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Ductal Carcinoma in Situ Research Resources

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Awarded NIH Grants

Population Science Studies
Project Title Principal Investigator Institution Sample Size Diagnosis Years Project Start & End Years
Risk Factors for Ductal Carcinoma In Situ Brody, Julia Silent Spring Institute n=224 patients from the Cape Cod Breast Cancer and Environment Study 1992-1998 2003-2006
Breast Carcinoma In-Situ: Mammographic Risk Factors Claus, Elizabeth Yale University n=875 with DCIS; n=123 with LCIS who are CT residents; n=999 controls 1994-1998 2004-2008
Cost-Effectiveness -- Treatments -- Ductal Carcinoma In Situ Dick, Andrew / Griggs, Jennifer University of Rochester SEER-Medicare   2002-2005
Microsatellite Markers of DCIS Prognosis Gabrielson, Edward Johns Hopkins Universtiy     1999-2002
Etiology of Early Breast Malignancy Greenberg, Robert Dartmouth College n=412 women with DCIS from NH and VT cancer registries
n=412 women with invasive breast cancer		   1996-2002
DCIS--Mammographic features and prognosis  Habel, Laurel Kaiser Foundation Research Institute n=1200 women with DCIS from the Northern California Kaiser Permanente Medical Care Program  1990-1997 1999-2005
Mammographic density and breast cancer after diagnosis of DCIS Habel, Laurel Kaiser Foundation Research Institute n=814 patients from the National Surgical Adjuvant Breast and Bowel Program Clinical Trial

   1999-2002
Clinical/Pathologic Predictors for Recurrence after DCIS Habel, Laurel Kaiser Foundation Research Institute n=3700 patients (n=490 with recurrence) from the CRN, Kaiser Permanente Northern California, Kaiser Permanente Souther California, Harvard Pilgrim Health Care 1990-2001 2003-2007
Surgical Treatment for Early State Breast Cancer Katz, Steven University of Michigan, Ann Arbor n=1880 patients from SEER catchment areas

  2001-2005
Predictors of Recurrence in Women with DCIS Kerlikowse, Karla University of California, San Francisco n=1,744 from Northern California SEER
n=457 from UCSF for the Breast Oncology Program database
n=1,3 10 women from the NSABPB-17 and NSABPB-24 trials.		 1983-1996 2003-2007
Treatment Decisions Comparing DCIS/Invasive BC patients Lantz, Paula University of Michigan, Ann Arbor n=200 patients with DCIS or invasive breast cancer reported to Detroit SEER Registry

   1997-1999
A Video DVD Program to Assist with Informed Consent Love, Neil NL Communications, Inc n=3000   2004-2005
Case-Control Study of Carcinoma In Situ Millikan, Bob University of North Carolina Chapel Hill n=400 cases of DCIS or LCIS from the Carolina Breast Cancer Study and frequency-matched controls 1995-2000 Not listed
Risk Factors and Biomarkers for In Situ Breast Cancer Newcomb, Polly and Titus-Ernstoff, Linda  Fred Hutchinson Cancer Research Center and Dartmouth College n=1575 cases of DCIS or LCIS from WI, MA, and NH state cancer registries
n=2205 population-based controls		   1996-2002
Cost Effectiveness Analysis of Breast Cancer Screening Plevritis, Sylvia Stanford University     1999-2003
Breast Cancer Trend Analysis Using Stochastic Stimulati Plevritis, Sylvia Stanford University     2000-2005

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Clinical Studies
Project Title Principal Investigator Institution Sample Size Project Start & End Years
A her-2/neu Pulsed DC1 Vaccine for Patients with DCIS Czerniecki, Brian University of Pennsylvania Practice-based recruitment 2003-2007
Cytogenic Screening of Mammary Epithelial Cells Haddad, Bassem Georgetown University n=50 controls; n=50 women with atypical ductal hyperplasia; n=50 women with DCIS; n=50 women with stage 1 breast cancer 2000-2003
Primary Hormonal Therapy for DCIS of the Breast Hwang, Shelley University of California, San Francisco n=40 postmenopausal patients with DCIS 2004-2009
MRI for Staging DCIS and Assessing Response to Treatment Hylton, Nola University of California, San Francisco Patients with biopsy-proven DCIS 2006-2011
PNI and Decision Making in Women Diagnosed with DCIS Janusek, Linda Loyola University of Chicago n=122 women with newly diagnosed DCIS 2004-2008
Quality of Life Over Time: DCIS vs Early Breast Cancer Jeffe, Donna Washington University Women with normal or benign mammograms will be identified surgeons 2003-2008
Synergy of Inverse Scatter & Vibro-Acoustics Johnson, Steven Techniscan, Inc Patients selected from a population with positive mammograms for micro calcifications 2004-2006
Fast Spectroscopic MR Imaging of Breast Cancer Karczmar, Gregory University of Chicago n=300 women scheduled for routine MRI exams prior to biopsy

 1999-2008
Immune Dysregulation by Psychosocial Distress Mathews, Herbert Loyola University of Chicago Women diagnosed with DCIS 2005-2008
Interactive Decision Making Program for DCIS Mort, Elizabeth Massachusetts General Hospital   1995-1999
New Approaches to Sampling and Analyzing Contrast Media Newstead, Gillian University of Chicago n=150 patients per year 2005-2008
Cyclin E Expression in Human Cancer Porter, Peggy Fred Hutchinson Cancer Research Center n=225 tissue samples from women with DCIS
n=913 tissue samples from women with invasive breast cancer		 2000-2004
Detecting Breast Cancer Protein Signatures in Body Fluid Trock, Bruce Johns Hopkins University fresh tumor tissue that contains invasive, in-situ and abnormal components; body fluids fromm women with normal breasts, DCIS, and stage 1 cancer 1999-2005
EGFR Pathway Modulation in DCIS of the Breast Truica, Christina Vanderbilt University Patients with DCIS 2003-2005
Psychosocial outcomes/health behaviors: women with DCIS Winer, Eric Dana Farber Cancer Institute n=450 women from academic and community health care institutions Not listed

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Basic Science Studies
Project Title Principal Investigator Institution Sample Project Start & End Years
Molecular Classification and Prognostic Profiling of Ductal Carcinoma in Situ Allred, Craig Baylor College of Medicine n=25 fresh-frozen DCIS samples and matched cases of normal breast and invasive breast cancer 2003-2007
Role of Cancer Stem Cells in Malignant Progression of Ductal Carcinoma in Situ Behbod, Fariba   Premalignant cell lines and subtypes of human DCIS 2007-2009
Role of Stat3 in Breast Cancer Tumorigenesis Bromberg, Jacqueline Sloan-Kettering Institute for Cancer Research Cell lines, transgenic animals, human tissue 2001-2006
Characterization of the Chromosome 17q23 Amplicon Couch, Fergus Mayo Clinic College of Medicine Breast tumors and cell lines 2002-2008
VPF/VEGF in Breast Cancer Angiogenesis Dvorak, Harold Beth Israel Deaconess Medical Center Human breast lesions and carcinomas from mice 1995-2000
Expression of Aryl Hydrocarbon Receptor in Breast Tumors Elton, Sakina Meharry Medical College Human breast cancer cell lines Not listed
Integrated Biomarkers to Characterize Breast Cancer Risk Esserman, Laura University of California San Francisco   2004-2009
A Hypersensitive ERa Mutant in Breast Cancer Progression Fuqua, Suzanne Baylor College of Medicine Clinical breast tumor bank 1996-2008
Molecular Variants of Estrogen and Progesterone Receptors in Breast Cancer Fuqua, Suzanne Baylor College of Medicine   Not listed
Mechanisms Regulating Reversal of Malignancy Furth, Priscilla Georgetown University Mouse model 2006-2010
Progression and Regression of Mammary Preneoplasia Furth, Priscilla Georgetown University Mouse model 2004-2009
Somatic Genetic Changes in Early Breast Cancer Geradts, Joseph Roswell Park Cancer Institute n=35 low grade DCIS samples, n=35 low grade DCIS samples associated with an invasive component 2005-2008
Immunologic Studies in Mouse and Human Breast Cancer Girardi, Anthony Coriell Institute for Medical Research    
Secreted Proteins as Breast Cancer Prevention Markers Gould, Michael University of Wisconsin, Madison Rat model 2003-2008
Neu Activation and the Etiology of Mammary Cancer Gould, Michael University of Wisconsin, Madison Cell lines  1993-1999
Characterizing a Breast Cancer Modifier Locus that Associated with Human Risk Gould, Michael University of Wisconsin, Madison Rat models and human studies 2006-2011
Modulation of Carcinogenesis by Monoterpenoids Gould, Michael University of Wisconsin, Madison Cell lines 1984-2000
Chemoprevention in a Mouse Model of DCIS Gregg, Jeffrey University of California, Davis Mouse model 2007-2009
CPG Island Methylator Phenotypes in Breast Cancer Huang, Tim H-M Ohio State Universtiy Human breast tumors 2007-2012
Wwox as a Critical Signal Mediator in Breast Can Huebner, Kay Ohio State Universtiy Breast cancer cell line and tissue 2006-2009
Cancer Prevention by Selenium-Enriched Allium Vegetables Ip, Clement  Roswell Park Cancer Institute   1980-2005
Molecular biomarkers of selenium chemoprevention Ip, Clement  Roswell Park Cancer Institute Human breast cell lines, mouse and rat models 2002-2008
Pilot -- AH Receptor in Human Breast Tumors Jensen, Roy Vanderbilt University Human breast carcinoma cell lines Not listed
Characterization of HIN1 Putative Tumor Supressor Krop, Ian Dana Farber Cancer Institute Normal and DCIS mammary epithelial cells 2002-2003
DNA Repair and Breast Cancer Latimer, Jean Magee Women's Health Corporation Tumor and non-tumor breast epithelium 1997-2005
Genomic Instability and Etiology of Extrogen Oncogenesis Li, Jonathan University of Kansas Medical Center   2003-2008
Application of Genomic Microarrays to Breast Cancer Lucito, Robert Cold Spring Harbor Laboratory   2002-2007
Differential Protein Expression by MALDI TOF MS Lubman, David University of Michigan, Ann Arbor Human breast epithelial cell line 2001-2004
MCF10DCIS.com As a Preclinical Chemopreventive Screen Miller, Fred Wayne State University Human breast epithelial cell line 2002-2005
Proteomics of Progression in MCF10 Xenograft Model Miller, Fred Wayne State University Human breast cell line  2002-2007
VP Peptides and Receptors in Diagnosis of Breast Cancer North, William Dartmouth College   2005-2007
GRSA Proteins in the Diagnosis of Breast Cancer North, William Dartmouth College   2001-2004
Molecular Genetic Markers of Pre-Malignant and Pre-Invasive Breast Disease O'Connell, Peter University of Texas Health Sciences Center Breast cancer specimens Not listed
Translational Research in Breast Cancer Osborne, Kent Baylor College of Medicine   1992-2007
Human Aldo Keto Reductases and Steroid Hormone Ac Penning, Trevor University of Pennsylvania Human breast cell lines and biopsy samples 2001-2007
Breast stem cell analysis in random periareolar fine needle aspirates from high r Petroff, Brian University of Kansas Medical Center Samples of breast tissue from women at high risk for breast cancer 2007-2009
Molecular Markers in DCIS Polyak, Kornelia Dana Farber Cancer Institute Benign, in situ, invasive breast tissue Not listed
HIN-1, A Novel Putative Breast Tumor Supressor Gene Polyak, Kornelia and Porter, Dale Dana Farber Cancer Institute Normal and cancerous breast tissue, and mouse model 2002-2008
Identification of Receptor for Tumor Suppressor HIN-1 Porter, Dale Dana Farber Cancer Institute Mammary epithelial cells 2002-2004
Epithelial-Stromal Cell Interactions in Breast Cancer Polyak, Kornelia Dana Farber Cancer Institute Human xenograft models in mice and human breast tumors 2006-2011
Immune Response to Breast Ductal Carcinoma In Situ Pruitt, Scott Duke University Guinea pig-to-Lewis rat model 1992-2000
Genetic Signatures of Preinvasive Breast Disease Rosenberg, Carol Boston Medical Center Breast cancer-containing tissue 2007-2008
Molecular Basis of Breast Cell Transformation Russo, Jose Fox Chase Cancer Center Human breast epithelial cells 1995-2000
Centrosome Hypertrophy in Human Breast Tumors Salisbury, Jeffrey Mayo Clinic College of Medicine Normal breast epithelial and breast tumor cell lines, and human breast tissue 1998-2001
Cripto in the Pathogeneis of Breast and Colon Cancer Salomon, David National Cancer Institute   2006
Prevention of Breast Cancer with Sphingolipids Schmelz, Eva Wayne State University Cell models for early and late stages of breast cancer 2003-2006
Molecular Markers for High Risk of Breast Cancer Smith, Helene University of California, San Francisco Cases of pure DCIS and DCIS associated with invasive cancers, and nonmalignant epithelium samples Not listed
Technology for Global and Quantitative Proteome Analysis Smith, Richard Battelle Pacific Northwest Laboratories  Breast tissue 2001-2003
Mechanisms of Mammary Gland Carcinogenesis of Heterocycl Snyderwine, Elizabeth National Cancer Institute Rat model, human breast tissue 2005
Molecular Alterations in Premalignant and In-Situ Breast Steeg, Patricia
   Cell lines Not listed
Molecular Markers for Breast Cancer Sukumar, Saraswati Johns Hopkins University Large panel of breast tumors 2000-2005
Selenium and Apoptosis in Cancer Prevention Thompson, Henry AMC Cancer Researh Center Rat model Not listed
Iron and Mammary Carcinogenesis Thompson, Henry AMC Cancer Researh Center Rat model 1996-2000
Risk Marker/Chemoprevention Target Identification Tlsty, Thea
 University of California, San Francisco Human mammary epithelial cells and human breast tissue 2003-2007
14-3-3zeta in ErbB2 Mediated Mammary Carcinogenesis Yu, Dihua University of Texas MD Anderson Cancer Center Mammary epithelial cells 2005-2010
14-3-3zeta in Early Stages of Breast Cancer Progression Yu, Dihua University of Texas MD Anderson Cancer Center Mammary epithelial cells and tissues from patients 2004-2009
Gene Amplification in Breast Cancer Wigler, Michael Sloan-Kettering Institute for Cancer Research   Not listed

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Other Studies
Project Title Principal Investigator Institution Project Start & End Years
SPORE in Breast Cancer Arteaga, Carlos L  Vanderbilt University 2003-2008
SPORE in Breast Cancer Bland, Kirby University of Alabama 2000-2007
SPORE in Breast Cancer Davidson, Nancy Johns Hopkins University 2000-2011
SPORE in Breast Cancer Earp, H University of North Carolina, Chapel Hill 1992-2006
SPORE in Breast Cancer Gray, Joe University of California San Francisco 1992-2007
SPORE in Breast Cancer Iglehart, James Dana Farber Cancer Institute/Harvard 2000-2008
San Francisco Mammography Registry -- A Research Resource Kerlikowske, Karla University of California, San Francisco 1994-2010
High Risk Patients and Families Core Li, Frederick Dana Farber Cancer Institute Not listed
Tissue and Outcomes Core Ljung, Britt-Marie University of California, San Francisco 2003-2007
Translational Research in Breast Cancer Osborne, C Kent Baylor College of Medicine 1992-2007
Cell Resources Core Pauley, Robert Wayne State University Not listed
Pathology Core Rosen, Peter Sloan-Kettering Institute for Cancer Research Not listed
Human Specimen Resource and Database Core Sherman, Mark Johns Hopkins University Not listed
Breast Cancer Cell Line Resource Core Ziff, Barbara Georgetown University Not listed

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Last modified:
29 Oct 2007
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