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Abstract

Title: No association between glutathione peroxidase Pro198Leu polymorphism and breast cancer risk.
Author: Ahn J, Gammon MD, Santella RM, Gaudet MM, Britton JA, Teitelbaum SL, Terry MB, Neugut AI, Ambrosone CB
Journal: Cancer Epidemiol Biomarkers Prev 14(10):2459-2461
Year: 2005
Month: October

Abstract: Selenium-dependent glutathione peroxidase (GPX1) is a cytosolic antioxidant enzyme that neutralizes H2O2 to water and oxygen (1). A GPX1 Pro!Leu polymorphism exists at codon 198, with the variant Leu allele being less responsive than the common Pro allele to the stimulation of enzyme activity during selenium supplementation (2). The Leu allele has been associated with increased risk of lung (3), bladder (4), and breast (2) cancer, although two other studies found a null association with breast cancer risk (5, 6). Because oxidative stress may play a role in breast carcinogenesis (7) and the GPX1 polymorphism may confer interindividual variability in the response to reactive oxygen species, we evaluated the association between the 198 GPX1 polymorphism (RS#1050450)and risk of breast cancer, and assessed potential modifying influences of diet and lifestyle factors, which may affect reactive oxygen species, and tumor characteristics on risk relationships in the Long Island Breast Cancer Study Project.