Absorption
- The passage of a chemical or drug across the tissue of the
gastrointestinal tract into the bloodstream that goes to the
liver, where it may undergo metabolism before entry into the
general circulation of the bloodstream.
Bioavailability
- The extent to which a chemical or drug crosses the tissue of
the gastrointestinal tract and through the liver, and enters the
general circulation of the bloodstream either as active drug or
metabolite(s).
Colostrum
- Breast fluid that is secreted during the first few days after
birth, before the onset of mature milk.
Concentration
- The amount of a substance in a given volume of body fluid.
The same as Level.
Ductus Arteriosus
- A blood vessel that connects the left pulmonary artery and
the aorta of the fetus.
Exclusive
Breastfeeding
- Feeding an infant with breastmilk alone, with no other intake
whatsoever. According to the American Academy of Pediatrics and
the World Health Organization, breastfeeding should be exclusive
breastfeeding for the first six months of the baby's life.
Excretion
- The elimination of a chemical or drug from the body, either
as unchanged drug or its metabolite(s), usually by the
kidneys.
Expressed Milk
- Milk that is extracted from the breast by means other than
nursing, such as by hand or using a breast pump.
Foremilk
- The first milk that is excreted from the breast at the
beginning of a nursing bout or at the beginning of expression. It
is relatively low in fat.
Galactorrhea
- Abnormal production of milk in nonpregnant, nonlactating
women or in men.
Gram (g)
- A unit of weight equal to about one-thirtieth of an
ounce.
Half-life
- The time required for one-half of the total concentration of
a chemical or drug in a body fluid, usually the general
bloodstream, to be eliminated. It takes two half-lives for 75% of
a drug to be eliminated and 5 half-lives for 97% of a drug to be
eliminated.
Hindmilk
- The last milk that is excreted from the breast at the end of
a nursing bout or at the end of expression. It is relatively high
in fat.
Infant
- A young child, from birth through one year of age.
In Utero
- Within the uterus.
Kilogram (kg)
- A unit of weight equal to 1,000 grams.
Lactation
- The normal secretion of milk by the breast following
pregnancy.
Level
- The amount of a substance in a given volume of body fluid.
The same as Concentration.
Liter (L)
- A volume of liquid equal to about 1.05 quarts.
Metabolism
- The process of the body's breaking down one chemical or drug
into another. Metabolism changes a substance into active or
inactive metabolite(s).
Metabolite
- A chemical or drug that is formed by the actions of the body,
usually the liver, on the parent compound. The metabolite may be
inactive or have activity that is the same or different from the
parent substance.
Microgram (mcg)
- One-millionth of a gram.
Milligram (mg)
- One-thousandth of a gram.
Milliliter (mL)
- One-thousandth of a liter of liquid.
Neonate
- An infant of 28 days of age or less. Same as a Newborn.
Newborn
- An infant of 28 days of age or less. Same as a Neonate.
Parent compound
- The original chemical or drug that is taken by the
mother.
Peak
- The highest concentration of a chemical, drug or metabolite
within a body fluid.
Plasma
- The fluid portion of the blood which contains no red or white
blood cells.
Postpartum
- The time right after delivery of an infant.
Prenatal
- Before birth.
Preterm
- Delivery of an infant prior to the 37th week of
gestation.
Prodrug
- A drug that is inactive when taken and then metabolized in
the body to an active drug.
Prolactin
- A hormone produced by the pituitary gland that stimulates
milk production.
Serum
- The clear fluid portion of the blood which contains no red or
white blood cells or blood platelets.
Steady-state
- The time at which the concentration of a substance remains
constant (such as in blood), because the rate of drug
administration equals the rate of drug elimination from the
body.
Trough
- The lowest concentration of a chemical, drug or metabolite
within in a body fluid.
Weight-adjusted
Dosage
- The dosage of a drug divided by the weight of the
individual.
|