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NTP - Review of Draft NTP Technical Reports - 12/9-10/97

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[Federal Register: November 18, 1997 (Volume 62, Number 222]
[Notices]
[Page 61520-61521]


Public Health Service

National Toxicology Program

National Toxicology Program (NTP) Board of Scientific Counselors' Meeting;
Review of Draft NTP Technical Reports

Pursuant to Public Law 92-463, notice is hereby given of the next meeting of the NTP Board of Scientific Counselors' Technical Reports Review Subcommittee on December 9 and 10, 1997, in the Conference Center, Building 101, South Campus, National Institute of Environmental Health Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North Carolina. The meeting will begin at 1:30 p.m. on December 9, and at 8:30 a.m. on December 10, and is open to the public. The agenda topic is the peer review of draft Technical Reports of long-term toxicology and carcinogenesis studies from the National Toxicology Program. Additionally, there will be a presentation made concerning data obtained from transgenic mouse models on several of the chemicals being reviewed.

Tentatively scheduled to be peer reviewed on December 9-10 are draft Technical Reports of 10 two-year studies, listed alphabetically, along with supporting information in the attached table. All studies were done using Fischer 344 rats and B6C3F1mice. The order of review is given in the far right column of the table. Copies of the draft Reports may be obtained, as available, from: Central Data Management, MD E1-02, P.O. Box 12233, Research Triangle Park, NC 27709 (919/541-3419), FAX (919/541-3687), email: CDM@niehs.nih.gov.

Public comment on any of the Technical Reports is welcome. Persons wanting to make a formal presentation regarding a particular Technical Report must notify the Executive Secretary by telephone, by FAX, by mail, or by email no later than December 4, 1997, and provide a written copy in advance of the meeting so copies can be made and distributed to all Subcommittee members, ad hoc expert consultants, and staff, and made available at the meeting for attendees. Written statements should supplement and may expand on the oral presentation. Oral presentations should be limited to no more than five minutes.

The program would welcome receiving toxicology and carcinogenesis information from completed, ongoing, or planned studies by others, as well as current production data, human exposure information, and use patterns for any of the chemicals listed in this announcement. Please contact Central Data Management at the address given above, and they will relay the information to the appropriate staff scientist.

The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, Research Triangle Park, North Carolina 27709 (telephone 919/541-3971; FAX 919/541-0295; email hart@niehs.nih.gov) will furnish agenda and a roster of Subcommittee members and expert consultants prior to the meeting. Summary minutes subsequent to the meeting will be available upon request to Central Data Management.

Attachment

Dated: November 7, 1997

_________________________
Charles E. Leasure, Jr.
Acting Director
National Toxicology Program

(Billing Code 4140-01-P)


Attachment

Summary Data for Technical Reports Tentatively Scheduled for Review
at the Meeting of the NTP Board of Scientific Counselor's Technical Reports Review Subcommittee
December 9 - 10, 1997


Chemical
CAS Number
Technical
Report Number

Primary Uses

Route
Exposure Levels

Review
Order
1-Chloro-2-Propanol, Technical
127-00-4
TR-477chemical intermediate for propylene oxide & other organic compounds Dosed-Water (deionized water): Rats: 0, 150, 325, or 650 ppm Mice: 0, 250, 500, or 1000 ppm (50/sex/group)
10
Coconut Oil Acid Diethanolamine Condensate
68603-42-9
TR-479foam stabilizer in shampoos and dishwashing liquids; dyeing assistant in textile processing Topical (95% ethanol): Rats: 0, 50, or 100 mg/kg Mice: 0, 100, or 200 mg/kg (50 sex/species/group)
2
Diethanolamine
111-42-2
TR-478 production of textile lubricants; rubber chemicals intermediate; emulsifier in agricultural chemicals, cosmetics, and pharmaceuticals; gas conditioning agent Topical (ethanol): Male Rats: 0, 16, 32, or 64 mg/kg; Female Rats: 0, 8, 16, or 32 mg/kg; Mice: 0, 40, 80, or 160 mg/kg (50/sex/species/group
1
Furfuryl Alcohol
98-00-0
TR-482 solvent for ethers and esters; in manufacture of phenolic and furan resins; chemical intermediate; wetting agent; liquid propellant; flavoring agent, obtained from processing corncobs, coffee beans Inhalation (air): Rats & Mice: 0, 2, 8, or 32 ppm (50/sex/species/group)
8
Isobutene
115-11-7
TR-487 production of diisobutylene, trimers, butyl rubber, antioxidants for foods, packaging, food supplements & plastics, isooctane, high-octane aviation gasoline, polyisobutene resins. (NTP Executive Summary) Inhalation (air): Rats & Mice: 0, 500, 2000, or 8000 ppm(50/sex/species/group)
6
Isoprene
78-79-5
TR-486 monomer and comonomer for elastomers, prepared from turpentine, petroleum products (Merck 1989) Inhalation (air): Rats: 0, 220, 700, or 7000 ppm; 50/sex/group
7
Lauric Acid Diethanolamine Condensate
120-40-1
TR-480foam stabilizer for liquid household detergents and shampoos Topical (95% ethanol): Rats: 0, 50, or 100 mg/kg Mice: 0, 100, or 200 mg/kg (50/sex/species/group
3
Oleic Acid Diethanolamine Condensate
93-83-4
TR-481surfactant in wax emulsion; to increase shampoo viscosity Topical (95% ethanol): Rats: 0, 50, or 100 mg/kg; 50/sex/group Mice: 0, 15, or 30 mg/kg; 55/sex/group
4
Pentachlorophenol, Purified
87-86-5
TR-483wood preservative, fungicide, soil fumigant for termites, preharvest defoliant, seed treatment for beans, preservative for paint, leather, textiles, inks, antibacterial agent in disinfectants & cleansers (HSDB 1990). Dosed-Feed (NIH-07): Rats: 0, 200, 400, or 600 ppm; 50/sex/group - 1000 ppm Stop Study (60/sex)
5
Pyridine
110-86-1
TR-470 solvent, organic synthesis, flavoring ingredient, manufacture of fungicides, pharmaceuticals, dyestuff, explosives, in manufacture of vitamins, sulfa drugs, intermediate in manufacture of diquat & paraquat, waterproofing textiles (HSDB 1990) Dosed-Water (deionized water): Rats: 0, 100, 200, or 400 ppm Male Mice: 0, 250, 500, or 1000 ppm Female Mice: 125, 250, or 500 ppm Male Wistar Rats: 0, 100, 200, or 400 ppm (50/sex/group)
9