Nominations to the Testing Program
Nominations in Review 2002
Substances Recommended for Study:
- Abrasive blasting agents
- 5-Amino-o-cresol
- tert-Butyl hydroperoxide
- Chloramine-T and p-Toluenesulfonamide
- Cobalt metal dust
- Ephedrine alkaloid dietary supplements
- Ethanone
- Hexafluorosilicic acid and Sodium hexafluorosilicate
- Ketamine hydrochloride
- Mercury, ((o-carboxyphenyl)thio)ethyl-, sodium salt (Thimerosal)
- Nitrogen trifluoride
- Sodium metasilicate
- Turpentine
- Welding fumes
Substances for Which No Study is Recommended at this Time
Chemicals studied by the NTP are selected mainly on the basis of human exposure, production levels, chemical structure, and available toxicological data. Selection of an agent for a study does not imply that the agent is hazardous or a potential carcinogen in laboratory animals; likewise, an agent not selected for toxicologic study by the Program should not be taken to mean that the agent is not potentially hazardous or potentially carcinogenic in laboratory rodents. Substances are identified by a common or generic name and CAS Registry No. where appropriate.
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax) [ Send Email ]
For information, questions or comments, contact:
Dr. Scott A. Masten
Office of Chemical Nomination and Selection
Environmental Toxicology Program
National Institute of Environmental Health Sciences
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax) [ Send Email ]
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Abrasive blasting agents
|
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Chronic inhalation (whole body) toxicity studies in rats with tissue burden and comprehensive pulmonary toxicological evaluations |
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Toxicological studies:
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Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
5-Amino-o-cresol [2835-95-2] |
National Cancer Institute |
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Toxicological studies:
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Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
tert-Butyl hydroperoxide [75-91-2] |
National Cancer Institute | Carcinogenicity |
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Chloramine-T and p-Toluenesulfonamide [127-65-1],[70-55-3] |
Private Individual | Toxicological characterization |
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Cobalt metal dust [7440-48-4] |
|
Toxicological characterization including carcinogenicity studies (inhalation) |
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Ephedrine alkaloid dietary supplements [No CAS No.] |
|
|
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Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Ethanone 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-(Iso-E Super) [54464-57-2] |
Private Individual | Toxicological characterization including neurotoxicity |
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Hexachloro-1,3-butadiene [87-68-3] |
Carcinogen Identification Committee (Advisory Body for |
Carcinogenicity (at doses intermediate to those used in previous studies) |
|
No toxicological studies at this time due to:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Hexafluorosilicic acid and Sodium hexafluorosilicate [16961-83-4],[16893-85-9] |
Private Individuals (multiple nominations) |
|
|
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Infrasound [no CAS No.] |
National Institute of Environmental Health Sciences | Toxicological characterization |
|
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Ketamine hydrochloride [1867-66-9] |
Comprehensive neurotoxicity assessment and toxicokinetics in non-human primates |
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Magnesium oxide [1309-48-4] |
National Cancer Institute |
|
|
No toxicological studies at this time due to adequate available toxicological data |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Mercury ((o-carboxyphenyl)thio)ethyl-, sodium salt (Thimerosal) [54-64-8] |
|
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Methylolurea [1000-82-4] |
National Institute of Environmental Health Sciences | Toxicological characterization |
|
No toxicological studies at this time due to inclusion in the High Production Volume Chemical Challenge Program |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
4-Methylquinoline [491-35-0] |
Carcinogen Identification Committee (Advisory Body for |
|
|
No toxicological studies at this time due to low commercial production volume and insufficient evidence of significant human exposure |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Nitrogen trifluoride [7783-54-2] |
National Cancer Institute |
|
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Sodium metasilicate [6834-92-0] |
National Institute for Occupational Safety and Health |
|
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Turpentine [8006-64-2] |
International Union, United Auto Workers |
|
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Welding fumes
|
|
|
|
Toxicological studies:
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Web page last updated on September 11, 2008