Periodic fever, familial, autosomal dominant
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Familial autosomal dominant periodic fever is an inherited condition characterized by episodes of fever, abdominal pain, diarrhea, painful red skin rashes, muscle pain and swelling around the eye. The former name of this syndrome was familial Hibernian fever and it is sometimes referred to as tumor necrosis factor receptor associated periodic syndrome or TRAPS.[1] Familial autosomal dominant periodic fever is caused by mutations in the Tumor Necrosis Factor Receptor gene (TNFRSF1A), which are inherited in an autosomal dominant fashion.[1][2] Although there is no proven definitive treatment to prevent or cure this condition, various anti-inflammatory agents may help to relieve symptoms. Nonetheless, most patients will experience episodes of symptoms throughout their life.[1]
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- More Information (Found: 7 Resources)
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eMedicine provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free
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The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
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The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) offers printed materials on this topic. We recommend calling toll-free at 877-226-4267 to request a copy of this information.
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Orphanet is a database dedicated to information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
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The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Periodic fever, familial, autosomal dominant. Click on the link to go to OMIM and review these resources.
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PubMed lists journal articles that discuss Periodic fever, familial, autosomal dominant. Click on the link to go to PubMed and review citations to these articles.
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The Cleveland Clinic provides information about familial autosomal dominant periodic fever. Click on the link above to access this information.
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ClinicalTrials.gov lists trials that are studying or have studied Periodic fever, familial, autosomal dominant. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
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GeneTests lists laboratories offering clinical genetic testing for this condition. Clinical genetic tests are ordered to help diagnose a person or family and to aid in decisions regarding medical care or reproductive issues. Talk to your health care provider or a genetic professional to learn more about your testing options.
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We recommend that you discuss this information and your concerns with a genetics professional. The following online resources can help you find a genetics professional in your community:
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* ResourceLink - A database of genetics counseling services, searchable by location, name, institution, type of practice, or specialty. Hosted by the National Society of Genetic Counselors.
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