| Principal Investigators
Maribeth V.
Eiden, Ph.D. |
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Dr.
Eiden is chief of the Section on Molecular Virology
in the NIMH Intramural Research Program (IRP). She received
her undergraduate degree in microbiology at the University
of Maryland, her doctoral degree in genetics at George
Washington University, and joined the Laboratory of
Cell Biology (now the Laboratory of Cellular and Molecular
Regulation) in 1986.
Dr. Eiden serves on the review board of Journal of Virology,
is chairman of the NIH Intramural Biosafety Committee
and is as a member of NIAID Virology Study Section. |
Research Interests |
The
Section on Molecular Virology expects to consolidate
progress in virus-mediated gene delivery, especially
in its application to gene transfer into fully differentiated
cells, and to determine critical post-binding steps
in viral entry exploitable for gene therapeutic application.
The study of emerging viruses, and the role of viral
envelope/receptor interactions in host range and pathogenicity,
is an important new focus of the group.
Dr. Eidens group is using the GALV receptor/phosphate
transporter as a model for integral membrane biogenesis
of a polytopic protein. Her laboratory has determined
that a region of the GALV receptor previously assumed
to function as the virus attachment site functions instead
as a topogenic determinant regulating the membrane integration
of this cell surface protein. She also has embarked
on the study of GALV as a model for emerging infections
in other mammalian species. Evidence of GALVs
ability to jump species has been most recently observed
in koalas where it is implicated in leukemias and lymphomas
and in immunosuppression within this marsupial population. |
Representative Selected Recent Publications: |
- Gemeniano M, Mpanju O, Salomon DR, Eiden MV, Wilson CA:
The infectivity and host range of the ecotropic porcine endogenous retrovirus, PERV-C, is modulated by residues in the C-terminal region of its surface envelope protein.
Virology, 2006, in press.
- Farrell KB, Eiden MB:
Dissection of gammaretroviral receptor function by using type III phosphate transporters as models.
Journal of Virology, 79: 9332-9336, 2005. (View PDF)
- Wang W, Jobbagy Z, Bird TH, Eiden MV, Anderson WB:
Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced synctium formation.
Journal Biological Chemistry, 280: 16772-16782, 2005. (View PDF)
- Feldman SA, Farrell KB, Murthy RK, Russ JL, Eiden MB:
Identification of an extracellular domain within the human PiT2 receptor that is required for amphotropic murine leukemia virus binding.
Journal of Virology, 78: 595-602, 2004. (View PDF)
- Khadeer MA, Tang Z, Tenenhouse HS, Eiden MV, Murer H, Hernando N, Weinman EJ, Chellaiah MA, Gupta A:
Na+-dependent phosphate transporters in the murine osteoclast: cellular distribution and protein interactions.
American Journal of Physiology, Cell Physiology, 284: C1633-44, 2003. (View PDF)
- Faix, P.H., S. A. Feldman, J. Overbaugh, and M. V. Eiden: Host
range and receptor binding properties of vectors bearing Feline Leukemia virus subgroup B envelopes is modulated by envelope sequences outside of the
receptor binding domain. Journal of Virology 76:12369-12375, 2002. (View PDF)
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