December 11, 1997
| Chemical [CAS Number] | Nomination source | Testing Recommendations | Study Rationale/ Remarks |
| 2-Acetylpyridine [1122-62-9] | NCI | - carcinogenicity | - potential for human exposure
- suspicion of carcinogenicity |
| 2-Chloropyridine [109-09-1] | NCI | - dermal carcinogenicity in transgenic mice | - increasing production
- occupational and environmental exposure |
| Comfrey [72698-57-8] Symphytine [22571-95-5] | NIEHS | - carcinogenicity;
- reproductive and developmental toxicity | - extensive use as a herbal supplement and medicinal - contains pyrrolizidine alkaloids, including symphytine |
| Glycoluril [496-46-8] | NCI | - in vitro and in vivo nitrosation studies | - moderate production
- potential human exposure - potential to form nitrosamides |
| Goldenseal Berberine [2086-83-1] Hydrastine [118-08-1] | NIEHS | - carcinogenicity
- reproductive and developmental toxicity | - extensive use as a herbal supplement and medicinal - contains active alkaloids berberine and hydrastine |
| 4-Methoxy-N-methyl-1,8- naphthalimide [3271-05-4] | NCI | - chemical disposition | - occupational exposure
- extensive consumer exposure |
| Myristicin [607-91-0] | NCI | - genetic toxicity;
- metabolism; - carcinogenicity in transgenic animals | - widespread natural product - extensive consumer exposure - similarity to known carcinogen safrole |
| 7-(2H-Naphthol[1,2-d]triazol- 2-yl)-3-phenylcoumarin [3333-62-8] | NCI | - chemical disposition | - moderate production
- extensive occupational and consumer exposure |
| Saw palmetto b-Sitosterol [83-46-5] | NIEHS | - carcinogenicity;
- multigeneration reproductive toxicity | - widely used herbal remedy for benign prostate hyperplasia - contains active sitosterols |
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