Genetic and Rare Diseases Information Center (GARD)


Other names people use for this condition
  • Idiopathic myelofibrosis
  • Myeloid metaplasia
  • Agnogenic myeloid metaplasia
  • Primary myelofibrosis

Myelofibrosis
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Myelofibrosis is a disorder of the bone marrow, in which the marrow is replaced by fibrous (scar) tissue.[1] Scarring of the bone marrow causes anemia, which can lead to fatigue and weakness, as well as pooling of the blood in abnormal sites like the liver and spleen, causing these organs to swell.[1][2] The cause of myelofibrosis in unknown and there are no known risk factors.[1] Although myelofibrosis can occur at any age, it typically develops after the age of 50.[1][2] In most cases, myelofibrosis gets progressively worse. Treatment is aimed at relieving signs and symptoms and may include medications, blood transfusions, chemotherapy, radiation therapy and surgery.[2]   

References
  1. Dugdale DC, Mason JR. Primary myelofibrosis. MedlinePlus. July 11, 2008 Available at: http://www.nlm.nih.gov/medlineplus/ency/article/000531.htm. Accessed January 7, 2008.
  2. Myelofibrosis. MayoClinic.com. February 1, 2007 Available at: http://www.mayoclinic.com/print/myelofibrosis/DS00886/DSECTION=all&METHOD=print. Accessed January 7, 2008.

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