• Roadmap Home
• Roadmap Initiatives
• Funding Opportunities
• Funded Research
• FAQ
• Recent Research Advances

Molecular Libraries and Imaging

Overview Implementation Group Members Funding Opportunities Funded Research Related Activities Meetings Mid-course Review Molecular Libraries Program PubChem MICAD IPDC

Funded Research Molecular Libraries Screening Centers and Small Molecule Repository RFA-RM-08-005 Molecular Libraries Probe Production Centers Network (MLPCN) (U54) – Limited Competition PI Name Institution Name Title AUSTIN, CHRIS NHGRI NIH Chemical Genomics Center (PDF, 2 pages) ROSEN, HUGH The Scripps Research Institute The Comprehensive Center for Chemical Probe Discovery and Optimization at Scripps REED, JOHN Burnham Institute for Medical Research Burnham Center for Chemical Genomics SCHREIBER, STUART Broad Institute Broad Institute Comprehensive Screening Center SKLAR, LARRY University of New Mexico University of New Mexico Center for Molecular Discovery LI, MIN Johns Hopkins University Johns Hopkins Ion Channel Center JONSSON, COLLEEN Southern Research Institute Southern Research Specialized Biocontainment Screening Center (SRSBSC) AUBE, JEFFREY University of Kansas University of Kansas Specialized Chemistry Center LINDSLEY, CRAIG Vanderbilt University The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development Special Terms and Conditions of the Award (PDF, 10 pages) RFA-RM-04-017 Molecular Libraries Screening Centers Network (MLSCN) PI Name Institution Name Title AUSTIN, CHRIS NHGRI NIH Chemical Genomics Center (NCGC) Additional Information DIAMOND, SCOTT UNIVERSITY OF PENNSYLVANIA The Penn Center for Molecular Discovery Additional Information Abstract (from CRISP) DINGLEDINE, RAYMOND EMORY UNIVERSITY Emory Chemistry-Biology Center in the MLSCN Abstract (from CRISP) LAZO, JOHN UNIVERSITY OF PITTSBURGH AT PITTSBURGH University of Pittsburgh Molecular Libraries Screening Center Additional Information Abstract (from CRISP) PIAZZA, GARY SOUTHERN RESEARCH INSTITUTE Southern Research Molecular Libraries Screening Center Abstract (from CRISP) REED, JOHN THE BURNHAM INSTITUTE San Diego Center for Chemical Genomics Abstract (from CRISP) ROSEN, HUGH THE SCRIPPS RESEARCH INSTITUTE Scripps Research Institute Molecular Screening Center Abstract (from CRISP) ROTHMAN, JAMES COLUMBIA UNIVERSITY MEDICAL CENTER MLSCN Center at Columbia University Abstract (from CRISP) SKLAR, LARRY UNIVERSITY OF NEW MEXICO ALBUQUERQUE New Mexico Molecular Libraries Screening Center Additional Information Abstract (from CRISP) WEAVER, C. DAVID VANDERBILT UNIVERSITY Vanderbilt Screening Center for GPCRs, Ion Channels, and Transporters Additional Information Abstract (from CRISP) Special Terms and Conditions of Roles and Responsibilities Standard to Each Screening Center (PDF, 6 pages) CONTRACTS PI Name Institution Name Title LIVINGSTON, DOUG Discovery Partners International Inc. Molecular Libraries Small Molecule Repository PAR-08-034 & PAR-08-035 Solicitation of Assays for HTS in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03/X01) PI Name Institution Name Title ABOOD, MARY E CALIFORNIA PACIFIC MED CTR RES INSTITUTE Screening for Selective Ligands for GPR55 (PDF, 1 page) ANDROPHY, ELLIOT J UNIV OF MASSACHUSETTS MED SCH WORCESTER High Throughput Screen for SMA BARAK, LAWRENCE S DUKE UNIVERSITY Agonists and Antagonists for the Kappa Opioid Receptor (PDF, 1 page) BRODSKY, JEFFREY L UNIVERSITY OF PITTSBURGH AT PITTSBURGH Identification of SV40 T Antigen Inhibitors: A Route to Novel Anti-Viral Reagent FLAUMENHAFT, ROBERT C BETH ISRAEL DEACONESS MEDICAL CENTER Chemical Genetic Analysis of Platelet Granule Secretion GARDINER, DONALD L QUEENSLAND INSTITUTE OF MEDICAL RESEARCH Identification of Inhibitors of the Plasmodium Falciparum M18 Metalloprotease HEILIG, MARKUS ALEXANDER U.S. NATIONAL INST ALCOHOL AB/ALCOHOLISM Identification of Small Molecule Antagonists for the Neuropeptide Receptor Using (PDF, 2 pages) KAUFMAN, RANDAL J UNIVERSITY OF MICHIGAN AT ANN ARBOR High Throughput Chemical Genomics to Identify Novel Inhibitors of CHOP LEVINE, ROSS L SLOAN-KETTERING INSTITUTE FOR CANCER RES High Throughput Screen for JAK2V617F Mutant Selective Inhibitors LITTMAN, DAN R NEW YORK UNIVERSITY SCHOOL OF MEDICINE Screen for Small Molecule Compounds that Modulate the Transcriptional Activity of MAKHINA, ELENA UNIVERSITY OF PITTSBURGH AT PITTSBURGH High Throughput Screening for Potassium Channel Modulators MAZIN, ALEXANDER V DREXEL UNIVERSITY A Screen for Modulators of Human Rad51, a Key DNA Repair Protein MCDONOUGH, PATRICK M VALA SCIENCES, INC A High Throughput Imaging Assay for Hepatic Lipid Droplet Formation MILLAN, JOSE LUIS BURNHAM INSTITUTE FOR MEDICAL RESEARCH The Role of PHOSPHO1 in the Initiation of Skeletal Calcification PELLECCHIA, MAURIZIO BURNHAM INSTITUTE FOR MEDICAL RESEARCH Novel Chemical Probes Targeting the FRB Domain of mTOR STOCKWELL, BRENT R COLUMBIA UNIV NEW YORK MORNINGSIDE Screen for RAS-Selective Lethal Compounds and VDAC Ligands SUN, HONGMIN UNIVERSITY OF MISSOURI-COLUMBIA High Throughput Screening for Small Compounds to Inhibit the Expression of Strept YANG, VINCENT W EMORY UNIVERSITY High Throughput Screen for Small Molecule Inhibitors of Colorectal Cancer Cell Pr CHEN, YUAN CITY OF HOPE/BECKMAN RESEARCH INSTITUTE A high throughput screening assay for the identification of SUMOylation inhibitor DENISON, MICHAEL STEVEN UNIVERSITY OF CALIFORNIA DAVIS High Throughput Screening for Activators of the Ah Receptor (PDF, 2 pages) HARDING, HEATHER P NEW YORK UNIVERSITY SCHOOL OF MEDICINE Screen for Inhibitors of 2' Phosphotransferase HASLAM, DAVID B WASHINGTON UNIVERSITY A SCREEN FOR SMALL MOLECULE INHIBITORS OF SHIGA TOXIN AND RICIN ACTIVITY HEIL, MARINTHA L SOUTHERN RESEARCH INSTITUTE A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activ KUPERSHMIDT, SABINA VANDERBILT UNIVERSITY Identification of compounds that protect HERG from block by proarrhythmic agents MISTELI, TOM U.S. NATIONAL CANCER INSTITUTE A high-throughput screen for pre-mRNA splicing modulators (PDF, 2 pages) MOORE, CLAIRE L; KUMAMOTO, CAROL A TUFTS UNIVERSITY BOSTON High throughput screening for polyadenylation inhibitors using the MLSCN library NAKAMURA, KAZUHIRO UNIVERSITY OF NORTH CAROLINA CHAPEL HILL TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain Interaction NOTHACKER, HANS-PETER UNIVERSITY OF CALIFORNIA IRVINE High-Throughput Assay for G-Protein Coupled Receptors in Pain Research PELLETIER, JERRY MC GILL UNIVERSITY Interdicting Eukaryotic Translation Initiation Factor-RNA Interaction REED, JOHN C BURNHAM INSTITUTE FOR MEDICAL RESEARCH High Throughput Screening Assays for NOD1 and NOD2 Inhibitors WANG, ZHIYONG SALK INSTITUTE FOR BIOLOGICAL STUDIES High throughput screen for the master regulator of obesity and diabetes p/CIP ZHENG, WEI U.S. NATIONAL HUMAN GENOME RESEARCH INST Identification of Activators and Inhibitors of alpha-Glucosidase as Potential Cha (PDF, 1 page) ZHENG, WEI U.S. NATIONAL HUMAN GENOME RESEARCH INST HTS for Identifying Activators and Inhibitors of Alpha-Galactosidase A for the Po (PDF, 1 page) PAR-06-259 & PAR-06-545 Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (R03/X01) PI Name Institution Name Title BALLATORE, CARLO UNIVERSITY OF PENNSYLVANIA High Throughput Screening for Small Molecule Inhibitors of Heparin-Induced Tau Fi BUGGE, THOMAS H U.S. NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH Quantitative High Throughput Screening for Anthrax Toxin Inhibitors BURKART, MICHAEL D UNIVERSITY OF CALIFORNIA SAN DIEGO A qHTS FRET-Quench Assay for 4?-Phosphopantethienyltransferases BUSHWELLER, JOHN H UNIVERSITY OF VIRGINIA CHARLOTTESVILLE High Throughput Screen for Novel Inhibitors of Platelet Integrin alphaIIb-beta3 BUSHWELLER, JOHN H UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Screening for Inhibitors of Runx and CBFb Translocation Products in Leukemia COOMBS, GARY UNIVERSITY OF UTAH The Role of Wnts in Stem Cell DAY, BILLY W UNIVERSITY OF PITTSBURGH AT PITTSBURGH HTS Assays for Microtubule Stabilizers FREEZE, HUDSON H BURNHAM INSTITUTE FOR MEDICAL RESEARCH Therapeutic Inhibitors of Phosphomannose Isomerase GARDINER, DONALD L QUEENSLAND INSTITUTE OF MEDICAL RESEARCH High Through-Put Screening of Plasmodium Falciparum Aminopeptidases GERSHENGORN, MARVIN C U.S. NATIONAL INST DIABETES/DIGST/KIDNEY Ligand Discovery for Thyroid-Stimulating Hormone Receptor (TSHR) by Virtual and H GLASS, JONATHAN DAVID EMORY UNIVERSITY Discovering Calpain Inhibitors of Neurological Diseases GRIMALDI, MAURIZIO SOUTHERN RESEARCH INSTITUTE An HTS Assay Based on Neuronal Human Cells to Identify Small Molecule Activators HASELBECK, ROBERT JOHN RX3 PHARMACEUTICALS, INC. Identification of Target-Specific Antimicrobials HELLER, STEFAN STANFORD UNIVERSITY Identification of Modulators of the TRPML3 and TRPN1 ion Channels HOLMAN, THEODORE R UNIVERSITY OF CALIFORNIA SANTA CRUZ High Throughput and Virtual Screening for Human 12-LO, 15-LO-1, and 15-LO-2 Inhibitors KOLE, RYSZARD UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Modulation of Alternative Splicing by HTS Identified Compounds LARSON, RICHARD S UNIVERSITY OF NEW MEXICO ALBUQUERQUE Multiplex Screening for ABC Transporter Inhibitors LEISSRING, MALCOLM A SCRIPPS RESEARCH INSTITUTE HTS for Modulators of Beta-Amyloid Catabolism by Insulin-Degrading Enzyme LEWIS, KIM NORTHEASTERN UNIVERSITY Screening C. Albicans Biofilms for Lethal Potentiators of Miconazole LI, QIANJUN SOUTHERN RESEARCH INSTITUTE A HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus Infections LIU, PU PAUL U.S. NATIONAL HUMAN GENOME RESEARCH INST High-Throughput Screening for Compounds Blocking Interaction Between CBFb-SMMHC a MARSHALL, WALLACE UNIVERSITY OF CALIFORNIA SAN FRANCISCO Small Molecule Inhibitors of Cilia MATTS, ROBERT L OKLAHOMA STATE UNIVERSITY STILLWATER High Throughput Screen for Hsp90 Inhibitors MCDONOUGH, PATRICK M VALA SCIENCES, INC. High Throughput Imaging Assay for Beta-Catenin MCNEIL, MICHAEL R COLORADO STATE UNIVERSITY – FORT COLLINS HTS Screen of TB RmIC & RmID dTDP-Rhamnose Formation Enzymes MILLAN, JOSE LUIS BURNHAM INSTITUTE FOR MEDICAL RESEARCH Activators of the Pyrophosphatase Activity of Alkaline Phosphatase MORRIS, JAMES CULVIN CLEMSON UNIVERSITY Identification of Inhibitors of Trypanosoma Brucei Hexokinases NATARAJAN, AMARNATH UNIVERSITY OF TEXAS MEDICAL BR GALVESTON HTS to Identify Small Molecule Inhibitors of Phospho-Specific Protein-Protein Int NUNNARI, JODI M UNIVERSITY OF CALIFORNIA DAVIS Chemical Genetic Screens for Mitochondrial Division and Fusion Inhibitors PASSER, BRENT J MASSACHUSETTS GENERAL HOSPITAL A High-Throughput Screen to Identify Small Molecule Compounds That Augment PELLECCHIA, MAURIZIO BURNHAM INSTITUTE FOR MEDICAL RESEARCH Novel Chemotypes Against Influenza A Virus PELLETIER, JERRY MCGILL UNIVERSITY Screening for Small Molecule Inhibitors of Eukaryotic Translation Initiation PLEMPER, RICHARD K. EMORY UNIVERSITY High Throughput Screening-Based Identification of Measles Virus Probes REED, JOHN C BURNHAM INSTITUTE FOR MEDICAL RESEARCH Chemical Antagonists of IAP-Family Anti-Apoptotic Proteins REED, JOHN C BURNHAM INSTITUTE FOR MEDICAL RESEARCH Chemical Inhibitors of ER Stress RON, DAVID NEW YORK UNIVERSITY SCHOOL OF MEDICINE Screening for Inhibitors of the Integrated Stress Response ROZANOV, DMITRI BURNHAM INSTITUTE FOR MEDICAL RESEARCH Screening for Chemicals that Potentiate TRAIL-Induced Apoptosis of Cancer Cells SEVERSON, WILLIAM E SOUTHERN RESEARCH INSTITUTE A Cell Based HTS Approach for the Discovery of New Inhibitors of the H5N1 Virus SEVERSON, WILLIAM E SOUTHERN RESEARCH INSTITUTE A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV SHOICHET, BRIAN K UNIVERSITY OF CALIFORNIA SAN FRANCISCO Promiscuous and Specific Inhibitors of Cruzain SMITH, SUSAN M.E. EMORY UNIVERSITY HTS to Find Inhibitors of p47phox, a Regulatory Protein of Noxes SMITHGALL, THOMAS EDWARD UNIVERSITY OF PITTSBURGH AT PITTSBURGH Targeting HIV-1 Nef with Small Molecules STAUFFACHER, CYNTHIA V PURDUE UNIVERSITY WEST LAFAYETTE Scaffolds for Synthesis of Probes Directed Against Class II HMG-CoA Reductases STOCKWELL, BRENT R COLUMBIA UNIV NEW YORK MORNINGSIDE Luciferase Screen for MDM2 E3 Ligase Inhibitors TOBIAS, PETER S SCRIPPS RESEARCH INSTITUTE High Throughput Screening for Toll-Like Receptors WANDINGER-NESS, ANGELA UNIVERSITY OF NEW MEXICO ALBUQUERQUE HTS to Identify Specific Small Molecule Inhibitors and Activators of Ras and Ras- WANG, QIMING JANE UNIVERSITY OF PITTSBURGH AT PITTSBURGH IMAP-Based Fluorescent Polarization Assay for High Throughput Screening of Protein YIN, XIAO-MING UNIVERSITY OF PITTSBURGH AT PITTSBURGH High-Content Cell-Based Screening for Modulators of Autophagy YUAN, JUNYING HARVARD UNIVERSITY (MEDICAL SCHOOL) A High Throughput Screen for Inhibitors of a Novel Necrotic Cell Death Pathway ZHENG, WEI U.S. NATIONAL HUMAN GENOME RESEARCH INSTITUTE HTS for Identifying the Cell-Membrane Permeable IMPase Inhibitors ZHENG, WEI U.S. NATIONAL HUMAN GENOME RESEARCH INSTITUTE HTS for Identification of Inhibitors Against the ERK Signaling Pathway using a Ho PAR-06-259 Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (X01) Reissue of PAR-05-147 PI Name Institution Name Title DE FIGUEIREDO, PAUL TEXAS A&M UNIVERSITY SYSTEM Drug Discovery for Bone Marrow Failure Diseases FRANK, DAVID A DANA-FARBER CANCER INSTITUTE Modulators of STAT transcription factors for the targeted therapy of cancer GRIFFIN, PATRICK R SCRIPPS RESEARCH INSTITUTE HTRF screen for identifying SRC-1 selective agonists of PPARgamma GU, HOWARD H OHIO STATE UNIVERSITY High Throughput Screening for Cocaine Antagonists KUHN, PETER SCRIPPS RESEARCH INSTITUTE EphB4-Ephrin-B2 Antagonists for Angiogenesis and Carcinogenesis Inhibition LIOU, HSIOU-CHI IMMUNETARGET, INC. Development of Screening Assays for NF-KB-Rel Inhibitors MARTINEZ, ELISABETH D UNIVERSITY OF TEXAS SW MED CTR/DALLAS High Throughput Screens for Epigenetic Modulators MERCOLA, MARK BURNHAM INSTITUTE FOR MEDICAL RESEARCH Screen for Compounds that Promote Cardiomyocyte Cell Cycle Entry NICHOLSON, BENJAMIN PROGENRA, INC. Identification of Compounds that Modulate Human Deubiquitinase Function NIRENBERG, MARSHALL WARREN U.S. NATIONAL HEART LUNG & BLOOD INS Molecules that Enhance CREB Activity QU, ZHICAN SOUTHERN RESEARCH INSTITUTE Cell-Based Screening for Anti-Angiogenic Agents REED, JOHN C BURNHAM INSTITUTE FOR MEDICAL RESEARCH High Throughput Screening Assay for Hsp70 Inhibitors ROGERS, JACK T MASSACHUSETTS GENERAL HOSPITAL MLSCN SCReen of the Amyloid precursor protein 5'untranslated region SEIDAH, NABIL G. CLINICAL RESEARCH INSTITUTE OF MONTREAL High Throughput Screens for targets of the Proprotein Convertases Furin, PC5, SKI-1 and PCSK9 Using Cell-Based Assays SHOICHET, BRIAN K. UNIVERSITY OF CALIFORNIA SAN FRANCISCO Promiscuous and Specific Inhibitors of B-lactamase SKLAR, LARRY A. UNIVERSITY OF NEW MEXICO ALBUQUERQUE HTS for BCI-2 Family Multiplex SUN, YI UNIVERSITY OF MICHIGAN-ANN ARBOR Synthetic Lethal Screen for Compounds to Kill Cancer Cells with p53 Mutation PAR-06-259 Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (X01) Reissue of PAR-05-147 PI Name Institution Name Title AULD, DOUGLAS S NIH/NHGRI Identification of lkappaBalpha Stabilizers in a Human Lymphoma Cell Line Using A BRISSON, MARNI J UNIVERSITY OF PITTSBURGH Homogeneous Flourescence Intensity High Throughput Assay for Cdc25B Phosphatase I DESAI, SANJAY A NAT'L INST OF ALLERGY/INFEC DISE High-Throughput Screen for Antagonists of the Plasmodial Surface Anion Channel (PSAC) FIELDS, GREGG B FLORIDA ATLANTIC UNIVERSITY ADAMTS/MMP Drug Development GRESHAM, HATTIE D UNIVERSITY OF NEW MEXICO ALBUQUERQUE Small Molecule Inhibition of Staphylococcus Aureus Virulence HAMMOCK, BRUCE D UNIVERSITY OF CALIFORNIA DAVIS Novel sEH Inhibitors for the Therapeutic Treatment of Hypertension and Inflammat HOFFMANN, MICHAEL UNIVERSITY OF WISCONSIN Targeting a Protein Interaction Site on Smad Transcription Factors KATZENELLENBOGEN, JOHN A UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Screen for Coactivator Binding Inhibitors to Block Estrogen Action KELLY, JEFFERY W SCRIPPS RESEARCH INSTITUTE High Throughput Screening for Protein Misfolding Disease Therapeutics LEYH, THOMAS S. YESHIVA UNIVERSITY Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae MCPIKE, MARK P ORTHOSYSTEMS, INC. Rapid Mix and Measure HTS Assays for Anti-NCp7 Drug Discovery PELLECCHIA, MAURIZIO BURNHAM INSTITUTE Chemical Tools to Investigate the Protein Folding/Degradation Machinery STRONGIN, ALEX BURNHAM INSTITUTE Screening Chemicals to Suppress MT1-MMP Synthesis in Cancer THOMPSON, TODD A UNIVERSITY OF NEW MEXICO ALBUQUERQUE Activators of Prostate Cell Differentiation WELLS, JAMES A UNIVERSITY OF CALIFORNIA SAN FRANCISCO Inhibitors of Caspase-1 and Caspase-7 WILLIAMSON, JAMES R SCRIPPS RESEARCH INSTITUTE High Throughput Screen for Inhibitors of the HIV Rev-RRE RNA Interaction YAFFE, MICHAEL MASSACHUSETTS INST OF TECHNOLO High Throughput Screening for Inhibitors of the Polo Box Domain of Human Polo-Lik ZHENG, WEI NIH/ NHGRI HTS for Identification of Glucocerebrosidase Activators and Inhibitors as Pharmac PAR-05-147 Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) (X01) Reissue of PAR-05-060 PI Name Institution Name Title CONN, P JEFFREY VANDERBILT UNIVERSITY Discovery of novel allosteric modulators of the M1 muscarinic receptor HARSAY, EDINA UNIVERSITY OF KANSAS LAWRENCE Chemical Genetics Screens to Identify Modulators of Post-Golgi Transport KURET, JEFF A OHIO STATE UNIVERSITY Ligands for premortem diagnosis and treatment of Alzheimer's disease LEWIS, KIM A NORTHEASTERN UNIVERSITY A Screen for Novel Antimicrobials LI, XIAOLING ORPHAGEN PHARMACEUTICALS High Throughput Screening of Select Orphan Nuclear Receptors MCHENRY, CHARLES S UNIVERSITY OF COLORADO DENVER/HSC AURORA Conducting a HTS against a Multi-protein DNA Replication System MERCOLA, MARK BURNHAM INSTITUTE Screening for Compounds That Modulate Insulin Promoter Activity in TRM-67 Cells MERCOLA, MARK BURNHAM INSTITUTE Screening for Compounds That Modules Insulin Promoter Activity in MIN-6 Cells MILLAN, JOSE LUIS BURNHAM INSTITUTE Pharmacological inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) MUSTELIN, TOMAS M BURNHAM INSTITUTE HTS for HePTP Inhibitors-a leukemia target MUSTELIN, TOMAS M BURNHAM INSTITUTE HTS for LYP inhibitors-an autoimmunity target NISWENDER, COLLEEN M VANDERBILT UNIVERSITY Discovery of novel allosteric agonists of the M4 muscarinic receptor PARNIAK, MICHAEL A UNIVERSITY OF PITTSBURGH AT PITTSBURGH HTS assays for inhibitors of HIV RNase H PASQUALE, ELENA B BURNHAM INSTITUTE EphA4 Receptor Antagonists for Nervous System Repair PAVITT, GRAHAM D UNIVERSITY OF MANCHESTER, UK High-throughput screen for a therapeutic agent for elF2B-related disorders PIAZZA, GARY A SOUTHERN RESEARCH INSTITUTE Identification of Molecular Probes that Reverse MRP-Mediated Drug Resistance PROSSNITZ, ERIC R UNIVERSITY OF NEW MEXICO ALBUQUERQUE MLSCN Assay for Ligands of GRP30 and Classical Estrogen Receptors PROSSNITZ, ERIC R UNIVERSITY OF NEW MEXICO ALBUQUERQUE MLSCN Assay for Inhibitors of Arrestin-GPR Interactions REED, JOHN C BURNHAM INSTITUTE Chemical Inhibitors of anti-apoptotic protein Bfl-1 REED, JOHN C BURNHAM INSTITUTE Chemical inhibitors of antigen receptor-induced NF-?Beta activation RUBENSTEIN, AMY L ZYGOGEN, LLC Zebrafish Lipid Metabolism Assay SHARLOW, ELIZABETH R. UNIVERSITY OF PITTSBURGH Fluroscence polarization assay for PLK1 inhibitors SKLAR, LARRY A UNIVERSITY OF NEW MEXICO ALBUQUERQUE MLSCN Assay for Allosteric Ligands for the VLA-4 Integrin SKOWYRA, DOROTA ST. LOUIS UNIVERSITY ATP Hydrolysis-dependent disassembly of the 26S proteosome as an HTS assay for fl STRONGIN, ALEX Y BURNHAM INSTITUTE Inhibitors of the NS3 Proteinase of West Nile and Dengue Viruses STURGESS, MICHAEL A CHAPERONE TECHNOLOGIES, INC. Development of a HTS assay for Inhibitors of bacterial DnaK WATTS, VAL J PURDUE UNIVERSITY WEST LAFAYETTE Allosteric Modulators of D1 Receptors YI, FANG YALE UNIVERSITY Identifying novel Hsp90 Inhibitors by disrupting its cochaperone interaction usin PAR-05-060 Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) (R03) PI Name Institution Name Title APPEL, BRUCE VANDERBILT UNIVERSITY A Screen For Drugs That Promote Oligodendrocyte Formation in Zebrafish CHEN, BENJAMIN P UNIVERSITY OF TEXAS SW MED CTR/DALLAS Screening of DNA-PKcs Autophosphorylation Blockers via a Cell-Based Approach CHENG, XIAODONG UNIVERSITY OF TEXAS MEDICAL BR GALVESTON Chemical Genetic Screening of Oncogene RAS-Based Inhibitors CHIOSIS, GABRIELA SLOAN-KETTERING INSTITUTE FOR CANCER RES FP Assay for Isolation of Hsp90 Inhibitors CHIOSIS, GABRIELA SLOAN-KETTERING INSTITUTE FOR CANCER RES Isolation of Inhibitors of Her-Kinase Expression DIAMOND, SCOTT L UNIVERSITY OF PENNSYLVANIA Multiplexed HTS of Serine and Cysteine Proteases EDWARDS, BRUCE UNIVERSITY OF NEW MEXICO ALBUQUERQUE Assay for Formylpeptide Receptor Family Ligands FU, HAIAN EMORY UNIVERSITY AlphaScreen Technology for High Throughput Screening of 14-3-3/Raf-1 Disruptors GOLDFARB, DAVID S UNIVERSITY OF ROCHESTER Yeast Lifespan Chemical Screening LAZO, JOHN S UNIVERSITY OF PITTSBURGH AT PITTSBURGH Chemical Complementation Assay for MKP-1 LAZO, JOHN S UNIVERSITY OF PITTSBURGH AT PITTSBURGH Chemical Complementation Assay for MKP-3 LAZO, JOHN S UNIVERSITY OF PITTSBURGH AT PITTSBURGH In Vitro High Throughput Screening Assay for MKP-1 LAZO, JOHN S UNIVERSITY OF PITTSBURGH AT PITTSBURGH In Vitro High Throughput Screening Assay for MKP-3 MAYER, THOMAS COLUMBIA UNIVERSITY HEALTH SCIENCES Cellular Assay for TNF Alpha Induced NF Kappa B Translocation MAYER, THOMAS COLUMBIA UNIVERSITY HEALTH SCIENCES Cellular Assay for TNF Alpha Induced E-Selectin Expression MAYER, THOMAS COLUMBIA UNIVERSITY HEALTH SCIENCES Cellular Assay for the Presentation of the Adhesion Molecule VCAM on the surface of HUVEC cells MUSTAEV, ARKADY PUBLIC HEALTH RESEARCH INSTITUTE Development of the HTS Assay for E. Coli RNA Polymerase (RNAP) NISWENDER, COLLEEN M VANDERBILT UNIVERSITY Measurement of GPCR-mediated thallium flux through GIRK Channels PAUMET, FABIENNE COLUMBIA UNIVERSITY HEALTH SCIENCES Unraveling the Molecular Mechanisms of Phagocytosis ROTHMAN, JAMES E COLUMBIA UNIVERSITY HEALTH SCIENCES Aggregation and Clearance of Mutant Huntingtin ROTHMAN, JAMES E COLUMBIA UNIVERSITY HEALTH SCIENCES Regulation of Neurotransmitter Transporter Recycling SANNA M. GERMANA SCRIPPS RESEARCH INSTITUTE MLSCN HTS Assays R03 - S1P1 TEITLER, MILT ALBANY MEDICAL COLLEGE OF UNION UNIV Human 5HT 1E Serotonin Receptor Drug Development WALKER, SUZANNE HARVARD UNIVERSITY (MEDICAL SCHOOL) Identification of O-GlcNAc Transferase Inhibitors by HTS WHITE, E. LUCILE SOUTHERN RESEARCH INSTITUTE High Throughput Screen for Mycobacterium Tuberculosis Pantothenate Synthetase WILKINSON, KEITH D EMORY UNIVERSITY HTS Assay for Inhibitors of BAP1, a BRCA1 Associated Deubiquitinating Enzyme WILLIAMS, DAVID L ILLINOIS STATE UNIVERSITY HTS for Inhibitors of Schistosoma Mansoni Peroxiredoxins ZHOU, MING COLUMBIA UNIVERSITY HEALTH SCIENCES Small-Molecule Modulators of a Family of Voltage-Dependent Potassium Channels Technology Development PAR-08-024 Assay Development for High Throughput Molecular Screening (R21) PI Name Institution Name Title BARIC, RALPH S. UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Yeast Based Assays for Chemical Screens Against SARS-CoV Target BRAUTIGAN, DAVID L. UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Triple threat screening for modifiers of Protein Ser/Thr Phosphatase 2C CHAUDHARY, PREET M. UNIVERSITY OF PITTSBURGH AT PITTSBURGH Small Molecule Inhibitors of K13-Induced NF-kB Activation CUI, LIWANG PENNSYLVANIA STATE UNIVERSITY-UNIV PARK Development of a cell-based method for high-throughput drug screening in malaria FABRIS, DANIELE UNIVERSITY OF MARYLAND BALT CO CAMPUS MS-based screening of candidate inhibitors of protein-RNA and RNA-RNA interaction FLOYD, SCOTT R MASSACHUSETTS INSTITUTE OF TECHNOLOGY High-content screening for modifiers of the DNA damage response JEGLA, TIMOTHY J. SCRIPPS RESEARCH INSTITUTE HTS Assays for Specific Modulators of Neuronal Acid-Sensitive K+ Channels LIEBERMAN, PAUL M. WISTAR INSTITUTE Assay For Inhibitors of Epstein-Barr Virus YANG, PRISCILLA LI-NING HARVARD UNIVERSITY (MEDICAL SCHOOL) Development of Cellular Assays of Dengue Virus Infection ZHAO, RICHARD YUQI UNIVERSITY OF MARYLAND BALTIMORE Fission Yeast as a HTS Platform for New Molecular Probes of HIV-1 VPR-Medicated A RFA-RM-07-008 Assay Development for High Throughput Molecular Screening (R21) This is a reissue of RFA-RM-07-001 PI Name Institution Name Title DAVISSON, VINCENT JO PURDUE UNIVERSITY WEST LAFAYETTE High-throughput Chemotyping of Yeast Signature Strains Reflecting Hsp90 Biology FENG, XU UNIVERSITY OF ALABAMA AT BIRMINGHAM Cell-Based Assays for Identifying Anti-RANK Signaling Agents GRAEF, ISABELLA A STANFORD UNIVERSITY HTS Assay Development for Modulators of a Nuclear Import/Export Switch GRANNEMAN, JAMES G WAYNE STATE UNIVERSITY HTS for Novel Activators of Adipocyte and Myocyte Lipolysis HARSAY, EDINA UNIVERSITY OF KANSAS LAWRENCE Pathway-Specific Inhibitors of Post-Golgi Transport ILAGAN, MA.XENIA G WASHINGTON UNIVERSITY Screening for Novel Modulators of Notch/RBPjk Interactions JOHNSON, JEFFREY DALE METABOLEX, INC. High Throughput Screening to Identify Inhibitors of a Fifth Mammalian Hexokinase KAO, GARY D UNIVERSITY OF PENNSYLVANIA The Zebrafish Radioresponse for High-Throughput and -Content Molecular Screening KAYE, KENNETH M BRIGHAM AND WOMEN'S HOSPITAL Chemical Probes of Kaposi's Sarcoma Herpesvirus Latent Infection KRANZ, ROBERT G WASHINGTON UNIVERSITY HTS for Cytochrome C Synthesis Pathways MAITRA, RANGAN RESEARCH TRIANGLE INSTITUTE Anti-inflammatory Assay for Cystic Fibrosis NIKOLOV, DIMITAR B SLOAN-KETTERING INSTITUTE FOR CANCER RES Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali PETRIE, HOWARD T SCRIPPS RESEARCH INSTITUTE Assay Development and Screening for Notch Agonists PETRUKHIN, KONSTANTIN COLUMBIA UNIVERSITY HEALTH SCIENCES Development of the HTS Assay for Agonists of the Orphan Nuclear Receptor NR2E3 PRICE, BRENDAN D DANA-FARBER CANCER INSTITUTE Identification of Inhibitors of the Tip60 Histone Acetyltransferase REICHMAN, MELVIN LANKENAU INSTITUTE FOR MEDICAL RESEARCH Fructosamine-3-Kinase Assay Development and Validation for HTS SALVESEN, GUY S BURNHAM INSTITUTE FOR MEDICAL RESEARCH Development of a High-Throughput Assay for Human Desumoylating Enzymes [SENPs] SCHNAUFER, ACHIM C SEATTLE BIOMEDICAL RESEARCH INSTITUTE A High Throughput Assay to Identify Onhibitors of Trypanosome RNA Editing Ligase WOLF, DIETER A BURNHAM INSTITUTE FOR MEDICAL RESEARCH Optimized High-Throughput Screen for Small Molecule Inhibitors of P27 Degradation XU, BO SOUTHERN RESEARCH INSTITUTE An HTS Assay for Inhibitors of NBS1-ATM Interactions ZHOU, JIANHUA UNIV OF MASSACHUSETTS MED SCH WORCESTER Cell Based Assays for Compounds That Regulate Tau Exon 10 Splicing RFA-RM-07-001 Assay Development for High Throughput Molecular Screening (R21) Reissue of RFA-RM-06-004, which was previously released November 2, 2005 RFA-RM-05-011; Reissue for FY2005 of RFA-RM-04-012 PI Name Institution Name Title ARANY, ZOLTAN P. DANA-FARBER CANCER INSTITUTE High throughput screening for modulators of the transcriptional coactivator PGC-1 ARGON, YAIR CHILDREN'S HOSPITAL OF PHILADELPHIA Developing HTS assays for the functions of the chaperone GRP94 BLENIS, JOHN HARVARD UNIVERSITY (MEDICAL SCHOOL) Development of a high content cell based screen for inhibitors of the mTOR signal CLARDY, JON HARVARD UNIVERSITY (MEDICAL SCHOOL) Target-Based High-Throughput Screens for Plasmodium falciparum Malaria CLEARY, MICHAEL L STANFORD UNIVERSITY Inhibitors of MLL-Menin Interaction DUTTA, ANINDYA UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Screen for TIP60 Inhibitors FIDOCK, DAVID A YESHIVA UNIVERSITY A cell-based HTS for delayed death inhibitors of the malarial parasite plastid GERACE, LARRY R SCRIPPS RESEARCH INSTITUTE Screen for Small Molecule Inhibitors of Nuclear Protein Import GINSBERG, MARK H UNIVERSITY OF CALIFORNIA SAN FRANCISCO Assay Development for HT Molecular Screening for Inhibitors of Integrin Signaling GOCHIN, MIRIAM TOURO UNIVERSITY CALIFORNIA High-Throughput Screening for Human Immunodeficiency Virus Fusion Inhibitors HARRIS, JASON B MASSACHUSETTS GENERAL HOSPITAL Development of a small molecule screen for PhoP regulon inhibitors in Salmonella HODDER, PETER SIMMONS SCRIPPS RESEARCH INSTITUTE HTS assays for discovery of novel beta-lactamase inhibitors via click chemistry HUANG, QIHONG WISTAR INSTITUTE A Cell-based Screen for Small Molecule Modulators of the miRNA Pathway JAIN, ANJALI CEDARS-SINAI MEDICAL CENTER Functional Genomics Tools for HER2 heterodimers and Androgen Receptor Signaling JARDETZKY, THEODORE S NORTHWESTERN UNIVERSITY HTS for Small Molecule Modulators of EB Virus Protein-Protein Interactions KAMPF, J PATRICK FFA SCIENCES, LLC An HTS Assay for the Discovery of Specific Inhibitors of Adipocyte FABP LAVAN, BRIAN METABOLEX, INC. High Throughput Screening for Identification of AKR1C3 Inhibitors LI, RONGBAO SOUTHERN RESEARCH INSTITUTE HTS Assay Development for Discovery of Specific PYK2 Inhibitors PETERSON, JEFFREY R INSTITUTE FOR CANCER RESEARCH Allosteric, Small-Molecule Inhibitors of Actin Nucleation by the Formin mDia1 PIAZZA, GARY A SOUTHERN RESEARCH INSTITUTE A Novel HTS Cell-Based Assay For Cyclic GMP ROGERS, JACK T MASSACHUSETTS GENERAL HOSPITAL MLSN Screen of the PD Alpha Synuclein 5'UTR ROGERS, MICHAEL S CHILDREN'S HOSPITAL BOSTON Assay for Inhibitors of Angiogenesis and Anthrax Toxin Receptor 1 RYDER, SEAN PATRICK UNIV OF MASSACHUSETTS MED SCH WORCESTER Small molecule effectors of maternal gene expression in C. elegans embryogenesis SANDER, CHRIS SLOAN-KETTERING INSTITUTE FOR CANCER RES High-throughput identification of compounds that modulate the TGF-beta pathway SMITH, LAYTON H SCRIPPS RESEARCH INSTITUTE HTS to identify chemical probes of the apelin receptor signaling pathway WUTTKE, DEBORAH S. UNIVERSITY OF COLORADO AT BOULDER Development of a HTS Assay Targeting End Protection of Telomeres RFA-RM-06-004 Assay Development for High Throughput Molecular Screening (R03/R21) Reissue for FY2006 of RFA-RM-05-011 PI Name Institution Name Title AGAISSE, HERVE F YALE UNIVERSITY SCHOOL OF MED High-throughput screen for compounds affecting intracellular pathogen infection AIKEN, CHRISTOPHER R VANDERBILT UNIVERSITY Discovering Novel Inhibitors of HIV-1 Maturation AYAD, NAGI G SCRIPPS FLORIDA RESEARCH INSTITUTE Small-molecule Inhibitors of Wee1 Degradation and Mitotic Entry BALK, STEVEN P BETH ISRAEL DEACONESS MEDICAL CENTER HTS for Androgen Receptor Antagonists that Recruit NCoR BOTTINI, NUNZIO UNIVERSITY OF SOUTHERN CALIFORNIA Fluorogenic PTP Assay for Use in HTS of Novel LYP Inhibitors BROWN, STEVEN J SCRIPPS RESEARCH INSTITUTE Development of a High Throughput Screening Galanin 3 Receptor Assay CRAWFORD, BRETT E ZACHARON PHARMACEUTICALS, INC. Development of cell-based assays for discovery of GIcNAc-TV inhibitors CUNNINGHAM, KYLE W JOHNS HOPKINS UNIVERSITY Assays for compounds that block or stimulate yeast cell death DAY, BILLY W UNIVERSITY OF PITTSBURGH AT PITTSBURGH High Throughput/Content Screens for Dynein Inhibitors DELISA, MATTHEW P CORNELL UNIVERSITY A cell-based screen for inhibitors of intracellular Abeta aggregation DENTON, JEROD S VANDERBILT UNIVERSITY Identification of novel modulators of ROMK K+ channel activity DESHMUKH, MOHANISH P UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Chemical Probes for Uncovering Differential Regulators of Apoptosis in Cells DJABALLAH, HAKIM SLOAN-KETTERING INSTITUTE FOR CANCER RES Novel & Selective Small Molecular Inhibitors of Human Peptide Deformylase HODGSON, LOUIS UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Screening for RhoC Activation and its modulation by GEFs HOFFMANN, F. MICHAEL UNIVERSITY OF WISCONSIN MADISON An HTS Assay for Inhibitors of Smad-dependent Transcriptional Responses to TGF-beta HOGENESCH, JOHN B UNIVERSITY OF PENNSYLVANIA A Dual Transcriptional and High Content Assay for Cryptochrome HUGHES, ROBERT E BUCK INSTITUTE FOR AGE RESEARCH A cell-based screen for small molecule binders of mutant huntingtin messenger RNA JEGLA, TIMOTHY J SCRIPPS RESEARCH INSTITUTE Development of HTS Assays for Sub-Threshold Potassium Channels JOHNSON, GARY L UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Inhibitor Screens for Five MAPK Kinase Kinases Important in Human Disease KHANNA, PYARE L DISCOVERX CORPORATION HTS Technology for Discovery of Drugs Targeting GPCR Oligomers LANDICK, ROBERT C UNIVERSITY OF WISCONSIN MADISON High-Throughput Identification of RNA polymerase inhibitors in vivo LEISNER, TINA M UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Developing HTS Assays for Novel Intracellular Regulators of Integrin Activation LEVINE, FRED UNIVERSITY OF CALIFORNIA SAN DIEGO High-Throughput Screen for Beta-Cell Replication LINDER, MAURINE E WASHINGTON UNIVERSITY Assay Development to Identify Palmitoylation Inhibitors of Neuronal Proteins LUO, HONGBO R CHILDREN'S HOSPITAL BOSTON High throughput screening for inhibitors of Akt plasma membrane translocation. MARZLUFF, WILLIAM F UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Screen for molecules inhibiting histone pre-mRNA processing MCNEIL, MICHAEL R COLORADO STATE UNIVERSITY-FORT COLLINS Glucosamine-1-phosphate and serine acetylases: HTS assays and configurations NETTLES, KENDALL W SCRIPPS RESEARCH INSTITUTE Assay Development for Identification of ER-NFkB Pathway Selective Agents NEUBIG, RICHARD R UNIVERSITY OF MICHIGAN Multiplexed flow cytometry screens for RGS inhibitors NIKOLOVSKA-COLESKA, ZANETA THE UNIVERSITY OF MICHIGAN Discovery and characterization of novel small molecule inhibitors of Mcl-1 PADGETT, RICHARD A CLEVELAND CLINIC FOUNDATION Screen for Small Molecule Inhibitors of Mammalian Spliceosomes PERRIMON, NORBERT HARVARD UNIVERSITY (MEDICAL SCHOOL) High-throughput screening assay development for axonopathic neurodegeration SALAVATI, REZA MCGILL UNIVERSITY RNA as the catalyst for screening drugs against trypanosomatids THACHER, SCOTT M ORPHAGEN PHARMACEUTICALS Small Molecule Screen for Circadian and Metabolic Transcription Factors TRAYNELIS, STEPHEN F EMORY UNIVERSITY Identification of protease activated receptor-2 modulators WAHLESTEDT, CLAES SCRIPPS RESEARCH INSTITUTE Assay Development Relating to the HTS of the Neuropeptide Y-Y2 Receptor WEISS, ERIC L NORTHWESTERN UNIVERSITY Development of a robust high throughput assay for the discovery of RAM network inhibitors WELLS, JAMES A UNIVERSITY OF CALIFORNIA SAN FRANCISCO Activators of Procaspase-7 WESSLING-RESNICK, MARIANNE HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) Fluorescence-based screen to probe hepcidin-ferroportin interactions WILLIAMSON, JAMES R SCRIPPS RESEARCH INSTITUTE HTS for Discovery of Inhibitors of STAR Protein-RNA complexes XIE, XINMIN SIMON SRI INTERNATIONAL Development of HTS Platform for Human Fatty Acid Transport Protein 4 Using FLIPR ZHU, MICHAEL X OHIO STATE UNIVERSITY High throughput screening of ligands of TRP channels RFA-RM-05-011 Assay Development for High Throughput Molecular Screening (R03/R21) Reissue of RM-04-012 PI Name Institution Name Title BACHER, ADELBERT TECHNICAL UNIVERSITY MUNICH HTS on Riboflavin and Terpene Biosynthetic Enzymes CAFFREY, MICHAEL S UNIVERSITY OF ILLINOIS AT CHICAGO High Throughput Screening of HIV Entry Inhibitors CARTEGNI, LUCA SLOAN-KETTERING INSTITUTE FOR CANCER RES Development of HTS Assays to Identify Specific Alternative Splicing Modulators CHRISTENSEN, KENNETH A CLEMSON UNIVERSITY Assay for Molecules that Inhibit Anthrax Intoxication and Pathological Angiogenes CLARDY, JON C HARVARD UNIVERSITY (MEDICAL SCHOOL) Phenotypic-based High Throughput Screens for Plasmodium Falciparum Malaria CRAWFORD, BRETT E ZACHARON PHARMACEUTICALS, INC. Cell-Based Screen for Inhibitors of Mucin-Type O-Linked Glycans CUEVAS, BRUCE D UNIVERSITY OF NORTH CAROLINA CHAPEL HILL MEKK2/3-MEK5 Protein Interaction/Activation/ERK5 Pathway DELPIRE, ERIC J VANDERBILT UNIVERSITY Identification of Novel Modulators of CL-dependent Transport Processes via HTS DEVI, LAKSHMI A MOUNT SINAI SCHOOL OF MEDICINE OF NYU Assay to Screen Ligands that Selectively Activate Opioid Receptor Heterodimers ENGELMAN, DONALD M YALE UNIVERSITY A High Capacity Screen for Membrane-Active Compounds GUPTA, VINEET MASSACHUSETTS GENERAL HOSPITAL Developing HTS Assays for Discovery of Small Molecule Regulators of Integrins JARSTFER, MICHAEL B UNIVERSITY OF NORTH CAROLINA CHAPEL HILL A High Throughput Screen for Telomerase Assembly KHANNA, PYARE L DISCOVERX CORPORATION HTS Cell Based EFC Assays for GPCR Drug Discovery KAMPF, J PATRICK TORREY PINES INSTITUTE/MOLECULAR STUDIES A Fluorescent HTS Assay for the Discovery of FABP Binding Inhibitors KAN, CHEN-CHEN KECK GRADUATE INST OF APPLIED LIFE SCIS Human CD4+ T Cell Based High Throughput Assay for Drug-Resistant HIV-1 Proteases KATZ, RICHARD A INSTITUTE FOR CANCER RESEARCH GFP-Based Assays to Probe Transcriptional and Post-Transcriptional Controls LANSBURY, PETER T BRIGHAM AND WOMEN'S HOSPITAL A High-Throughput Assay for SOD1 Aggregation Inhibitors MARSH-ARMSTRONG, NICHOLAS R KENNEDY KRIEGER RESEARCH INSTITUTE, INC. Photoreceptor Degeneration Assay in Transgenic Xenopus Reporter Line MCKERROW, JAMES H UNIVERSITY OF CALIFORNIA SAN FRANCISCO High Throughput Assay for Screening Compounds Against T. Brucei MECSAS, JOAN C TUFTS UNIVERSITY BOSTON Inhibitors of Yersinia Yop Type III Secretion and Translocation MOHAN, ROYCE UNIVERSITY OF KENTUCKY Novel High Content Vascular Patterning Assay MORRIS, DAVID G YALE UNIVERSITY High Throughput Molecular Screening for Compounds that Alter Tgfb1 Signaling Tgfb1 Signaling NISWENDER, COLLEEN M VANDERBILT UNIVERSITY A Direct Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as the Prototype PASQUALE, ELENA B BURNHAM INSTITUTE EphA4 Receptor Antagonists for CNS Regeneration ROGERS, JACK T MASSACHUSETTS GENERAL HOSPITAL Small HTS Molecules Targeting APP 5' Untranslated Region SCHARENBERG, ANDREW M CHILDREN'S HOSPITAL AND REG MEDICAL CTR TRPM2 HTS Screening Assay Development SCHMID, MOLLY B KECK GRADUATE INST OF APPLIED LIFE SCIS Genetic-Based Whole Cell Assays for Discovery of Novel Antibacterials SCHMIDT, WALTER K UNIVERSITY OF GEORGIA HTS-Based Identification of Novel Rce1p Inhibitors SIDEROVSKI, DAVID P UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Real-Time Fluorescence Assays of RGS Domain GAP Activity SPERANDIO, VANESSA UNIVERSITY OF TEXAS SW MED CTR/DALLAS Screen for Quorum Sensing Molecular Inhibitors STIVERS, JAMES T JOHNS HOPKINS UNIVERSITY High Throughput Assay for Topoisomerase Enzyme Targets STUDER, LORENZ SLOAN-KETTERING INSTITUTE FOR CANCER RES HTS Screen for Neural Differentiation in Human ES Cells SWAAN, PETER W UNIVERSITY OF MARYLAND BALT PROF SCHOOL High-Throughput Assay for the Intestinal Peptide Transporter TRUBETSKOY, VLADIMIR S QUINTESSENCE BIOSCIENCES Development of a Robust HTS Assay to Profile Glucuronidation of Small Molecules WALDMAN, TODD GEORGETOWN UNIVERSITY Isogenic Cell-Based Screens for Cancer - Targeting Oncogenic B-Catenin WEIS, KARSTEN UNIVERSITY OF CALIFORNIA BERKELEY Using Chemical Biology to Study the Small GTPase Ran XIE, XINMIN S SRI INTERNATIONAL Development of HTS Assay for K(ATP) Channels Using FLIPR YE, QI-ZHUANG UNIVERSITY OF KANSAS LAWRENCE A Fluorescence Polarization Assay for Methyltransferases ZACHARIAS, DAVID A UNIVERSITY OF FLORIDA A Cell-Based HT Imaging Assay for Palmitoylation RFA-RM-04-012 High Throughput Molecular Screening Assay Development (R03) PI Name Institution Name Title BEZPROZVANNY, ILYA B UNIVERSITY OF TEXAS SW MED CTR/DALLAS Screen for blockers of a CaV2.2-Mint-PDZ1 association BURGESS, RICHARD R UNIVERSITY OF WISCONSIN MADISON LRET-based HT Screening for Inhibitors of Transcription BURNS, CHARLES G MASSACHUSETTS GENERAL HOSPITAL HTS assay for zebrafish embryonic heart function CHIOSIS, GABRIELA SLOAN-KETTERING INSTITUTE FOR CANCER RES Development of HTS assays probing Hsp90 inhibition CHUNG, RAYMOND T MASSACHUSETTS GENERAL HOSPITAL Chemical Genetics to Identify Cellular Regulators of HCV CLARDY, JON C HARVARD UNIVERSITY (MEDICAL SCHOOL) High-throughput Screens for P. falciparum Malaria CONN, P JEFFREY VANDERBILT UNIVERSITY Development of a High Throughput Assay for Allosteric P* DAVID, SUNIL A UNIVERSITY OF KANSAS LAWRENCE Novel High-throghput Assay for Angiogenesis Inhibitors FENTON, ROBERT G UNIVERSITY OF MARYLAND BALT PROF SCHOOL High-throughput screen for inhibitors of Mcl-1 FRANK, DAVID A DANA-FARBER CANCER INSTITUTE High Throughput Screening for Modulators of STAT5 GOLDFARB, DAVID S UNIVERSITY OF ROCHESTER Molecular Screen for Lifespan Extension in Yeast HARSAY, EDINA UNIVERSITY OF KANSAS LAWRENCE Identifying compounds that target post-Golgi secretion JAYARAMAN, VASANTHI UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON High throughout screening assay for glutamate receptors KIEFF, ELLIOTT D. BRIGHAM AND WOMEN'S HOSPITAL Screening of Epstein Barr Virus Replication KIRKEN, ROBERT A UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON Screening for small molecule inhibitors of Stat5 KUTSCH, OLAF UNIVERSITY OF ALABAMA AT BIRMINGHAM A GFP Based HTS Assay for HIV-1 Tat Inhibitors LITHGOW, GORDON BUCK INSTITUTE FOR AGE RESEARCH C. elegans, Aging and High Throughput Screening LU, YILING UNIVERSITY OF TEXAS MD ANDERSON CAN CTR Tissue Lysate Arrays for Molecular Screening MANION, MICHAEL K FRED HUTCHINSON CANCER RESEARCH CENTER Methods to identify BCL-2 "gain of function" inhibitors MORISSEAU, CHRISTOPHE HP UNIVERSITY OF CALIFORNIA DAVIS Cyanohydrin based fluorescent substrates of sEH PERRIMON, NORBERT HARVARD UNIVERSITY (MEDICAL SCHOOL) High-throughput screen for host factors in Listeria infection ROSENFELD, STEVEN S UNIVERSITY OF ALABAMA AT BIRMINGHAM Development of High Throughput Screening Assays to Targ* THACHER, SCOTT M ORPHAGEN PHARMACEUTICALS Small Molecular Screen for Thymocyte Drug Target TORTORELLA, DOMENICO MOUNT SINAI SCHOOL OF MEDICINE OF NYU Luminescent assay to identify ER dislocation inhibitors TSE-DINH, YUK-CHING NEW YORK MEDICAL COLLEGE Development of a HTS system in E. coli for topoisomeras* WALDMAN, TODD A GEORGETOWN UNIVERSITY Isogenic Cell-Based Screens for Cancer: Targeting PTEN WILSON, ROBERT B UNIVERSITY OF PENNSYLVANIA High throughput screen for cyclin D1 inhibitors WRIGHT, KENNETH L H. LEE MOFFITT CANCER CTR & RESEARCH INS High Throughput H3-K9 Methyltransferase Inhibitor Screen XIE, SIMON X SRI INTERNATIONAL HTS Assay for Ca 3 T-type Channels Using FLIPR YAFFE, MICHAEL B MASSACHUSETTS INSTITUTE OF TECHNOLOGY High-Throughput Assay Design for Polo Kinase Inhibitors RFA-RM-05-012 Exploratory Centers for Cheminformatics Research (P20) PI Name Institution Name Title BRENEMAN, CURTIS M RENSSELAER POLYTECHNIC INSTITUTE Establishment of the RPI Exploratory Center for Cheminformatics CLEMONS, PAUL A MASSACHUSETTS INSTITUTE OF TECHNOLOGY General Data-analysis Tools to Relate Chemical Diversity to Biological Outcomes FOX, GEOFFREY C INDIANA UNIVERSITY BLOOMINGTON Chemical Informatics Cyberinfrastructure HUGHES-OLIVER, JACQUELINE M NORTH CAROLINA STATE UNIVERSITY RALEIGH Comparative and Web-Enabled Virtual Screening SHEDDEN, KERBY UNIVERSITY OF MICHIGAN AT ANN ARBOR MACE - Michigan Alliance for Cheminformatic Exploration TROPSHA, ALEXANDER UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Carolina Exploratory Center for Cheminformatics Research RFA-RM-06-003 Pilot-Scale Libraries for High-Throughput Screening (P41) – Reissue for FY2006 of RFA-RM-05-014 (07 awards) PI Name Institution Name Title GEORG, GUNDA I UNIVERSITY OF MINNESOTA TWIN CITIES Libraries for HTS: Privileged Structures in Sparsely Populated Chemical Space HOUGHTEN, RICHARD A TORREY PINES INST FOR MOLECULAR STUDIES Highly Diverse and Structurally Varied Heterocyclic Libraries for the MLSMR KWON, OHYUN UNIVERSITY OF CALIFORNIA LOS ANGELES Pilot-Scale Library Production Based on Phosphine Catalysis of Allenes MEINWALD, JERROLD CORNELL UNIVERSITY ITHACA Arthropod-Based Libraries for High Throughput Screening SMITH, AMOS B UNIVERSITY OF PENNSYLVANIA Pilot-Scale Libraries for High-throughput Screening (P41) ZHANG, WEI FLUOROUS TECHNOLOGIES, INC. Diversity-Oriented Synthesis of Novel Heterocyclic and Natural Product-Like Libraries RFA-RM-06-003 Pilot-Scale Libraries for High-Throughput Screening (P41) PI Name Institution Name Title BAURES, PAUL WILLIAM UNIVERSITY OF TULSA Molecular Libraries from Imidazole-4,5-Dicarboxylic Acid GILBERTSON, SCOTT R UNIVERSITY OF TEXAS MEDICAL BR GALVESTON Synthesis of Pilot Libraries Based on Medicinal Relevant Scaffolds GRAY, NATHANAEL S DANA-FARBER CANCER INSTITUTE Inhibitors of Kinase Activation HOUGHTEN, RICHARD A TORREY PINES INST FOR MOLECULAR STUDIES Stereochemically /Structurally Diverse Pilot Scale Libra KRCHNAK, VIKTOR UNIVERSITY OF NOTRE DAME Combinational synthesis of bisheterocyclic libraries LAROCK, RICHARD C IOWA STATE UNIVERSITY Heterocyclic /Carbocyclic Libraries for High Throughput PARKER, MATTHEW A CHEMDIV, INC. New Regions of Diversity Space in Ergot-Based Libraries WEST, LYNDON M UNIVERSITY OF GEORGIA (UGA) “Drug-Like” Marine Natural Products Library RFA-RM-08-003 Pilot-Scale Libraries (PSL) for High-Throughput Screening (P41) This is a reissue of RFA-RM-05-014 PI Name Institution Name Title HANSON, PAUL R UNIVERSITY OF KANSAS LAWRENCE Probing Diversity Space with Novel Pilot Scale Libraries LUESCH, HENDRIK (Contact) PAUL, VALERIE J UNIVERSITY OF FLORIDA Pilot-Scale Libraries of Marine Cyanobacterial Natural Products MARTIN, STEPHEN UNIVERSITY OF TEXAS AUSTIN Generating Diverse Pilot-Scale Libraries for Screening MOLANDER, GARY A UNIVERSITY OF PENNSYLVANIA Novel Boronic Acids for Pilot-Scale Screening REYNOLDS, ROBERT C SOUTHERN RESEARCH INSTITUTE Pilot-Scale Libraries Based on Nucleoside Templates for the ML Initiative SCHAUS, SCOTT EDWARD BOSTON UNIVERSITY Structural and Sterochemically Diverse Heterocycles for the Small Molecule Reposi WIPF, PETER UNIVERSITY OF PITTSBURGH AT PITTSBURGH Novel Heterocyclic Libraries RFA-RM-05-014 Pilot-Scale Libraries for High-Throughput Screening (P41) PI Name Institution Name Title BURGESS, KEVIN TEXAS A&M UNIVERSITY SYSTEM Evolving Libraries of Bivalent Compounds HANSON, PAUL R UNIVERSITY OF KANSAS LAWRENCE Probing Diversity Space with Novel Pilot Scale Libraries KURTH, MARK J UNIVERSITY OF CALIFORNIA DAVIS UCD Combinatorial Center - Novel and Diverse Pilot-Scale Library Production LEE, KUO-HSIUNG UNIVERSITY OF NORTH CAROLINA CHAPEL HILL CHEMICAL DIVERSITY LIBRARIES FROM MEDICINAL PLANTS PORCO, JOHN A BOSTON UNIVERSITY CHARLES RIVER CAMPUS Generation of Stereochemically and Structurally Complex Chemical Libraries SCHREIBER, STUART L MASSACHUSETTS INSTITUTE OF TECHNOLOGY Versatile Diversity-oriented Small Molecule Libraries for Chemogenetics TAN, DEREK S MEMORIAL SLOAN-KETTERING CANCER CENTER Diversity-Oriented Synthesis of Natural Product-based Libraries for the MLSCN WRIGHT, JEFFREY L UNIVERSITY OF NORTH CAROLINA WILMINGTON Diverse Chemical Libraries from Photosynthetic Marine Microalgae RFA-RM-08-004 New Methodologies for Natural Products Chemistry (R01) This is a reissue of RFA-RM-05-013 PI Name Institution Name Title CLARDY, JON HARVARD UNIVERSITY (MEDICAL SCHOOL) Molecule-to-gene approaches to new natural products PETERS, REUBEN J IOWA STATE UNIVERSITY A Modular Approach for Combinatorial Biosynthesis of Functionalized Terpenoids ROMO, DANIEL TEXAS A&M UNIVERSITY SYSTEM New Methods for Simultaneous Arming and SAR Studies of Natural Products RFA-RM-05-013 New Methodologies for Natural Products Chemistry (R01) PI Name Institution Name Title BURKART, MICHAEL UNIVERSITY OF CALIFORNIA SAN DIEGO Proteomic Methodologies for Polyketide Biosynthesis DOYLE, DONALD F GEORGIA INSTITUTE OF TECHNOLOGY Natural Product Biosynthesis by Chemical Complementation HANDELSMAN, JO E UNIVERSITY OF WISCONSIN MADISON Intracellular Screens for Discovery of Natural Products in Metagenomic Libraries MILLER, MARVIN J UNIVERSITY OF NOTRE DAME Novel Derivatization/Functionalization of Natural Products ORJALA, JIMMY UNIVERSITY OF ILLINOIS AT CHICAGO Microscale LC-MS and NMR Methodology for Rapid Natural Products Chemistry WANG, CLAY C UNIVERSITY OF SOUTHERN CALIFORNIA Platforms for Nonribosomal Peptide Manipulation Additional Information Abstract (from CRISP) RFA-RM-04-020 Molecular Libraries Screening Instrumentation (R01) PI Name Institution Name Title GASCOYNE, PETER R UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER Reconfigurable microfluidic assay platform for molecular Library Screening KRON, STEPHEN J UNIVERSITY OF CHICAGO Molecular Library Screening By MALDI-TOF Scanning of Functional Peptide Arrays LARSON, DALE N HARVARD UNIVERSITY (MEDICAL SCHOOL) HTS of Small Molecule-Protein Interactions LITVINOV, DMITRI UNIVERSITY OF HOUSTON Development of Nanomagnetic Sensor Array For High Throughput Molecular Screening MA, HAICHING REACTION BIOLOGY CORPORATION Microarraying and Screening Chemical Libraries PRICE, JEFFREY H BURNHAM INSTITUTE Continuous-Imaging HT Screening Instrument VO-DINH, TUAN UT-BATTELLE, LLC-OAK RIDGE NATIONAL LAB Ultra-High-Throughput Screening (uHTS) Based on Surface-Enhanced Raman Scattering ZHU, XIANGDONG UNIVERSITY OF CALIFORNIA DAVIS High-Speed Label-Free Optical Detection System for Small-Molecule Microarrays RFA-RM-04-023 Novel Preclinical Tools for Predictive ADME-Toxicology (R21) PI Name Institution Name Title BENET, LESLIE Z UNIVERSITY OF CALIFORNIA SAN FRANCISCO Transporter-Enzyme Interplay Evaluation via Microfluidic HTS Cell Culture Devices GANEY, PATRICIA E MICHIGAN STATE UNIVERSITY Gene Expression in Drug-inflammation Models as Predictive of Idiosyncratic ADRs HAYSTEAD, TIMOTHY A DUKE UNIVERSITY Proteome Mining as a Predicitve Tool of Drug Toxicity HOPFINGER, ANTON J CHEM21 GROUP, INC. Novel Descriptors and Informatics Methods for Predictive ADMET Modeling MA, PETER X UNIVERSITY OF MICHIGAN AT ANN ARBOR Nano Fibers for ADME/Toxicology MACDONALD, JEFFREY M UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Human Enterohepatic Cell Model for Predictive Toxicology MACRAE, CALUM A MASSACHUSETTS GENERAL HOSPITAL Zebrafish Assays Predictive for Drug-Induced Cardiac Repolarization Toxicity PS-149 SUMNER, SUSAN J RESEARCH TRIANGLE INSTITUTE Metabolomics: Markers of Drug-Induced Liver Injury TROPSHA, ALEXANDER E UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Robust computational framework for predictive ADME-Tox Modeling ZACHAREWSKI, TIMOTHY R MICHIGAN STATE UNIVERSITY Human Stem Cells for Toxicity Screening Development of High Resolution Probes for Cellular Imaging RFA-RM-04-021 Innovation In Molecular Imaging Probes (R21) PI Name Institution Name Title BOLSKAR, ROBERT D TDA RESEARCH, INC. Cut Nanotube Capsules for MR Imaging BOPPART, STEPHEN A UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Magnetomotive Optical Molecular Imaging Probes BOYLE, TIMOTHY J SANDIA CORP-SANDIA NATIONAL LABORATORIES Flourescent Ceramic Nanoprobes BULTE, JEFF W JOHNS HOPKINS UNIVERSITY Developing a CEST Reporter Gene DAYTON, PAUL A UNIVERSITY OF CALIFORNIA DAVIS High-Sensitivity Molecular Imaging with Ultrasound DOUGLAS, TREVOR MONTANA STATE UNIVERSITY (BOZEMAN) Targeted MRI with Protein Cage Architectures GAO, JINMING UNIVERSITY OF TEXAS SW MED CTR/DALLAS MFe2O4-Loaded Polymer Micelles as Ultra-Sensitive MR Molecular Probes HALPERN, HOWARD J UNIVERSITY OF CHICAGO Magnitude Improvement of Molecular Signaling Imaging KURHANEWICZ, JOHN UNIVERSITY OF CALIFORNIA SAN FRANCISCO Hyperpolarized 13c NMR Studies of Prostate Cancer MATTREY, ROBERT F UNIVERSITY OF CALIFORNIA SAN DIEGO Molecular Imaging with Ultrasound Contrast Agents POMPER, MARTIN G JOHNS HOPKINS UNIVERSITY PSMA-based Gene Reporter-Probe System RFA-RM-04-001 Development of High Resolution Probes for Cellular Imaging (P20) PI Name Institution Name Title BURGESS, KEVIN TEXAS A&M UNIVERSITY SYSTEM Fluorescent Probes for Multiplexed Intracellular Imaging DICKSON, ROBERT M GEORGIA INSTITUTE OF TECHNOLOGY Sub-nm dendrimer-metal nanoclusters as ultrabright, mod* MOERNER, WILLIAM E STANFORD UNIVERSITY Single-Molecule Fluorophores for Cellular Imaging NIE, SHUMING EMORY UNIVERSITY Bioaffinity Nanoparticle Probes for Bioimaging PISTON, DAVID W VANDERBILT UNIVERSITY Probes for Quantitative Optical and Electron Microscopy SIMON, SANFORD M ROCKEFELLER UNIVERSITY Imaging single proteins in vivo with quantum dots SINGER, ROBERT H YESHIVA UNIVERSITY Light-Activated Gene Expression in Single Cells TING, ALICE Y MASSACHUSETTS INSTITUTE OF TECHNOLOGY Library-based development of new optical imaging probes TSIEN, ROGER UNIVERSITY OF CALIFORNIA SAN DIEGO Genetically Targetable Labels For Light and EM PDF documents require the free Adobe Reader. Up to Top

This page last reviewed: October 7, 2008

DPCPSI Home | NIH Office of the Director | Contact Us | Site Map | Privacy Policy | Accessibility | FOIA | Disclaimers

Division of Program Coordination, Planning, and Strategic Initiatives • National Institutes of Health • Bethesda, Maryland 20892