Mechanisms of Membrane Fusion in the Secretory Pathway
 


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Air date: Wednesday, March 28, 2007, 3:00:00 PM
Category: Wednesday Afternoon Lectures
Runtime: 67 minutes
NLM Title: Mechanisms of membrane fusion in the secretory pathway [electronic resource] / Reinhard Jahn.
Series: NIH director's Wednesday afternoon lecture series
Author: Jahn, Reinhard.
National Institutes of Health (U.S.)
Publisher: [Bethesda, Md. : National Institutes of Health, 2007]
Other Title(s): NIH director's Wednesday afternoon lecture series
Abstract: (CIT): Membrane traffic in eukaryotic cells involves transport of vesicles that bud from a donor compartment and fuse with an acceptor compartment. In recent years, SNARE proteins have emerged as key candidates for the catalysis of all fusion events in the secretory pathway. Appropriate sets of SNARE proteins assemble into SNARE complexes that are structurally highly conserved and that are dissociated by the AAA-ATPase NSF in conjunction with SNAP-cofactors. According to current ideas, assembly of SNAREs residing in the membranes destined to fuse operate as nanomachines that pull membranes tightly together. Indeed, reconstitution of SNAREs in artificial membranes resulted of fusion of these membranes in a SNARE-dependent manner but it is controversially discussed to which extent these experiments can serve as model for the biological reactions.
Subjects: Membrane Fusion--physiology
SNARE Proteins--physiology
Publication Types: Government Publications
Lectures
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NLM Classification: QU 375
NLM ID: 101303664
CIT File ID: 13722
CIT Live ID: 5194
Permanent link: http://videocast.nih.gov/launch.asp?13722

 

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