Polyglutamine-Induced Neurodegeneration: Pathogenesis is Linked to Native Protein Biochemistry Function |
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| Launch in standalone player | |
| Air date: | Monday, November 19, 2007, 12:00:00 PM |
| Category: | Neuroscience |
| Runtime: | 75 minutes |
| NLM Title: | Polyglutamine-induced neurodegeneration : pathogenesis is linked to native protein biochemistry function [electronic resource] / Harry Orr. |
| Series: | Molecular basis of the polyglutamine neurogeneerative disease SCA1 |
| Author: | Orr, Harry. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2007] |
| Other Title(s): | Molecular basis of the polyglutamine neurogeneerative disease SCA1 |
| Abstract: | (CIT): Dr. Orr discovered that an expanded glutamine tract in the ataxin-1 gene is the cause of the inherited neurodegenerative disease, spinocerebellar ataxia type 1 (SCA1). His current research focuses on understanding how polyglutamine tracts lead to neuronal dysfunction and neurodegeneration. His development of a conditional mouse model of Sca1 has yielded a number of insights into the molecular defects caused by the mutant ataxin-1 and how this affects Purkinje cell and cerebellar function and development. |
| Subjects: | Nerve Tissue Proteins Nuclear Proteins Spinocerebellar Ataxias--etiology |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | WL 320 |
| NLM ID: | 101322969 |
| CIT File ID: | 14157 |
| CIT Live ID: | 6169 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14157 |
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| Description | Runtime | Description | Runtime | |||
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Enhanced Audio Podcast | 1:04:31 |
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Enhanced Video Podcast | 1:04:31 | |