Nominations to the Testing Program
Nominations Reviewed 2000
Substances Recommended for Study:
- Aluminum complexes
- Bilberry fruit extract
- Black cohosh
- Blue-Green algae (dietary supplements)
- Cefuroxime
- Clarithromycin
- D&C Red No. 27 and D&C Red No. 28
- N,N-Dimethyl-p-toluidine
- Lemon Oil and Lime Oil
- Local anesthetics that metabolize to 2,6-xylidine or o-toluidine
- Microcystin-LR
- Organotins occurring in drinking water
- All-trans-retinyl palmitate
- S-Adenosylmethionine
- Senna
Substances for Which No Study is Recommended at this Time:
- Dichloropropane & Dichloropropene
- 1,3-Dichloropropane
- 2,2-Dichloropropane
- 1,1-Dichloropropane
- Hydergine
- Yohimbe bark extract/Yohimbine
Chemicals studied by the NTP are selected mainly on the basis of human exposure, production levels, chemical structure, and available toxicological data. Selection of an agent for a study does not imply that the agent is hazardous or a potential carcinogen in laboratory animals; likewise, an agent not selected for toxicologic study by the Program should not be taken to mean that the agent is not potentially hazardous or potentially carcinogenic in laboratory rodents. Substances are identified by a common or generic name and CAS Registry No. where appropriate.
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)
[Send Email]
For information, questions or comments, contact:
Dr. Scott A. Masten
Office of Chemical Nomination and Selection
Environmental Toxicology Program
National Institute of Environmental Health Sciences
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)
[Send Email]
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Aluminum Complexes found in drinking water
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Drinking water contaminants with a high health research priority; known neurotoxicity of aluminum; need for better understanding of pharmacokinetics and toxicity of aluminum species occurring in drinking water |
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Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Bilberry fruit extract [84082-34-8] |
National Cancer Institute |
|
In vitro and in vivo genotoxicity testing |
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Black cohosh [84776-26-1] |
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|
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Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Blue-Green algae (dietary supplements and selected toxins) [No CAS No.] |
National Cancer Institute |
|
|
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Cefuroxime [55268-75-2] |
Food and Drug Administration |
|
|
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Clarithromycin [81103-11-9] |
Food and Drug Administration |
|
Genotoxicity testing (Syrian hamster embryo in vitro cell transformation assay; in vivo micronucleus assay) |
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
D&C Red No. 27 and D&C Red No. 28 [13473-26-2],[18472-87-2] |
Food and Drug Administration |
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|
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
N,N-Dimethyl-p-toluidine [99-97-8] |
National Cancer Institute |
|
Subchronic toxicity testing pending review of industry test plans and/or data developed under EPA's High Production Volume Chemical Challenge Program |
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Lemon Oil and Lime Oil [8008-56-8],[8008-26-2] |
Food and Drug Administration |
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|
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Local anesthetics that metabolize to 2,6-xylidine or o-toluidine
|
|
|
Short-term in vitro/in vivo mechanistic studies to evaluate carcinogenic metabolite formation and genotoxicity of representative local anesthetic compounds |
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Microcystin-LR [101043-37-2] |
National Institute of Environmental Health Sciences |
|
|
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Organotins occurring in drinking water
|
Environmental Protection Agency; National Institute of Environmental Health Sciences |
|
|
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
All-trans-retinyl palmitate [79-81-2] |
Food and Drug Administration |
|
Phototoxicity and photocarcinogenicity testing |
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
S-Adenosylmethionine [29908-03-0] |
National Cancer Institute |
|
|
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Senna [8013-11-4] |
Food and Drug Administration |
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Carcinogenicity testing in p53 transgenic mouse model |
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Additional Information Needed |
---|---|---|---|
Dichloropropane & Dichloropropene
|
Environmental Protection Agency; National Institute of Environmental Health Sciences |
|
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Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Additional Information Needed |
---|---|---|---|
Hydergine [8067-24-1] |
National Cancer Institute |
|
|
Substance [CAS No.] |
Nominated by | Nomination Rationale (Principles) |
Additional Information Needed |
---|---|---|---|
Yohimbe bark extract/Yohimbine [85117-22-2],[146-48-5] |
National Cancer Institute |
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Web page last updated on September 23, 2008