|
Funded Research
Molecular Libraries Screening Centers and Small Molecule Repository |
RFA-RM-08-005
Molecular Libraries Probe Production Centers Network (MLPCN) (U54) – Limited Competition |
PI Name |
Institution Name |
Title |
AUSTIN, CHRIS |
NHGRI |
NIH Chemical Genomics Center (PDF, 2 pages) |
ROSEN, HUGH |
The Scripps Research Institute |
The Comprehensive Center for Chemical Probe Discovery and Optimization at Scripps |
REED, JOHN |
Burnham Institute for Medical Research |
Burnham Center for Chemical Genomics |
SCHREIBER, STUART |
Broad Institute |
Broad Institute Comprehensive Screening Center |
SKLAR, LARRY |
University of New Mexico |
University of New Mexico Center for Molecular Discovery |
LI, MIN |
Johns Hopkins University |
Johns Hopkins Ion Channel Center |
JONSSON, COLLEEN |
Southern Research Institute |
Southern Research Specialized Biocontainment Screening Center (SRSBSC) |
AUBE, JEFFREY |
University of Kansas |
University of Kansas Specialized Chemistry Center |
LINDSLEY, CRAIG |
Vanderbilt University |
The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development |
|
RFA-RM-04-017
Molecular Libraries Screening Centers Network (MLSCN) |
PI Name |
Institution Name |
Title |
AUSTIN, CHRIS |
NHGRI |
NIH Chemical Genomics Center (NCGC)
|
DIAMOND, SCOTT |
UNIVERSITY OF PENNSYLVANIA |
The Penn Center for Molecular Discovery
|
DINGLEDINE, RAYMOND |
EMORY UNIVERSITY |
Emory Chemistry-Biology Center in the MLSCN
|
LAZO, JOHN |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
University of Pittsburgh Molecular Libraries Screening Center
|
PIAZZA, GARY |
SOUTHERN RESEARCH INSTITUTE |
Southern Research Molecular Libraries Screening Center
|
REED, JOHN |
THE BURNHAM INSTITUTE |
San Diego Center for Chemical Genomics
|
ROSEN, HUGH |
THE SCRIPPS RESEARCH INSTITUTE |
Scripps Research Institute Molecular Screening Center
|
ROTHMAN, JAMES |
COLUMBIA UNIVERSITY MEDICAL CENTER |
MLSCN Center at Columbia University
|
SKLAR, LARRY |
UNIVERSITY OF NEW MEXICO ALBUQUERQUE |
New Mexico Molecular Libraries Screening Center
|
WEAVER, C. DAVID |
VANDERBILT UNIVERSITY |
Vanderbilt Screening Center for GPCRs, Ion Channels, and Transporters
|
|
PAR-08-034 & PAR-08-035
Solicitation of Assays for HTS in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03/X01) |
PI Name |
Institution Name |
Title |
ABOOD, MARY E |
CALIFORNIA PACIFIC MED CTR RES INSTITUTE |
Screening for Selective Ligands for GPR55 (PDF, 1 page) |
ANDROPHY, ELLIOT J |
UNIV OF MASSACHUSETTS MED SCH WORCESTER |
High Throughput Screen for SMA |
BARAK, LAWRENCE S |
DUKE UNIVERSITY |
Agonists and Antagonists for the Kappa Opioid Receptor (PDF, 1 page) |
BRODSKY, JEFFREY L |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
Identification of SV40 T Antigen Inhibitors: A Route to Novel Anti-Viral Reagent |
FLAUMENHAFT, ROBERT C |
BETH ISRAEL DEACONESS MEDICAL CENTER |
Chemical Genetic Analysis of Platelet Granule Secretion |
GARDINER, DONALD L |
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH |
Identification of Inhibitors of the Plasmodium Falciparum M18 Metalloprotease |
HEILIG, MARKUS ALEXANDER |
U.S. NATIONAL INST ALCOHOL AB/ALCOHOLISM |
Identification of Small Molecule Antagonists for the Neuropeptide Receptor Using (PDF, 2 pages) |
KAUFMAN, RANDAL J |
UNIVERSITY OF MICHIGAN AT ANN ARBOR |
High Throughput Chemical Genomics to Identify Novel Inhibitors of CHOP |
LEVINE, ROSS L |
SLOAN-KETTERING INSTITUTE FOR CANCER RES |
High Throughput Screen for JAK2V617F Mutant Selective Inhibitors |
LITTMAN, DAN R |
NEW YORK UNIVERSITY SCHOOL OF MEDICINE |
Screen for Small Molecule Compounds that Modulate the Transcriptional Activity of |
MAKHINA, ELENA |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
High Throughput Screening for Potassium Channel Modulators |
MAZIN, ALEXANDER V |
DREXEL UNIVERSITY |
A Screen for Modulators of Human Rad51, a Key DNA Repair Protein |
MCDONOUGH, PATRICK M |
VALA SCIENCES, INC |
A High Throughput Imaging Assay for Hepatic Lipid Droplet Formation |
MILLAN, JOSE LUIS |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
The Role of PHOSPHO1 in the Initiation of Skeletal Calcification |
PELLECCHIA, MAURIZIO |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
Novel Chemical Probes Targeting the FRB Domain of mTOR |
STOCKWELL, BRENT R |
COLUMBIA UNIV NEW YORK MORNINGSIDE |
Screen for RAS-Selective Lethal Compounds and VDAC Ligands |
SUN, HONGMIN |
UNIVERSITY OF MISSOURI-COLUMBIA |
High Throughput Screening for Small Compounds to Inhibit the Expression of Strept |
YANG, VINCENT W |
EMORY UNIVERSITY |
High Throughput Screen for Small Molecule Inhibitors of Colorectal Cancer Cell Pr |
CHEN, YUAN |
CITY OF HOPE/BECKMAN RESEARCH INSTITUTE |
A high throughput screening assay for the identification of SUMOylation inhibitor |
DENISON, MICHAEL STEVEN |
UNIVERSITY OF CALIFORNIA DAVIS |
High Throughput Screening for Activators of the Ah Receptor (PDF, 2 pages) |
HARDING, HEATHER P |
NEW YORK UNIVERSITY SCHOOL OF MEDICINE |
Screen for Inhibitors of 2' Phosphotransferase |
HASLAM, DAVID B |
WASHINGTON UNIVERSITY |
A SCREEN FOR SMALL MOLECULE INHIBITORS OF SHIGA TOXIN AND RICIN ACTIVITY |
HEIL, MARINTHA L |
SOUTHERN RESEARCH INSTITUTE |
A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activ |
KUPERSHMIDT, SABINA |
VANDERBILT UNIVERSITY |
Identification of compounds that protect HERG from block by proarrhythmic agents |
MISTELI, TOM |
U.S. NATIONAL CANCER INSTITUTE |
A high-throughput screen for pre-mRNA splicing modulators (PDF, 2 pages) |
MOORE, CLAIRE L; KUMAMOTO, CAROL A |
TUFTS UNIVERSITY BOSTON |
High throughput screening for polyadenylation inhibitors using the MLSCN library |
NAKAMURA, KAZUHIRO |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain Interaction |
NOTHACKER, HANS-PETER |
UNIVERSITY OF CALIFORNIA IRVINE |
High-Throughput Assay for G-Protein Coupled Receptors in Pain Research |
PELLETIER, JERRY |
MC GILL UNIVERSITY |
Interdicting Eukaryotic Translation Initiation Factor-RNA Interaction |
REED, JOHN C |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
High Throughput Screening Assays for NOD1 and NOD2 Inhibitors |
WANG, ZHIYONG |
SALK INSTITUTE FOR BIOLOGICAL STUDIES |
High throughput screen for the master regulator of obesity and diabetes p/CIP |
ZHENG, WEI |
U.S. NATIONAL HUMAN GENOME RESEARCH INST |
Identification of Activators and Inhibitors of alpha-Glucosidase as Potential Cha (PDF, 1 page) |
ZHENG, WEI |
U.S. NATIONAL HUMAN GENOME RESEARCH INST |
HTS for Identifying Activators and Inhibitors of Alpha-Galactosidase A for the Po (PDF, 1 page) |
PAR-06-259 & PAR-06-545
Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (R03/X01) |
PI Name |
Institution Name |
Title |
BALLATORE, CARLO |
UNIVERSITY OF PENNSYLVANIA |
High Throughput Screening for Small Molecule Inhibitors of Heparin-Induced Tau Fi |
BUGGE, THOMAS H |
U.S. NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH |
Quantitative High Throughput Screening for Anthrax Toxin Inhibitors |
BURKART, MICHAEL D |
UNIVERSITY OF CALIFORNIA SAN DIEGO |
A qHTS FRET-Quench Assay for 4?-Phosphopantethienyltransferases |
BUSHWELLER, JOHN H |
UNIVERSITY OF VIRGINIA CHARLOTTESVILLE |
High Throughput Screen for Novel Inhibitors of Platelet Integrin alphaIIb-beta3 |
BUSHWELLER, JOHN H |
UNIVERSITY OF VIRGINIA CHARLOTTESVILLE |
Screening for Inhibitors of Runx and CBFb Translocation Products in Leukemia |
COOMBS, GARY |
UNIVERSITY OF UTAH |
The Role of Wnts in Stem Cell |
DAY, BILLY W |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
HTS Assays for Microtubule Stabilizers |
FREEZE, HUDSON H |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
Therapeutic Inhibitors of Phosphomannose Isomerase |
GARDINER, DONALD L |
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH |
High Through-Put Screening of Plasmodium Falciparum Aminopeptidases |
GERSHENGORN, MARVIN C |
U.S. NATIONAL INST DIABETES/DIGST/KIDNEY |
Ligand Discovery for Thyroid-Stimulating Hormone Receptor (TSHR) by Virtual and H |
GLASS, JONATHAN DAVID |
EMORY UNIVERSITY |
Discovering Calpain Inhibitors of Neurological Diseases |
GRIMALDI, MAURIZIO |
SOUTHERN RESEARCH INSTITUTE |
An HTS Assay Based on Neuronal Human Cells to Identify Small Molecule Activators |
HASELBECK, ROBERT JOHN |
RX3 PHARMACEUTICALS, INC. |
Identification of Target-Specific Antimicrobials |
HELLER, STEFAN |
STANFORD UNIVERSITY |
Identification of Modulators of the TRPML3 and TRPN1 ion Channels |
HOLMAN, THEODORE R |
UNIVERSITY OF CALIFORNIA SANTA CRUZ |
High Throughput and Virtual Screening for Human 12-LO, 15-LO-1, and 15-LO-2 Inhibitors |
KOLE, RYSZARD |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
Modulation of Alternative Splicing by HTS Identified Compounds |
LARSON, RICHARD S |
UNIVERSITY OF NEW MEXICO ALBUQUERQUE |
Multiplex Screening for ABC Transporter Inhibitors |
LEISSRING, MALCOLM A |
SCRIPPS RESEARCH INSTITUTE |
HTS for Modulators of Beta-Amyloid Catabolism by Insulin-Degrading Enzyme |
LEWIS, KIM |
NORTHEASTERN UNIVERSITY |
Screening C. Albicans Biofilms for Lethal Potentiators of Miconazole |
LI, QIANJUN |
SOUTHERN RESEARCH INSTITUTE |
A HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus Infections |
LIU, PU PAUL |
U.S. NATIONAL HUMAN GENOME RESEARCH INST |
High-Throughput Screening for Compounds Blocking Interaction Between CBFb-SMMHC a |
MARSHALL, WALLACE |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO |
Small Molecule Inhibitors of Cilia |
MATTS, ROBERT L |
OKLAHOMA STATE UNIVERSITY STILLWATER |
High Throughput Screen for Hsp90 Inhibitors |
MCDONOUGH, PATRICK M |
VALA SCIENCES, INC. |
High Throughput Imaging Assay for Beta-Catenin |
MCNEIL, MICHAEL R |
COLORADO STATE UNIVERSITY – FORT COLLINS |
HTS Screen of TB RmIC & RmID dTDP-Rhamnose Formation Enzymes |
MILLAN, JOSE LUIS |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
Activators of the Pyrophosphatase Activity of Alkaline Phosphatase |
MORRIS, JAMES CULVIN |
CLEMSON UNIVERSITY |
Identification of Inhibitors of Trypanosoma Brucei Hexokinases |
NATARAJAN, AMARNATH |
UNIVERSITY OF TEXAS MEDICAL BR GALVESTON |
HTS to Identify Small Molecule Inhibitors of Phospho-Specific Protein-Protein Int |
NUNNARI, JODI M |
UNIVERSITY OF CALIFORNIA DAVIS |
Chemical Genetic Screens for Mitochondrial Division and Fusion Inhibitors |
PASSER, BRENT J |
MASSACHUSETTS GENERAL HOSPITAL |
A High-Throughput Screen to Identify Small Molecule Compounds That Augment |
PELLECCHIA, MAURIZIO |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
Novel Chemotypes Against Influenza A Virus |
PELLETIER, JERRY |
MCGILL UNIVERSITY |
Screening for Small Molecule Inhibitors of Eukaryotic Translation Initiation |
PLEMPER, RICHARD K. |
EMORY UNIVERSITY |
High Throughput Screening-Based Identification of Measles Virus Probes |
REED, JOHN C |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
Chemical Antagonists of IAP-Family Anti-Apoptotic Proteins |
REED, JOHN C |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
Chemical Inhibitors of ER Stress |
RON, DAVID |
NEW YORK UNIVERSITY SCHOOL OF MEDICINE |
Screening for Inhibitors of the Integrated Stress Response |
ROZANOV, DMITRI |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
Screening for Chemicals that Potentiate TRAIL-Induced Apoptosis of Cancer Cells |
SEVERSON, WILLIAM E |
SOUTHERN RESEARCH INSTITUTE |
A Cell Based HTS Approach for the Discovery of New Inhibitors of the H5N1 Virus |
SEVERSON, WILLIAM E |
SOUTHERN RESEARCH INSTITUTE |
A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV |
SHOICHET, BRIAN K |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO |
Promiscuous and Specific Inhibitors of Cruzain |
SMITH, SUSAN M.E. |
EMORY UNIVERSITY |
HTS to Find Inhibitors of p47phox, a Regulatory Protein of Noxes |
SMITHGALL, THOMAS EDWARD |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
Targeting HIV-1 Nef with Small Molecules |
STAUFFACHER, CYNTHIA V |
PURDUE UNIVERSITY WEST LAFAYETTE |
Scaffolds for Synthesis of Probes Directed Against Class II HMG-CoA Reductases |
STOCKWELL, BRENT R |
COLUMBIA UNIV NEW YORK MORNINGSIDE |
Luciferase Screen for MDM2 E3 Ligase Inhibitors |
TOBIAS, PETER S |
SCRIPPS RESEARCH INSTITUTE |
High Throughput Screening for Toll-Like Receptors |
WANDINGER-NESS, ANGELA |
UNIVERSITY OF NEW MEXICO ALBUQUERQUE |
HTS to Identify Specific Small Molecule Inhibitors and Activators of Ras and Ras- |
WANG, QIMING JANE |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
IMAP-Based Fluorescent Polarization Assay for High Throughput Screening of Protein |
YIN, XIAO-MING |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
High-Content Cell-Based Screening for Modulators of Autophagy |
YUAN, JUNYING |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
A High Throughput Screen for Inhibitors of a Novel Necrotic Cell Death Pathway |
ZHENG, WEI |
U.S. NATIONAL HUMAN GENOME RESEARCH INSTITUTE |
HTS for Identifying the Cell-Membrane Permeable IMPase Inhibitors |
ZHENG, WEI |
U.S. NATIONAL HUMAN GENOME RESEARCH INSTITUTE |
HTS for Identification of Inhibitors Against the ERK Signaling Pathway using a Ho |
PAR-06-259
Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (X01) Reissue of PAR-05-147 |
PI Name |
Institution Name |
Title |
DE FIGUEIREDO, PAUL |
TEXAS A&M UNIVERSITY SYSTEM |
Drug Discovery for Bone Marrow Failure Diseases |
FRANK, DAVID A |
DANA-FARBER CANCER INSTITUTE |
Modulators of STAT transcription factors for the targeted therapy of cancer |
GRIFFIN, PATRICK R |
SCRIPPS RESEARCH INSTITUTE |
HTRF screen for identifying SRC-1 selective agonists of PPARgamma |
GU, HOWARD H |
OHIO STATE UNIVERSITY |
High Throughput Screening for Cocaine Antagonists |
KUHN, PETER |
SCRIPPS RESEARCH INSTITUTE |
EphB4-Ephrin-B2 Antagonists for Angiogenesis and Carcinogenesis Inhibition |
LIOU, HSIOU-CHI |
IMMUNETARGET, INC. |
Development of Screening Assays for NF-KB-Rel Inhibitors |
MARTINEZ, ELISABETH D |
UNIVERSITY OF TEXAS SW MED CTR/DALLAS |
High Throughput Screens for Epigenetic Modulators |
MERCOLA, MARK |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
Screen for Compounds that Promote Cardiomyocyte Cell Cycle Entry |
NICHOLSON, BENJAMIN |
PROGENRA, INC. |
Identification of Compounds that Modulate Human Deubiquitinase Function |
NIRENBERG, MARSHALL WARREN |
U.S. NATIONAL HEART LUNG & BLOOD INS |
Molecules that Enhance CREB Activity |
QU, ZHICAN |
SOUTHERN RESEARCH INSTITUTE |
Cell-Based Screening for Anti-Angiogenic Agents |
REED, JOHN C |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
High Throughput Screening Assay for Hsp70 Inhibitors |
ROGERS, JACK T |
MASSACHUSETTS GENERAL HOSPITAL |
MLSCN SCReen of the Amyloid precursor protein 5'untranslated region |
SEIDAH, NABIL G. |
CLINICAL RESEARCH INSTITUTE OF MONTREAL |
High Throughput Screens for targets of the Proprotein Convertases Furin, PC5, SKI-1 and PCSK9 Using Cell-Based Assays |
SHOICHET, BRIAN K. |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO |
Promiscuous and Specific Inhibitors of B-lactamase |
SKLAR, LARRY A. |
UNIVERSITY OF NEW MEXICO ALBUQUERQUE |
HTS for BCI-2 Family Multiplex |
SUN, YI |
UNIVERSITY OF MICHIGAN-ANN ARBOR |
Synthetic Lethal Screen for Compounds to Kill Cancer Cells with p53 Mutation |
PAR-06-259
Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (X01) Reissue of PAR-05-147 |
PI Name |
Institution Name |
Title |
AULD, DOUGLAS S |
NIH/NHGRI |
Identification of lkappaBalpha Stabilizers in a Human Lymphoma Cell Line Using A |
BRISSON, MARNI J |
UNIVERSITY OF PITTSBURGH |
Homogeneous Flourescence Intensity High Throughput Assay for Cdc25B Phosphatase I |
DESAI, SANJAY A |
NAT'L INST OF ALLERGY/INFEC DISE |
High-Throughput Screen for Antagonists of the Plasmodial Surface Anion Channel (PSAC) |
FIELDS, GREGG B |
FLORIDA ATLANTIC UNIVERSITY |
ADAMTS/MMP Drug Development |
GRESHAM, HATTIE D |
UNIVERSITY OF NEW MEXICO ALBUQUERQUE |
Small Molecule Inhibition of Staphylococcus Aureus Virulence |
HAMMOCK, BRUCE D |
UNIVERSITY OF CALIFORNIA DAVIS |
Novel sEH Inhibitors for the Therapeutic Treatment of Hypertension and Inflammat |
HOFFMANN, MICHAEL |
UNIVERSITY OF WISCONSIN |
Targeting a Protein Interaction Site on Smad Transcription Factors |
KATZENELLENBOGEN, JOHN A |
UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN |
Screen for Coactivator Binding Inhibitors to Block Estrogen Action |
KELLY, JEFFERY W |
SCRIPPS RESEARCH INSTITUTE |
High Throughput Screening for Protein Misfolding Disease Therapeutics |
LEYH, THOMAS S. |
YESHIVA UNIVERSITY |
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae |
MCPIKE, MARK P |
ORTHOSYSTEMS, INC. |
Rapid Mix and Measure HTS Assays for Anti-NCp7 Drug Discovery |
PELLECCHIA, MAURIZIO |
BURNHAM INSTITUTE |
Chemical Tools to Investigate the Protein Folding/Degradation Machinery |
STRONGIN, ALEX |
BURNHAM INSTITUTE |
Screening Chemicals to Suppress MT1-MMP Synthesis in Cancer |
THOMPSON, TODD A |
UNIVERSITY OF NEW MEXICO ALBUQUERQUE |
Activators of Prostate Cell Differentiation |
WELLS, JAMES A |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO |
Inhibitors of Caspase-1 and Caspase-7 |
WILLIAMSON, JAMES R |
SCRIPPS RESEARCH INSTITUTE |
High Throughput Screen for Inhibitors of the HIV Rev-RRE RNA Interaction |
YAFFE, MICHAEL |
MASSACHUSETTS INST OF TECHNOLO |
High Throughput Screening for Inhibitors of the Polo Box Domain of Human Polo-Lik |
ZHENG, WEI |
NIH/ NHGRI |
HTS for Identification of Glucocerebrosidase Activators and Inhibitors as Pharmac |
PAR-05-147
Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) (X01) Reissue of PAR-05-060 |
PI Name |
Institution Name |
Title |
CONN, P JEFFREY |
VANDERBILT UNIVERSITY |
Discovery of novel allosteric modulators of the M1 muscarinic receptor |
HARSAY, EDINA |
UNIVERSITY OF KANSAS LAWRENCE |
Chemical Genetics Screens to Identify Modulators of Post-Golgi Transport |
KURET, JEFF A |
OHIO STATE UNIVERSITY |
Ligands for premortem diagnosis and treatment of Alzheimer's disease |
LEWIS, KIM A |
NORTHEASTERN UNIVERSITY |
A Screen for Novel Antimicrobials |
LI, XIAOLING |
ORPHAGEN PHARMACEUTICALS |
High Throughput Screening of Select Orphan Nuclear Receptors |
MCHENRY, CHARLES S |
UNIVERSITY OF COLORADO DENVER/HSC AURORA |
Conducting a HTS against a Multi-protein DNA Replication System |
MERCOLA, MARK |
BURNHAM INSTITUTE |
Screening for Compounds That Modulate Insulin Promoter Activity in TRM-67 Cells |
MERCOLA, MARK |
BURNHAM INSTITUTE |
Screening for Compounds That Modules Insulin Promoter Activity in MIN-6 Cells |
MILLAN, JOSE LUIS |
BURNHAM INSTITUTE |
Pharmacological inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) |
MUSTELIN, TOMAS M |
BURNHAM INSTITUTE |
HTS for HePTP Inhibitors-a leukemia target |
MUSTELIN, TOMAS M |
BURNHAM INSTITUTE |
HTS for LYP inhibitors-an autoimmunity target |
NISWENDER, COLLEEN M |
VANDERBILT UNIVERSITY |
Discovery of novel allosteric agonists of the M4 muscarinic receptor |
PARNIAK, MICHAEL A |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
HTS assays for inhibitors of HIV RNase H |
PASQUALE, ELENA B |
BURNHAM INSTITUTE |
EphA4 Receptor Antagonists for Nervous System Repair |
PAVITT, GRAHAM D |
UNIVERSITY OF MANCHESTER, UK |
High-throughput screen for a therapeutic agent for elF2B-related disorders |
PIAZZA, GARY A |
SOUTHERN RESEARCH INSTITUTE |
Identification of Molecular Probes that Reverse MRP-Mediated Drug Resistance |
PROSSNITZ, ERIC R |
UNIVERSITY OF NEW MEXICO ALBUQUERQUE |
MLSCN Assay for Ligands of GRP30 and Classical Estrogen Receptors |
PROSSNITZ, ERIC R |
UNIVERSITY OF NEW MEXICO ALBUQUERQUE |
MLSCN Assay for Inhibitors of Arrestin-GPR Interactions |
REED, JOHN C |
BURNHAM INSTITUTE |
Chemical Inhibitors of anti-apoptotic protein Bfl-1 |
REED, JOHN C |
BURNHAM INSTITUTE |
Chemical inhibitors of antigen receptor-induced NF-?Beta activation |
RUBENSTEIN, AMY L |
ZYGOGEN, LLC |
Zebrafish Lipid Metabolism Assay |
SHARLOW, ELIZABETH R. |
UNIVERSITY OF PITTSBURGH |
Fluroscence polarization assay for PLK1 inhibitors |
SKLAR, LARRY A |
UNIVERSITY OF NEW MEXICO ALBUQUERQUE |
MLSCN Assay for Allosteric Ligands for the VLA-4 Integrin |
SKOWYRA, DOROTA |
ST. LOUIS UNIVERSITY |
ATP Hydrolysis-dependent disassembly of the 26S proteosome as an HTS assay for fl |
STRONGIN, ALEX Y |
BURNHAM INSTITUTE |
Inhibitors of the NS3 Proteinase of West Nile and Dengue Viruses |
STURGESS, MICHAEL A |
CHAPERONE TECHNOLOGIES, INC. |
Development of a HTS assay for Inhibitors of bacterial DnaK |
WATTS, VAL J |
PURDUE UNIVERSITY WEST LAFAYETTE |
Allosteric Modulators of D1 Receptors |
YI, FANG |
YALE UNIVERSITY |
Identifying novel Hsp90 Inhibitors by disrupting its cochaperone interaction usin |
PAR-05-060
Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) (R03) |
PI Name |
Institution Name |
Title |
APPEL, BRUCE |
VANDERBILT UNIVERSITY |
A Screen For Drugs That Promote Oligodendrocyte Formation in Zebrafish |
CHEN, BENJAMIN P |
UNIVERSITY OF TEXAS SW MED CTR/DALLAS |
Screening of DNA-PKcs Autophosphorylation Blockers via a Cell-Based Approach |
CHENG, XIAODONG |
UNIVERSITY OF TEXAS MEDICAL BR GALVESTON |
Chemical Genetic Screening of Oncogene RAS-Based Inhibitors |
CHIOSIS, GABRIELA |
SLOAN-KETTERING INSTITUTE FOR CANCER RES |
FP Assay for Isolation of Hsp90 Inhibitors |
CHIOSIS, GABRIELA |
SLOAN-KETTERING INSTITUTE FOR CANCER RES |
Isolation of Inhibitors of Her-Kinase Expression |
DIAMOND, SCOTT L |
UNIVERSITY OF PENNSYLVANIA |
Multiplexed HTS of Serine and Cysteine Proteases |
EDWARDS, BRUCE |
UNIVERSITY OF NEW MEXICO ALBUQUERQUE |
Assay for Formylpeptide Receptor Family Ligands |
FU, HAIAN |
EMORY UNIVERSITY |
AlphaScreen Technology for High Throughput Screening of 14-3-3/Raf-1 Disruptors |
GOLDFARB, DAVID S |
UNIVERSITY OF ROCHESTER |
Yeast Lifespan Chemical Screening |
LAZO, JOHN S |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
Chemical Complementation Assay for MKP-1 |
LAZO, JOHN S |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
Chemical Complementation Assay for MKP-3 |
LAZO, JOHN S |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
In Vitro High Throughput Screening Assay for MKP-1 |
LAZO, JOHN S |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
In Vitro High Throughput Screening Assay for MKP-3 |
MAYER, THOMAS |
COLUMBIA UNIVERSITY HEALTH SCIENCES |
Cellular Assay for TNF Alpha Induced NF Kappa B Translocation |
MAYER, THOMAS |
COLUMBIA UNIVERSITY HEALTH SCIENCES |
Cellular Assay for TNF Alpha Induced E-Selectin Expression |
MAYER, THOMAS |
COLUMBIA UNIVERSITY HEALTH SCIENCES |
Cellular Assay for the Presentation of the Adhesion Molecule VCAM on the surface of HUVEC cells |
MUSTAEV, ARKADY |
PUBLIC HEALTH RESEARCH INSTITUTE |
Development of the HTS Assay for E. Coli RNA Polymerase (RNAP) |
NISWENDER, COLLEEN M |
VANDERBILT UNIVERSITY |
Measurement of GPCR-mediated thallium flux through GIRK Channels |
PAUMET, FABIENNE |
COLUMBIA UNIVERSITY HEALTH SCIENCES |
Unraveling the Molecular Mechanisms of Phagocytosis |
ROTHMAN, JAMES E |
COLUMBIA UNIVERSITY HEALTH SCIENCES |
Aggregation and Clearance of Mutant Huntingtin |
ROTHMAN, JAMES E |
COLUMBIA UNIVERSITY HEALTH SCIENCES |
Regulation of Neurotransmitter Transporter Recycling |
SANNA M. GERMANA |
SCRIPPS RESEARCH INSTITUTE |
MLSCN HTS Assays R03 - S1P1 |
TEITLER, MILT |
ALBANY MEDICAL COLLEGE OF UNION UNIV |
Human 5HT 1E Serotonin Receptor Drug Development |
WALKER, SUZANNE |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
Identification of O-GlcNAc Transferase Inhibitors by HTS |
WHITE, E. LUCILE |
SOUTHERN RESEARCH INSTITUTE |
High Throughput Screen for Mycobacterium Tuberculosis Pantothenate Synthetase |
WILKINSON, KEITH D |
EMORY UNIVERSITY |
HTS Assay for Inhibitors of BAP1, a BRCA1 Associated Deubiquitinating Enzyme |
WILLIAMS, DAVID L |
ILLINOIS STATE UNIVERSITY |
HTS for Inhibitors of Schistosoma Mansoni Peroxiredoxins |
ZHOU, MING |
COLUMBIA UNIVERSITY HEALTH SCIENCES |
Small-Molecule Modulators of a Family of Voltage-Dependent Potassium Channels |
PAR-08-024
Assay Development for High Throughput Molecular Screening (R21) |
PI Name |
Institution Name |
Title |
BARIC, RALPH S. |
UNIVERSITY OF VIRGINIA CHARLOTTESVILLE |
Yeast Based Assays for Chemical Screens Against SARS-CoV Target |
BRAUTIGAN, DAVID L. |
UNIVERSITY OF VIRGINIA CHARLOTTESVILLE |
Triple threat screening for modifiers of Protein Ser/Thr Phosphatase 2C |
CHAUDHARY, PREET M. |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
Small Molecule Inhibitors of K13-Induced NF-kB Activation |
CUI, LIWANG |
PENNSYLVANIA STATE UNIVERSITY-UNIV PARK |
Development of a cell-based method for high-throughput drug screening in malaria |
FABRIS, DANIELE |
UNIVERSITY OF MARYLAND BALT CO CAMPUS |
MS-based screening of candidate inhibitors of protein-RNA and RNA-RNA interaction |
FLOYD, SCOTT R |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
High-content screening for modifiers of the DNA damage response |
JEGLA, TIMOTHY J. |
SCRIPPS RESEARCH INSTITUTE |
HTS Assays for Specific Modulators of Neuronal Acid-Sensitive K+ Channels |
LIEBERMAN, PAUL M. |
WISTAR INSTITUTE |
Assay For Inhibitors of Epstein-Barr Virus |
YANG, PRISCILLA LI-NING |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
Development of Cellular Assays of Dengue Virus Infection |
ZHAO, RICHARD YUQI |
UNIVERSITY OF MARYLAND BALTIMORE |
Fission Yeast as a HTS Platform for New Molecular Probes of HIV-1 VPR-Medicated A |
RFA-RM-07-008
Assay Development for High Throughput Molecular Screening (R21) This is a reissue of RFA-RM-07-001 |
PI Name |
Institution Name |
Title |
DAVISSON, VINCENT JO |
PURDUE UNIVERSITY WEST LAFAYETTE |
High-throughput Chemotyping of Yeast Signature Strains Reflecting Hsp90 Biology |
FENG, XU |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
Cell-Based Assays for Identifying Anti-RANK Signaling Agents |
GRAEF, ISABELLA A |
STANFORD UNIVERSITY |
HTS Assay Development for Modulators of a Nuclear Import/Export Switch |
GRANNEMAN, JAMES G |
WAYNE STATE UNIVERSITY |
HTS for Novel Activators of Adipocyte and Myocyte Lipolysis |
HARSAY, EDINA |
UNIVERSITY OF KANSAS LAWRENCE |
Pathway-Specific Inhibitors of Post-Golgi Transport |
ILAGAN, MA.XENIA G |
WASHINGTON UNIVERSITY |
Screening for Novel Modulators of Notch/RBPjk Interactions |
JOHNSON, JEFFREY DALE |
METABOLEX, INC. |
High Throughput Screening to Identify Inhibitors of a Fifth Mammalian Hexokinase |
KAO, GARY D |
UNIVERSITY OF PENNSYLVANIA |
The Zebrafish Radioresponse for High-Throughput and -Content Molecular Screening |
KAYE, KENNETH M |
BRIGHAM AND WOMEN'S HOSPITAL |
Chemical Probes of Kaposi's Sarcoma Herpesvirus Latent Infection |
KRANZ, ROBERT G |
WASHINGTON UNIVERSITY |
HTS for Cytochrome C Synthesis Pathways |
MAITRA, RANGAN |
RESEARCH TRIANGLE INSTITUTE |
Anti-inflammatory Assay for Cystic Fibrosis |
NIKOLOV, DIMITAR B |
SLOAN-KETTERING INSTITUTE FOR CANCER RES |
Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali |
PETRIE, HOWARD T |
SCRIPPS RESEARCH INSTITUTE |
Assay Development and Screening for Notch Agonists |
PETRUKHIN, KONSTANTIN |
COLUMBIA UNIVERSITY HEALTH SCIENCES |
Development of the HTS Assay for Agonists of the Orphan Nuclear Receptor NR2E3 |
PRICE, BRENDAN D |
DANA-FARBER CANCER INSTITUTE |
Identification of Inhibitors of the Tip60 Histone Acetyltransferase |
REICHMAN, MELVIN |
LANKENAU INSTITUTE FOR MEDICAL RESEARCH |
Fructosamine-3-Kinase Assay Development and Validation for HTS |
SALVESEN, GUY S |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
Development of a High-Throughput Assay for Human Desumoylating Enzymes [SENPs] |
SCHNAUFER, ACHIM C |
SEATTLE BIOMEDICAL RESEARCH INSTITUTE |
A High Throughput Assay to Identify Onhibitors of Trypanosome RNA Editing Ligase |
WOLF, DIETER A |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
Optimized High-Throughput Screen for Small Molecule Inhibitors of P27 Degradation |
XU, BO |
SOUTHERN RESEARCH INSTITUTE |
An HTS Assay for Inhibitors of NBS1-ATM Interactions |
ZHOU, JIANHUA |
UNIV OF MASSACHUSETTS MED SCH WORCESTER |
Cell Based Assays for Compounds That Regulate Tau Exon 10 Splicing |
RFA-RM-07-001
Assay Development for High Throughput Molecular Screening (R21) Reissue of RFA-RM-06-004, which was previously released November 2, 2005 RFA-RM-05-011; Reissue for FY2005 of RFA-RM-04-012 |
PI Name |
Institution Name |
Title |
ARANY, ZOLTAN P. |
DANA-FARBER CANCER INSTITUTE |
High throughput screening for modulators of the transcriptional coactivator PGC-1 |
ARGON, YAIR |
CHILDREN'S HOSPITAL OF PHILADELPHIA |
Developing HTS assays for the functions of the chaperone GRP94 |
BLENIS, JOHN |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
Development of a high content cell based screen for inhibitors of the mTOR signal |
CLARDY, JON |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
Target-Based High-Throughput Screens for Plasmodium falciparum Malaria |
CLEARY, MICHAEL L |
STANFORD UNIVERSITY |
Inhibitors of MLL-Menin Interaction |
DUTTA, ANINDYA |
UNIVERSITY OF VIRGINIA CHARLOTTESVILLE |
Screen for TIP60 Inhibitors |
FIDOCK, DAVID A |
YESHIVA UNIVERSITY |
A cell-based HTS for delayed death inhibitors of the malarial parasite plastid |
GERACE, LARRY R |
SCRIPPS RESEARCH INSTITUTE |
Screen for Small Molecule Inhibitors of Nuclear Protein Import |
GINSBERG, MARK H |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO |
Assay Development for HT Molecular Screening for Inhibitors of Integrin Signaling |
GOCHIN, MIRIAM |
TOURO UNIVERSITY CALIFORNIA |
High-Throughput Screening for Human Immunodeficiency Virus Fusion Inhibitors |
HARRIS, JASON B |
MASSACHUSETTS GENERAL HOSPITAL |
Development of a small molecule screen for PhoP regulon inhibitors in Salmonella |
HODDER, PETER SIMMONS |
SCRIPPS RESEARCH INSTITUTE |
HTS assays for discovery of novel beta-lactamase inhibitors via click chemistry |
HUANG, QIHONG |
WISTAR INSTITUTE |
A Cell-based Screen for Small Molecule Modulators of the miRNA Pathway |
JAIN, ANJALI |
CEDARS-SINAI MEDICAL CENTER |
Functional Genomics Tools for HER2 heterodimers and Androgen Receptor Signaling |
JARDETZKY, THEODORE S |
NORTHWESTERN UNIVERSITY |
HTS for Small Molecule Modulators of EB Virus Protein-Protein Interactions |
KAMPF, J PATRICK |
FFA SCIENCES, LLC |
An HTS Assay for the Discovery of Specific Inhibitors of Adipocyte FABP |
LAVAN, BRIAN |
METABOLEX, INC. |
High Throughput Screening for Identification of AKR1C3 Inhibitors |
LI, RONGBAO |
SOUTHERN RESEARCH INSTITUTE |
HTS Assay Development for Discovery of Specific PYK2 Inhibitors |
PETERSON, JEFFREY R |
INSTITUTE FOR CANCER RESEARCH |
Allosteric, Small-Molecule Inhibitors of Actin Nucleation by the Formin mDia1 |
PIAZZA, GARY A |
SOUTHERN RESEARCH INSTITUTE |
A Novel HTS Cell-Based Assay For Cyclic GMP |
ROGERS, JACK T |
MASSACHUSETTS GENERAL HOSPITAL |
MLSN Screen of the PD Alpha Synuclein 5'UTR |
ROGERS, MICHAEL S |
CHILDREN'S HOSPITAL BOSTON |
Assay for Inhibitors of Angiogenesis and Anthrax Toxin Receptor 1 |
RYDER, SEAN PATRICK |
UNIV OF MASSACHUSETTS MED SCH WORCESTER |
Small molecule effectors of maternal gene expression in C. elegans embryogenesis |
SANDER, CHRIS |
SLOAN-KETTERING INSTITUTE FOR CANCER RES |
High-throughput identification of compounds that modulate the TGF-beta pathway |
SMITH, LAYTON H |
SCRIPPS RESEARCH INSTITUTE |
HTS to identify chemical probes of the apelin receptor signaling pathway |
WUTTKE, DEBORAH S. |
UNIVERSITY OF COLORADO AT BOULDER |
Development of a HTS Assay Targeting End Protection of Telomeres |
RFA-RM-06-004
Assay Development for High Throughput Molecular Screening (R03/R21) Reissue for FY2006 of RFA-RM-05-011 |
PI Name |
Institution Name |
Title |
AGAISSE, HERVE F |
YALE UNIVERSITY SCHOOL OF MED |
High-throughput screen for compounds affecting intracellular pathogen infection |
AIKEN, CHRISTOPHER R |
VANDERBILT UNIVERSITY |
Discovering Novel Inhibitors of HIV-1 Maturation |
AYAD, NAGI G |
SCRIPPS FLORIDA RESEARCH INSTITUTE |
Small-molecule Inhibitors of Wee1 Degradation and Mitotic Entry |
BALK, STEVEN P |
BETH ISRAEL DEACONESS MEDICAL CENTER |
HTS for Androgen Receptor Antagonists that Recruit NCoR |
BOTTINI, NUNZIO |
UNIVERSITY OF SOUTHERN CALIFORNIA |
Fluorogenic PTP Assay for Use in HTS of Novel LYP Inhibitors |
BROWN, STEVEN J |
SCRIPPS RESEARCH INSTITUTE |
Development of a High Throughput Screening Galanin 3 Receptor Assay |
CRAWFORD, BRETT E |
ZACHARON PHARMACEUTICALS, INC. |
Development of cell-based assays for discovery of GIcNAc-TV inhibitors |
CUNNINGHAM, KYLE W |
JOHNS HOPKINS UNIVERSITY |
Assays for compounds that block or stimulate yeast cell death |
DAY, BILLY W |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
High Throughput/Content Screens for Dynein Inhibitors |
DELISA, MATTHEW P |
CORNELL UNIVERSITY |
A cell-based screen for inhibitors of intracellular Abeta aggregation |
DENTON, JEROD S |
VANDERBILT UNIVERSITY |
Identification of novel modulators of ROMK K+ channel activity |
DESHMUKH, MOHANISH P |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
Chemical Probes for Uncovering Differential Regulators of Apoptosis in Cells |
DJABALLAH, HAKIM |
SLOAN-KETTERING INSTITUTE FOR CANCER RES |
Novel & Selective Small Molecular Inhibitors of Human Peptide Deformylase |
HODGSON, LOUIS |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
Screening for RhoC Activation and its modulation by GEFs |
HOFFMANN, F. MICHAEL |
UNIVERSITY OF WISCONSIN MADISON |
An HTS Assay for Inhibitors of Smad-dependent Transcriptional Responses to TGF-beta |
HOGENESCH, JOHN B |
UNIVERSITY OF PENNSYLVANIA |
A Dual Transcriptional and High Content Assay for Cryptochrome |
HUGHES, ROBERT E |
BUCK INSTITUTE FOR AGE RESEARCH |
A cell-based screen for small molecule binders of mutant huntingtin messenger RNA |
JEGLA, TIMOTHY J |
SCRIPPS RESEARCH INSTITUTE |
Development of HTS Assays for Sub-Threshold Potassium Channels |
JOHNSON, GARY L |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
Inhibitor Screens for Five MAPK Kinase Kinases Important in Human Disease |
KHANNA, PYARE L |
DISCOVERX CORPORATION |
HTS Technology for Discovery of Drugs Targeting GPCR Oligomers |
LANDICK, ROBERT C |
UNIVERSITY OF WISCONSIN MADISON |
High-Throughput Identification of RNA polymerase inhibitors in vivo |
LEISNER, TINA M |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
Developing HTS Assays for Novel Intracellular Regulators of Integrin Activation |
LEVINE, FRED |
UNIVERSITY OF CALIFORNIA SAN DIEGO |
High-Throughput Screen for Beta-Cell Replication |
LINDER, MAURINE E |
WASHINGTON UNIVERSITY |
Assay Development to Identify Palmitoylation Inhibitors of Neuronal Proteins |
LUO, HONGBO R |
CHILDREN'S HOSPITAL BOSTON |
High throughput screening for inhibitors of Akt plasma membrane translocation. |
MARZLUFF, WILLIAM F |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
Screen for molecules inhibiting histone pre-mRNA processing |
MCNEIL, MICHAEL R |
COLORADO STATE UNIVERSITY-FORT COLLINS |
Glucosamine-1-phosphate and serine acetylases: HTS assays and configurations |
NETTLES, KENDALL W |
SCRIPPS RESEARCH INSTITUTE |
Assay Development for Identification of ER-NFkB Pathway Selective Agents |
NEUBIG, RICHARD R |
UNIVERSITY OF MICHIGAN |
Multiplexed flow cytometry screens for RGS inhibitors |
NIKOLOVSKA-COLESKA, ZANETA |
THE UNIVERSITY OF MICHIGAN |
Discovery and characterization of novel small molecule inhibitors of Mcl-1 |
PADGETT, RICHARD A |
CLEVELAND CLINIC FOUNDATION |
Screen for Small Molecule Inhibitors of Mammalian Spliceosomes |
PERRIMON, NORBERT |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
High-throughput screening assay development for axonopathic neurodegeration |
SALAVATI, REZA |
MCGILL UNIVERSITY |
RNA as the catalyst for screening drugs against trypanosomatids |
THACHER, SCOTT M |
ORPHAGEN PHARMACEUTICALS |
Small Molecule Screen for Circadian and Metabolic Transcription Factors |
TRAYNELIS, STEPHEN F |
EMORY UNIVERSITY |
Identification of protease activated receptor-2 modulators |
WAHLESTEDT, CLAES |
SCRIPPS RESEARCH INSTITUTE |
Assay Development Relating to the HTS of the Neuropeptide Y-Y2 Receptor |
WEISS, ERIC L |
NORTHWESTERN UNIVERSITY |
Development of a robust high throughput assay for the discovery of RAM network inhibitors |
WELLS, JAMES A |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO |
Activators of Procaspase-7 |
WESSLING-RESNICK, MARIANNE |
HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) |
Fluorescence-based screen to probe hepcidin-ferroportin interactions |
WILLIAMSON, JAMES R |
SCRIPPS RESEARCH INSTITUTE |
HTS for Discovery of Inhibitors of STAR Protein-RNA complexes |
XIE, XINMIN SIMON |
SRI INTERNATIONAL |
Development of HTS Platform for Human Fatty Acid Transport Protein 4 Using FLIPR |
ZHU, MICHAEL X |
OHIO STATE UNIVERSITY |
High throughput screening of ligands of TRP channels |
RFA-RM-05-011
Assay Development for High Throughput Molecular Screening (R03/R21) Reissue of RM-04-012 |
PI Name |
Institution Name |
Title |
BACHER, ADELBERT |
TECHNICAL UNIVERSITY MUNICH |
HTS on Riboflavin and Terpene Biosynthetic Enzymes |
CAFFREY, MICHAEL S |
UNIVERSITY OF ILLINOIS AT CHICAGO |
High Throughput Screening of HIV Entry Inhibitors |
CARTEGNI, LUCA |
SLOAN-KETTERING INSTITUTE FOR CANCER RES |
Development of HTS Assays to Identify Specific Alternative Splicing Modulators |
CHRISTENSEN, KENNETH A |
CLEMSON UNIVERSITY |
Assay for Molecules that Inhibit Anthrax Intoxication and Pathological Angiogenes |
CLARDY, JON C |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
Phenotypic-based High Throughput Screens for Plasmodium Falciparum Malaria |
CRAWFORD, BRETT E |
ZACHARON PHARMACEUTICALS, INC. |
Cell-Based Screen for Inhibitors of Mucin-Type O-Linked Glycans |
CUEVAS, BRUCE D |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
MEKK2/3-MEK5 Protein Interaction/Activation/ERK5 Pathway |
DELPIRE, ERIC J |
VANDERBILT UNIVERSITY |
Identification of Novel Modulators of CL-dependent Transport Processes via HTS |
DEVI, LAKSHMI A |
MOUNT SINAI SCHOOL OF MEDICINE OF NYU |
Assay to Screen Ligands that Selectively Activate Opioid Receptor Heterodimers |
ENGELMAN, DONALD M |
YALE UNIVERSITY |
A High Capacity Screen for Membrane-Active Compounds |
GUPTA, VINEET |
MASSACHUSETTS GENERAL HOSPITAL |
Developing HTS Assays for Discovery of Small Molecule Regulators of Integrins |
JARSTFER, MICHAEL B |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
A High Throughput Screen for Telomerase Assembly |
KHANNA, PYARE L |
DISCOVERX CORPORATION |
HTS Cell Based EFC Assays for GPCR Drug Discovery |
KAMPF, J PATRICK |
TORREY PINES INSTITUTE/MOLECULAR STUDIES |
A Fluorescent HTS Assay for the Discovery of FABP Binding Inhibitors |
KAN, CHEN-CHEN |
KECK GRADUATE INST OF APPLIED LIFE SCIS |
Human CD4+ T Cell Based High Throughput Assay for Drug-Resistant HIV-1 Proteases |
KATZ, RICHARD A |
INSTITUTE FOR CANCER RESEARCH |
GFP-Based Assays to Probe Transcriptional and Post-Transcriptional Controls |
LANSBURY, PETER T |
BRIGHAM AND WOMEN'S HOSPITAL |
A High-Throughput Assay for SOD1 Aggregation Inhibitors |
MARSH-ARMSTRONG, NICHOLAS R |
KENNEDY KRIEGER RESEARCH INSTITUTE, INC. |
Photoreceptor Degeneration Assay in Transgenic Xenopus Reporter Line |
MCKERROW, JAMES H |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO |
High Throughput Assay for Screening Compounds Against T. Brucei |
MECSAS, JOAN C |
TUFTS UNIVERSITY BOSTON |
Inhibitors of Yersinia Yop Type III Secretion and Translocation |
MOHAN, ROYCE |
UNIVERSITY OF KENTUCKY |
Novel High Content Vascular Patterning Assay |
MORRIS, DAVID G |
YALE UNIVERSITY |
High Throughput Molecular Screening for Compounds that Alter Tgfb1 Signaling Tgfb1 Signaling |
NISWENDER, COLLEEN M |
VANDERBILT UNIVERSITY |
A Direct Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as the Prototype |
PASQUALE, ELENA B |
BURNHAM INSTITUTE |
EphA4 Receptor Antagonists for CNS Regeneration |
ROGERS, JACK T |
MASSACHUSETTS GENERAL HOSPITAL |
Small HTS Molecules Targeting APP 5' Untranslated Region |
SCHARENBERG, ANDREW M |
CHILDREN'S HOSPITAL AND REG MEDICAL CTR |
TRPM2 HTS Screening Assay Development |
SCHMID, MOLLY B |
KECK GRADUATE INST OF APPLIED LIFE SCIS |
Genetic-Based Whole Cell Assays for Discovery of Novel Antibacterials |
SCHMIDT, WALTER K |
UNIVERSITY OF GEORGIA |
HTS-Based Identification of Novel Rce1p Inhibitors |
SIDEROVSKI, DAVID P |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
Real-Time Fluorescence Assays of RGS Domain GAP Activity |
SPERANDIO, VANESSA |
UNIVERSITY OF TEXAS SW MED CTR/DALLAS |
Screen for Quorum Sensing Molecular Inhibitors |
STIVERS, JAMES T |
JOHNS HOPKINS UNIVERSITY |
High Throughput Assay for Topoisomerase Enzyme Targets |
STUDER, LORENZ |
SLOAN-KETTERING INSTITUTE FOR CANCER RES |
HTS Screen for Neural Differentiation in Human ES Cells |
SWAAN, PETER W |
UNIVERSITY OF MARYLAND BALT PROF SCHOOL |
High-Throughput Assay for the Intestinal Peptide Transporter |
TRUBETSKOY, VLADIMIR S |
QUINTESSENCE BIOSCIENCES |
Development of a Robust HTS Assay to Profile Glucuronidation of Small Molecules |
WALDMAN, TODD |
GEORGETOWN UNIVERSITY |
Isogenic Cell-Based Screens for Cancer - Targeting Oncogenic B-Catenin |
WEIS, KARSTEN |
UNIVERSITY OF CALIFORNIA BERKELEY |
Using Chemical Biology to Study the Small GTPase Ran |
XIE, XINMIN S |
SRI INTERNATIONAL |
Development of HTS Assay for K(ATP) Channels Using FLIPR |
YE, QI-ZHUANG |
UNIVERSITY OF KANSAS LAWRENCE |
A Fluorescence Polarization Assay for Methyltransferases |
ZACHARIAS, DAVID A |
UNIVERSITY OF FLORIDA |
A Cell-Based HT Imaging Assay for Palmitoylation |
RFA-RM-04-012
High Throughput Molecular Screening Assay Development (R03) |
PI Name |
Institution Name |
Title |
BEZPROZVANNY, ILYA B |
UNIVERSITY OF TEXAS SW MED CTR/DALLAS |
Screen for blockers of a CaV2.2-Mint-PDZ1 association |
BURGESS, RICHARD R |
UNIVERSITY OF WISCONSIN MADISON |
LRET-based HT Screening for Inhibitors of Transcription |
BURNS, CHARLES G |
MASSACHUSETTS GENERAL HOSPITAL |
HTS assay for zebrafish embryonic heart function |
CHIOSIS, GABRIELA |
SLOAN-KETTERING INSTITUTE FOR CANCER RES |
Development of HTS assays probing Hsp90 inhibition |
CHUNG, RAYMOND T |
MASSACHUSETTS GENERAL HOSPITAL |
Chemical Genetics to Identify Cellular Regulators of HCV |
CLARDY, JON C |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
High-throughput Screens for P. falciparum Malaria |
CONN, P JEFFREY |
VANDERBILT UNIVERSITY |
Development of a High Throughput Assay for Allosteric P* |
DAVID, SUNIL A |
UNIVERSITY OF KANSAS LAWRENCE |
Novel High-throghput Assay for Angiogenesis Inhibitors |
FENTON, ROBERT G |
UNIVERSITY OF MARYLAND BALT PROF SCHOOL |
High-throughput screen for inhibitors of Mcl-1 |
FRANK, DAVID A |
DANA-FARBER CANCER INSTITUTE |
High Throughput Screening for Modulators of STAT5 |
GOLDFARB, DAVID S |
UNIVERSITY OF ROCHESTER |
Molecular Screen for Lifespan Extension in Yeast |
HARSAY, EDINA |
UNIVERSITY OF KANSAS LAWRENCE |
Identifying compounds that target post-Golgi secretion |
JAYARAMAN, VASANTHI |
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON |
High throughout screening assay for glutamate receptors |
KIEFF, ELLIOTT D. |
BRIGHAM AND WOMEN'S HOSPITAL |
Screening of Epstein Barr Virus Replication |
KIRKEN, ROBERT A |
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON |
Screening for small molecule inhibitors of Stat5 |
KUTSCH, OLAF |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
A GFP Based HTS Assay for HIV-1 Tat Inhibitors |
LITHGOW, GORDON |
BUCK INSTITUTE FOR AGE RESEARCH |
C. elegans, Aging and High Throughput Screening |
LU, YILING |
UNIVERSITY OF TEXAS MD ANDERSON CAN CTR |
Tissue Lysate Arrays for Molecular Screening |
MANION, MICHAEL K |
FRED HUTCHINSON CANCER RESEARCH CENTER |
Methods to identify BCL-2 "gain of function" inhibitors |
MORISSEAU, CHRISTOPHE HP |
UNIVERSITY OF CALIFORNIA DAVIS |
Cyanohydrin based fluorescent substrates of sEH |
PERRIMON, NORBERT |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
High-throughput screen for host factors in Listeria infection |
ROSENFELD, STEVEN S |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
Development of High Throughput Screening Assays to Targ* |
THACHER, SCOTT M |
ORPHAGEN PHARMACEUTICALS |
Small Molecular Screen for Thymocyte Drug Target |
TORTORELLA, DOMENICO |
MOUNT SINAI SCHOOL OF MEDICINE OF NYU |
Luminescent assay to identify ER dislocation inhibitors |
TSE-DINH, YUK-CHING |
NEW YORK MEDICAL COLLEGE |
Development of a HTS system in E. coli for topoisomeras* |
WALDMAN, TODD A |
GEORGETOWN UNIVERSITY |
Isogenic Cell-Based Screens for Cancer: Targeting PTEN |
WILSON, ROBERT B |
UNIVERSITY OF PENNSYLVANIA |
High throughput screen for cyclin D1 inhibitors |
WRIGHT, KENNETH L |
H. LEE MOFFITT CANCER CTR & RESEARCH INS |
High Throughput H3-K9 Methyltransferase Inhibitor Screen |
XIE, SIMON X |
SRI INTERNATIONAL |
HTS Assay for Ca 3 T-type Channels Using FLIPR |
YAFFE, MICHAEL B |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
High-Throughput Assay Design for Polo Kinase Inhibitors |
RFA-RM-06-003
Pilot-Scale Libraries for High-Throughput Screening (P41) |
PI Name |
Institution Name |
Title |
BAURES, PAUL WILLIAM |
UNIVERSITY OF TULSA |
Molecular Libraries from Imidazole-4,5-Dicarboxylic Acid |
GILBERTSON, SCOTT R |
UNIVERSITY OF TEXAS MEDICAL BR GALVESTON |
Synthesis of Pilot Libraries Based on Medicinal Relevant Scaffolds |
GRAY, NATHANAEL S |
DANA-FARBER CANCER INSTITUTE |
Inhibitors of Kinase Activation |
HOUGHTEN, RICHARD A |
TORREY PINES INST FOR MOLECULAR STUDIES |
Stereochemically /Structurally Diverse Pilot Scale Libra |
KRCHNAK, VIKTOR |
UNIVERSITY OF NOTRE DAME |
Combinational synthesis of bisheterocyclic libraries |
LAROCK, RICHARD C |
IOWA STATE UNIVERSITY |
Heterocyclic /Carbocyclic Libraries for High Throughput |
PARKER, MATTHEW A |
CHEMDIV, INC. |
New Regions of Diversity Space in Ergot-Based Libraries |
WEST, LYNDON M |
UNIVERSITY OF GEORGIA (UGA) |
“Drug-Like” Marine Natural Products Library |
RFA-RM-04-023
Novel Preclinical Tools for Predictive ADME-Toxicology (R21) |
PI Name |
Institution Name |
Title |
BENET, LESLIE Z |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO |
Transporter-Enzyme Interplay Evaluation via Microfluidic HTS Cell Culture Devices |
GANEY, PATRICIA E |
MICHIGAN STATE UNIVERSITY |
Gene Expression in Drug-inflammation Models as Predictive of Idiosyncratic ADRs |
HAYSTEAD, TIMOTHY A |
DUKE UNIVERSITY |
Proteome Mining as a Predicitve Tool of Drug Toxicity |
HOPFINGER, ANTON J |
CHEM21 GROUP, INC. |
Novel Descriptors and Informatics Methods for Predictive ADMET Modeling |
MA, PETER X |
UNIVERSITY OF MICHIGAN AT ANN ARBOR |
Nano Fibers for ADME/Toxicology |
MACDONALD, JEFFREY M |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
Human Enterohepatic Cell Model for Predictive Toxicology |
MACRAE, CALUM A |
MASSACHUSETTS GENERAL HOSPITAL |
Zebrafish Assays Predictive for Drug-Induced Cardiac Repolarization Toxicity PS-149 |
SUMNER, SUSAN J |
RESEARCH TRIANGLE INSTITUTE |
Metabolomics: Markers of Drug-Induced Liver Injury |
TROPSHA, ALEXANDER E |
UNIVERSITY OF NORTH CAROLINA CHAPEL HILL |
Robust computational framework for predictive ADME-Tox Modeling |
ZACHAREWSKI, TIMOTHY R |
MICHIGAN STATE UNIVERSITY |
Human Stem Cells for Toxicity Screening |
Development of High Resolution Probes for Cellular Imaging |
RFA-RM-04-021
Innovation In Molecular Imaging Probes (R21) |
PI Name |
Institution Name |
Title |
BOLSKAR, ROBERT D |
TDA RESEARCH, INC. |
Cut Nanotube Capsules for MR Imaging |
BOPPART, STEPHEN A |
UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN |
Magnetomotive Optical Molecular Imaging Probes |
BOYLE, TIMOTHY J |
SANDIA CORP-SANDIA NATIONAL LABORATORIES |
Flourescent Ceramic Nanoprobes |
BULTE, JEFF W |
JOHNS HOPKINS UNIVERSITY |
Developing a CEST Reporter Gene |
DAYTON, PAUL A |
UNIVERSITY OF CALIFORNIA DAVIS |
High-Sensitivity Molecular Imaging with Ultrasound |
DOUGLAS, TREVOR |
MONTANA STATE UNIVERSITY (BOZEMAN) |
Targeted MRI with Protein Cage Architectures |
GAO, JINMING |
UNIVERSITY OF TEXAS SW MED CTR/DALLAS |
MFe2O4-Loaded Polymer Micelles as Ultra-Sensitive MR Molecular Probes |
HALPERN, HOWARD J |
UNIVERSITY OF CHICAGO |
Magnitude Improvement of Molecular Signaling Imaging |
KURHANEWICZ, JOHN |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO |
Hyperpolarized 13c NMR Studies of Prostate Cancer |
MATTREY, ROBERT F |
UNIVERSITY OF CALIFORNIA SAN DIEGO |
Molecular Imaging with Ultrasound Contrast Agents |
POMPER, MARTIN G |
JOHNS HOPKINS UNIVERSITY |
PSMA-based Gene Reporter-Probe System |
RFA-RM-04-001
Development of High Resolution Probes for Cellular Imaging (P20) |
PI Name |
Institution Name |
Title |
BURGESS, KEVIN |
TEXAS A&M UNIVERSITY SYSTEM |
Fluorescent Probes for Multiplexed Intracellular Imaging |
DICKSON, ROBERT M |
GEORGIA INSTITUTE OF TECHNOLOGY |
Sub-nm dendrimer-metal nanoclusters as ultrabright, mod* |
MOERNER, WILLIAM E |
STANFORD UNIVERSITY |
Single-Molecule Fluorophores for Cellular Imaging |
NIE, SHUMING |
EMORY UNIVERSITY |
Bioaffinity Nanoparticle Probes for Bioimaging |
PISTON, DAVID W |
VANDERBILT UNIVERSITY |
Probes for Quantitative Optical and Electron Microscopy |
SIMON, SANFORD M |
ROCKEFELLER UNIVERSITY |
Imaging single proteins in vivo with quantum dots |
SINGER, ROBERT H |
YESHIVA UNIVERSITY |
Light-Activated Gene Expression in Single Cells |
TING, ALICE Y |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
Library-based development of new optical imaging probes |
TSIEN, ROGER |
UNIVERSITY OF CALIFORNIA SAN DIEGO |
Genetically Targetable Labels For Light and EM |
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