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The NTP relies upon voluntary allocations from the program's core agencies-NIEHS, NCTR, and NIOSH to support its research, testing, centers and outreach. The program focuses its resources on three major program activities: toxicology studies, methods development, and validation. Within each of these program activities, the NTP targets multiple areas broadly including genetic toxicology, toxicological characterizations (includes immunotoxicology, epidemiology, exposure assessment and general toxicology), reproduction and development, and carcinogenesis. In 2004, the total budget for the NTP was approximately $192.2 M (direct plus indirect costs). The NTP primarily conducts its research studies in-house, at the core agencies, or through contract laboratories, but also supports cooperative and/or collaborative agreements. Funds are also used to sponsor workshops and conferences and to produce and distribute programmatic materials.