Structure and Function of the Anthrax Toxin Pore |
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| Launch in standalone player | |
| Air date: | Tuesday, December 02, 2008, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | Anthrax toxin represents an interesting example of how a proteinaceous pore transports large globular proteins across a biological membrane. One component of the toxin, termed protective antigen (PA), forms an oligomeric pore in the endosomal membrane and translocates the two enzymatic moieties of the toxin, the lethal factor and the edema factor, across the membrane to the cytosolic compartment. This presentation will summarize current knowledge of the structure of the pore, how it inserts into the endosomal membrane, and how it mediates translocation of its substrate proteins across the bilayer. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. |
| Author: | R. John Collier, Ph.D., Professor of Microbiology and Molecular Genetics, Harvard Medical School |
| Runtime: | 60 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 14804 |
| CIT Live ID: | 7022 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14804 |
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Enhanced Audio Podcast | 1:06:01 |
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Enhanced Video Podcast | 1:06:01 | |