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Abstract
Grant Number: 1R03MH076390-01 Project Title: In Vitro High Throughput Screening Assay for MKP-3(RMI)
PI Information: Name Title LAZO, JOHN S. lazo@pitt.edu PROFESSOR AND PROGRAM LEADER, MOLECULAR Abstract: DESCRIPTION (provided by applicant): Mitogen activated protein kinase phosphatase-3 (MKP-3) is a dual specificity phosphatase that has a central role regulating intracellular signal transduction by controlling the phosphorylation status of mitogen activated protein kinases. There is considerable evidence indicating MKP-3 could be a potential molecular target for several human diseases. Nonetheless, no potent or selective small molecule inhibitors of this protein phosphatase have been identified. This proposal will provide sufficient reagents to permit a high throughput screening of 100,000 compounds
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
combinatorial chemistry, drug screening /evaluation, high throughput technology, phosphatase inhibitor, protein tyrosine phosphatase, technology /technique development
biological signal transduction, mitogen activated protein kinase, small molecule
biotechnology
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH 350 THACKERAY HALL PITTSBURGH, PA 15260 Fiscal Year: 2005 Department: PHARMACOLOGY AND CHEMICAL BIOLOGY Project Start: 15-SEP-2005 Project End: 14-SEP-2006 ICD: NATIONAL INSTITUTE OF MENTAL HEALTH IRG: ZMH1