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Abstract

Grant Number:	1R03MH082342-01A1
Project Title:	High Through-Put Screening of Plasmodium Falciparum Aminopeptidases

PI Information:	Name	Email	Title
	DALTON, JOHN PIUS.
	GARDINER, DONALD L. (Contact)	dong@qimr.edu.au
	TRENHOLME, KATHARINE RUTH.

Abstract: DESCRIPTION (provided by applicant): Malaria remains a significant cause of morbidity and mortality worldwide with an estimated 2 million people dying from this disease every year. The majority are children under 5 living in Sub-Saharan Africa. Drug resistance to the commonly available drugs is widespread, and with a safe and effective vaccine still many years away, new chemotherapeutic agents are required to ensure that cheap and effective treatment can be maintained. Aminopeptidases are involved in the catabolism of proteins in all organisms studied to date. In the apicomplexan parasite of the genus Plasmodium the cause of malaria, we have shown that it is possible to selectively target these enzymes such that we can kill the parasite both in the laboratory and in a mouse model. We have generated recombinant proteins from two of these enzymes that are suitable for adaptation to high throughput screening to identify new and novel compounds that can target these enzymes.

Public Health Relevance:
This Public Health Relevance is not available.

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Institution:	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
	300 Herston Road
	BRISBANE, 4006
Fiscal Year:	2008
Department:
Project Start:	10-JAN-2008
Project End:	31-DEC-2008
ICD:	NATIONAL INSTITUTE OF MENTAL HEALTH
IRG:	ZMH1

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