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Nominations to the Testing Program
Nominations to the Testing Program
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* Note: The terms "initial toxicological characterization" and "comprehensive toxicological characterization" in this table refer to the approximate scope of a research program to address toxicological data needs. The types of toxicological studies that would be considered by NTP staff during the conceptualization and design of a research program for each are:
See here for further Description of NTP Study Types.
For information, questions or comments, contact:
Dr. Scott A. Masten
Director, Office of Nomination and Selection
National Toxicology Program
National Institute of Environmental Health Sciences
Substance
[CAS No.] |
Nominated by |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Bisphenol AF
[1478-61-1] |
National Institute of Environmental Health Sciences | Moderate production and use in polymer synthesis; short-term studies suggest potential for endocrine disruption and adverse reproductive effects; lack of adequate toxicity data |
|
Substance
[CAS No.] |
Nominated by |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Dimethylamine borane
[74-94-2] |
National Institute for Occupational Safety and Health | Possible contact sensitizer and systemic toxicant but insufficient evidence as determined by the NIOSH Dermal Subject Matter Expert Workgroup |
|
Substance
[CAS No.] |
Nominated by |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Ethylene glycol 2-ethylhexyl ether
[1559-35-9] |
National Institute of Environmental Health Sciences | High production volume; potential worker exposures; suspicion of toxicity based on chemical structure; lack of adequate toxicity data |
|
Substance
[CAS No.] |
Nominated by |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Hydroxyurea
[127-07-1]
|
|
Long term safety concern when used as therapy for sickle cell anemia; NTP Center for the Evaluation of Risks to Human Reproduction (CERHR) Expert Panel identified a critical data need for multi-generation experimental animal studies to assess the long-term effects of prenatal and postnatal exposures on postnatal development including developmental neurotoxicity, reproductive function, and carcinogenicity | No experimental animal toxicity studies at this time; human studies currently being considered by the NIH and other federal agencies may address outstanding safety concerns |
Substance
[CAS No.] |
Nominated by |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
---|---|---|---|
L-beta-Methylaminoalanine
[15920-93-1] |
National Institute of Environmental Health Sciences | Natural product of cyanobacteria with localized and potentially widespread environmental occurrence; suspected risk factor for neurological disease(s); lack of adequate toxicity data |
|
Substance
[CAS No.] |
Nominated by |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
---|---|---|---|
Triclosan
[3380-34-5] |
|
Widespread use in consumer products; frequent and long-term exposure for all age groups; lack of adequate toxicity data for dermal exposures |
|
Web page last updated on October 21, 2008
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.